SG11201508358RA - 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer - Google Patents

2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer

Info

Publication number
SG11201508358RA
SG11201508358RA SG11201508358RA SG11201508358RA SG11201508358RA SG 11201508358R A SG11201508358R A SG 11201508358RA SG 11201508358R A SG11201508358R A SG 11201508358RA SG 11201508358R A SG11201508358R A SG 11201508358RA SG 11201508358R A SG11201508358R A SG 11201508358RA
Authority
SG
Singapore
Prior art keywords
acetylnaphtho
dione
furan
treating cancer
cancer
Prior art date
Application number
SG11201508358RA
Inventor
Chiang J Li
Wei Li
David Leggett
Youzhi Li
David Kerstein
Matt Hilton
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Publication of SG11201508358RA publication Critical patent/SG11201508358RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201508358RA 2013-04-09 2014-04-09 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer SG11201508358RA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361810117P 2013-04-09 2013-04-09
US201361830068P 2013-06-01 2013-06-01
US201461932179P 2014-01-27 2014-01-27
US201461938386P 2014-02-11 2014-02-11
PCT/US2014/033566 WO2014169078A2 (en) 2013-04-09 2014-04-09 Methods for treating cancer

Publications (1)

Publication Number Publication Date
SG11201508358RA true SG11201508358RA (en) 2015-11-27

Family

ID=50687714

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201508358RA SG11201508358RA (en) 2013-04-09 2014-04-09 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
SG10201801205YA SG10201801205YA (en) 2013-04-09 2014-04-09 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201801205YA SG10201801205YA (en) 2013-04-09 2014-04-09 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer

Country Status (13)

Country Link
US (3) US20160030384A1 (en)
EP (1) EP2983790A2 (en)
JP (3) JP6433085B2 (en)
KR (1) KR20150139955A (en)
CN (2) CN113491690B (en)
AU (1) AU2014250940A1 (en)
BR (1) BR112015025347A2 (en)
CA (1) CA2908380A1 (en)
HK (1) HK1220155A1 (en)
MX (1) MX2015014181A (en)
RU (1) RU2015147696A (en)
SG (2) SG11201508358RA (en)
WO (1) WO2014169078A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
SG11201508358RA (en) 2013-04-09 2015-11-27 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
US20180098959A1 (en) * 2015-04-17 2018-04-12 Boston Biomedical, Inc. Methods for treating cancer
AU2016249157A1 (en) 2015-04-17 2017-11-02 Boston Biomedical, Inc. Methods for treating cancer
EA201792287A1 (en) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. METHODS OF TREATING CANCER
MX2017013816A (en) * 2015-04-27 2018-11-12 Boston Biomedical Inc Methods for treating cancer with a stat3 pathway inhibitor and kinase inhibitor.
US20180140572A1 (en) 2015-06-03 2018-05-24 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
WO2017013865A1 (en) * 2015-07-17 2017-01-26 大日本住友製薬株式会社 Method for producing 2-acetyl-4h,9h-naphtho[2,3-b]furan-4,9-dione
US20190076392A1 (en) 2016-01-20 2019-03-14 Boston Biomedical, Inc. Methods for treating cancer
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
WO2018102427A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018183089A1 (en) 2017-03-30 2018-10-04 Boston Biomedical, Inc. Compositions for treating and/or preventing cancer
CA3062656A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
WO2019232214A1 (en) * 2018-05-31 2019-12-05 Boston Biomedical, Inc. Methods of using napabucasin
MX2021004151A (en) 2018-10-12 2021-09-08 1Globe Biomedical Co Ltd New combination solution for treating chemotherapy refractory cancer.

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2472133A (en) 1947-03-20 1949-06-07 Du Pont Thiophanthraquinone derivatives
SU1049490A1 (en) 1982-05-18 1983-10-23 Ордена Трудового Красного Знамени Институт Химии Ан Мсср (3ar,9as,9bs)-6,6,9a-trimethyltransperhydronaphth(2,2-b)-furan as scent component of perfumery composition
JPS6112632A (en) * 1984-06-27 1986-01-21 Eisai Co Ltd Composition containing fat-soluble drug
JPS6199787A (en) 1984-10-19 1986-05-17 株式会社日立製作所 Band type piping supporter
JPS63196576A (en) 1987-02-10 1988-08-15 Tetsuo Ikegawa Furalnaphthoquinone derivative and carcinostatic agent and production thereof
US5846534A (en) 1988-02-12 1998-12-08 British Technology Group Limited Antibodies to the antigen campath-1
JPH04139177A (en) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc Furalbenzoquinone derivative, its production and carcinostatic agent
EP0757292B1 (en) 1990-07-10 1999-12-22 Canon Kabushiki Kaisha Electrophotographic photosensitive member
TW252136B (en) 1992-10-08 1995-07-21 Ciba Geigy
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
DK0669836T3 (en) 1992-11-13 1996-10-14 Idec Pharma Corp Therapeutic use of chimeric and radiolabeled antibodies and human B lymphocyte restricted differentiation antigen for the treatment of B cell lymphoma
DE4322826A1 (en) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmaceutical preparation
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
GB9603507D0 (en) 1996-02-20 1996-04-17 Isis Innovation Antibody variants
JP3598168B2 (en) 1996-03-18 2004-12-08 独立行政法人 科学技術振興機構 Antiviral agent
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
JPH1121284A (en) 1997-06-30 1999-01-26 Kotobuki:Kk Furanonaphthoquinone derivative and medicine containing the same
JPH1165141A (en) 1997-08-11 1999-03-05 Canon Inc Electrophotographic photoreceptor and process cartridge and electrophotographic apparatus each having this photoreceptor
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
EP1897540A3 (en) 1999-01-27 2008-07-23 University Of South Florida Inhibition of STAT3 signal transduction for human cancer therapy
AU2736400A (en) 1999-01-27 2000-08-18 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
BRPI0009448B8 (en) 1999-04-01 2021-05-25 Univ Texas kit for use in treating a neoplasm in a mammal
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
JP3961827B2 (en) 1999-08-02 2007-08-22 エフ．ホフマン−ラ ロシュ アーゲー Novel selective retinoid agonist
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
ES2282133T3 (en) 1999-08-24 2007-10-16 Medarex, Inc. ANTIBODIES AGAINST HUMAN CTLA-4 AND ITS USES.
JP2001097860A (en) 1999-09-29 2001-04-10 Japan Science & Technology Corp Anti-drug-resistant bacterium agent and anti-chlamydia agent
UA75055C2 (en) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Benzoimidazole derivatives being used as antiproliferative agent, pharmaceutical composition based thereon
KR20010100194A (en) 2000-03-13 2001-11-14 박호군 Composition and formulation for solubilization of various compounds and preparation method thereof
AU2001293995B2 (en) 2000-10-09 2005-10-13 Cytomx Therapeutics, Inc. Therapeutic antibodies
US7090843B1 (en) 2000-11-28 2006-08-15 Seattle Genetics, Inc. Recombinant anti-CD30 antibodies and uses thereof
US7998947B2 (en) 2001-03-28 2011-08-16 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
US20030139466A1 (en) 2001-11-29 2003-07-24 Peritt David L. Methods for pretreating a subject with extracorporeal photopheresis
AU2003215524A1 (en) 2002-03-15 2003-09-29 Natimmune A/S Pharmaceutical compositions comprising mannose binding lectin
CA2481515C (en) 2002-04-10 2013-10-01 Genentech, Inc. Anti-her2 antibody variants
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
EP2283869A3 (en) 2002-07-15 2012-06-27 Board of Regents, The University of Texas System Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in the treatment of viral infections and cancer
US20060142271A1 (en) 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
CA2502552C (en) 2002-10-17 2019-02-12 Genmab A/S Human monoclonal antibodies against cd20
CL2003002353A1 (en) 2002-11-15 2005-02-04 Vertex Pharma COMPOUNDS DERIVED FROM DIAMINOTRIAZOLS, INHIBITORS D ELA PROTEINA QUINASA; PHARMACEUTICAL COMPOSITION; PREPARATION PROCEDURE; AND ITS USE OF THE COMPOUND IN THE TREATMENT OF DISEASES OF ALLERGIC DISORDERS, PROLIFERATION, AUTOIMMUNES, CONDIC
TWI323662B (en) 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
IS6633A (en) 2002-11-22 2004-05-23 Omega Farma Ehf. Compositions of finasteride tablets
KR20060031809A (en) * 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 Compositions and methods for treating and diagnosing cancer
CN104059147A (en) 2003-06-27 2014-09-24 艾默根佛蒙特有限公司 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
JP4804357B2 (en) 2003-11-01 2011-11-02 メルク パテント ゲーエムベーハー Modified anti-CD52 antibody
SG148215A1 (en) 2003-12-02 2008-12-31 Cleveland Clinic Foundation Methods of protecting against radiation using flagellin
SI1701941T1 (en) 2003-12-11 2012-09-28 Univ Texas Compounds for treatment of cell proliferative diseases
DE10359828A1 (en) 2003-12-12 2005-07-28 Zoser B. Dr.Rer.Nat. Salama CHP gemcitabine combination agents and their use as antitumor agents, in particular anti-metastatic agents
CA2563305A1 (en) 2004-04-09 2005-11-24 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (en) 2004-04-21 2004-08-12 Japan Science & Technology Agency Antibacterial agent
DK2287195T3 (en) 2004-07-01 2019-08-19 Innate Pharma PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND USE IN DIAGNOSTICS AND THERAPY
MX2007000265A (en) 2004-07-02 2007-07-20 Icos Corp Compounds useful for inhibiting chk1.
JP2008507520A (en) 2004-07-22 2008-03-13 ジェネンテック・インコーポレーテッド HER2 antibody composition
AU2005273704A1 (en) 2004-08-18 2006-02-23 Astrazeneca Ab Selected fused heterocyclics and uses thereof
CA2587276A1 (en) 2004-11-08 2006-05-18 Baxter International Inc. Nanoparticulate compositions of tubulin inhibitor compounds
AU2005309019A1 (en) 2004-11-24 2006-06-01 Novartis Ag Combinations of JAK inhibitors and at least one of Bcr-Abl, Flt-3, FAK or RAF kinase inhibitors
WO2006065894A2 (en) 2004-12-14 2006-06-22 University Of South Florida Methods for inhibiting stat3 signaling in immune cells
WO2006071812A2 (en) 2004-12-23 2006-07-06 H. Lee Moffitt Cancer Center And Research Institute Platinum iv complex inhibitor
WO2006091837A2 (en) 2005-02-25 2006-08-31 The Regent Of The University Of Michigan Small molecule inhibitors of stat3 and the uses thereof
JP2006248978A (en) 2005-03-10 2006-09-21 Mebiopharm Co Ltd New liposome preparation
JP2006290871A (en) 2005-03-16 2006-10-26 Taheebo Japan Kk Compound exhibiting anti-cancer property, intermediate therefor and method for producing the same
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
CN109485727A (en) 2005-05-09 2019-03-19 小野药品工业株式会社 The human monoclonal antibodies of programmed death-1 (PD-1) and the method for carrying out treating cancer using anti-PD-1 antibody
MX2007015942A (en) 2005-07-01 2008-03-07 Medarex Inc Human monoclonal antibodies to programmed death ligand 1 (pd-l1).
US20070009532A1 (en) 2005-07-06 2007-01-11 Branimir Sikic Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar
UA96139C2 (en) 2005-11-08 2011-10-10 Дженентек, Інк. Anti-neuropilin-1 (nrp1) antibody
AR057579A1 (en) 2005-11-23 2007-12-05 Merck & Co Inc SPIROCICLICAL COMPOUNDS AS INHIBITORS OF ACETYLASE HISTONE (HDAC)
JP2007145680A (en) 2005-11-30 2007-06-14 Idemitsu Kosan Co Ltd Hydrogen generating material and hydrogen generating method
CA2628728A1 (en) 2005-12-24 2007-07-05 Biotica Technology Ltd. 21-deoxymacbecin analogues useful as antitumor agents
US20090012075A1 (en) 2006-01-12 2009-01-08 Miller Thomas A Fluorinated Arylamide Derivatives
CA2635797C (en) 2006-02-09 2015-03-31 Macusight, Inc. Stable formulations, and methods of their preparation and use
US20070243192A1 (en) 2006-02-21 2007-10-18 Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
WO2007095753A1 (en) 2006-02-24 2007-08-30 Merck Frosst Canada Ltd. 2-(phenyl or heterocyclic) - 1h-phenanthro [9,10-d] imidazoles
JP5654233B2 (en) 2006-03-31 2015-01-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Orally bioavailable caffeic acid-related anticancer agents
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2008094321A2 (en) 2006-10-04 2008-08-07 Universtiy Of South Florida Akt sensitization of cancer cells
WO2008077062A2 (en) 2006-12-19 2008-06-26 Board Of Regents, The University Of Texas System Suppression of stat3 reactivation after src kinase inhibition to treat cancer
JP4077863B1 (en) 2007-05-31 2008-04-23 タヒボジャパン株式会社 Process for producing optically active 2- (1-hydroxyethyl) -5-hydroxynaphtho [2,3-b] furan-4,9-dione having anticancer activity
DK2170959T3 (en) 2007-06-18 2014-01-13 Merck Sharp & Dohme ANTIBODIES AGAINST HUMAN PROGRAMMED DEATH RECEPTOR PD-1
CN101842381A (en) 2007-08-27 2010-09-22 波士顿生物医药公司 Composition of asymmetric RNA duplex as microrna mimetic or inhibitor
HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
WO2009060282A2 (en) 2007-11-06 2009-05-14 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
JP2011506319A (en) * 2007-12-06 2011-03-03 デュレクト コーポレーション Useful methods for the treatment of pain, joint inflammation symptoms, or inflammation associated with chronic diseases
US20100297118A1 (en) 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
WO2010014784A2 (en) 2008-08-01 2010-02-04 Bristol-Myers Squibb Company Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
AU2009288289B2 (en) 2008-08-25 2012-11-08 Amplimmune, Inc. PD-1 antagonists and methods of use thereof
TWI686405B (en) 2008-12-09 2020-03-01 建南德克公司 Anti-pd-l1 antibodies and their use to enhance t-cell function
CA2939492C (en) 2009-05-13 2019-03-19 Genzyme Corporation Anti-human cd52 immunoglobulins
US8267122B2 (en) 2009-06-30 2012-09-18 Ge Aviation Systems Llc Method and systems for bleed air supply
EP2504028A4 (en) 2009-11-24 2014-04-09 Amplimmune Inc Simultaneous inhibition of pd-l1/pd-l2
RS60033B1 (en) 2009-11-24 2020-04-30 Medimmune Ltd Targeted binding agents against b7-h1
WO2011084694A1 (en) 2009-12-17 2011-07-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Stabilized stat3 decoy oligonucleotides and uses therefor
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
PH12018501083A1 (en) 2010-03-04 2019-02-18 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
EP3295796A1 (en) 2010-03-19 2018-03-21 1Globe Biomedical Co., Ltd. Novel compounds and compositions for targeting cancer stem cells
CA2793526C (en) 2010-03-19 2018-05-01 Boston Biomedical, Inc. Naphthofuran compounds and compositions for targeting cancer stem cells
BR112012023660B8 (en) * 2010-03-19 2021-05-25 Boston Biomedical Inc uses of a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof, for the treatment of cancer
AU2015218436B9 (en) 2010-03-19 2017-03-09 Boston Biomedical, Inc. Novel Methods For Targeting Cancer Stem Cells
JP5208239B2 (en) 2010-09-29 2013-06-12 タヒボジャパン株式会社 Novel production method of anticancer active tricyclic compounds by alkyne coupling
US9919017B2 (en) * 2011-02-01 2018-03-20 Kaneka Corporation Biologically active substance-containing water-solubilizing preparation and method for producing the same
CN103402993A (en) 2011-03-04 2013-11-20 舟山海中洲新生药业有限公司 Novel esters of 4,9-dihydroxy-naphtho[2,3-b]furans for disease therapies
KR102031020B1 (en) 2011-03-31 2019-10-14 머크 샤프 앤드 돔 코포레이션 Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments
US8977803B2 (en) 2011-11-21 2015-03-10 Western Digital Technologies, Inc. Disk drive data caching using a multi-tiered memory
WO2013166618A1 (en) 2012-05-08 2013-11-14 Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE
US9212224B2 (en) 2012-05-15 2015-12-15 Bristol-Myers Squibb Company Antibodies that bind PD-L1 and uses thereof
WO2013172918A1 (en) 2012-05-15 2013-11-21 University Of Southern California Ksr1 gene polymorphism for use in predicting outcome and therapy selection
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
SG11201508358RA (en) 2013-04-09 2015-11-27 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
JP6199787B2 (en) 2014-03-28 2017-09-20 京セラドキュメントソリューションズ株式会社 Image forming apparatus
DK3043778T3 (en) 2013-09-13 2017-11-27 Bayer Pharma AG PHARMACEUTICAL COMPOSITIONS CONTAINING REFAMETINIB
TW201622731A (en) 2014-04-08 2016-07-01 泰瓦藥品工業有限公司 Unit dosage form comprising Emtricitabine, Tenofovir, Darunavir and Ritonavir and a monolithic tablet comprising darunavir and ritonavir
ES2792851T3 (en) 2014-06-09 2020-11-12 Kyoto Pharma Ind Naphthofuran derivatives for use as antineoplastic agents
JP2016016973A (en) 2014-07-10 2016-02-01 株式会社リコー Sheet processing device
WO2016030455A1 (en) 2014-08-28 2016-03-03 Medimmune Limited Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer
CN106470697B (en) 2014-09-16 2019-10-25 兴盟生物医药(苏州)有限公司 Anti-egfr antibodies with and application thereof
US20180098959A1 (en) 2015-04-17 2018-04-12 Boston Biomedical, Inc. Methods for treating cancer
EA201792287A1 (en) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. METHODS OF TREATING CANCER
AU2016249157A1 (en) 2015-04-17 2017-11-02 Boston Biomedical, Inc. Methods for treating cancer
MX2017013816A (en) 2015-04-27 2018-11-12 Boston Biomedical Inc Methods for treating cancer with a stat3 pathway inhibitor and kinase inhibitor.
US20180140572A1 (en) 2015-06-03 2018-05-24 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
US20190076392A1 (en) 2016-01-20 2019-03-14 Boston Biomedical, Inc. Methods for treating cancer
US20190375723A1 (en) 2016-11-22 2019-12-12 Boston Biomedical, Inc. New Naphtho[2,3-B]Furan Derivatives
WO2018183089A1 (en) 2017-03-30 2018-10-04 Boston Biomedical, Inc. Compositions for treating and/or preventing cancer
CA3062656A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer

Also Published As

Publication number Publication date
SG10201801205YA (en) 2018-04-27
CN106211758A (en) 2016-12-07
US10543189B2 (en) 2020-01-28
BR112015025347A2 (en) 2017-07-18
JP2020186269A (en) 2020-11-19
WO2014169078A2 (en) 2014-10-16
US20200397740A1 (en) 2020-12-24
JP6433085B2 (en) 2018-12-05
KR20150139955A (en) 2015-12-14
JP2019011369A (en) 2019-01-24
MX2015014181A (en) 2016-05-24
WO2014169078A3 (en) 2015-03-05
CN113491690B (en) 2023-03-14
US20160030384A1 (en) 2016-02-04
US20190388382A1 (en) 2019-12-26
AU2014250940A1 (en) 2015-10-22
EP2983790A2 (en) 2016-02-17
CN113491690A (en) 2021-10-12
JP2016516776A (en) 2016-06-09
CA2908380A1 (en) 2014-10-16
CN106211758B (en) 2021-03-23
RU2015147696A (en) 2017-05-12
HK1220155A1 (en) 2017-04-28

Similar Documents

Publication Publication Date Title
SG10201801205YA (en) 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
IL245731A0 (en) Combination therapy for treating cancer
IL241543B (en) Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas
ZA201601726B (en) New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
HK1212699A1 (en) Substituted-imidazo[1,2-b]pyridazines as mknk1 inhibitors mknk1 [12-b]
HK1213886A1 (en) N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases n--3-
EP2968343A4 (en) Combination therapy for treating cancer
EP2980831A4 (en) Underlayer-film-forming composition for imprinting, and pattern formation method
SG11201603050TA (en) Methods for treating cancers
EP2944323A4 (en) Agents for treating tumours, use and method thereof
IL240599A0 (en) Combination therapy for neoplasia treatment
IL240825B (en) Dihydropyridazine - 3, 5 - dione derivative
HK1218120A1 (en) Tricyclic benzoxaborole compound, preparation method therefor, and use thereof
HK1216749A1 (en) 1,7-naphthyridine derivatives 17-
IL240612A0 (en) Tricyclic heterocycles as anticancer agents
HK1220356A1 (en) Novel therapy for prostate carcinoma
LT3016682T (en) Methods for treating cancer
HK1202453A1 (en) Therapeutic composition for treating cancers
GB2514124B (en) Turf Treatment
GB201321531D0 (en) Treatment for cancers
TH1401005856A (en) New thienopyrimidine derivatives, processes for their preparation and therapeutic uses thereof.
IL230199A0 (en) Hydraulic muscle
GB201300546D0 (en) Cancer Treatment
HUP1300270A2 (en) Bone treating device, especially skull drill