SG11201608438YA - Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors - Google Patents

Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors

Info

Publication number: SG11201608438YA
Authority: SG; Singapore
Prior art keywords: pyrazolo; analogs; parp inhibitors; benzimidazole compounds; benzimidazole
Prior art date: 2014-04-10

Application number

SG11201608438YA

Inventor

Xuehai Wang

Zhaozhong Ding

Yong Xu

Shuhui Chen

Lie Li

Gang Li

Ronghua Tu

Cailin Wang

Yang Yue

Zhibo Zhang

Hailiang Chen

Wenjie Sun

Lu Huang

Original Assignee

Hubei Bio Pharmaceutical Ind Technological Inst Inc

Humanwell Healthcare Group Co Ltd

Medshine Discovery Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-04-10

Filing date

2015-03-30

Publication date

2016-11-29

2014-04-10 Priority claimed from CN201410144173.0A external-priority patent/CN104974161B/en

2015-03-30 Application filed by Hubei Bio Pharmaceutical Ind Technological Inst Inc, Humanwell Healthcare Group Co Ltd, Medshine Discovery Inc filed Critical Hubei Bio Pharmaceutical Ind Technological Inst Inc

2016-11-29 Publication of SG11201608438YA publication Critical patent/SG11201608438YA/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SG11201608438YA 2014-04-10 2015-03-30 Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors SG11201608438YA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CN201410144173.0A CN104974161B (en)	2014-04-10	2014-04-10	The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor
CN201510113090		2015-03-13
PCT/CN2015/075363 WO2015154630A1 (en)	2014-04-10	2015-03-30	Analogues of 4h-pyrazolo[1,5-α]benzimidazole compound as parp inhibitors

Publications (1)

Publication Number	Publication Date
SG11201608438YA true SG11201608438YA (en)	2016-11-29

Family

ID=54287319

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201608438YA SG11201608438YA (en)	2014-04-10	2015-03-30	Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors

Country Status (22)

Country	Link
US (1)	US9856262B2 (en)
EP (1)	EP3130592B1 (en)
JP (1)	JP6359175B2 (en)
KR (1)	KR101921486B1 (en)
CN (1)	CN106459057B (en)
AU (1)	AU2015245786B2 (en)
BR (1)	BR112016023397B1 (en)
CA (1)	CA2944801C (en)
DK (1)	DK3130592T3 (en)
ES (1)	ES2754590T3 (en)
HU (1)	HUE047410T2 (en)
IL (1)	IL248258B (en)
MX (1)	MX368496B (en)
NZ (1)	NZ725165A (en)
PL (1)	PL3130592T3 (en)
PT (1)	PT3130592T (en)
RU (1)	RU2672722C2 (en)
SA (1)	SA516380051B1 (en)
SG (1)	SG11201608438YA (en)
TW (1)	TWI671301B (en)
WO (1)	WO2015154630A1 (en)
ZA (1)	ZA201607736B (en)

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CN104974161B (en) *	2014-04-10	2019-11-01	湖北生物医药产业技术研究院有限公司	The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor
AU2016333293B2 (en) *	2015-09-30	2020-07-30	Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.	Salt type and crystal type of 4H-pyrazolo (1, 5-alpha) benzimidazole compound and preparation method and intermediate thereof
WO2017156350A1 (en)	2016-03-09	2017-09-14	K-Gen, Inc.	Methods of cancer treatment
MX2019012803A (en)	2017-04-27	2020-01-23	Bayer Animal Health Gmbh	New bicyclic pyrazole derivatives.
CN115028641B (en) *	2022-07-19	2024-05-28	湖南大学	Method for synthesizing 5, 8-difunctional substituted imidazo [1,2-a ] pyrazine compound by cobalt catalysis
CN116969954B (en) *	2023-09-21	2023-11-28	广东省农业科学院农业质量标准与监测技术研究所	Tricyclic fused heterocyclic compounds containing lactam and application thereof
CN117534677B (en) *	2024-01-09	2024-03-12	广东省农业科学院农业质量标准与监测技术研究所	Imine-containing tricyclic fused heterocyclic compound and application thereof

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US4916051A (en) *	1987-04-07	1990-04-10	Konica Corporation	Silver halide color photographic light-sensitive material
NZ547990A (en) *	2003-12-22	2010-04-30	Smithkline Beecham Cork Ltd	CRF receptor antagonists and methods relating thereto
WO2007076127A2 (en)	2005-12-22	2007-07-05	Biogen Idec Ma Inc	Condensed imidazoles or pyrazoles and their use as transforming growth factor modulators
WO2007144669A1 (en) *	2006-06-15	2007-12-21	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa	Pyrazolo[1,5-a]quinazolin-5(4h)-ones as inhibitors of poly(adp-ribose)polymerase (parp)
JP5284955B2 (en) *	2006-06-20	2013-09-11	アボット・ラボラトリーズ	Pyrazoloquinazolinones as PARP inhibitors
GB0701273D0 (en) *	2007-01-24	2007-02-28	Angeletti P Ist Richerche Bio	New compounds
ES2535511T3 (en)	2012-04-26	2015-05-12	Helmut Schickaneder	Esters of bendamustine and related compounds, and medical use thereof
PT2844659T (en)	2012-05-04	2016-08-31	Merck Patent Gmbh	Pyrrolotriazinone derivatives
EP2666775A1 (en)	2012-05-21	2013-11-27	Domain Therapeutics	Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
MX2014014832A (en)	2012-06-07	2015-02-12	Hoffmann La Roche	Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase.
IN2015MN00002A (en) *	2012-07-09	2015-10-16	Lupin Ltd
CN103570725B (en)	2012-08-01	2017-03-22	中国科学院上海药物研究所	Piperazidinoltriazole compound as well as preparation method and application thereof
KR102083154B1 (en) *	2012-08-08	2020-03-02	메르크 파텐트 게엠베하	(aza-)isoquinolinone derivatives
CN104974161B (en)	2014-04-10	2019-11-01	湖北生物医药产业技术研究院有限公司	The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor

2015
- 2015-03-30 JP JP2017504223A patent/JP6359175B2/en active Active
- 2015-03-30 EP EP15777444.9A patent/EP3130592B1/en active Active
- 2015-03-30 CA CA2944801A patent/CA2944801C/en active Active
- 2015-03-30 PT PT157774449T patent/PT3130592T/en unknown
- 2015-03-30 ES ES15777444T patent/ES2754590T3/en active Active
- 2015-03-30 HU HUE15777444A patent/HUE047410T2/en unknown
- 2015-03-30 US US15/302,588 patent/US9856262B2/en active Active
- 2015-03-30 RU RU2016144202A patent/RU2672722C2/en active
- 2015-03-30 KR KR1020167031520A patent/KR101921486B1/en active IP Right Grant
- 2015-03-30 AU AU2015245786A patent/AU2015245786B2/en active Active
- 2015-03-30 WO PCT/CN2015/075363 patent/WO2015154630A1/en active Application Filing
- 2015-03-30 SG SG11201608438YA patent/SG11201608438YA/en unknown
- 2015-03-30 DK DK15777444T patent/DK3130592T3/en active
- 2015-03-30 CN CN201580017657.1A patent/CN106459057B/en active Active
- 2015-03-30 NZ NZ725165A patent/NZ725165A/en unknown
- 2015-03-30 BR BR112016023397-2A patent/BR112016023397B1/en active IP Right Grant
- 2015-03-30 PL PL15777444T patent/PL3130592T3/en unknown
- 2015-03-30 MX MX2016013265A patent/MX368496B/en active IP Right Grant
- 2015-04-08 TW TW104111236A patent/TWI671301B/en active
2016
- 2016-10-09 IL IL248258A patent/IL248258B/en active IP Right Grant
- 2016-10-10 SA SA516380051A patent/SA516380051B1/en unknown
- 2016-11-09 ZA ZA2016/07736A patent/ZA201607736B/en unknown

Also Published As

Publication number	Publication date
ZA201607736B (en)	2017-09-27
KR101921486B1 (en)	2018-11-26
PT3130592T (en)	2019-11-21
JP6359175B2 (en)	2018-07-18
CN106459057A (en)	2017-02-22
BR112016023397B1 (en)	2022-08-16
US20170029430A1 (en)	2017-02-02
EP3130592A4 (en)	2017-09-06
NZ725165A (en)	2018-04-27
KR20170005807A (en)	2017-01-16
ES2754590T3 (en)	2020-04-20
CA2944801C (en)	2019-02-12
PL3130592T3 (en)	2020-05-18
TW201620913A (en)	2016-06-16
DK3130592T3 (en)	2019-11-04
RU2016144202A (en)	2018-05-15
BR112016023397A2 (en)	2017-08-15
SA516380051B1 (en)	2020-05-17
JP2017510653A (en)	2017-04-13
HUE047410T2 (en)	2020-04-28
EP3130592B1 (en)	2019-08-14
AU2015245786B2 (en)	2018-03-15
US9856262B2 (en)	2018-01-02
RU2016144202A3 (en)	2018-05-15
IL248258B (en)	2018-11-29
CN106459057B (en)	2019-06-07
RU2672722C2 (en)	2018-11-19
WO2015154630A1 (en)	2015-10-15
EP3130592A1 (en)	2017-02-15
MX2016013265A (en)	2017-05-03
TWI671301B (en)	2019-09-11
MX368496B (en)	2019-10-04
CA2944801A1 (en)	2015-10-15
AU2015245786A1 (en)	2016-11-03

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