SG11201610857TA - Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof - Google Patents
Cultured mammalian limbal stem cells, methods for generating the same, and uses thereofInfo
- Publication number
- SG11201610857TA SG11201610857TA SG11201610857TA SG11201610857TA SG11201610857TA SG 11201610857T A SG11201610857T A SG 11201610857TA SG 11201610857T A SG11201610857T A SG 11201610857TA SG 11201610857T A SG11201610857T A SG 11201610857TA SG 11201610857T A SG11201610857T A SG 11201610857TA
- Authority
- SG
- Singapore
- Prior art keywords
- generating
- methods
- same
- stem cells
- cultured mammalian
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462018396P | 2014-06-27 | 2014-06-27 | |
PCT/US2015/038384 WO2015200920A1 (en) | 2014-06-27 | 2015-06-29 | Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201610857TA true SG11201610857TA (en) | 2017-01-27 |
Family
ID=54938873
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201610857TA SG11201610857TA (en) | 2014-06-27 | 2015-06-29 | Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof |
SG10201806498RA SG10201806498RA (en) | 2014-06-27 | 2015-06-29 | Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201806498RA SG10201806498RA (en) | 2014-06-27 | 2015-06-29 | Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US20170233698A1 (en) |
EP (1) | EP3161127A4 (en) |
JP (1) | JP2017522016A (en) |
KR (1) | KR20170020527A (en) |
CN (1) | CN107075469A (en) |
CA (1) | CA2953524A1 (en) |
IL (1) | IL249828A0 (en) |
MX (1) | MX2017000181A (en) |
SG (2) | SG11201610857TA (en) |
WO (1) | WO2015200920A1 (en) |
Families Citing this family (24)
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EP4036228A1 (en) * | 2015-11-13 | 2022-08-03 | Avellino Lab USA, Inc. | Methods for the treatment of corneal dystrophies |
KR101645901B1 (en) * | 2015-12-31 | 2016-08-04 | 가톨릭대학교 산학협력단 | Method for culturing limbal stem cell using amniotic membrane slide scaffold |
CN106011065B (en) * | 2016-07-15 | 2019-08-02 | 江苏大学 | Human eye bulbar conjunctiva triangular mass of mucous membrane growing from the inner corner of the eye stem cells strain |
CN106591220A (en) * | 2016-12-29 | 2017-04-26 | 深圳市永生原代细胞生物科技有限公司 | Human normal skin epithelial cell and use thereof |
WO2018131491A1 (en) * | 2017-01-13 | 2018-07-19 | 国立大学法人大阪大学 | Method for producing corneal epithelial cell mass |
US11851659B2 (en) | 2017-03-22 | 2023-12-26 | Novartis Ag | Compositions and methods for immunooncology |
WO2020018868A1 (en) * | 2018-07-19 | 2020-01-23 | Texas Tech University System | Corneal epithelial cells and their products for treating corneal diseases |
CN109321599B (en) * | 2018-09-27 | 2023-08-22 | 同济大学 | Construction and application of lineage tracing system in human pluripotent stem cells |
UY38427A (en) * | 2018-10-26 | 2020-05-29 | Novartis Ag | METHODS AND COMPOSITIONS FOR EYE CELL THERAPY |
WO2020160197A1 (en) * | 2019-01-29 | 2020-08-06 | The Regents Of The University Of California | Novel treatments of glaucoma |
CN109897823A (en) * | 2019-01-31 | 2019-06-18 | 华中科技大学 | A method of tissue engineering comea edge is prepared based on Matrigel |
JP2022528737A (en) * | 2019-04-01 | 2022-06-15 | ステムサイト オイ | How to Obtain or Maintain ABCG2-Positive Corneal Ring Stem Cells |
WO2021009778A2 (en) * | 2019-07-18 | 2021-01-21 | Pandorum Technologies Private Limited | Methods for culturing mesenchymal stem cells, products thereof, and applications thereof |
US20220265659A1 (en) * | 2019-09-02 | 2022-08-25 | Inserm (Institut National De La Santé Et De Al Recherche Médicale) | Methods and compositions for treating pax6-deficiency related disease |
EP4054595A4 (en) * | 2019-11-07 | 2023-11-15 | Massachusetts Eye and Ear Infirmary | Cultivated autologous limbal epithelial cell (calec) transplantation |
CN111500526B (en) * | 2020-03-31 | 2022-02-18 | 厦门大学 | Composition for in-vitro culture of primary mouse corneal epithelial cells and application thereof |
CN115667504A (en) * | 2020-04-27 | 2023-01-31 | 诺华股份有限公司 | Methods and compositions for ocular cell therapy |
CN113736735B (en) * | 2020-05-27 | 2024-02-20 | 深圳华大生命科学研究院 | Method and kit for in vitro induction of limbal-like stem cells |
WO2022139573A1 (en) * | 2020-12-23 | 2022-06-30 | Universiti Kebangsaan Malaysia | A corneal-healing device and method for producing the same |
CN112626019A (en) * | 2020-12-28 | 2021-04-09 | 武汉爱尔眼科医院有限公司 | Preparation method of single cell suspension of cornea and corneal limbus |
CN115068504A (en) * | 2021-03-12 | 2022-09-20 | 广州康睿生物医药科技股份有限公司 | Cornea repairing material and preparation method and application thereof |
WO2023182856A1 (en) * | 2022-03-24 | 2023-09-28 | 서울대학교산학협력단 | Pharmaceutical composition including rho-kinase inhibitor for prevention or treatment of cutaneous fibrotic disorders such as keloid, etc. and use thereof |
CN115094038A (en) * | 2022-07-15 | 2022-09-23 | 中国医学科学院北京协和医院 | Primary culture method of corneal stromal cells |
PL442250A1 (en) * | 2022-09-12 | 2024-03-18 | Acellmed Spółka Z Ograniczoną Odpowiedzialnością | Fibrin dressing containing corneal epithelial cells and method of producing the dressing |
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CN1289156C (en) * | 2003-07-25 | 2006-12-13 | 吕伟光 | Tissue engineering autologous cornea epithelium and its preparation method |
US20050186672A1 (en) | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
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JP2013000121A (en) * | 2011-06-16 | 2013-01-07 | Tokyo Women's Medical College | Epithelial cell culture medium, method for culturing epithelial cell using the same, and epithelial cell obtained therefrom |
ES2667620T3 (en) * | 2011-07-15 | 2018-05-11 | Osaka University | Method to prepare a corneal endothelial cell |
WO2013061608A1 (en) * | 2011-10-27 | 2013-05-02 | 国立大学法人東京医科歯科大学 | Technique for isolating/culturing colorectal epithelial stem cell, and technique for transplanting colorectal epithelium employing said technique |
JP5991368B2 (en) * | 2012-03-16 | 2016-09-14 | 株式会社日立製作所 | Cell sheet, cell culture method and cell culture apparatus |
CN102952779B (en) * | 2012-11-30 | 2014-07-16 | 山东大学 | Cultural method for inducing human embryonic stem cell to directionally differentiate into corneal limbal stem cell |
CN103053511A (en) * | 2012-12-10 | 2013-04-24 | 山东省眼科研究所 | Cornea metaphase preservation solution, and preparing and using methods thereof |
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2015
- 2015-06-29 KR KR1020177002448A patent/KR20170020527A/en unknown
- 2015-06-29 JP JP2016575401A patent/JP2017522016A/en active Pending
- 2015-06-29 MX MX2017000181A patent/MX2017000181A/en unknown
- 2015-06-29 CN CN201580046185.2A patent/CN107075469A/en active Pending
- 2015-06-29 US US15/322,423 patent/US20170233698A1/en not_active Abandoned
- 2015-06-29 WO PCT/US2015/038384 patent/WO2015200920A1/en active Application Filing
- 2015-06-29 CA CA2953524A patent/CA2953524A1/en not_active Abandoned
- 2015-06-29 SG SG11201610857TA patent/SG11201610857TA/en unknown
- 2015-06-29 SG SG10201806498RA patent/SG10201806498RA/en unknown
- 2015-06-29 EP EP15812593.0A patent/EP3161127A4/en not_active Withdrawn
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2016
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JP2017522016A (en) | 2017-08-10 |
EP3161127A4 (en) | 2018-06-06 |
MX2017000181A (en) | 2017-05-01 |
IL249828A0 (en) | 2017-02-28 |
WO2015200920A8 (en) | 2017-04-06 |
EP3161127A1 (en) | 2017-05-03 |
KR20170020527A (en) | 2017-02-22 |
CA2953524A1 (en) | 2015-12-30 |
WO2015200920A1 (en) | 2015-12-30 |
CN107075469A (en) | 2017-08-18 |
US20170233698A1 (en) | 2017-08-17 |
SG10201806498RA (en) | 2018-08-30 |
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