SG11201606147SA - Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening - Google Patents

Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening

Info

Publication number
SG11201606147SA
SG11201606147SA SG11201606147SA SG11201606147SA SG11201606147SA SG 11201606147S A SG11201606147S A SG 11201606147SA SG 11201606147S A SG11201606147S A SG 11201606147SA SG 11201606147S A SG11201606147S A SG 11201606147SA SG 11201606147S A SG11201606147S A SG 11201606147SA
Authority
SG
Singapore
Prior art keywords
fluorogens
light
emission characteristics
drug screening
induced emission
Prior art date
Application number
SG11201606147SA
Inventor
Bin Liu
Jinjun Shao
Youyong Yuan
Jing Liang
Benzhong Tang
Zhegang Song
Yilong Chen
Tsz Kin Kwok
Original Assignee
Univ Singapore
Univ Hong Kong Science & Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore, Univ Hong Kong Science & Techn filed Critical Univ Singapore
Publication of SG11201606147SA publication Critical patent/SG11201606147SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • A61K49/146Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086Platinum compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/12Esters of phosphoric acids with hydroxyaryl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13Labelling of peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086Platinum compounds
    • C07F15/0093Platinum compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0896Compounds with a Si-H linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1021Tetrapeptides with the first amino acid being acidic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123Tripeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769Measurement method of reaction-produced change in sensor
    • G01N2021/7786Fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/916Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201606147SA 2014-01-27 2015-01-27 Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening SG11201606147SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461932007P 2014-01-27 2014-01-27
PCT/SG2015/000022 WO2015112092A2 (en) 2014-01-27 2015-01-27 Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening

Publications (1)

Publication Number Publication Date
SG11201606147SA true SG11201606147SA (en) 2016-08-30

Family

ID=53682080

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201606147SA SG11201606147SA (en) 2014-01-27 2015-01-27 Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening

Country Status (4)

Country Link
US (1) US20160356723A1 (en)
CN (1) CN106461641A (en)
SG (1) SG11201606147SA (en)
WO (1) WO2015112092A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201400944QA (en) 2011-09-01 2014-09-26 Univ Hong Kong Science & Techn Biocompatible nanoparticles with aggregation induced emission characteristics as fluorescent bioprobes and methods of using the same for in vitro and in vivo imaging
CN106470964A (en) * 2014-04-25 2017-03-01 新加坡国立大学 There is the application in the treatment of imaging and imaging guiding of the polymer of aggregation-induced emission property and oligomer
WO2016165616A1 (en) * 2015-04-13 2016-10-20 Benzhong Tang Photostable aie fluorogens for accurate and sensitive detection of s-phase dna synthesis and cell proliferation
WO2016165487A1 (en) * 2015-04-13 2016-10-20 The Hong Kong University Of Science And Technology Real-time monitoring mitophagy process by fluorescent photostable mitochondrial specific bioprobe with aie characteristics
GB201512372D0 (en) * 2015-07-15 2015-08-19 Nuclera Nucleics Ltd Novel method
WO2017080413A1 (en) * 2015-11-10 2017-05-18 The Hong Kong University Of Science And Technology Aie bioprobes emitting red or yellow fluorescence
US10905781B2 (en) 2016-03-02 2021-02-02 The Brigham And Women's Hospital, Inc. Reporter platform for real time monitoring of drug efficacy
WO2017176216A1 (en) * 2016-04-06 2017-10-12 Agency For Science, Technology And Research A multimodal fluorescent probe
CN105924410B (en) * 2016-04-22 2019-01-04 武汉大学 A kind of ligand and complex of aggregation-induced emission
CN106187880A (en) * 2016-07-13 2016-12-07 西安电子科技大学 Colored cyanines fluorescent probe based on aggregation-induced emission effect and preparation method and application
CN108658790A (en) * 2017-03-28 2018-10-16 南开大学 A kind of aggregation-induced emission probe sensed for multi-analyte immunoassay and immunoassay
CN107189775B (en) * 2017-05-08 2019-06-11 中国科学技术大学 Antibody-drug/probe conjugate and its preparation method and application with fluorescent emission property
CN106967167B (en) * 2017-05-08 2020-05-05 中国科学技术大学 Protein/polypeptide-polymer conjugate with fluorescence emission property and preparation method and application thereof
US11129909B2 (en) 2017-05-08 2021-09-28 University Of Science And Technology Of China Conjugate and block copolymer containing fluorescent chromophore and preparation method therefor and use thereof
CN107367495B (en) * 2017-07-19 2019-09-06 湖南大学 A kind of sedimentation type alkaline phosphatase fluorescence probe and its synthetic method and application
CN108358837B (en) * 2018-02-01 2020-11-13 浙江工业大学 Synthesis method of hydroxyl pyridone compound containing amino
CN112218855B (en) * 2018-06-15 2024-01-05 香港科技大学 NIR-II emissive luminophores
CN110606859B (en) * 2018-06-15 2022-11-22 香港科技大学 Aggregation-induced emission compound, preparation method thereof and application thereof in virus detection
CN112424314A (en) * 2018-07-13 2021-02-26 香港科技大学 Dual-function aggregation-induced emission material for monitoring and killing multi-drug-resistant bacteria
WO2020147653A1 (en) * 2019-01-15 2020-07-23 The Hong Kong University Of Science And Technology Photostable fluorescent compounds for organelle imaging in live cells and deep tissues
CN110241254A (en) * 2019-05-08 2019-09-17 天津大学 Sendai virus Fast Labeling and tracing method based on aggregation-induced emission molecule
CN113171470B (en) * 2020-01-24 2024-06-04 香港科技大学 Aggregation-induced emission molecule-phage bioconjugate
CN111533637A (en) * 2020-03-12 2020-08-14 苏州百灵威超精细材料有限公司 Process method for preparing [1- (4-vinyl phenyl) -1,2, 2-triphenyl ] ethylene
EP4211468A2 (en) * 2020-09-11 2023-07-19 Glympse Bio, Inc. Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment
CN112441965A (en) * 2020-12-18 2021-03-05 西北师范大学 Preparation method of nano assembly with AIE effect
CN112964682B (en) * 2021-02-05 2022-02-25 中国科学院高能物理研究所 Method for visually and quantitatively marking aggregated functional protein in cells
CN113789324B (en) * 2021-08-17 2023-08-25 广东省大湾区华南理工大学聚集诱导发光高等研究院 AIE probe, preparation method thereof and application thereof in fluorescent quantitative PCR (polymerase chain reaction) method
CN113735762B (en) * 2021-08-31 2022-07-19 武汉工程大学 Water-soluble fluorescent probe with aggregation-induced emission characteristic and preparation method and application thereof
CN114507247B (en) * 2022-01-19 2023-08-11 华南理工大学 Amphiphilic gadolinium complex and nano micelle for realizing diagnosis and treatment integration
CN114835638B (en) * 2022-03-04 2023-05-23 中国地质大学(武汉) AIE molecule with double-end-group modified site, multi-module probe, preparation method and application thereof
CN114652846B (en) * 2022-03-17 2024-01-09 天津工业大学 Enzyme-sensitive, tumor active targeting and intracellular quick drug release polymer prodrug, and preparation method and application thereof
CN117569014B (en) * 2023-11-16 2024-06-18 齐鲁工业大学(山东省科学院) H (H)2O2Preparation method of gas film sensing material

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9475768B2 (en) * 2011-03-17 2016-10-25 The Hong Kong University Of Science And Technology Luminogen compounds and the use of the same for biosensing and cellular imaging
GB2502306A (en) * 2012-05-22 2013-11-27 Univ Singapore Microparticle sensor

Also Published As

Publication number Publication date
WO2015112092A3 (en) 2015-11-26
CN106461641A (en) 2017-02-22
WO2015112092A2 (en) 2015-07-30
US20160356723A1 (en) 2016-12-08
WO2015112092A8 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
SG11201606147SA (en) Light-up probes based on fluorogens with aggregation induced emission characteristics for cellular imaging and drug screening
IL250934A0 (en) Low field magnetic resonance imaging methods and apparatus
EP3152549C0 (en) Method and means for multispectral imaging
EP3408349A4 (en) Chemiluminescent probes for diagnostics and in vivo imaging
SG10201610521VA (en) Full-wafer inspection methods having selectable pixel density
IL246832B (en) System and method for imaging with pinhole arrays
HK1243904A1 (en) Mesh suture with anti-roping characteristics
HK1244722A1 (en) Retractable needle syringe
GB2595592B (en) Domino circuit and related architectures and methods for carrier aggregation
GB201421212D0 (en) Retractable needle assemblies
EP3183592C0 (en) Magnet for head and extremity imaging
PT3261782T (en) Apparatus for imaging, sorting and batching whole fish
ZA201607682B (en) Radiofrequency probes with retractable multi-tined electrodes
IL247532A (en) Imaging spectrometer with extended resolution
TWI563843B (en) Imaging and lighting apparatus
GB201709389D0 (en) An improved airship
GB2523326B (en) Detection apparatus with self-test function
GB201412266D0 (en) Carrier aggregation mode selection
HK1244522A1 (en) Emission signature modification device
GB201710743D0 (en) Luminescence imaging apparatus and methods
GB2531388B (en) Stack emission testing
GB2541341B (en) Point-of-transactionworkstation for, and method of, imaging sheet-like targets
GB201704179D0 (en) An internal cake support apparatus and associated methods
GB201406801D0 (en) MRI Apparatus and methods
GB201705653D0 (en) Methods and means for imaging