SG11201704577TA - Bispecific antibodies against cd3epsilon and bcma - Google Patents
Bispecific antibodies against cd3epsilon and bcmaInfo
- Publication number
- SG11201704577TA SG11201704577TA SG11201704577TA SG11201704577TA SG11201704577TA SG 11201704577T A SG11201704577T A SG 11201704577TA SG 11201704577T A SG11201704577T A SG 11201704577TA SG 11201704577T A SG11201704577T A SG 11201704577TA SG 11201704577T A SG11201704577T A SG 11201704577TA
- Authority
- SG
- Singapore
- Prior art keywords
- bcma
- antibodies against
- bispecific antibodies
- cd3epsilon
- against cd3epsilon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14194151.8A EP3023437A1 (en) | 2014-11-20 | 2014-11-20 | Bispecific antibodies against CD3epsilon and BCMA |
| PCT/EP2015/076959 WO2016079177A1 (en) | 2014-11-20 | 2015-11-18 | Bispecific antibodies against cd3epsilon and bcma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201704577TA true SG11201704577TA (en) | 2017-07-28 |
Family
ID=51945756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201704577TA SG11201704577TA (en) | 2014-11-20 | 2015-11-18 | Bispecific antibodies against cd3epsilon and bcma |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170327579A1 (en) |
| EP (2) | EP3023437A1 (en) |
| JP (1) | JP2018502062A (en) |
| KR (1) | KR20170109529A (en) |
| CN (1) | CN107428839A (en) |
| AU (1) | AU2015348380A1 (en) |
| CA (1) | CA2968443A1 (en) |
| SG (1) | SG11201704577TA (en) |
| WO (1) | WO2016079177A1 (en) |
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| AU2012264890C1 (en) | 2011-05-27 | 2016-03-10 | Glaxo Group Limited | BCMA (CD269/TNFRSF17) -binding proteins |
| TWI687439B (en) | 2011-06-30 | 2020-03-11 | 中外製藥股份有限公司 | Heterodimerized polypeptide |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| TWI679212B (en) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | Binding molecules for e3 of bcma and cd3 |
| ES2816078T3 (en) | 2011-12-20 | 2021-03-31 | Medimmune Llc | Modified Polypeptides for Bispecific Antibody Scaffolds |
| WO2013154760A1 (en) | 2012-04-11 | 2013-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
| NZ630551A (en) | 2012-04-20 | 2017-11-24 | Merus Nv | Methods and means for the production of ig-like molecules |
| SG11201407644UA (en) | 2012-06-05 | 2014-12-30 | Regeneron Pharma | Methods for making fully human bispecific antibodies using a common light chain |
| KR20150064068A (en) * | 2012-10-08 | 2015-06-10 | 로슈 글리카트 아게 | FC-FREE ANTIBODIES COMPRISING TWO Fab-FRAGMENTS AND METHODS OF USE |
| CN104968682A (en) | 2013-02-05 | 2015-10-07 | 英格玛布股份公司 | Bispecific antibodies against CD3[epsilon] and BCMA |
| US10047163B2 (en) | 2013-02-08 | 2018-08-14 | Abbvie Stemcentrx Llc | Multispecific constructs |
| RU2015140915A (en) * | 2013-02-26 | 2017-04-03 | Роше Гликарт Аг | BSPECIFIC ANTI-BINDING MOLECULES ACTIVATING T-CELLS |
| AR095374A1 (en) * | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | UNION MOLECULES FOR BCMA AND CD3 |
-
2014
- 2014-11-20 EP EP14194151.8A patent/EP3023437A1/en not_active Ceased
-
2015
- 2015-11-18 SG SG11201704577TA patent/SG11201704577TA/en unknown
- 2015-11-18 AU AU2015348380A patent/AU2015348380A1/en not_active Abandoned
- 2015-11-18 WO PCT/EP2015/076959 patent/WO2016079177A1/en active Application Filing
- 2015-11-18 JP JP2017527591A patent/JP2018502062A/en active Pending
- 2015-11-18 CA CA2968443A patent/CA2968443A1/en not_active Abandoned
- 2015-11-18 KR KR1020177016520A patent/KR20170109529A/en unknown
- 2015-11-18 EP EP15797085.6A patent/EP3221354A1/en not_active Withdrawn
- 2015-11-18 US US15/528,325 patent/US20170327579A1/en not_active Abandoned
- 2015-11-18 CN CN201580074033.3A patent/CN107428839A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3023437A1 (en) | 2016-05-25 |
| EP3221354A1 (en) | 2017-09-27 |
| KR20170109529A (en) | 2017-09-29 |
| US20170327579A1 (en) | 2017-11-16 |
| AU2015348380A1 (en) | 2017-06-15 |
| WO2016079177A1 (en) | 2016-05-26 |
| CN107428839A (en) | 2017-12-01 |
| JP2018502062A (en) | 2018-01-25 |
| CA2968443A1 (en) | 2016-05-26 |
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