SG11201700481YA - Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof - Google Patents
Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereofInfo
- Publication number
- SG11201700481YA SG11201700481YA SG11201700481YA SG11201700481YA SG11201700481YA SG 11201700481Y A SG11201700481Y A SG 11201700481YA SG 11201700481Y A SG11201700481Y A SG 11201700481YA SG 11201700481Y A SG11201700481Y A SG 11201700481YA SG 11201700481Y A SG11201700481Y A SG 11201700481YA
- Authority
- SG
- Singapore
- Prior art keywords
- salts
- ursodeoxycholic
- combinations
- preparation
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462030140P | 2014-07-29 | 2014-07-29 | |
US201462030147P | 2014-07-29 | 2014-07-29 | |
US201562128077P | 2015-03-04 | 2015-03-04 | |
PCT/CN2015/085350 WO2016015634A1 (en) | 2014-07-29 | 2015-07-28 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201700481YA true SG11201700481YA (en) | 2017-02-27 |
Family
ID=55216773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700481YA SG11201700481YA (en) | 2014-07-29 | 2015-07-28 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
Country Status (16)
Country | Link |
---|---|
US (4) | US10301303B2 (en) |
EP (1) | EP3174874B1 (en) |
JP (4) | JP6917144B2 (en) |
KR (2) | KR20230134598A (en) |
CN (2) | CN106687460B (en) |
AU (2) | AU2015296098B2 (en) |
BR (1) | BR112017001623B1 (en) |
CA (2) | CA3194562A1 (en) |
DK (1) | DK3174874T3 (en) |
EA (1) | EA032971B1 (en) |
ES (1) | ES2835874T3 (en) |
IL (3) | IL294063A (en) |
MX (3) | MX2017001372A (en) |
NZ (1) | NZ728488A (en) |
SG (1) | SG11201700481YA (en) |
WO (1) | WO2016015634A1 (en) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
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AU2016245590A1 (en) * | 2015-04-06 | 2017-10-19 | Shenzhen Hightide Biopharmaceutical, Ltd. | Conjugate compounds of ursodeoxycholic, berberine or L-carnitine, and compositions and methods thereof |
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US10471007B2 (en) * | 2016-12-16 | 2019-11-12 | Jeffrey R Olynyk | Sublingual therapeutic solutions and methods |
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Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5529075B2 (en) * | 1971-08-20 | 1980-07-31 | ||
IT1136624B (en) | 1981-05-21 | 1986-09-03 | Erregierre Ind Chim Spa | COLIC ACID SALTIFICATION PRODUCTS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT INCLUDE THEM AS AN ACTIVE PRINCIPLE |
JPS60163897A (en) | 1984-02-06 | 1985-08-26 | Tokyo Tanabe Co Ltd | Ursodeoxycholic acid meglumine salt and injection containing same |
JPS6256192A (en) | 1985-09-06 | 1987-03-11 | Hitachi Ltd | Thernal transfer material |
IT1245889B (en) | 1991-04-12 | 1994-10-25 | Alfa Wassermann Spa | PHARMACEUTICAL FORMULATIONS FOR ORAL USE GAS RESISTANT CONTAINING SALTS OF BILE ACIDS. |
JPH06256192A (en) | 1993-03-05 | 1994-09-13 | Nitsusui Seiyaku Kk | Production of liquid medicine |
FR2796551B1 (en) * | 1999-07-23 | 2003-07-25 | Lipha | NOVEL METFORMIN SALTS, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
KR20050081477A (en) | 2004-02-13 | 2005-08-19 | 켐젠주식회사 | Bile acid salt of amlodipine, the preparation method and pharmaceutical composition comprising the same for oral administration |
CN1759834B (en) | 2004-09-17 | 2010-06-23 | 中国医学科学院医药生物技术研究所 | Application of berberine or associated with Simvastatin in preparing product for preventing or curing disease or symptom related to blood fat |
CN1762367A (en) | 2004-10-18 | 2006-04-26 | 孙民富 | Ursodeoxycholic acid pills formula and its preparation method |
US20070116643A1 (en) | 2005-07-01 | 2007-05-24 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
WO2007005643A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxyphenylpropanamines |
CN101273024A (en) | 2005-07-29 | 2008-09-24 | 康瑟特制药公司 | Novel benzo[D][1,3]-dioxol derivatives |
CA2616366A1 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
CN100509840C (en) | 2006-05-10 | 2009-07-08 | 华中科技大学 | Tubeimuside and bile acid derivative and their medicine composition |
CN101113149B (en) * | 2006-07-25 | 2011-04-27 | 复旦大学 | Aliphatic organic acid salt of berberine type alkaloid and preparation method and usage thereof |
KR101394802B1 (en) * | 2007-02-28 | 2014-05-15 | 덴카 세이켄 가부시키가이샤 | Reagent for determination of quantity of small dense low-density lipoprotein |
EP2727915B1 (en) * | 2007-09-13 | 2016-04-13 | Concert Pharmaceuticals Inc. | Synthesis of deuterated catechols and benzo[d][1,3]dioxoles and derivatives thereof |
US8642094B2 (en) | 2008-05-01 | 2014-02-04 | Afexa Life Sciences Inc. | Synergistic pharmaceutical composition, method of making same and use of same |
IT1393095B1 (en) * | 2009-02-19 | 2012-04-11 | Prodotti Chimici Alimentari | PROCESS FOR SYNTHESIS OF THE DISODIUM SALT OF URSODESOSICOLICO ACID 3,7-DISOLPHATE. |
MX2011009757A (en) * | 2009-03-17 | 2012-02-28 | Axcan Pharma Inc | Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid. |
JP2010246578A (en) * | 2009-04-10 | 2010-11-04 | Utsunomiya Univ | Examination method and examination device for blood cholesterol |
CN101987860B (en) | 2009-08-06 | 2011-12-14 | 中山百灵生物技术有限公司 | Preparation method of ursodesoxycholic acid |
CN101879162A (en) * | 2010-02-23 | 2010-11-10 | 江苏格林生物科技有限公司 | Weight-losing medicament formed by matching alpha-ricinoleic acid ethyl ester with berberine |
WO2011155705A2 (en) * | 2010-06-10 | 2011-12-15 | (주)애드바이오텍 | Composition for inhibiting hyperlipidemia and obesity by inhibiting intestinal absorption of cholesterol |
CN101935319A (en) | 2010-09-09 | 2011-01-05 | 陕西科技大学 | Berberine organic acid salt, berberine organic acid salt inclusion compound and preparation methods thereof |
CN102078418B (en) | 2011-01-14 | 2012-04-18 | 广东药学院 | Compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder and preparation method thereof |
CN102225961A (en) | 2011-04-21 | 2011-10-26 | 东北林业大学 | Novel berberine 9-position coupled cholic acid derivative and preparation method thereof |
CN102370643A (en) | 2011-07-20 | 2012-03-14 | 吉林敖东集团大连药业股份有限公司 | Berberine hydrochloride medicinal composition and preparation method thereof |
CN104080471B (en) * | 2011-10-14 | 2018-08-10 | 诺华股份有限公司 | Antibody and method for Wnt approach relevant diseases |
CN102580087B (en) * | 2012-03-08 | 2013-08-21 | 董萍 | In-situ adipocyte composite inhibitor for local weight loss and body care of human bodies and preparation method thereof |
CN103319479B (en) | 2012-03-20 | 2015-08-26 | 王从品 | Rhubarb yellow berberine ion-pair compound, preparation method and application |
US8652518B2 (en) * | 2012-04-15 | 2014-02-18 | Jahahreeh Finley | Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation |
CN102702190B (en) * | 2012-07-02 | 2016-04-27 | 东北制药集团股份有限公司 | A kind of Berberine electrostatic complexes and preparation method thereof |
KR20150043505A (en) * | 2012-09-07 | 2015-04-22 | 사노피 | Fusion proteins for treating a metabolic syndrome |
CA2912302A1 (en) | 2013-05-14 | 2014-11-20 | University Of Prince Edward Island | Compositions and methods for treating cardiometabolic diseases and disorders |
CN103989677A (en) | 2013-12-20 | 2014-08-20 | 中国药科大学 | Use of demethyleneberberine in preparation of blood sugar-reduction drug |
US20150284406A1 (en) * | 2014-04-04 | 2015-10-08 | North American Biomedical Research Center Usa, Inc | Berberine-ursodeoxycholic acid conjugate for treating the liver |
WO2015183794A1 (en) * | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
CA3194562A1 (en) * | 2014-07-29 | 2016-02-04 | Shenzhen Hightide Biopharmaceutical, Ltd. | Berberine-ursodeoxycholic salt, method of preparation and application therof |
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