SG11201702831XA - Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes - Google Patents

Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Info

Publication number
SG11201702831XA
SG11201702831XA SG11201702831XA SG11201702831XA SG11201702831XA SG 11201702831X A SG11201702831X A SG 11201702831XA SG 11201702831X A SG11201702831X A SG 11201702831XA SG 11201702831X A SG11201702831X A SG 11201702831XA SG 11201702831X A SG11201702831X A SG 11201702831XA
Authority
SG
Singapore
Prior art keywords
translocation
quantification
identification
nucleic acid
copy number
Prior art date
Application number
SG11201702831XA
Inventor
Francis Barany
John William Efcavitch
Rueda Cristian Ruiz
Jianmin Huang
Philip B Feinberg
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of SG11201702831XA publication Critical patent/SG11201702831XA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
SG11201702831XA 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes SG11201702831XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061376P 2014-10-08 2014-10-08
US201562103894P 2015-01-15 2015-01-15
PCT/US2015/054759 WO2016057832A2 (en) 2014-10-08 2015-10-08 Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention

Publications (1)

Publication Number Publication Date
SG11201702831XA true SG11201702831XA (en) 2017-05-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201702831XA SG11201702831XA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes
SG10202008961UA SG10202008961UA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202008961UA SG10202008961UA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Country Status (13)

Country Link
US (2) US10344321B2 (en)
EP (3) EP3690060B1 (en)
JP (3) JP6871160B2 (en)
CN (2) CN107002145B (en)
AU (2) AU2015330844B2 (en)
BR (1) BR112017007033B1 (en)
CA (2) CA2963687C (en)
DK (2) DK3204520T3 (en)
ES (2) ES2784342T3 (en)
IL (3) IL296204B1 (en)
PT (2) PT3690060T (en)
SG (2) SG11201702831XA (en)
WO (1) WO2016057832A2 (en)

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US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
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US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN109971852A (en) 2014-04-21 2019-07-05 纳特拉公司 Detect the mutation and ploidy in chromosome segment
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
ES2886640T3 (en) * 2017-04-03 2021-12-20 Qiagen Gmbh Method to analyze the expression of one or more biomarker RNA molecules
CN108179176B (en) * 2018-02-08 2021-08-03 斯格特生物 Method for detecting miRNA (micro ribonucleic acid) by carrying out bidirectional extension on two non-overlapping amplification primers based on miRNA bridging
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
US20190390282A1 (en) * 2018-05-22 2019-12-26 Biochain Institute, Inc. Target enrichment and sequencing of modified nucleic acids for human cancer detection
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN109385464A (en) * 2018-07-27 2019-02-26 中山大学附属第六医院 A kind of DNA methylation detection kit and method
CN109161594A (en) * 2018-08-17 2019-01-08 中山大学达安基因股份有限公司 A kind of method and its kit detecting BRAF gene mutation
CN108998535B (en) * 2018-09-11 2021-09-10 广州市宝创生物技术有限公司 KRAS gene multiple mutation site detection kit
BR112021006044A2 (en) * 2018-12-21 2021-06-29 Illumina, Inc. nuclease-based RNA depletion
US20220205050A1 (en) * 2019-05-03 2022-06-30 Cornell University Method and markers for identifying and quantifying of nucleic acid sequence, mutation, copy number, or methylation changes
EP3963095A4 (en) * 2019-05-03 2023-01-25 Cornell University Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
JP2023524067A (en) * 2020-05-01 2023-06-08 コーネル ユニバーシティー Methods for identification and relative quantification of nucleic acid sequence, mutation, copy number or methylation changes using nuclease, ligation, deamination, DNA repair and polymerase reactions in combination with carryover prevention and marker
JPWO2022149575A1 (en) * 2021-01-06 2022-07-14
JP2024507210A (en) * 2021-02-17 2024-02-16 エーシーティー ジェノミックス （アイピー） リミテッド DNA fragment linkage detection method and its kit
AU2022227563A1 (en) 2021-02-23 2023-08-24 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
US20230295741A1 (en) * 2022-03-21 2023-09-21 Billiontoone, Inc. Molecule counting of methylated cell-free dna for treatment monitoring

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Also Published As

Publication number Publication date
ES2784342T3 (en) 2020-09-24
DK3204520T3 (en) 2020-04-20
BR112017007033A2 (en) 2017-12-12
DK3690060T3 (en) 2022-01-17
IL286496A (en) 2021-10-31
JP2017533697A (en) 2017-11-16
JP7209762B2 (en) 2023-01-20
ES2904909T3 (en) 2022-04-06
IL251513B (en) 2021-10-31
EP4026914A1 (en) 2022-07-13
EP3204520A4 (en) 2018-03-07
PT3204520T (en) 2020-04-16
EP3204520B1 (en) 2020-02-12
JP2023040174A (en) 2023-03-22
WO2016057832A3 (en) 2016-06-16
US20190316187A1 (en) 2019-10-17
EP3204520A2 (en) 2017-08-16
AU2022200229A1 (en) 2022-02-10
EP3690060B1 (en) 2021-12-08
PT3690060T (en) 2022-01-27
JP6871160B2 (en) 2021-05-12
WO2016057832A2 (en) 2016-04-14
CA3187713A1 (en) 2016-04-14
SG10202008961UA (en) 2020-10-29
US11466311B2 (en) 2022-10-11
JP2021106608A (en) 2021-07-29
IL251513A0 (en) 2017-05-29
CN107002145A (en) 2017-08-01
AU2015330844A1 (en) 2017-04-27
CN113481281A (en) 2021-10-08
BR112017007033B1 (en) 2023-10-31
IL296204B1 (en) 2024-04-01
EP3690060A1 (en) 2020-08-05
CA2963687C (en) 2023-03-28
AU2015330844B2 (en) 2022-02-03
IL296204A (en) 2022-11-01
CN107002145B (en) 2021-07-30
CA2963687A1 (en) 2016-04-14
US10344321B2 (en) 2019-07-09
US20180265917A1 (en) 2018-09-20

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