SG11201608658SA - Novel manufacturing process for triazine, pyrimidine and pyridine derivatives - Google Patents

Novel manufacturing process for triazine, pyrimidine and pyridine derivatives

Info

Publication number
SG11201608658SA
SG11201608658SA SG11201608658SA SG11201608658SA SG11201608658SA SG 11201608658S A SG11201608658S A SG 11201608658SA SG 11201608658S A SG11201608658S A SG 11201608658SA SG 11201608658S A SG11201608658S A SG 11201608658SA SG 11201608658S A SG11201608658S A SG 11201608658SA
Authority
SG
Singapore
Prior art keywords
triazine
pyrimidine
manufacturing process
pyridine derivatives
novel manufacturing
Prior art date
Application number
SG11201608658SA
Inventor
Paul Hebeisen
Florent Beaufils
Jean-Baptiste Langlois
Original Assignee
Univ Basel
Piqur Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Basel, Piqur Therapeutics Ag filed Critical Univ Basel
Publication of SG11201608658SA publication Critical patent/SG11201608658SA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/127—Preparation from compounds containing pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
SG11201608658SA 2014-04-22 2015-04-20 Novel manufacturing process for triazine, pyrimidine and pyridine derivatives SG11201608658SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14165418 2014-04-22
PCT/EP2015/058493 WO2015162084A1 (en) 2014-04-22 2015-04-20 Novel manufacturing process for triazine, pyrimidine and pyridine derivatives

Publications (1)

Publication Number Publication Date
SG11201608658SA true SG11201608658SA (en) 2016-11-29

Family

ID=50489013

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201608658SA SG11201608658SA (en) 2014-04-22 2015-04-20 Novel manufacturing process for triazine, pyrimidine and pyridine derivatives

Country Status (13)

Country Link
US (2) US10100031B2 (en)
EP (1) EP3134388B1 (en)
JP (1) JP6513105B2 (en)
KR (1) KR102472711B1 (en)
CN (1) CN106458968B (en)
AU (1) AU2015250994B2 (en)
BR (1) BR112016023811B8 (en)
CA (1) CA2944697C (en)
ES (1) ES2713452T3 (en)
IL (1) IL248272B (en)
RU (1) RU2688665C2 (en)
SG (1) SG11201608658SA (en)
WO (1) WO2015162084A1 (en)

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CN109414415B (en) * 2016-05-18 2023-05-02 拓客股份有限公司 Treatment of skin lesions
CN107793394A (en) * 2017-08-03 2018-03-13 上海厚璞生物科技有限公司 A kind of serial key intermediate for producing selective PI3K inhibitor
BR112020009855A8 (en) 2017-11-23 2023-01-10 Piqur Therapeutics Ag TREATMENT OF SKIN DISORDERS
CN110204529A (en) * 2018-02-28 2019-09-06 朱允涛 A kind of preparation method and purposes of deuterated compound in triazine class
WO2019199864A1 (en) * 2018-04-10 2019-10-17 Neuropore Therapies, Inc. Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways

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US3707725A (en) 1970-06-19 1972-12-26 Ibm Program execution tracing system improvements
US4727145A (en) 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
CO5271680A1 (en) 2000-02-21 2003-04-30 Smithkline Beecham Corp COMPOUNDS
GB0027987D0 (en) 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
GB0127433D0 (en) 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
KR101121292B1 (en) 2005-09-27 2012-04-13 에프. 호프만-라 로슈 아게 Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
CA2691448A1 (en) 2007-08-31 2009-03-05 Dominique Swinnen Triazolopyridine compounds and their use as ask inhibitors
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
US8598163B2 (en) 2009-02-04 2013-12-03 Vitae Pharmaceuticals, Inc. Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
WO2011109932A1 (en) 2010-03-09 2011-09-15 F.Hoffmann-La Roche Ag Novel process for the manufacture of 5-halogenated-7-azaindoles
AU2011308856B2 (en) * 2010-10-01 2015-04-23 Novartis Ag Manufacturing process for pyrimidine derivatives
RU2013141559A (en) * 2011-02-11 2015-03-20 Дана-Фарбер Кэнсер Инститьют, Инк. METHOD FOR INHIBITING HAMARTOMA TUMOR CELL CELLS
US9617268B2 (en) 2011-12-30 2017-04-11 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
CN103214481B (en) 2012-01-21 2016-08-03 中国科学院上海药物研究所 Novel imidazole also [1,2-a] pyridine compounds and their, its preparation method, comprise the medical composition and its use of this compounds
EA028722B1 (en) 2012-07-13 2017-12-29 Юсб Байофарма Спрл Imidazopyridine derivatives as modulators of tnf activity
US9145433B2 (en) 2012-10-05 2015-09-29 Rigel Pharmaceuticals, Inc. GDF-8 inhibitors
RU2646760C2 (en) 2012-10-23 2018-03-07 Новартис Аг Improved method of preparing the 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethyl pyridine-2-amine
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Also Published As

Publication number Publication date
IL248272B (en) 2020-03-31
CA2944697C (en) 2022-07-19
CN106458968A (en) 2017-02-22
JP6513105B2 (en) 2019-05-15
JP2017513888A (en) 2017-06-01
BR112016023811B8 (en) 2023-01-10
IL248272A0 (en) 2016-11-30
US10766874B2 (en) 2020-09-08
KR20160144402A (en) 2016-12-16
AU2015250994B2 (en) 2018-12-20
CA2944697A1 (en) 2015-10-29
RU2688665C2 (en) 2019-05-22
US20170037027A1 (en) 2017-02-09
AU2015250994A1 (en) 2016-11-03
EP3134388B1 (en) 2019-01-09
BR112016023811B1 (en) 2022-06-28
RU2016138800A3 (en) 2018-10-19
EP3134388A1 (en) 2017-03-01
RU2016138800A (en) 2018-05-22
WO2015162084A1 (en) 2015-10-29
US20190016698A1 (en) 2019-01-17
US10100031B2 (en) 2018-10-16
BR112016023811A2 (en) 2017-08-15
ES2713452T3 (en) 2019-05-21
KR102472711B1 (en) 2022-12-01
CN106458968B (en) 2019-06-25

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