SG11201510814YA - O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof - Google Patents

O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof

Info

Publication number
SG11201510814YA
SG11201510814YA SG11201510814YA SG11201510814YA SG11201510814YA SG 11201510814Y A SG11201510814Y A SG 11201510814YA SG 11201510814Y A SG11201510814Y A SG 11201510814YA SG 11201510814Y A SG11201510814Y A SG 11201510814YA SG 11201510814Y A SG11201510814Y A SG 11201510814YA
Authority
SG
Singapore
Prior art keywords
mannosyltransferase
methods
filamentous fungal
fungal cells
deficient filamentous
Prior art date
Application number
SG11201510814YA
Inventor
Jari Natunen
Jukka Hiltunen
Anne Huuskonen
Markku Saloheimo
Christian Ostermeier
Benjamin Patrick Sommer
Ramon Wahl
Original Assignee
Novartis Ag
Glykos Finland Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48740957&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201510814Y(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Glykos Finland Oy filed Critical Novartis Ag
Publication of SG11201510814YA publication Critical patent/SG11201510814YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01109—Dolichyl-phosphate-mannose-protein mannosyltransferase (2.4.1.109)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
SG11201510814YA 2013-07-04 2014-07-03 O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof SG11201510814YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13175141 2013-07-04
PCT/EP2014/064248 WO2015001049A1 (en) 2013-07-04 2014-07-03 O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201510814YA true SG11201510814YA (en) 2016-01-28

Family

ID=48740957

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201510814YA SG11201510814YA (en) 2013-07-04 2014-07-03 O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof

Country Status (15)

Country Link
US (4) US20160376570A1 (en)
EP (1) EP3016970B1 (en)
KR (1) KR102111078B1 (en)
CN (1) CN105492457A (en)
BR (1) BR112015032695A2 (en)
CA (1) CA2916594C (en)
DK (1) DK3016970T3 (en)
ES (1) ES2739280T3 (en)
HR (1) HRP20191069T1 (en)
MX (1) MX364532B (en)
PL (1) PL3016970T3 (en)
RU (1) RU2016103373A (en)
SG (1) SG11201510814YA (en)
SI (1) SI3016970T1 (en)
WO (1) WO2015001049A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108064266A (en) 2014-07-21 2018-05-22 格利科斯芬兰公司 The preparation of the glycoprotein with mammal sample N- glycan in filamentous fungi
US20210388310A1 (en) * 2018-09-20 2021-12-16 Perfect Day, Inc. Methods and compositions for producing homokaryotic filamentous fungal cells
JP2022513649A (en) * 2018-11-28 2022-02-09 ノボザイムス アクティーゼルスカブ Modified filamentous fungus host cell
CN110885810B (en) * 2019-12-16 2021-03-23 华中农业大学 Bacteriostatic protease CmYC1 prepared by eukaryotic fermentation and application thereof
CN115976033B (en) * 2022-12-14 2024-05-17 西南大学 Melon fly TSSK and TSSK genes and application thereof

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4743546A (en) 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
GB2276169A (en) 1990-07-05 1994-09-21 Celltech Ltd Antibodies specific for carcinoembryonic antigen
DE4226971C2 (en) 1992-08-14 1997-01-16 Widmar Prof Dr Tanner Modified fungal cells and processes for the production of recombinant products
EP0966521A1 (en) 1996-09-13 1999-12-29 Novo Nordisk Biotech, Inc. Cells having dna insertion mutations which produce altered amounts of a polypeptide
DE19754622A1 (en) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Plant GntI sequences and the use thereof for obtaining plants with reduced or missing N-acetylglucosaminyltransferase I (GnTI) activity
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
GB0021421D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
MXPA03004853A (en) 2000-12-05 2005-02-14 Penn State Res Found Methods and compositions for highly efficient production of heterologous proteins in yeast.
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
BR0315943A (en) 2002-12-20 2005-09-13 Unilever Nv Method for the production of an antifreeze protein and composition
ES2380022T3 (en) 2003-12-03 2012-05-07 Monika KRÖZ Interleukin-11 fusion proteins
NZ548612A (en) 2004-02-09 2009-11-27 Human Genome Sciences Inc Albumin fusion proteins comprising tandem GLP-1
WO2006036817A2 (en) 2004-09-24 2006-04-06 Microbia, Inc. Fungal variants and uses thereof
ATE514770T1 (en) * 2005-10-17 2011-07-15 Novozymes As USE OF FUNGAL MUTANTS TO EXPRESS ANTIBODIES
JP5284789B2 (en) * 2005-11-15 2013-09-11 グライコフィ， インコーポレイテッド Production of glycoproteins with reduced O-glycosylation
CN101605887B (en) 2006-05-16 2012-09-05 协和发酵麒麟株式会社 High secretion production method of protein
EP2102366A4 (en) 2006-12-10 2010-01-27 Dyadic International Inc Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi
GB0711424D0 (en) 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
EP2604623A3 (en) 2007-08-08 2013-10-02 Novozymes Biopharma DK A/S Transferrin variants and conjugates
CN101945998B (en) * 2008-02-20 2013-09-18 格利科菲公司 Vectors and yeast strains for protein production
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
EP2300446B1 (en) 2008-05-20 2011-12-07 Merck Sharp & Dohme Corp. Efficient production of heterologous proteins using mannosyl transferase inhibitors
US8507224B2 (en) 2008-08-12 2013-08-13 Glycofi, Inc. Vectors and yeast strains for protein production: Ca2+ ATPase overexpression
WO2010034708A1 (en) 2008-09-23 2010-04-01 Unilever Plc A polynucleotide expression cassette
EP3243835B1 (en) 2009-02-11 2024-04-10 Albumedix Ltd Albumin variants and conjugates
CN102459330B (en) 2009-05-07 2014-11-05 诺维信生物制药丹麦公司 Method of controlling o-linked glycosylation of antibodies
US9403898B2 (en) 2009-05-07 2016-08-02 Novozymes Biopharma Dk A/S Method for purifying albumin
WO2010135678A1 (en) 2009-05-22 2010-11-25 Research Corporation Technologies, Inc. Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins
CN104031961A (en) 2009-10-16 2014-09-10 默沙东公司 Method for producing a mature human erythropoietin and composition comprising the mature human erythropoietin obtained from the method
EP3000871A1 (en) 2009-12-18 2016-03-30 Novozymes, Inc. Methods for producing polypeptides in protease-deficient mutants of trichoderma
EP2534255B1 (en) 2010-02-10 2017-05-10 Biocon Limited Method of reducing glycosylation of proteins, processes and proteins thereof
AU2011220878A1 (en) * 2010-02-24 2012-08-23 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
AU2011258425B2 (en) 2010-05-27 2015-12-10 Merck Sharp & Dohme Llc Method for preparing antibodies having improved properties
US20120135461A1 (en) 2010-07-30 2012-05-31 William James Cook Production of glycoproteins with reduced o-glycosylation comprising the use of an alpha-1,2-mannosidase
CA2819071A1 (en) 2010-11-24 2012-05-31 Novartis International Pharmaceutical Ltd. Fusion enzymes
JP5885191B2 (en) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 Sugar chain-modified yeast and method for producing glycoprotein using the same
KR20140114278A (en) 2011-02-25 2014-09-26 머크 샤프 앤드 돔 코포레이션 Yeast strain for the production of proteins with modified o-glycosylation
US9328170B2 (en) 2011-05-25 2016-05-03 Merck Sharp & Dohme Corp. Method for preparing Fc containing polypeptides having improved properties
AR087433A1 (en) 2011-08-08 2014-03-26 Merck Sharp & Dohme N-GLICOSILATED INSULIN ANALOGS
EP2771477A4 (en) * 2011-10-27 2015-04-22 Merck Sharp & Dohme Controlling o-glycosylation in lower eukaryotes
CA2853809A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
WO2013066765A1 (en) 2011-11-01 2013-05-10 Merck Sharp & Dohme Corp. Mutation of tup1 in glycoengineered yeast
EP2780463A4 (en) 2011-11-18 2015-07-01 Merck Sharp & Dohme Fc CONTAINING POLYPEPTIDES HAVING INCREASED ANTI-INFLAMMATORY PROPERTIES AND INCREASED FcRN BINDING
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
JP6383359B2 (en) 2012-10-22 2018-08-29 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． CRZ1 mutant fungal cells
US20150337274A1 (en) 2012-12-17 2015-11-26 Ming-Tang Chen Pmt2-, och1-, pmt5- mutant cells
WO2014126787A1 (en) 2013-02-13 2014-08-21 Merck Sharp & Dohme Corp. Methods for increasing n-glycan occupancy and reducing production of hybrid n-glycans in pichia pastoris strains lacking alg3 expression
CA2903739A1 (en) 2013-03-06 2014-09-12 Glaxosmithkline Llc Host cells and methods of use
SG11201509201WA (en) 2013-05-06 2015-12-30 Cell Machines Inc Methods and compositions related to large scale production of proteins
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
WO2015013116A1 (en) 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
US20160215061A1 (en) 2013-10-08 2016-07-28 Merck Sharp & Dohme Corp. Fc CONTAINING POLYPEPTIDES HAVING INCREASED BINDING TO FcGammaRIIB
WO2015073307A2 (en) 2013-11-13 2015-05-21 Merck Sharp & Dohme Corp. Fc CONTAINING POLYPEPTIDES HAVING INCREASED BINDING TO HUMAN DC-SIGN

Also Published As

Publication number Publication date
HRP20191069T1 (en) 2019-11-01
MX364532B (en) 2019-04-29
DK3016970T3 (en) 2019-06-24
US10724013B2 (en) 2020-07-28
CA2916594A1 (en) 2015-01-08
PL3016970T3 (en) 2019-09-30
WO2015001049A1 (en) 2015-01-08
US20160376570A1 (en) 2016-12-29
SI3016970T1 (en) 2019-08-30
CA2916594C (en) 2020-03-10
US20200040314A1 (en) 2020-02-06
ES2739280T3 (en) 2020-01-30
KR102111078B1 (en) 2020-05-18
US20200362319A1 (en) 2020-11-19
KR20160030127A (en) 2016-03-16
EP3016970A1 (en) 2016-05-11
MX2016000128A (en) 2016-03-01
BR112015032695A2 (en) 2017-10-24
US20220213451A1 (en) 2022-07-07
EP3016970B1 (en) 2019-05-22
RU2016103373A (en) 2017-08-10
RU2016103373A3 (en) 2018-03-26
CN105492457A (en) 2016-04-13

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