SG11201610636VA - Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor - Google Patents

Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor

Info

Publication number
SG11201610636VA
SG11201610636VA SG11201610636VA SG11201610636VA SG11201610636VA SG 11201610636V A SG11201610636V A SG 11201610636VA SG 11201610636V A SG11201610636V A SG 11201610636VA SG 11201610636V A SG11201610636V A SG 11201610636VA SG 11201610636V A SG11201610636V A SG 11201610636VA
Authority
SG
Singapore
Prior art keywords
active ingredient
preparation
method therefor
pharmaceutical preparation
containing entecavir
Prior art date
Application number
SG11201610636VA
Inventor
Hong Ryeol Jeon
Do-Woo Kwon
Bong-Sang Lee
Su-Jun Park
Jiyeong Han
Myeongcheol Kil
Min Seop Kim
Original Assignee
Ctc Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctc Bio Inc filed Critical Ctc Bio Inc
Publication of SG11201610636VA publication Critical patent/SG11201610636VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201610636VA 2014-06-20 2015-06-22 Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor SG11201610636VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140075457 2014-06-20
PCT/KR2015/006329 WO2015194923A1 (en) 2014-06-20 2015-06-22 Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor

Publications (1)

Publication Number Publication Date
SG11201610636VA true SG11201610636VA (en) 2017-01-27

Family

ID=54935824

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201610636VA SG11201610636VA (en) 2014-06-20 2015-06-22 Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor

Country Status (9)

Country Link
US (1) US10045993B2 (en)
EP (1) EP3158998A4 (en)
JP (1) JP6582000B2 (en)
KR (1) KR102435064B1 (en)
CN (1) CN106573003B (en)
MY (1) MY185605A (en)
PH (1) PH12016502544B1 (en)
SG (1) SG11201610636VA (en)
WO (1) WO2015194923A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107714676B (en) * 2017-10-27 2020-05-15 苏州大学 Entecavir oral instant film agent and preparation method thereof
WO2021166987A1 (en) * 2020-02-19 2021-08-26 大日本住友製薬株式会社 Transdermal absorption preparation
CN114632073A (en) * 2020-12-15 2022-06-17 南京海辰药业股份有限公司 Propofol fumarate and tenofovir oral instant film agent and preparation method thereof
CN113063881B (en) * 2021-04-15 2023-03-17 安徽万邦医药科技股份有限公司 Related substance analysis method of entecavir oral solution
CN113730367B (en) * 2021-09-28 2022-12-02 海南海灵化学制药有限公司 Preparation process of entecavir tablets

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1642582A1 (en) * 2000-02-29 2006-04-05 Bristol-Myers Squibb Company Low dose entecavir formulation and use
MY131488A (en) * 2002-04-08 2007-08-30 Bristol Myers Squibb Co Low dose liquid entecavir formulations and use
DE10224612A1 (en) * 2002-06-04 2003-12-24 Lohmann Therapie Syst Lts Active substance-containing film-like preparations with improved chemical stability, and process for their preparation
CN101278938A (en) 2008-03-20 2008-10-08 黑龙江加州国际投资咨询有限公司 Compound preparation of tenofovir and entecavir and its application against hepatitis B virus
CN101756890A (en) 2008-11-25 2010-06-30 天津太平洋制药有限公司 Parenteral preparation containing active entecavir and preparation method thereof
US20120328675A1 (en) 2010-03-03 2012-12-27 Kowa Co., Ltd. Film preparation containing medicament with unpleasant taste
US20110290694A1 (en) * 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
KR20120100683A (en) * 2011-09-09 2012-09-12 (주)차바이오앤디오스텍 Stable orodispersible film formulation
US20140315930A1 (en) 2011-11-14 2014-10-23 Hetero Research Foundation Fast release solid oral compositions of entecavir
WO2013114389A1 (en) 2011-12-21 2013-08-08 Mylan Laboratories Limited. Process for preparing solid oral formulations comprising low dose of entecavir
KR101285008B1 (en) 2012-04-18 2013-07-10 제일약품주식회사 A method for preparing oral formulation of low dose entecavir
CA2779052A1 (en) 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
KR102142539B1 (en) * 2012-12-11 2020-08-07 롯데정밀화학 주식회사 Composition for complex, complex formed therefrom, and orally ingestible composition including the same
CN103181903B (en) 2012-12-21 2016-06-01 上海景峰制药股份有限公司 A kind of mixing granulation method of Entecavir
KR101462018B1 (en) 2013-04-01 2014-11-19 썬시스템즈(주) Orally Disintegrating Film Formulation Containing Entecavir
CN103301071A (en) 2013-06-03 2013-09-18 北京阜康仁生物制药科技有限公司 Stable entecavir sugarless granules and preparation method thereof

Also Published As

Publication number Publication date
CN106573003B (en) 2022-04-01
EP3158998A1 (en) 2017-04-26
EP3158998A4 (en) 2018-02-14
PH12016502544A1 (en) 2017-04-10
KR102435064B1 (en) 2022-08-22
US20170136025A1 (en) 2017-05-18
KR20150145730A (en) 2015-12-30
JP2017522285A (en) 2017-08-10
MY185605A (en) 2021-05-25
PH12016502544B1 (en) 2017-04-10
WO2015194923A1 (en) 2015-12-23
CN106573003A (en) 2017-04-19
US10045993B2 (en) 2018-08-14
JP6582000B2 (en) 2019-09-25

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