SG11201508061UA - Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency - Google Patents

Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency

Info

Publication number
SG11201508061UA
SG11201508061UA SG11201508061UA SG11201508061UA SG11201508061UA SG 11201508061U A SG11201508061U A SG 11201508061UA SG 11201508061U A SG11201508061U A SG 11201508061UA SG 11201508061U A SG11201508061U A SG 11201508061UA SG 11201508061U A SG11201508061U A SG 11201508061UA
Authority
SG
Singapore
Prior art keywords
opa1
haploinsufficiency
treatment
transcription factors
diseases caused
Prior art date
Application number
SG11201508061UA
Inventor
Albert Neutzner
Josef Flammer
Alice Huxley
Original Assignee
Aliophtha Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aliophtha Ag filed Critical Aliophtha Ag
Publication of SG11201508061UA publication Critical patent/SG11201508061UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
SG11201508061UA 2013-04-03 2014-04-02 Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency SG11201508061UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13162189 2013-04-03
PCT/EP2014/056590 WO2014161881A1 (en) 2013-04-03 2014-04-02 Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency

Publications (1)

Publication Number Publication Date
SG11201508061UA true SG11201508061UA (en) 2015-10-29

Family

ID=48044671

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201508061UA SG11201508061UA (en) 2013-04-03 2014-04-02 Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency

Country Status (16)

Country Link
US (1) US20160039893A1 (en)
EP (1) EP2981550A1 (en)
JP (1) JP2016515596A (en)
KR (1) KR20160003691A (en)
CN (1) CN105358568A (en)
AR (1) AR095983A1 (en)
AU (1) AU2014247131A1 (en)
BR (1) BR112015025285A2 (en)
CA (1) CA2908419A1 (en)
EA (1) EA201591626A1 (en)
MA (1) MA38543A1 (en)
PH (1) PH12015502294A1 (en)
SG (1) SG11201508061UA (en)
TN (1) TN2015000436A1 (en)
TW (1) TW201514200A (en)
WO (1) WO2014161881A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020506948A (en) * 2017-02-07 2020-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Gene therapy for haploinsufficiency
CA3091799A1 (en) * 2018-02-27 2019-09-06 The Board Of Trustees Of The Leland Stanford Junior University Engineered immune cells as diagnostic probes of disease
CN110857440B (en) 2018-08-23 2021-02-19 武汉纽福斯生物科技有限公司 Recombinant human II type mitochondrial dynamic protein sample GTP enzyme gene sequence and application thereof
WO2023129940A1 (en) 2021-12-30 2023-07-06 Regel Therapeutics, Inc. Compositions for modulating expression of sodium voltage-gated channel alpha subunit 1 and uses thereof

Also Published As

Publication number Publication date
JP2016515596A (en) 2016-05-30
EP2981550A1 (en) 2016-02-10
CN105358568A (en) 2016-02-24
PH12015502294A1 (en) 2016-02-15
AR095983A1 (en) 2015-11-25
US20160039893A1 (en) 2016-02-11
TW201514200A (en) 2015-04-16
EA201591626A1 (en) 2016-05-31
AU2014247131A1 (en) 2015-10-22
MA38543A1 (en) 2017-02-28
WO2014161881A1 (en) 2014-10-09
TN2015000436A1 (en) 2017-01-03
BR112015025285A2 (en) 2017-10-10
CA2908419A1 (en) 2014-10-09
KR20160003691A (en) 2016-01-11

Similar Documents

Publication Publication Date Title
LTC2785706I2 (en) SUBSTITUTED 4-PHENYL-PYRIDINES FOR THE TREATMENT OF NK-RECEPTOR-RELATED DISEASES
IL266648B (en) Method for treatment of parkinson's disease
IL243976B (en) Kdm1a inhibitors for the treatment of disease
EP3076948A4 (en) Intracameral implant for treatment of an ocular condition
HK1220324A1 (en) Methods, compounds, and compositions for the treatment of angiotensin-related diseases
EP2981252A4 (en) Methods of treating diseases characterized by excessive wnt signalling
IL239851B (en) Methods and compositions for treatment of demyelinating diseases
EP2994460A4 (en) Compounds for treatment of angiogenesis-mediated diseases
IL244042A0 (en) Method for the treatment of fibrotic disease
EP2893903A4 (en) Implantable device for moulding the curvature of the cornea
HK1219653A1 (en) Methods for the treatment of mitochondrial disease
EP2967062A4 (en) Desethylhydroxychloroquine for the treatment of diseases associated with inflammation
HK1225385A1 (en) Heteroaryl derivatives for the treatment of respiratory diseases
HK1225384A1 (en) Benzhydryl derivatives for the treatment of respiratory diseases
HK1221190A1 (en) The local treatment of inflammatory ophthalmic diseases
EP3021119A4 (en) Method for diagnosis of diseases using morphological characteristics of luterial
SG11201508061UA (en) Artificial transcription factors for the treatment of diseases caused by opa1 haploinsufficiency
IL243637B (en) Ppar-sparing compounds for the treatment of metabolic diseases
IL234796B (en) Compounds for the treatment of ischemia-reperfusion-related diseases
EP3030261A4 (en) Methods of treatment of hpv related diseases
IL241482B (en) Method for treatment of parkinson's disease
GB201306413D0 (en) The local treatment of ophthalmic diseases
AU2013901161A0 (en) Methods of treating diseases characterized by excessive wnt signalling