SG11201705019PA - Botulinum toxin prefilled container - Google Patents

Botulinum toxin prefilled container

Info

Publication number
SG11201705019PA
SG11201705019PA SG11201705019PA SG11201705019PA SG11201705019PA SG 11201705019P A SG11201705019P A SG 11201705019PA SG 11201705019P A SG11201705019P A SG 11201705019PA SG 11201705019P A SG11201705019P A SG 11201705019PA SG 11201705019P A SG11201705019P A SG 11201705019PA
Authority
SG
Singapore
Prior art keywords
botulinum toxin
prefilled container
toxin prefilled
container
botulinum
Prior art date
Application number
SG11201705019PA
Inventor
Markus Vogt
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52302037&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201705019P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of SG11201705019PA publication Critical patent/SG11201705019PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0222—Materials for reducing friction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
SG11201705019PA 2014-12-23 2015-12-22 Botulinum toxin prefilled container SG11201705019PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14004394 2014-12-23
PCT/EP2015/002602 WO2016102068A1 (en) 2014-12-23 2015-12-22 Botulinum toxin prefilled container

Publications (1)

Publication Number Publication Date
SG11201705019PA true SG11201705019PA (en) 2017-07-28

Family

ID=52302037

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201705019PA SG11201705019PA (en) 2014-12-23 2015-12-22 Botulinum toxin prefilled container

Country Status (15)

Country Link
US (3) US10549042B2 (en)
EP (2) EP3236939B1 (en)
JP (1) JP6798993B2 (en)
KR (1) KR102557798B1 (en)
CN (1) CN107106780B (en)
AR (1) AR103243A1 (en)
AU (1) AU2015371726B2 (en)
CA (1) CA2971238C (en)
ES (1) ES2788999T3 (en)
IL (1) IL252749B (en)
MX (1) MX2017007476A (en)
RU (1) RU2694820C9 (en)
SG (1) SG11201705019PA (en)
TW (1) TWI669129B (en)
WO (1) WO2016102068A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1861112A4 (en) * 2005-03-03 2009-07-22 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
NO2379104T3 (en) 2008-12-31 2018-07-28
JP6043627B2 (en) 2009-06-25 2016-12-14 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Botulinum toxin preparation without albumin
KR102557798B1 (en) * 2014-12-23 2023-07-19 메르츠 파마 게엠베하 운트 코. 카가아 Botulinum Toxin Prefilled Containers
US10406290B2 (en) * 2015-02-03 2019-09-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled plastic syringe
CN116870298A (en) * 2016-07-11 2023-10-13 贝克顿迪金森法国公司 Method for reducing the amount of sub-visible particles in a pharmaceutical composition
MX2019009860A (en) 2017-03-24 2019-10-15 Merz Pharma Gmbh & Co Kgaa Improved use of botulinum neurotoxin in the treatment of sialorrhea.
KR102091452B1 (en) * 2017-12-19 2020-03-20 대화제약 주식회사 Method for preparing prefilled syringe comprising local anesthetics and hyaluronic acid hydrogel
JP2022521237A (en) 2019-02-21 2022-04-06 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン New uses of botulinum neurotoxin for the treatment of tremor
EP3851421A1 (en) * 2020-01-16 2021-07-21 Schott Ag Glass container for pharamceutical, medical or cosmetic applications
JP2023521123A (en) * 2020-04-08 2023-05-23 メディトックス インク． Botulinum toxin pre-filled syringe dosage form that is easy to control and stable

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2604597Y2 (en) * 1993-03-02 2000-05-22 生化学工業株式会社 Drug injection
JP3634560B2 (en) * 1997-05-20 2005-03-30 テルモ株式会社 Filled chemical container
TW574036B (en) 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
EP1398038B2 (en) * 2000-02-08 2011-01-26 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20060269575A1 (en) 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
AU2001266557A1 (en) * 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
US7374896B2 (en) 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US7183066B2 (en) 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
DE10333317A1 (en) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulation for protein medicines without the addition of human serum albumin (HSA)
US20050075611A1 (en) 2003-10-01 2005-04-07 Hetzler Kevin G. Low extractable, thermoplastic syringe and tip cap
US8379864B2 (en) 2004-07-09 2013-02-19 Nokia Corporation Software plug-in framework to modify decryption methods in terminals
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
US20080045889A1 (en) * 2004-07-21 2008-02-21 Gerondale Scott J Botoxo Needle Injector
DE102004043009A1 (en) 2004-09-06 2006-03-23 Toxogen Gmbh Transport protein for introducing chemical compounds into nerve cells
DE102005019302A1 (en) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier for targeting nerve cells
US8137677B2 (en) 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
EP1834962A1 (en) 2006-03-15 2007-09-19 Biotecon Therapeutics GmbH PEGylated mtutated Clostridium botulinum toxin
EP2081964A4 (en) * 2006-10-12 2012-07-11 Univ Johns Hopkins Alginate and alginate lyase compositions and methods of use
EP2094780B1 (en) 2006-12-22 2010-10-20 Basell Poliolefine Italia S.R.L. Polyolefin composition for pipe systems and sheets
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
EP2117584B1 (en) * 2007-02-15 2013-10-09 Allergan, Inc. Use of botulinum toxin and enzymes for treating bladder disorders
CA2686637A1 (en) 2007-06-01 2008-12-04 Merz Pharma Gmbh & Co. Kgaa Process for providing a temperature - stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in solid form
EP2048156A1 (en) * 2007-10-12 2009-04-15 Merz Pharma GmbH & Co.KGaA Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
EP1997509A1 (en) * 2007-06-01 2008-12-03 Merz Pharma GmbH & Co.KGaA Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
WO2009003010A2 (en) 2007-06-25 2008-12-31 Becton, Dickinson And Company Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution
KR101087017B1 (en) * 2007-07-10 2011-12-09 (주)메디톡스 Stable liquid composition of Botulinum Toxin
WO2009015840A2 (en) 2007-07-27 2009-02-05 Merz Pharma Gmbh & Co. Kgaa Polypeptide for targeting of neural cells
EP3556770A1 (en) 2008-03-14 2019-10-23 Allergan, Inc. Immuno-based botulinum toxin serotype a activity assays
WO2010022979A1 (en) 2008-08-29 2010-03-04 Merz Pharma Gmbh & Co. Kgaa Clostridial neurotoxins with altered persistency
US9066851B2 (en) 2008-12-04 2015-06-30 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
US20100216667A1 (en) 2008-12-17 2010-08-26 Meyer Brian K Method for determining compatibility of an active pharmaceutical ingredient with materials
US8535062B2 (en) * 2008-12-23 2013-09-17 Simskin, Llc Cutaneous surgical training model of the head, neck and shoulders
NO2379104T3 (en) * 2008-12-31 2018-07-28
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
JP6043627B2 (en) 2009-06-25 2016-12-14 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Botulinum toxin preparation without albumin
CN102471765B9 (en) 2009-07-02 2016-07-27 莫茨制药有限及两合公司 Neurotoxins exhibiting shortened biological activity
EP2839855A3 (en) 2009-10-19 2015-08-19 Terumo Medical Corporation Syringe assemblies having detachable needle assemblies and low dead space
US10471212B2 (en) * 2009-10-29 2019-11-12 W. L. Gore & Associates, Inc. Silicone free drug delivery devices
WO2011080543A1 (en) * 2009-12-31 2011-07-07 Becton Dickinson France Medical components having coated surfaces exhibiting low friction and/or low gas/liquid permeability
US20130078295A1 (en) * 2010-06-09 2013-03-28 Lipotec S.A. Skin antiaging treatment
MX2013003677A (en) 2010-10-06 2013-05-31 Allergan Inc System for storage and subsequent handling of botulinum toxin.
US9217172B2 (en) 2011-09-29 2015-12-22 Cellsnap, Llc Compositions and methods for toxigenicity testing
EP4218937A3 (en) 2011-10-31 2023-10-25 F. Hoffmann-La Roche AG Anti-il13 antibody formulations
ES2638333T3 (en) 2011-11-09 2017-10-19 Merz Pharma Gmbh & Co. Kgaa Neurotoxins that have reduced biological activity
CN103930595A (en) * 2011-11-11 2014-07-16 Sio2医药产品公司 Passivation, ph protective or lubricity coating for pharmaceutical package, coating process and apparatus
US20150297800A1 (en) * 2012-07-03 2015-10-22 Sio2 Medical Products, Inc. SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS
US9133412B2 (en) 2012-07-09 2015-09-15 Tribofilm Research, Inc. Activated gaseous species for improved lubrication
WO2014026161A1 (en) * 2012-08-10 2014-02-13 Aquavit Pharmaceuticals, Inc. Vitamin supplement compositions for injection
US10980865B2 (en) * 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2015020982A2 (en) * 2013-08-04 2015-02-12 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2014052792A1 (en) 2012-09-28 2014-04-03 Sio2 Medical Products, Inc. Halogenated or parylene polymer coating
EP2961858B1 (en) * 2013-03-01 2022-09-07 Si02 Medical Products, Inc. Coated syringe.
US9937099B2 (en) * 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
CN110074968B (en) * 2013-03-11 2021-12-21 Sio2医药产品公司 Coated packaging material
WO2014144926A1 (en) * 2013-03-15 2014-09-18 Sio2 Medical Products, Inc. Coating method
JP6608357B2 (en) 2013-06-28 2019-11-20 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー Means and methods for determining biological activity of neurotoxin polypeptides in cells
WO2015014487A1 (en) * 2013-07-30 2015-02-05 Merz Pharma Gmbh & Co. Kgaa Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof
DE102014101305A1 (en) * 2014-02-03 2015-08-06 Heraeus Medical Gmbh Device for storing and mixing bone cement
RU2708974C2 (en) 2014-10-30 2019-12-12 Ф. Хоффманн-Ля Рош Аг Syringe and syringe preparation method
KR102557798B1 (en) * 2014-12-23 2023-07-19 메르츠 파마 게엠베하 운트 코. 카가아 Botulinum Toxin Prefilled Containers
US10406290B2 (en) * 2015-02-03 2019-09-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled plastic syringe
WO2016187078A1 (en) * 2015-05-15 2016-11-24 Carilion Clinic Syringes and methods of using them to treat overactive bladder
US20180128133A1 (en) * 2015-05-15 2018-05-10 Eaton Corporation Latch orientation mechanism
US9827282B2 (en) * 2015-07-24 2017-11-28 Bao Tran Medication dispensing system
US10110405B2 (en) 2015-11-05 2018-10-23 Qualcomm Incorporated System and method for narrowband uplink single tone transmissions
TWI737742B (en) * 2016-06-22 2021-09-01 德商梅茲製藥有限兩合公司 Botulinum toxin prefilled syringe system, kit having the same and use thereof

Also Published As

Publication number Publication date
RU2017120836A3 (en) 2019-01-31
AU2015371726B2 (en) 2020-10-22
US20210316077A1 (en) 2021-10-14
EP3236939B1 (en) 2020-04-01
IL252749A0 (en) 2017-08-31
RU2017120836A (en) 2019-01-24
RU2694820C2 (en) 2019-07-17
EP3236939A1 (en) 2017-11-01
EP3590500A1 (en) 2020-01-08
AR103243A1 (en) 2017-04-26
US10549042B2 (en) 2020-02-04
CA2971238A1 (en) 2016-06-30
US20200121855A1 (en) 2020-04-23
JP6798993B2 (en) 2020-12-09
US20170340823A1 (en) 2017-11-30
WO2016102068A1 (en) 2016-06-30
CN107106780B (en) 2020-10-16
TW201636046A (en) 2016-10-16
KR102557798B1 (en) 2023-07-19
AU2015371726A1 (en) 2017-07-06
IL252749B (en) 2020-09-30
RU2694820C9 (en) 2019-08-12
CN107106780A (en) 2017-08-29
JP2018500109A (en) 2018-01-11
US11167090B2 (en) 2021-11-09
TWI669129B (en) 2019-08-21
CA2971238C (en) 2022-12-13
MX2017007476A (en) 2018-01-25
ES2788999T3 (en) 2020-10-23
KR20170103837A (en) 2017-09-13

Similar Documents

Publication Publication Date Title
IL286448A (en) Auto-injector
IL253429B (en) Botulinum toxin prefilled container
IL256063A (en) Autoinjector
IL252749B (en) Botulinum toxin prefilled container
AU362787S (en) Containers
GB201407352D0 (en) Container
AU355959S (en) Container
AU355958S (en) Container
GB201403902D0 (en) Container assembly
AU360618S (en) Container
GB201406075D0 (en) Container
AU359811S (en) Container
AU360000S (en) Container
AU361947S (en) Container
PL3122658T3 (en) Container having inner spacer element
TWM488998U (en) Syringe
GB201408162D0 (en) Container
GB201400437D0 (en) Container
GB201400222D0 (en) Sub-dividable container
PL3377148T3 (en) Autoinjector
SG11201704819WA (en) Syringe
GB201417037D0 (en) Containers
GB201402610D0 (en) Container
AU362786S (en) Containers
AU361340S (en) Container