SG11201507720PA - Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor - Google Patents

Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor

Info

Publication number
SG11201507720PA
SG11201507720PA SG11201507720PA SG11201507720PA SG11201507720PA SG 11201507720P A SG11201507720P A SG 11201507720PA SG 11201507720P A SG11201507720P A SG 11201507720PA SG 11201507720P A SG11201507720P A SG 11201507720PA SG 11201507720P A SG11201507720P A SG 11201507720PA
Authority
SG
Singapore
Prior art keywords
selective inhibitor
pi3kbeta
pi3kalpha
tumoral
composition
Prior art date
Application number
SG11201507720PA
Inventor
Hélène Bonnevaux
Carlos Garcia-Echeverria
Angela Virone-Oddos
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201507720PA publication Critical patent/SG11201507720PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
SG11201507720PA 2013-04-05 2014-04-03 Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor SG11201507720PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13305448 2013-04-05
PCT/EP2014/056696 WO2014161938A1 (en) 2013-04-05 2014-04-03 Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor

Publications (1)

Publication Number Publication Date
SG11201507720PA true SG11201507720PA (en) 2015-10-29

Family

ID=48142712

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507720PA SG11201507720PA (en) 2013-04-05 2014-04-03 Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor

Country Status (11)

Country Link
US (1) US20160030440A1 (en)
EP (1) EP2981261A1 (en)
KR (1) KR20150123931A (en)
CN (1) CN105163736A (en)
AU (1) AU2014247032A1 (en)
BR (1) BR112015025101A2 (en)
CA (1) CA2908640A1 (en)
MX (1) MX2015014063A (en)
RU (1) RU2015142258A (en)
SG (1) SG11201507720PA (en)
WO (1) WO2014161938A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA104147C2 (en) * 2008-09-10 2014-01-10 Новартис Аг Pyrrolidine dicarboxylic acid derivative and use thereof in the treatment of proliferative diseases
SI2448927T1 (en) 2009-07-02 2014-06-30 Sanofi Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
WO2012062694A1 (en) * 2010-11-08 2012-05-18 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
US9675616B2 (en) * 2010-11-11 2017-06-13 Bayer Intellectual Property Gmbh Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines
EP2640367A2 (en) * 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
EP2570127A1 (en) * 2011-09-16 2013-03-20 Sanofi Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors

Also Published As

Publication number Publication date
BR112015025101A2 (en) 2017-07-18
CN105163736A (en) 2015-12-16
WO2014161938A1 (en) 2014-10-09
KR20150123931A (en) 2015-11-04
US20160030440A1 (en) 2016-02-04
RU2015142258A (en) 2017-05-12
CA2908640A1 (en) 2014-10-09
AU2014247032A1 (en) 2015-10-29
MX2015014063A (en) 2015-12-11
EP2981261A1 (en) 2016-02-10

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