SG11201701998XA - Triazole compounds as t-type calcium channel blockers - Google Patents
Triazole compounds as t-type calcium channel blockersInfo
- Publication number
- SG11201701998XA SG11201701998XA SG11201701998XA SG11201701998XA SG11201701998XA SG 11201701998X A SG11201701998X A SG 11201701998XA SG 11201701998X A SG11201701998X A SG 11201701998XA SG 11201701998X A SG11201701998X A SG 11201701998XA SG 11201701998X A SG11201701998X A SG 11201701998XA
- Authority
- SG
- Singapore
- Prior art keywords
- calcium channel
- channel blockers
- type calcium
- triazole compounds
- triazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2014069592 | 2014-09-15 | ||
PCT/EP2015/070934 WO2016041892A1 (en) | 2014-09-15 | 2015-09-14 | Triazole compounds as t-type calcium channel blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201701998XA true SG11201701998XA (en) | 2017-04-27 |
Family
ID=54106361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201701998XA SG11201701998XA (en) | 2014-09-15 | 2015-09-14 | Triazole compounds as t-type calcium channel blockers |
Country Status (16)
Country | Link |
---|---|
US (1) | US10246426B2 (en) |
EP (1) | EP3194374B1 (en) |
JP (1) | JP6500092B2 (en) |
KR (1) | KR102424750B1 (en) |
CN (1) | CN107074822B (en) |
AU (1) | AU2015317022B2 (en) |
CA (1) | CA2956816C (en) |
CL (1) | CL2017000616A1 (en) |
EA (1) | EA032873B1 (en) |
ES (1) | ES2693052T3 (en) |
IL (1) | IL251042A0 (en) |
MX (1) | MX367519B (en) |
PH (1) | PH12017500447A1 (en) |
PL (1) | PL3194374T3 (en) |
SG (1) | SG11201701998XA (en) |
WO (1) | WO2016041892A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA40281B1 (en) | 2014-06-03 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Pyrazole compounds and their use as calcium channel blocking agents of type t |
CN110072521B (en) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | Pharmaceutical combination comprising a T-type calcium channel blocker |
US10899695B2 (en) | 2017-02-06 | 2021-01-26 | Idorsia Pharmaceuticals Ltd | Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
KR102645911B1 (en) | 2017-07-05 | 2024-03-08 | 이도르시아 파마슈티컬스 리미티드 | N-[1-(5-cyano-pyridin-2-ylmethyl)-1H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-ah Crystalline Form of Setamide |
BR112022000429A2 (en) | 2019-07-11 | 2022-03-29 | Praxis Prec Medicines Inc | Formulations of t-type calcium channel modulators and methods of using them |
WO2023240205A1 (en) | 2022-06-10 | 2023-12-14 | Neurocrine Biosciences, Inc. | Deuterated compounds |
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AU695230B2 (en) | 1994-06-24 | 1998-08-06 | Euro-Celtique S.A. | Compounds for and method of inhibiting phosphodiesterase IV |
CZ225699A3 (en) | 1996-12-23 | 2000-09-13 | Du Pont Pharmaceuticals Company | Nitrogenous heteroaromatic compounds functioning as inhibitors of Xa factor |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
EP1353674A1 (en) | 2000-12-29 | 2003-10-22 | Alteon, Inc. | Method for treating glaucoma ivb |
EP1359911A2 (en) | 2000-12-29 | 2003-11-12 | Alteon, Inc. | Method for treating fibrotic diseases or other indications ivc |
WO2003037274A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
JP4286146B2 (en) | 2001-12-18 | 2009-06-24 | メルク エンド カムパニー インコーポレーテッド | Heteroaryl-substituted pyrazole modulators of metabotropic glutamate receptor-5 |
JP4299139B2 (en) | 2001-12-18 | 2009-07-22 | メルク エンド カムパニー インコーポレーテッド | Heteroaryl-substituted triazole modulators of metabotropic glutamate receptor-5 |
SE0201658D0 (en) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
JP2006522164A (en) | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | Diaryl-substituted pyrazole modulators of metabotropic glutamate receptor-5 |
WO2004089306A2 (en) | 2003-04-04 | 2004-10-21 | Merck & Co., Inc. | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 |
US20040220170A1 (en) | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
GB0328796D0 (en) | 2003-12-12 | 2004-01-14 | Biofocus Plc | Compounds which interact with the G-protein coupled receptor family |
GB0508472D0 (en) | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
GB0508463D0 (en) | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
JP2009521471A (en) | 2005-12-22 | 2009-06-04 | アイカジェン, インコーポレイテッド | Calcium channel antagonist |
AU2007238755B2 (en) | 2006-04-12 | 2012-07-12 | Merck Sharp & Dohme Llc | Pyridyl amide T-type calcium channel antagonists |
RU2009105818A (en) | 2006-07-24 | 2010-08-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Pyrazoles as glucokinase activators |
US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
US20110038850A1 (en) | 2007-01-05 | 2011-02-17 | Didier Bagnol | G Protein-Coupled Receptor and Modulators Thereof For The Treatment of Gaba-Related Neurological Disorders Including Sleep-Related Disorders |
US8367706B2 (en) | 2007-06-20 | 2013-02-05 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
DE102007047738A1 (en) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | imidazole derivatives |
JP5580201B2 (en) | 2007-10-08 | 2014-08-27 | アドビヌス・セラピューティクス・プライベート・リミテッド | Acetamide derivatives as glucokinase activators, their preparation and pharmaceutical applications |
KR20100072266A (en) | 2007-10-24 | 2010-06-30 | 머크 샤프 앤드 돔 코포레이션 | Heterocycle phenyl amide t-type calcium channel antagonists |
WO2009054982A1 (en) | 2007-10-24 | 2009-04-30 | Merck & Co., Inc. | Pyrazinyl amide t-type calcium channel antagonists |
US20100249176A1 (en) | 2007-10-24 | 2010-09-30 | Barrow James C | Heterocycle amide t-type calcium channel antagonists |
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WO2011022315A1 (en) | 2009-08-19 | 2011-02-24 | Merck Sharp & Dohme Corp. | Pyrazinyl phenyl amide t-type calcium channel antagonists |
US8987310B2 (en) | 2009-10-30 | 2015-03-24 | Merck Sharp & Dohme Corp. | Heterocycle amide T-type calcium channel antagonists |
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EP2402327B1 (en) | 2010-06-29 | 2018-03-07 | Impetis Biosciences Ltd. | Acetamide compounds as glucokinase activators, their process and medicinal applications |
KR20120063283A (en) | 2010-12-07 | 2012-06-15 | 제일약품주식회사 | Novel pyrazolopyridine derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same |
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US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
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KR101685993B1 (en) | 2014-05-15 | 2016-12-13 | 한국과학기술연구원 | N-(pyrazolylmethyl)arylsulfonamide compounds capable of inhibiting voltage gated calcium ion channel, and pharmaceutical compositions comprising the same |
MA40281B1 (en) * | 2014-06-03 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Pyrazole compounds and their use as calcium channel blocking agents of type t |
JP6728198B2 (en) | 2015-01-30 | 2020-07-22 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | Substituted triazoles and methods relating thereto |
-
2015
- 2015-09-14 MX MX2017003362A patent/MX367519B/en active IP Right Grant
- 2015-09-14 JP JP2017514443A patent/JP6500092B2/en active Active
- 2015-09-14 WO PCT/EP2015/070934 patent/WO2016041892A1/en active Application Filing
- 2015-09-14 CN CN201580049589.7A patent/CN107074822B/en active Active
- 2015-09-14 CA CA2956816A patent/CA2956816C/en active Active
- 2015-09-14 PL PL15763321T patent/PL3194374T3/en unknown
- 2015-09-14 SG SG11201701998XA patent/SG11201701998XA/en unknown
- 2015-09-14 EP EP15763321.5A patent/EP3194374B1/en active Active
- 2015-09-14 EA EA201790613A patent/EA032873B1/en not_active IP Right Cessation
- 2015-09-14 ES ES15763321T patent/ES2693052T3/en active Active
- 2015-09-14 AU AU2015317022A patent/AU2015317022B2/en active Active
- 2015-09-14 KR KR1020177010036A patent/KR102424750B1/en active IP Right Grant
- 2015-09-14 US US15/510,980 patent/US10246426B2/en active Active
-
2017
- 2017-03-09 PH PH12017500447A patent/PH12017500447A1/en unknown
- 2017-03-09 IL IL251042A patent/IL251042A0/en unknown
- 2017-03-14 CL CL2017000616A patent/CL2017000616A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112017005179A2 (en) | 2017-12-05 |
JP2017532309A (en) | 2017-11-02 |
MX2017003362A (en) | 2017-06-28 |
KR102424750B1 (en) | 2022-07-22 |
AU2015317022B2 (en) | 2020-01-16 |
AU2015317022A1 (en) | 2017-04-27 |
CA2956816A1 (en) | 2016-03-24 |
KR20170052686A (en) | 2017-05-12 |
EA201790613A8 (en) | 2018-10-31 |
CA2956816C (en) | 2023-02-14 |
EA032873B1 (en) | 2019-07-31 |
IL251042A0 (en) | 2017-04-30 |
EP3194374B1 (en) | 2018-08-01 |
MX367519B (en) | 2019-08-26 |
CN107074822A (en) | 2017-08-18 |
CL2017000616A1 (en) | 2017-11-24 |
CN107074822B (en) | 2020-01-03 |
PL3194374T3 (en) | 2019-01-31 |
BR112017005179A8 (en) | 2017-12-26 |
PH12017500447A1 (en) | 2017-07-31 |
US10246426B2 (en) | 2019-04-02 |
EA201790613A1 (en) | 2017-12-29 |
EP3194374A1 (en) | 2017-07-26 |
ES2693052T3 (en) | 2018-12-07 |
WO2016041892A1 (en) | 2016-03-24 |
US20180230109A1 (en) | 2018-08-16 |
JP6500092B2 (en) | 2019-04-10 |
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