SG11201605721XA - Substituted bicyclic heteroaryl compounds as rxr agonists - Google Patents

Substituted bicyclic heteroaryl compounds as rxr agonists

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Publication number
SG11201605721XA
SG11201605721XA SG11201605721XA SG11201605721XA SG11201605721XA SG 11201605721X A SG11201605721X A SG 11201605721XA SG 11201605721X A SG11201605721X A SG 11201605721XA SG 11201605721X A SG11201605721X A SG 11201605721XA SG 11201605721X A SG11201605721X A SG 11201605721XA
Authority
SG
Singapore
Prior art keywords
bicyclic heteroaryl
substituted bicyclic
heteroaryl compounds
rxr agonists
rxr
Prior art date
Application number
SG11201605721XA
Inventor
Madhavan Gurram Ranga
Jagannath Madanahalli Ranganath Rao
Chandra Sekhar Gudla
Original Assignee
Connexios Life Sciences Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connexios Life Sciences Pvt Ltd filed Critical Connexios Life Sciences Pvt Ltd
Publication of SG11201605721XA publication Critical patent/SG11201605721XA/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
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    • C07D333/58—Radicals substituted by nitrogen atoms
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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SG11201605721XA 2014-01-14 2015-01-09 Substituted bicyclic heteroaryl compounds as rxr agonists SG11201605721XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN161CH2014 2014-01-14
PCT/IN2015/000010 WO2015107549A1 (en) 2014-01-14 2015-01-09 Substituted bicyclic heteroaryl compounds as rxr agonists

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EP (1) EP3094626B1 (en)
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KR (1) KR102372599B1 (en)
CN (1) CN107074800B (en)
AU (1) AU2015207690B2 (en)
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CA (1) CA2936162C (en)
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CN106565761A (en) * 2016-11-15 2017-04-19 贵州大学 Preparing technology for 4-carboxyphenylboronic acid
CN112047901B (en) * 2020-09-21 2023-01-24 自然资源部第三海洋研究所 Benzothiazole heteroterpenoid and derivative thereof, preparation method and application
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US11919873B1 (en) 2023-08-29 2024-03-05 King Faisal University 1,3-benzothiazol-2-yl-N′-(benzoyloxy)ethanimidamide as an antitumor and antimicrobial compound
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