SG11201603026PA - Compositions and methods for modulating farnesoid x receptors - Google Patents

Compositions and methods for modulating farnesoid x receptors

Info

Publication number
SG11201603026PA
SG11201603026PA SG11201603026PA SG11201603026PA SG11201603026PA SG 11201603026P A SG11201603026P A SG 11201603026PA SG 11201603026P A SG11201603026P A SG 11201603026PA SG 11201603026P A SG11201603026P A SG 11201603026PA SG 11201603026P A SG11201603026P A SG 11201603026PA
Authority
SG
Singapore
Prior art keywords
receptors
compositions
methods
modulating farnesoid
farnesoid
Prior art date
Application number
SG11201603026PA
Other languages
English (en)
Inventor
Donatella Chianelli
Xiaodong Liu
Valentina Molteni
John Nelson
Jason Roland
Paul Rucker
David Tully
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51982773&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201603026P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201603026PA publication Critical patent/SG11201603026PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
SG11201603026PA 2013-11-05 2014-11-04 Compositions and methods for modulating farnesoid x receptors SG11201603026PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361900013P 2013-11-05 2013-11-05
PCT/US2014/063948 WO2015069666A1 (fr) 2013-11-05 2014-11-04 Compositions et procédés pour moduler des récepteurs farnesoïde x

Publications (1)

Publication Number Publication Date
SG11201603026PA true SG11201603026PA (en) 2016-05-30

Family

ID=51982773

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201603026PA SG11201603026PA (en) 2013-11-05 2014-11-04 Compositions and methods for modulating farnesoid x receptors

Country Status (42)

Country Link
US (5) US9682939B2 (fr)
EP (1) EP3065738B1 (fr)
JP (1) JP6424231B2 (fr)
KR (1) KR102350357B1 (fr)
CN (1) CN105682656B (fr)
AP (1) AP2016009165A0 (fr)
AR (1) AR098316A1 (fr)
AU (1) AU2014346919B2 (fr)
BR (1) BR112016009630B1 (fr)
CA (1) CA2927705C (fr)
CL (1) CL2016000982A1 (fr)
CR (1) CR20160212A (fr)
CU (1) CU24375B1 (fr)
CY (1) CY1120273T1 (fr)
DK (1) DK3065738T3 (fr)
EA (1) EA030430B1 (fr)
ES (1) ES2670984T3 (fr)
GT (1) GT201600085A (fr)
HR (1) HRP20180817T1 (fr)
HU (1) HUE039155T2 (fr)
IL (1) IL245242B (fr)
JO (1) JO3454B1 (fr)
LT (1) LT3065738T (fr)
MA (1) MA39088B1 (fr)
MX (1) MX364834B (fr)
MY (1) MY175903A (fr)
NO (1) NO3105103T3 (fr)
NZ (1) NZ719078A (fr)
PE (1) PE20160682A1 (fr)
PH (1) PH12016500777B1 (fr)
PL (1) PL3065738T3 (fr)
PT (1) PT3065738T (fr)
RS (1) RS57179B1 (fr)
SG (1) SG11201603026PA (fr)
SI (1) SI3065738T1 (fr)
SV (1) SV2016005192A (fr)
TN (1) TN2016000143A1 (fr)
TR (1) TR201807321T4 (fr)
TW (1) TWI662027B (fr)
UY (1) UY35818A (fr)
WO (1) WO2015069666A1 (fr)
ZA (1) ZA201602555B (fr)

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EP2545964A1 (fr) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
CU24375B1 (es) 2013-11-05 2018-12-05 Novartis Ag Derivados de pirazol fusionados activos como moduladores del receptor de farnesoide x
TWI698430B (zh) 2015-02-13 2020-07-11 南北兄弟藥業投資有限公司 三環化合物及其在藥物中的應用
WO2016174616A1 (fr) * 2015-04-30 2016-11-03 Novartis Ag Dérivés de pyrazole tricycliques fusionnés utiles pour moduler des récepteurs farnésoïdes x
CN108697702A (zh) 2016-02-22 2018-10-23 诺华股份有限公司 使用fxr激动剂的方法
PL3730487T3 (pl) 2016-06-13 2022-08-16 Gilead Sciences, Inc. Pochodne azetydyny jako modulatory fxr (nr1h4)
CA2968836A1 (fr) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Composes modulant fxr (nr1h4)
JOP20190040A1 (ar) * 2016-09-14 2019-03-10 Novartis Ag توليفة من ناهضات fxr
WO2018051229A1 (fr) * 2016-09-14 2018-03-22 Novartis Ag Nouveaux régimes d'agonistes de fxr
JP2019530696A (ja) * 2016-10-05 2019-10-24 ノバルティス アーゲー 線維性、硬変性の疾患もしくは障害を治療または予防するためのｆｘｒアゴニストを含む組合せ組成物
CN107973790A (zh) * 2016-10-22 2018-05-01 合帕吉恩治疗公司 杂环fxr调节剂
ES2927019T3 (es) 2017-03-28 2022-11-02 Gilead Sciences Inc Combinaciones terapéuticas para el tratamiento de enfermedades hepáticas
EP3634966B1 (fr) * 2017-06-05 2024-06-05 National University of Singapore Composés utiles pour inhiber le facteur 3 en feuille de trèfle humain
UY37848A (es) 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
CN111093773A (zh) 2017-08-15 2020-05-01 英夫拉索姆有限公司 作为nlrp3抑制剂的磺酰脲和磺酰硫脲
WO2019034693A1 (fr) 2017-08-15 2019-02-21 Inflazome Limited Sulfonylurées et sulfonylthiourées utilisés en tant qu'inhibiteurs de nlrp3
JP2020533339A (ja) * 2017-09-13 2020-11-19 ノバルティス アーゲー Ｆｘｒアゴニストを含む組合せ
CN110128432B (zh) * 2018-02-02 2021-03-02 广东东阳光药业有限公司 含氮三环化合物及其在药物中的应用
EP3759077A1 (fr) 2018-03-02 2021-01-06 Inflazome Limited Nouveaux composés
US20210308140A1 (en) 2018-07-25 2021-10-07 Novartis Ag Nlrp3 inflammasome inhibitors
CR20210385A (es) 2019-01-15 2021-09-14 Gilead Sciences Inc Compuestos moduladores de fxr (nr1h4)
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
CA3233305A1 (fr) 2019-02-19 2020-08-27 Gilead Sciences, Inc. Formes solides d'agonistes de fxr
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
US20220241376A1 (en) 2019-07-18 2022-08-04 Enyo Pharma Method for decreasing adverse-effects of interferon
WO2021044351A1 (fr) 2019-09-06 2021-03-11 Novartis Ag Procédés de traitement d'une maladie hépatique à l'aide d'inhibiteurs de lta4h
CN114945361A (zh) 2020-01-15 2022-08-26 法国国家卫生及研究医学协会 Fxr激动剂在治疗丁型肝炎病毒感染中的用途
CN113387828A (zh) * 2020-03-14 2021-09-14 江巨东 一种阿利克仑中间体的制备方法
WO2022037663A1 (fr) * 2020-08-21 2022-02-24 苏州晶云药物科技股份有限公司 Nouvelle forme cristalline d'un dérivé d'acide benzoïque et son procédé de préparation
EP4277622A1 (fr) 2021-01-14 2023-11-22 ENYO Pharma Effet synergique d'un agoniste de fxr et d'ifn pour le traitement d'une infection par le virus de l'hépatite b
WO2022229302A1 (fr) 2021-04-28 2022-11-03 Enyo Pharma Potentialisation forte d'effets d'agonistes de tlr3 à l'aide d'agonistes de fxr en tant que traitement combiné
US20240067627A1 (en) 2022-08-03 2024-02-29 Novartis Ag Nlrp3 inflammasome inhibitors
WO2024044778A2 (fr) * 2022-08-26 2024-02-29 Celmatix Inc. Nouveaux modulateurs de fshr et leurs utilisations

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US20050143449A1 (en) * 2002-11-15 2005-06-30 The Salk Institute For Biological Studies Non-steroidal farnesoid X receptor modulators and methods for the use thereof
MX2008014854A (es) * 2006-05-24 2008-12-05 Lilly Co Eli Antagonistas de fxr.
BRPI0716901B1 (pt) * 2006-09-15 2020-04-22 Thales Avionics Inc sistema para transferir conteúdo e método para entregar conteúdo entre um veículo e outra entidade
TW200906823A (en) * 2007-07-16 2009-02-16 Lilly Co Eli Compounds and methods for modulating FXR
CU24152B1 (es) * 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
CU24375B1 (es) 2013-11-05 2018-12-05 Novartis Ag Derivados de pirazol fusionados activos como moduladores del receptor de farnesoide x
WO2016174616A1 (fr) 2015-04-30 2016-11-03 Novartis Ag Dérivés de pyrazole tricycliques fusionnés utiles pour moduler des récepteurs farnésoïdes x

Also Published As

Publication number Publication date
JO3454B1 (ar) 2020-07-05
PT3065738T (pt) 2018-06-04
NZ719078A (en) 2018-07-27
HUE039155T2 (hu) 2018-12-28
US20200247757A1 (en) 2020-08-06
US20210253534A1 (en) 2021-08-19
CY1120273T1 (el) 2019-07-10
BR112016009630A8 (pt) 2020-04-07
AU2014346919B2 (en) 2017-02-02
CA2927705C (fr) 2021-09-21
US20190062283A1 (en) 2019-02-28
TN2016000143A1 (en) 2017-10-06
MX2016005865A (es) 2016-07-13
PH12016500777A1 (en) 2016-05-30
ES2670984T3 (es) 2018-06-04
CR20160212A (es) 2016-07-22
NO3105103T3 (fr) 2018-05-12
EA201690930A1 (ru) 2016-08-31
HRP20180817T1 (hr) 2018-06-29
KR20160079091A (ko) 2016-07-05
US11021446B2 (en) 2021-06-01
US20170275256A1 (en) 2017-09-28
US20160340317A1 (en) 2016-11-24
CL2016000982A1 (es) 2016-10-07
JP6424231B2 (ja) 2018-11-14
SV2016005192A (es) 2016-11-21
KR102350357B1 (ko) 2022-01-14
US10683271B2 (en) 2020-06-16
MA39088B1 (fr) 2018-06-29
BR112016009630B1 (pt) 2021-02-09
AR098316A1 (es) 2016-05-26
US9682939B2 (en) 2017-06-20
MY175903A (en) 2020-07-15
LT3065738T (lt) 2018-05-10
TW201612163A (en) 2016-04-01
CN105682656B (zh) 2019-11-05
PE20160682A1 (es) 2016-07-23
CU20160063A7 (es) 2016-09-30
CA2927705A1 (fr) 2015-05-14
WO2015069666A1 (fr) 2015-05-14
EP3065738B1 (fr) 2018-02-28
GT201600085A (es) 2019-07-19
MX364834B (es) 2019-05-08
TR201807321T4 (tr) 2018-06-21
ZA201602555B (en) 2017-06-28
IL245242B (en) 2019-03-31
IL245242A0 (en) 2016-06-30
MA39088A1 (fr) 2017-07-31
EA030430B1 (ru) 2018-08-31
RS57179B1 (sr) 2018-07-31
US10077240B2 (en) 2018-09-18
SI3065738T1 (en) 2018-06-29
CU24375B1 (es) 2018-12-05
TWI662027B (zh) 2019-06-11
EP3065738A1 (fr) 2016-09-14
UY35818A (es) 2015-05-29
AP2016009165A0 (en) 2016-04-30
DK3065738T3 (en) 2018-06-06
PH12016500777B1 (en) 2016-05-30
JP2016535784A (ja) 2016-11-17
AU2014346919A1 (en) 2016-05-12
PL3065738T3 (pl) 2018-07-31
CN105682656A (zh) 2016-06-15

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