SG11201507393TA - Oncolytic adenovirus compositions - Google Patents

Oncolytic adenovirus compositions

Info

Publication number
SG11201507393TA
SG11201507393TA SG11201507393TA SG11201507393TA SG11201507393TA SG 11201507393T A SG11201507393T A SG 11201507393TA SG 11201507393T A SG11201507393T A SG 11201507393TA SG 11201507393T A SG11201507393T A SG 11201507393TA SG 11201507393T A SG11201507393T A SG 11201507393TA
Authority
SG
Singapore
Prior art keywords
oncolytic adenovirus
adenovirus compositions
compositions
oncolytic
adenovirus
Prior art date
Application number
SG11201507393TA
Inventor
Clodagh O'shea
Shigeki Miyake-Stoner
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of SG11201507393TA publication Critical patent/SG11201507393TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
SG11201507393TA 2013-03-14 2014-03-14 Oncolytic adenovirus compositions SG11201507393TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361782932P 2013-03-14 2013-03-14
PCT/US2014/029587 WO2014153204A1 (en) 2013-03-14 2014-03-14 Oncolytic adenovirus compositions

Publications (1)

Publication Number Publication Date
SG11201507393TA true SG11201507393TA (en) 2015-10-29

Family

ID=51581449

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507393TA SG11201507393TA (en) 2013-03-14 2014-03-14 Oncolytic adenovirus compositions

Country Status (8)

Country Link
US (2) US11077156B2 (en)
EP (1) EP2971008B1 (en)
JP (1) JP6576326B2 (en)
KR (1) KR102089121B1 (en)
AU (1) AU2014236207B2 (en)
CA (2) CA2903582C (en)
SG (1) SG11201507393TA (en)
WO (1) WO2014153204A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2971008B1 (en) 2013-03-14 2018-07-25 Salk Institute for Biological Studies Oncolytic adenovirus compositions
DK3161129T3 (en) * 2014-06-27 2019-11-04 Angiocrine Bioscience Inc NERV CELLS THAT EXPRESS ADENOVIRUS E4ORF1 AND PROCEDURES FOR PREPARING AND USING THE SAME
CA2961748A1 (en) * 2014-09-24 2016-03-31 Salk Institute For Biological Studies Oncolytic tumor viruses and methods of use
CA3000462C (en) 2015-10-05 2024-04-02 Salk Institute For Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
KR102471633B1 (en) 2016-02-23 2022-11-25 솔크 인스티튜트 포 바이올로지칼 스터디즈 Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
EP3390428B1 (en) 2016-02-23 2019-09-25 Salk Institute for Biological Studies High throughput assay for measuring adenovirus replication kinetics
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
JP7260173B2 (en) 2017-04-21 2023-04-18 ベイラー カレッジ オブ メディスン Oncolytic virus therapy and immunotherapy
WO2018204677A1 (en) * 2017-05-04 2018-11-08 Epicentrx, Inc. Oncolytic adenovirus formulation
SG11202007873VA (en) * 2018-03-05 2020-09-29 Klinikum Rechts Der Isar Der Technischen Univ Muenchen Treatment of tumors by a combination of an oncolytic adenovirus and a cdk4/6 inhibitor
EP3775175A4 (en) * 2018-04-09 2022-02-09 Salk Institute for Biological Studies Oncolytic adenovirus compositions with enhanced replication properties
TW202011977A (en) * 2018-04-20 2020-04-01 貝勒醫學院 Oncolytic virotherapy and immunotherapy

Family Cites Families (328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US6410010B1 (en) 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
FR2688514A1 (en) 1992-03-16 1993-09-17 Centre Nat Rech Scient Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them
DE69426841T2 (en) 1993-02-16 2001-09-06 Onyx Pharma Inc Cytopatic viruses for the therapy and prophylaxis of neoplasia
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US7045347B2 (en) 1993-06-24 2006-05-16 Advec, Inc. Helper dependent adenovirus vectors based on integrase family site-specific recombinases
US20010006629A1 (en) 1993-10-25 2001-07-05 Richard J. Gregory Recombinant adenoviral vector and methods of use
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5962311A (en) 1994-09-08 1999-10-05 Genvec, Inc. Short-shafted adenoviral fiber and its use
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
FR2726285B1 (en) 1994-10-28 1996-11-29 Centre Nat Rech Scient ADENOVIRUSES CONTAINING VIABLE CONTAMINANT PARTICLES, PREPARATION AND USE
JPH10510987A (en) 1994-12-12 1998-10-27 ジェネティック セラピー，インコーポレイテッド Improved adenovirus vectors and producer cells
US6127525A (en) 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US20030026789A1 (en) 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
US6506379B1 (en) 1995-06-07 2003-01-14 Ariad Gene Therapeutics, Inc. Intramuscular delivery of recombinant AAV
AUPN477695A0 (en) 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
US5945335A (en) * 1995-11-09 1999-08-31 Avigen, Inc. Adenovirus helper-free system for producing recombinant AAV virions lacking oncogenic sequences
US6083720A (en) 1995-11-13 2000-07-04 Chroboczek; Jadwiga Dodecahedral adenoviral protein complex, composition containing same and uses thereof
EP1616961A1 (en) 1995-11-28 2006-01-18 Genvec, Inc. Vectors and methods for gene transfer to cells
US6133243A (en) 1996-02-22 2000-10-17 Onyx Pharmaceuticals, Inc. Liposomal-viral DNA complexes for treating disease
FR2746110B1 (en) 1996-03-14 1998-04-17 METHOD OF TREATING GENE THERAPY OF HUMAN TUMORS AND CORRESPONDING RECOMBINANT VIRUSES
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
CA2258158A1 (en) 1996-07-01 1998-01-08 Francis Blanche Method for producing recombinant adenovirus
US7232899B2 (en) 1996-09-25 2007-06-19 The Scripps Research Institute Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
US5922315A (en) 1997-01-24 1999-07-13 Genetic Therapy, Inc. Adenoviruses having altered hexon proteins
US6403370B1 (en) 1997-02-10 2002-06-11 Genstar Therapeutics Corporation Oncolytic/immunogenic complementary-adenoviral vector system
US20050287120A1 (en) 1997-03-21 2005-12-29 Fisher Paul B Cancer - targeted viral vectors
FR2761689B1 (en) 1997-04-02 1999-06-25 Transgene Sa MODIFIED ADENOVIRAL FIBER AND TARGET ADENOVIRUS
CA2291323A1 (en) 1997-05-28 1998-12-03 Genvec, Inc. Alternatively targeted adenovirus
US6200799B1 (en) 1997-06-03 2001-03-13 University Of Lausanne Somatic gene therapy to suppress secondary cataract formation following eye surgery
DE69820450T2 (en) 1997-06-09 2004-05-27 Genvec, Inc. CHIMEAR VECTORS CONTAINING THE PACKAGING REGION OF A PHAGE GENENOM AND PART OF THE GENOME OF AN EUKARYONTIC VIRUS
EP1044280A1 (en) 1997-12-12 2000-10-18 Onyx Pharmaceuticals, Inc. SELECTIVE KILLING AND DIAGNOSIS OF p53?+ NEOPLASTIC CELLS
US7297542B2 (en) 1998-02-06 2007-11-20 The Uab Research Foundation Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
CA2321135A1 (en) 1998-02-17 1999-08-19 Uab Research Foundation Modified adenovirus containing a fiber replacement protein
US20050095231A1 (en) 1998-02-17 2005-05-05 Curiel David T. Modified adenovirus containing a fiber replacement protein
AU2796799A (en) 1998-03-03 1999-09-20 Uab Research Foundation, The Amplification of gene transfer and gene therapy by controlled replication
AU3358999A (en) 1998-03-20 1999-10-11 Genzyme Corporation Chimeric adenoviral vectors for targeted gene delivery
US6670188B1 (en) 1998-04-24 2003-12-30 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US7829329B2 (en) 1998-04-24 2010-11-09 Onyx Pharmaceuticals, Inc. Adenoviral vectors for treating disease
PT1199368E (en) 1998-07-07 2004-04-30 Transgene Sa USING ADENOVIRAL REGION E4 BLOCKS TO IMPROVE EXPRESSION OF A RELEVANT GENE
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
JP2002523105A (en) 1998-08-27 2002-07-30 アバンテイス・フアルマ・エス・アー Targeted adenovirus vectors for delivery of heterologous genes
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
CA2342396A1 (en) 1998-09-11 2000-03-23 Genvec, Inc. Alternatively targeted adenovirus
US6841540B1 (en) 1998-09-29 2005-01-11 The Uab Research Foundation Immunomodulation by genetic modification of dendritic cells and B cells
CZ301506B6 (en) 1998-10-15 2010-03-31 Canji, Inc. Selectively replicating viral vectors and process of its preparation, pharmaceutical formulation, method of killing a cell having defective pathway, transformed cell and promoter responsive to p53 and TGF-{beta} pathways
US20020037274A1 (en) 1998-10-26 2002-03-28 Angelica Williams Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
AU772630B2 (en) 1999-01-14 2004-05-06 Novartis Ag Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
US6395875B1 (en) 1999-01-25 2002-05-28 Brookhaven Science Associates Llc Recombinant soluble adenovirus receptor
US7157266B2 (en) 1999-01-25 2007-01-02 Brookhaven Science Associates Llc Structure of adenovirus bound to cellular receptor car
WO2000052186A1 (en) 1999-03-04 2000-09-08 Introgene B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
US6869936B1 (en) 1999-03-04 2005-03-22 Crucell Holland B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
AU767904B2 (en) 1999-05-12 2003-11-27 Uab Research Foundation, The Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
US20040175362A1 (en) 1999-05-12 2004-09-09 Curiel David T. Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
AU777041B2 (en) 1999-05-17 2004-09-30 Crucell Holland B.V. Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35
US20050232900A1 (en) 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US7094398B1 (en) 1999-06-01 2006-08-22 University Of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
AU5464000A (en) 1999-06-01 2000-12-18 University Of Washington Recombinant adenoviral vectors for cell specific infection and genome integration and expressing chimeric fiber proteins
EP1593742A3 (en) 1999-06-01 2006-02-01 The University of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection
DE19929569A1 (en) 1999-06-21 2000-12-28 Holm Per Sonne Composition for treating malignant disease, comprising E1A-defective adenovirus that can replicate in presence of YB-1 protein
CN1359391A (en) 1999-07-06 2002-07-17 哥德－A－基因股份公司 Recombinant adenovirus
US7589069B1 (en) 1999-07-12 2009-09-15 Saint Louis University Replication-competent anti-cancer vectors
EP1124977A1 (en) 1999-08-27 2001-08-22 Transgene S.A. Modified adenoviral fibre and uses thereof
AU1070901A (en) 1999-09-23 2001-04-24 Genvec, Inc. Method of treating cells of the prostate prophylactically or therapeutically
AU773019B2 (en) 1999-09-24 2004-05-13 Uab Research Foundation, The Capsid-modified recombinant adenovirus and methods of use
WO2001023004A1 (en) 1999-09-30 2001-04-05 The Trustees Of The University Of Pennsylvania Replication selective adenoviruses for use in cancer therapy
AU1087701A (en) 1999-10-15 2001-04-30 Canji, Inc. Targeted vectors
CA2388807C (en) 1999-11-12 2013-08-06 Matthew C. Coffey Viruses for the treatment of cellular proliferative disorders
DK1230378T3 (en) 1999-11-15 2007-10-08 Onyx Pharma Inc An oncolytic adenovirus
US6867022B1 (en) 2000-01-21 2005-03-15 Regents Of The University Of Michigan Replication deficient adenovirus vectors and methods of making and using them
WO2001058940A2 (en) 2000-02-09 2001-08-16 Genvec, Inc. Adenoviral capsid containing chimeric protein ix
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
AU4764801A (en) 2000-03-24 2001-10-08 Calydon Inc Cell-specific adenovirus vectors comprising an internal ribosome entry site
US6911200B2 (en) 2000-03-24 2005-06-28 Cell Genesys, Inc. Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation
US20030082146A1 (en) 2000-04-26 2003-05-01 Van Es Helmuth H. G. Adenovirus vectors with knobless fibers, and their uses
CA2407881A1 (en) 2000-05-01 2001-11-08 Novartis Ag Vectors for ocular transduction and use thereof for genetic therapy
US7332337B2 (en) 2000-05-16 2008-02-19 Galapagos Nv Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
EP1157999A1 (en) 2000-05-24 2001-11-28 Introgene B.V. Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof
JP4744771B2 (en) 2000-05-26 2011-08-10 大日本住友製薬株式会社 Novel recombinant adenovirus vector with reduced side effects
EP1301612A2 (en) 2000-05-31 2003-04-16 Genvec, Inc. Method and composition for targeting an adenoviral vector
EP1285079A2 (en) 2000-05-31 2003-02-26 University of Saskatchewan Modified bovine adenovirus having altered tropism
US7754201B2 (en) 2000-06-02 2010-07-13 GenPhar, Inc Method of vaccination through serotype rotation
EP1167533A1 (en) 2000-06-23 2002-01-02 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Methods and means for the complementation of viral protein expression in stable cell lines
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US20020106382A1 (en) 2000-07-14 2002-08-08 Young Charles S.H. Modified adenovirus and uses thereof
US7022496B2 (en) 2000-07-14 2006-04-04 The Johns Hopkins University Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
GB0017720D0 (en) 2000-07-19 2000-09-06 Got A Gene Ab Modified virus
ATE315095T1 (en) 2000-08-10 2006-02-15 Crucell Holland Bv ADENOVIRUS VECTORS FOR TRANSDUCTION OF CHONDROCYTES
US7235233B2 (en) 2000-09-26 2007-06-26 Crucell Holland B.V. Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts
CA2430947A1 (en) 2000-12-08 2002-06-13 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US20030095989A1 (en) 2000-12-18 2003-05-22 Irving John M. Chimeric cytolytic viruses for cancer treatment
US6635466B2 (en) 2001-01-09 2003-10-21 University Of Iowa Research Foundation Adenovirus serotype 30 (Ad30)
AU2002250081A1 (en) 2001-02-14 2002-08-28 Uab Research Foundation Combined transductional and transcriptional targeting system for improved gene delivery
IL152420A0 (en) 2001-02-23 2003-05-29 Novartis Ag Novel oncolytic adenoviral vectors
WO2002079507A2 (en) 2001-04-02 2002-10-10 Bayer Aktiengesellschaft Method for specifically detecting, isolating and characterizing cells from body samples by transfecting nucleic acid constructs
US20030219899A1 (en) 2001-04-17 2003-11-27 Nikolay Korokhov Mosaic adenoviral vectors
US20030138405A1 (en) * 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways
WO2002083880A1 (en) 2001-04-17 2002-10-24 Vectorlogics, Inc. Mosaic adenoviral vectors
ATE530672T1 (en) 2001-06-22 2011-11-15 Univ Pennsylvania RECOMBINANT ADENOVIRUSES WITH MONKEY ADENOVIRUS PROTEINS AND USE THEREOF.
US6844192B2 (en) * 2001-06-29 2005-01-18 Wake Forest University Adenovirus E4 protein variants for virus production
US6905678B2 (en) 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
US20030021768A1 (en) 2001-07-23 2003-01-30 Yuqiao Shen Viral mutants that selectively replicate in targeted human cancer cells
US6838285B2 (en) 2001-09-18 2005-01-04 Becton Dickinson Site specific recombinase based method for producing adenoviral vectors
US7569217B2 (en) * 2001-09-24 2009-08-04 University Of Saskatchewan Porcine adenovirus E1 and E4 regions
EP1446479B1 (en) 2001-09-29 2012-08-15 Chae-Ok Yun Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus
BR0214350A (en) 2001-11-21 2005-05-10 Univ Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same and methods of use
CN100475966C (en) 2001-11-23 2009-04-08 上海三维生物技术有限公司 New-type adenovirus with tumor cell specific infection and transgenic expression capability
EP1327688A1 (en) 2002-01-14 2003-07-16 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Adenoviruses with enhanced lytic potency
CA2474763A1 (en) 2002-01-24 2003-07-31 The Scripps Research Institute Fiber shaft modifications for efficient targeting
EP1470233A1 (en) 2002-02-01 2004-10-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated with pods
US20030220284A1 (en) 2002-02-22 2003-11-27 Patricia Yotnda Delivery of adenoviral DNA in a liposomal formulation for treatment of disease
US20040005710A1 (en) 2002-03-09 2004-01-08 Ho-Sun Son Method for producing recombinant viruses using site-specific recombination
JP2005526099A (en) 2002-03-26 2005-09-02 オンコリティクス バイオテック， インコーポレイティッド Use of adenovirus with mutated VA gene for cancer treatment
JP4495587B2 (en) * 2002-04-25 2010-07-07 クルセル ホランド ベー ヴェー Recombinant adenovirus vector and use thereof
EP1499332A4 (en) 2002-04-29 2006-12-06 Hadasit Med Res Service Compositions and methods for treating cancer with an oncolytic viral agent
EP1504016A4 (en) 2002-05-08 2006-11-22 Intronn Inc Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses
KR101083450B1 (en) 2002-05-27 2011-11-16 페르 손네 홀름 Novel use of adenoviruses and nucleic acids coding therefor
JP2006514538A (en) 2002-07-10 2006-05-11 トランスジーン ソシエテ アノニム Modified adenovirus fibers with removed binding to cellular receptors
AU2003253992A1 (en) 2002-07-18 2004-02-09 Robert P. Bennett Viral vectors containing recombination sites
US7364727B2 (en) 2002-07-22 2008-04-29 Cell Genesys, Inc. Metastatic colon cancer specific promoter and uses thereof
EP1539937A4 (en) * 2002-08-22 2006-07-26 Merck & Co Inc Methods for propagating adenovirus and virus produced thereby
CN1720066B (en) 2002-10-01 2012-05-23 杜克大学 Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors
EP1413586A1 (en) 2002-10-21 2004-04-28 Centre National De La Recherche Scientifique (Cnrs) Regulation of the Cre recombinase using a dissociation/re-association system of said recombinase
US20040102382A1 (en) 2002-11-27 2004-05-27 Transgene, S.A. Targeting peptides
WO2004083418A1 (en) 2003-03-17 2004-09-30 Merck & Co., Inc. Adenovirus serotype 24 vectors, nucleic acids and virus produced thereby
US20040191761A1 (en) 2003-03-27 2004-09-30 Routes John M. Modified adenoviral E1A constructs and methods of use thereof
CA2519207A1 (en) 2003-03-28 2004-11-11 Merck & Co., Inc. Adenovirus serotype 34 vectors, nucleic acids and virus produced thereby
CA2519680A1 (en) 2003-03-28 2004-11-18 The Scripps Research Institute Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes
US20040213764A1 (en) 2003-03-28 2004-10-28 William Wold Adenovirus replication-competent vectors expressing trail
US20050095705A1 (en) 2003-04-15 2005-05-05 Michael Kadan Method for production of oncolytic adenoviruses
US20060281090A1 (en) 2003-05-01 2006-12-14 University Of Washington Uw Tech Transfer- Invention Licensing Capsid-modified adenovirus vectors and methods of using the same
WO2004101799A2 (en) 2003-05-14 2004-11-25 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Broadening adenovirus tropism
US20050079158A1 (en) 2003-06-05 2005-04-14 Shenzhen Allucks Biotech Co., Ltd. Construct of anti-cancer recombinant adenovirus, method for preparing the same and use thereof
CA2527721C (en) 2003-06-10 2016-05-10 University Of Saskatchewan Chimeric adenovirus capsid proteins
JP2007531507A (en) 2003-06-11 2007-11-08 ザ スクリップス リサーチ インスティテュート Modified fiber protein for efficient receptor binding
ES2478625T3 (en) 2003-06-20 2014-07-22 The Trustees Of The University Of Pennsylvania Method of generating chimeric adenoviruses and uses of such chimeric adenoviruses
US7291498B2 (en) 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
US20050036989A1 (en) 2003-07-18 2005-02-17 Onyx Pharmaceuticals, Inc. Subgroup B adenoviral vectors for treating disease
ES2391975T3 (en) 2003-07-25 2012-12-03 Genvec, Inc. Adenoviral vector based vaccines
US20050186178A1 (en) 2003-08-28 2005-08-25 Ennist David L. Oncolytic adenoviral vectors encoding GM-CSF
AU2003265873A1 (en) 2003-08-28 2005-04-14 Cell Genesys, Inc. Oncolytic adenoviral vectors encoding gm-csf
EP1664099A2 (en) 2003-09-09 2006-06-07 Niels Rudi Pedersen Adenoviral epitopes
US7482156B2 (en) 2003-10-15 2009-01-27 Cell Genesys, Inc. Hepatocellular carcinoma specific promoter and uses thereof
CA2546178A1 (en) 2003-11-14 2005-06-09 Per Sonne Holm New use of adenovirus and nucleic acids coding therefor
US20050201978A1 (en) 2003-11-17 2005-09-15 Lipton James S. Tumor and infectious disease therapeutic compositions
EP1702071B1 (en) 2003-12-31 2012-02-22 Kalobios Inc. Transactivation system for mammalian cells
WO2005075506A1 (en) 2004-01-09 2005-08-18 The Scripps Research Institute Identification of endogenous trimerization domains in the adenovirus fiber protein that allow detargeting and retargeting of viral vectors
CN107723298A (en) 2004-01-23 2018-02-23 Msd意大利有限公司 Chimpanzee adenovirus vaccine carriers
US20050201936A1 (en) 2004-02-12 2005-09-15 Wold William S.M. Models for viral-based cancer therapy
WO2005086922A2 (en) 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
WO2006075819A1 (en) 2004-03-30 2006-07-20 Industry-Academic Cooperation Foundation, Yonsei University Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin
US20080292592A1 (en) 2004-04-30 2008-11-27 Sunil Chada Oncolytic Adenovirus Armed with Therapeutic Genes
EP1743041B1 (en) 2004-05-03 2012-06-27 Stefan Kochanek Modified viral vector particles
GB0411428D0 (en) 2004-05-21 2004-06-23 Got A Gene Ab Vectors
ATE491799T1 (en) 2004-05-26 2011-01-15 Bayer Schering Pharma Ag CHIMERIC ADENOVIRUSES FOR USE IN CANCER TREATMENT
US20050271622A1 (en) 2004-06-03 2005-12-08 Shenzhen Allucks Biotech Co., Ltd. Construct of tumor-selective recombinant adenovirus, method for preparing the same and use thereof
WO2005117993A2 (en) 2004-06-04 2005-12-15 Genvec, Inc. Method of using adenoviral vectors with improved safety and efficacy for the treatment of cancer
CN100361710C (en) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 Construction and application of oncolytic adenovirus recombinant of tumor cell specifically expressing immunoregulation factor GM-CSF
US20060292682A1 (en) 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
GB0416487D0 (en) 2004-07-23 2004-08-25 Isis Innovation Modified virus
US7776322B2 (en) 2004-08-16 2010-08-17 Stefan Kochanek Modified viral vector particles
EP1784493A2 (en) 2004-09-01 2007-05-16 The Government of the United States of America as Represented by The Department of Health and Human Services Adenoviral vectors able to transduce apcs, potential use in immune response generation
US7943373B2 (en) 2004-09-29 2011-05-17 Oncolys Biopharma, Inc. Telomelysin/GFP-expressing recombinant virus
AP2351A (en) 2004-10-13 2012-01-25 Crucell Holland Bv Improved adenoviral vectors and uses thereof.
BRPI0517021A (en) 2004-10-25 2008-09-30 Novartis Ag tor polynucleotides and polypeptides, and methods of use
IL166049A0 (en) 2004-12-30 2006-01-15 Gavish Galilee Bio Appl Ltd Method for obtaining modified proteins and viruseswith intact native binding
US20090232800A1 (en) 2004-12-31 2009-09-17 Per Sonne Holm E1-minus adenoviruses and use thereof
KR101527213B1 (en) 2004-12-31 2015-06-09 페르 손네 홀름 Method for reversing multiple resistance in animal cells
WO2006086357A2 (en) 2005-02-10 2006-08-17 Merck & Co., Inc. Adenovirus serotype 36 vectors, nucleic acid and viruses produced thereby
JP2008538894A (en) 2005-02-11 2008-11-13 メルク エンド カムパニー インコーポレーテッド Adenovirus serotype 26 vector, nucleic acid and virus produced thereby
KR100747646B1 (en) 2005-02-25 2007-08-08 연세대학교 산학협력단 Gene Delivery System Containing Decorin Gene and Pharmaceutical Composition for Treating Cancer containing the System
WO2006119449A2 (en) 2005-05-04 2006-11-09 Vectorlogics, Inc. Modified adenovirus containing a stabilized antibody
WO2007050128A2 (en) 2005-05-31 2007-05-03 Vectorlogics, Inc. Shielded adenoviral vectors and methods of use
ES2948791T3 (en) 2005-06-17 2023-09-19 Msd Italia Srl Hepatitis C virus nucleic acid vaccine
WO2007027860A2 (en) 2005-08-31 2007-03-08 Genvec, Inc. Adenoviral vector-based malaria vaccines
KR100723009B1 (en) 2005-11-30 2007-05-29 한국원자력연구원 A pharmaceutical composition for treating malignant tumors containing human p31 genes
ES2304281B1 (en) 2006-02-01 2009-08-12 Dnatrix Inc. ADENOVIRUS ONCOLITICOS FOR THE TREATMENT OF CANCER.
WO2007094653A1 (en) 2006-02-13 2007-08-23 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles.
WO2007103825A2 (en) 2006-03-02 2007-09-13 The Board Of Regents Of The University Of Texas System Combination therapy with oncolytic adenovirus
US20070292954A1 (en) 2006-04-21 2007-12-20 The Brigham And Women's Hospital, Inc. Generation of recombinant DNA by sequence-and ligation-independent cloning
WO2008010864A2 (en) 2006-04-28 2008-01-24 The Trustees Of The University Of Pennsylvania Modified adenovirus hexon protein and uses thereof
US20080242608A1 (en) 2006-06-02 2008-10-02 Azad Bonni Methods and compositions for treating and preventing neurologic disorders
EP2041291A1 (en) 2006-06-19 2009-04-01 Institut Gustave Roussy Inhibition of the liver tropism of adenoviral vectors
JP2008048621A (en) 2006-08-22 2008-03-06 Chiba Prefecture Method for creating chimeric adenovirus and pharmaceutical using the same
GR20060100496A (en) 2006-09-01 2008-04-15 Παρθενιος Μπουλικας LIPOSOMALLY ENCAPSULATED HYBRID ADENOVIRUS-SEMLIKI FOREST VIRUS (SFV) VECTORS CARRYING RNAi CONSTRUCTS AND THERAPEUTIC GENES FOR USE AGAINST CANCER TARGETS AND OTHER DISEASES.
US20100098668A1 (en) 2006-09-29 2010-04-22 Northshore University Health System Oncolytic Adenoviruses and Uses Thereof
US20100272753A1 (en) 2006-10-26 2010-10-28 The Johns Hopkins University Recombinant Adenovirus Vaccines
ES2422299T3 (en) 2006-11-28 2013-09-10 Nerviano Medical Sciences Srl Indocyls (4,5-dihydro) tricyclic indoles
WO2008095168A2 (en) 2007-02-01 2008-08-07 University Of Chicago Compositions and methods related to a recombinant adenoviral vector that targets il 13 receptors
CN101702918B (en) 2007-03-14 2013-03-27 卡塔拉肿瘤研究所 Adenovirus with mutations in the endoplasmic reticulum retention domain of the e3-19k protein and use in cancer treatment thereof
US20090081639A1 (en) 2007-05-31 2009-03-26 Phil Hill Assay for sensitivity to chemotherapeutic agents
WO2009065800A1 (en) 2007-11-20 2009-05-28 Crucell Holland B.V. Recombinant human adenoviruses for eliciting mucosal immune responses
CA2706258C (en) 2007-11-28 2017-06-06 The Trustees Of The University Of Pennsylvania Simian subfamily e adenoviruses sadv-39, -25.2, -26, -30, -37, and -38 and uses thereof
DK2220242T3 (en) 2007-11-28 2017-03-27 Univ Pennsylvania ABE-ADENOVIRA OF GROUP B, SADV-28,27, -29, -32, -33 AND -35 AND APPLICATIONS THEREOF
EP2463362B1 (en) 2007-11-28 2017-11-08 The Trustees Of The University Of Pennsylvania Simian subfamily c adenovirus SAdv-31 and uses thereof
US20110104788A1 (en) 2008-02-07 2011-05-05 Andrew Baker Modulation of Adenoviral Tropism
JP5661476B2 (en) 2008-03-04 2015-01-28 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Simian adenovirus SAdV-36, -42.1, -42.2 and -44 and their uses
WO2009117656A2 (en) 2008-03-21 2009-09-24 Vectorlogics,Inc. Capsid-incorporated antigen for novel adenovirus vaccine
US20110086063A1 (en) 2008-06-04 2011-04-14 Cornell University Vaccines for prevention and treatment of addiction
BRPI0914223A2 (en) 2008-06-19 2019-09-24 Millennium Pharm Inc thiophene or thiazole derivatives and their uses as p13k inhibitors
KR101034811B1 (en) 2008-08-25 2011-05-16 단국대학교 산학협력단 Recombinant adenovirus comprising tissu-specific promoter and tumor-targeting trans-splicing ribozyme and uses thereof
KR20110081222A (en) 2008-09-26 2011-07-13 어번 유니버시티 Immunization of avians by mucosal administration of non-replicating vectored vaccines
EP2774985B1 (en) 2008-10-31 2016-12-14 The Trustees Of The University Of Pennsylvania Simian adenovirus SAdV-43 and uses thereof
ES2612889T3 (en) 2008-12-22 2017-05-19 Targovax Oy Oncolytic adenoviral vectors and related procedures and uses
US9345787B2 (en) 2008-12-22 2016-05-24 Targovax Oy Adenoviral vectors and methods and uses related thereto
KR101763093B1 (en) 2009-02-02 2017-07-28 글락소스미스클라인 바이오로지칼즈 에스.에이. Simian Adenovirus Nucleic Acid- and Amino Acid-Sequences, Vectors Containing Same, and Uses Thereof
ES2750305T3 (en) 2009-03-02 2020-03-25 Univ California E1A and E1B mutants of tumor-selective adenoviruses
ES2385251B1 (en) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge ONCOLYTIC ADENOVIRUSES FOR THE TREATMENT OF CANCER.
WO2010138675A1 (en) 2009-05-29 2010-12-02 The Trustees Of The University Of Pennsylvania Simian adenovirus 41 and uses thereof
KR20120052369A (en) 2009-07-31 2012-05-23 팍스박스, 인코포레이티드 Adenoviral-based vectors
US9555089B2 (en) 2009-08-18 2017-01-31 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
WO2011022002A1 (en) 2009-08-18 2011-02-24 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
KR101248912B1 (en) 2009-12-31 2013-03-29 한양대학교 산학협력단 Recombinant Adenovirus Having Anti―Angiogenesis Activity
WO2011101869A1 (en) 2010-02-22 2011-08-25 Transgene Biotek Ltd. Adeno-associated virus 2/8 - micro rna-101 therapy for liver cancer
CN102191245B (en) 2010-03-15 2013-11-13 浙江东方基因生物制品有限公司 Method and reagent for detecting tumor cell in circulatory blood by applying tumor peculiar promoter to express reporter gene
US9682133B2 (en) 2010-03-17 2017-06-20 Cornell University Disrupted adenovirus-based vaccine against drugs of abuse
US20130058897A1 (en) 2010-04-14 2013-03-07 Mogam Biotechnology Research Institute Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same
WO2011133040A2 (en) 2010-04-23 2011-10-27 Orca Therapeutics B.V. Replication-competent adenoviruses
US9018182B2 (en) 2010-04-26 2015-04-28 Green Cross Corporation Tumor specific promoter and oncolytic virus vector comprising the same
EP2580234B1 (en) 2010-06-10 2017-03-08 University Of Washington Through Its Center For Commercialization Methods and systems for adenovirus interaction with desmoglein 2 (dsg2)
WO2012003287A2 (en) 2010-06-30 2012-01-05 The Johns Hopkins University Compositions and methods for detecting and quantifying circulating tumor cells ctcs
WO2012024350A2 (en) 2010-08-16 2012-02-23 Salk Institute For Biological Studies Anti-cancer adenoviruses
WO2012024351A2 (en) 2010-08-16 2012-02-23 Salk Institute For Biological Studies Adenoviral assembly method
WO2012022496A2 (en) 2010-08-19 2012-02-23 Per Sonne Holm Method for killing tumor stem cells
BR112013006699A2 (en) 2010-09-24 2016-06-14 Oncos Therapeutics Oy oncolytic adenoviral vector encoding monoclonal anti-ct4-4 antibodies, cell and pharmaceutical composition comprising the same, method of producing ctla-4 specific human monoclonal antibody in a cell and use of said adenoviral vector
JP2013541945A (en) 2010-09-24 2013-11-21 オンコス セラピュティックス オサケ ユキチュア Oncolytic adenoviral vectors and related methods and uses
AU2011332025B2 (en) 2010-11-23 2015-06-25 The Trustees Of The University Of Pennsylvania Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
WO2012083297A2 (en) 2010-12-17 2012-06-21 Genvec, Inc. Adenoviral vectors with modified hexon regions
WO2012088041A1 (en) 2010-12-20 2012-06-28 Genvec, Inc. Adenoviral vector-based dengue fever vaccine
CN102174479B (en) 2011-03-02 2013-04-03 北京锤特生物科技有限公司 Oncolytic virus for targeted treatment of human tumors and application thereof
WO2012132369A1 (en) 2011-03-25 2012-10-04 国立大学法人鹿児島大学 Viral vector targeting cancer stem cells
WO2012156933A1 (en) 2011-05-16 2012-11-22 Institut Gustave Roussy Combination of oncolytic adenoviruses with histone deacetylase inhibitors
WO2012162342A2 (en) 2011-05-23 2012-11-29 The Wistar Institute Of Anatomy And Biology Influenza vaccines containing modified adenovirus vectors
GB201108879D0 (en) 2011-05-25 2011-07-06 Isis Innovation Vector
CN102260712B (en) 2011-05-31 2013-10-02 北京锤特生物科技有限公司 Construction and application of type B adenovirus hominis Ad11 mutant with enhanced tumor dissolving ability
KR101946666B1 (en) 2011-08-23 2019-02-11 고쿠리츠 켄큐 카이하츠 호진 이야쿠 키반 켄코 에이요 켄큐쇼 Conditionally replication-competent adenovirus
WO2013036791A2 (en) 2011-09-09 2013-03-14 Beth Israel Deaconess Medical Center, Inc. Modified adenoviral vectors and methods of treatment using same
JP6757120B2 (en) 2011-10-05 2020-09-16 ジェンヴェック エルエルシー Afen adenovirus (gorilla) or adenovirus vector, and how to use
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
US9267153B2 (en) 2011-12-15 2016-02-23 Washington University Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
CA2863523A1 (en) 2012-02-02 2013-08-08 Juan FUEYO-MARGARETO Recombinant adenovirus expressing cancer antigens
SI2825640T1 (en) 2012-03-12 2016-08-31 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
EP2825649B1 (en) 2012-03-13 2019-07-31 The Salk Institute for Biological Studies Selective cell targeting using adenovirus and chemical dimers
CN107267554A (en) 2012-03-14 2017-10-20 萨克生物研究学院 Adenovirus diagnosing tumor method
US9017672B2 (en) 2012-05-11 2015-04-28 Immunicum Aktiebolag Hexon Tat-PTD modified adenovirus and uses thereof
CN105473723A (en) 2012-05-18 2016-04-06 宾夕法尼亚大学托管会 Subfamily E simian adenoviruses A1302, A1320, A1331 and A1337 and uses thereof
US9476061B2 (en) 2012-05-24 2016-10-25 Janssen Vaccines & Prevention B.V. Adenoviral vectors for transduction of vascular tissue
EP2855669B1 (en) 2012-05-29 2018-10-10 GenVec, Inc. Modified serotype 28 adenoviral vectors
AU2013203696A1 (en) 2012-06-25 2014-01-16 University Of Canberra Recombinant Viral Vectors and Uses Therefor
US20150246949A1 (en) 2012-09-25 2015-09-03 University Of Washington Through Its Center For Commercialization Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor
KR101429696B1 (en) 2012-11-21 2014-08-13 국립암센터 Recombinant adenovirus with enhanced safety and anti-cancer activity and use thereof
CN105189739A (en) 2013-02-28 2015-12-23 普赛奥克苏斯治疗公司 A process for the production of adenovirus
WO2014160475A1 (en) 2013-03-13 2014-10-02 Aboody Karen S Tropic cell based virotherapy for the treatment of cancer
EP2971008B1 (en) 2013-03-14 2018-07-25 Salk Institute for Biological Studies Oncolytic adenovirus compositions
AU2014255733B2 (en) 2013-04-18 2019-05-16 Tilt Biotherapeutics Oy Enhanced adoptive cell therapy
RU2689553C2 (en) 2013-06-18 2019-05-28 Днатрикс, Инк. Cerebral cancer treatment with oncolytic adenovirus
BR112016006564B1 (en) 2013-09-24 2023-11-21 University Of Washington Through Its Center For Commercialization RECOMBINANT ADB-2/3 FIBER POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION
SG10201907841UA (en) 2013-11-22 2019-10-30 Dnatrix Inc Adenovirus expressing immune cell stimulatory receptor agonist(s)
GB201415579D0 (en) 2014-09-03 2014-10-15 Psioxus Therapeutics Ltd A process
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
EP2940128A1 (en) 2014-04-30 2015-11-04 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Adenovirus comprising an albumin-binding moiety
ES2714921T3 (en) 2014-05-19 2019-05-30 Valo Therapeutics Oy Coated oncolytic adenovirus for cancer vaccines
CN106459930B (en) 2014-05-28 2020-03-03 国立大学法人冈山大学 Conditionally replicating adenovirus expressing REIC gene
CA2961748A1 (en) 2014-09-24 2016-03-31 Salk Institute For Biological Studies Oncolytic tumor viruses and methods of use
US10617729B2 (en) 2014-12-24 2020-04-14 The Uab Research Foundation Multitargeting onocolytic adenovirus, methods of use, and methods of making
EP3247807B1 (en) 2015-01-20 2020-12-16 Adcure Biotechnologies, LLC. Detargeted adenovirus variants and related methods
US20180051301A1 (en) 2015-03-02 2018-02-22 Washington University Induction of pacemaker-like cells from cardiomyocytes
JP6754532B2 (en) 2015-03-17 2020-09-16 ティーアイエルティー・バイオセラピューティクス・オーワイＴＩＬＴ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ Ｏｙ Oncolytic adenovirus encoding bispecific antibodies and related methods and uses
EP3072900A1 (en) 2015-03-27 2016-09-28 Medizinische Hochschule Hannover Anti-tumour medicament based on adenovirus
GB201505860D0 (en) 2015-04-07 2015-05-20 Agalimmune Ltd Therapeutic compositions and methods of use for treating cancer
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
WO2017039313A1 (en) 2015-09-01 2017-03-09 한양대학교 산학협력단 Antitumor immunity enhancing composition containing adenovirus simultaneously expressing il-12 and shvegf
CA3000462C (en) 2015-10-05 2024-04-02 Salk Institute For Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
WO2017070110A1 (en) 2015-10-19 2017-04-27 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
US11246896B2 (en) 2015-10-28 2022-02-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
EP3390428B1 (en) 2016-02-23 2019-09-25 Salk Institute for Biological Studies High throughput assay for measuring adenovirus replication kinetics
KR102471633B1 (en) 2016-02-23 2022-11-25 솔크 인스티튜트 포 바이올로지칼 스터디즈 Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
JP7208492B2 (en) 2016-03-10 2023-01-19 シージー オンコロジー， インコーポレイテッド Methods of treating solid tumors or lymphoid tumors with combination therapy
US20170314044A1 (en) 2016-05-02 2017-11-02 Regents Of The University Of Minnesota Adenovirus constructs and methods
WO2017205423A1 (en) 2016-05-23 2017-11-30 Washington University Pulmonary targeted cas9/crispr for in vivo editing of disease genes
WO2017205875A1 (en) 2016-05-27 2017-11-30 Dnatrix, Inc. Adenovirus and immunomodulator combination therapy
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector
CA3038968A1 (en) 2016-09-30 2018-04-05 Genvec, Inc. Adenovectors for delivery of therapeutic genetic material into t cells
FI20165814A (en) 2016-10-27 2018-04-28 Tilt Biotherapeutics Oy INTERLEUKIN 8 (IL-8) AS A PROGNOSTIC AND PROUDIC BIOMARKER AND COMPOSITIONS AND VECTORS FOR USE IN ONCOLYTIC IMMUNOTHERAPY
US20190275092A1 (en) 2016-11-01 2019-09-12 Dnatrix, Inc. Combination therapy for treatment of brain cancers
WO2018083258A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083257A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
US20190350992A1 (en) 2016-11-17 2019-11-21 Vcn Biosciences Sl Use of viral vectors in the treatment of retinoblastoma
GB201620968D0 (en) 2016-12-09 2017-01-25 Glaxosmithkline Biologicals Sa Adenovirus polynucleotides and polypeptides
EP3551644B1 (en) 2016-12-09 2023-08-16 GlaxoSmithKline Biologicals SA Chimpanzee adenovirus constructs with lyssavirus antigens
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
WO2018125970A1 (en) 2016-12-30 2018-07-05 Salk Institute For Biological Studies Synthetic adenoviruses targeting bone tissue and uses thereof
US10232053B2 (en) 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
BR112019015514A2 (en) 2017-01-30 2020-04-07 Epicentrx Inc tumor-selective tata-box and caat-box mutants
EP3574090A4 (en) 2017-01-30 2021-01-06 EpicentRx, Inc. Multiple transgene recombinant adenovirus
EA201990822A1 (en) 2017-04-12 2020-01-09 Эписентарикс, Инк. IMMUNOMODULATING FUSION PROTEINS
JP7260173B2 (en) 2017-04-21 2023-04-18 ベイラー カレッジ オブ メディスン Oncolytic virus therapy and immunotherapy
WO2018201017A1 (en) 2017-04-27 2018-11-01 Washington University Dendritic cell targeted adenovirus for vaccination
WO2018204677A1 (en) 2017-05-04 2018-11-08 Epicentrx, Inc. Oncolytic adenovirus formulation
US20200155625A1 (en) 2017-05-24 2020-05-21 Epicentrx, Inc. Anti-angiogenic adenovirus
US11542312B2 (en) 2017-06-19 2023-01-03 Medicenna Therapeutics, Inc. IL-2 superagonists in combination with anti-PD-1 antibodies
WO2019016756A1 (en) 2017-07-21 2019-01-24 Glaxosmithkline Biologicals Sa Chikungunya virus antigen constructs
PL3460052T3 (en) 2017-09-20 2020-05-18 Immunicum Ab Improved allogeneic dendritic cells for use in cancer treatment
WO2019073059A1 (en) 2017-10-12 2019-04-18 Freeline Therapeutics Limited Life-cycle-defective adenovirus helper viruses, their production and use for producing raav
MA50502A (en) 2017-10-31 2020-09-09 Janssen Vaccines & Prevention Bv ADENOVIRUS AND RELATED USES
MX2020004492A (en) 2017-10-31 2020-11-24 Janssen Vaccines & Prevention Bv Adenovirus and uses thereof.
CN111295391B (en) 2017-10-31 2023-12-05 扬森疫苗与预防公司 Adenovirus and use thereof
CA3077630A1 (en) 2017-10-31 2019-05-09 Janssen Vaccines & Prevention B.V. Adenovirus vectors and uses thereof
GB201802539D0 (en) 2018-02-16 2018-04-04 Univ College Cardiff Consultants Ltd Modified adenoviruses
GB201804473D0 (en) 2018-03-21 2018-05-02 Valo Therapeutics Oy Modified oncolytic adenoviruses
GB201804468D0 (en) 2018-03-21 2018-05-02 Valo Therapeutics Oy PeptiCRAd Cancer Therapy
US20210015878A1 (en) 2018-03-28 2021-01-21 Epicentrx, Inc. Personalized cancer vaccines
EP3775175A4 (en) 2018-04-09 2022-02-09 Salk Institute for Biological Studies Oncolytic adenovirus compositions with enhanced replication properties
TW202011977A (en) 2018-04-20 2020-04-01 貝勒醫學院 Oncolytic virotherapy and immunotherapy
JP2021526831A (en) 2018-06-12 2021-10-11 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Adenovirus polynucleotides and polypeptides
WO2020014539A1 (en) 2018-07-11 2020-01-16 Epicentrx, Inc. Methods and compositions for targeting cancer cells for treatment
JP2022500013A (en) 2018-08-31 2022-01-04 オルカ セラピューティクス ビー．ブイ． Methods for Killing Recombinant Viruses and Abnormal Cells Containing the Coding Region of Glycogen Synthase Kinase-3 (GSK3)
EP3864159A4 (en) 2018-10-09 2022-11-02 Nikegen Limited Compositions and methods for preparing viral vectors

Also Published As

Publication number Publication date
JP6576326B2 (en) 2019-09-18
AU2014236207B2 (en) 2019-05-23
KR102089121B1 (en) 2020-03-13
US11077156B2 (en) 2021-08-03
EP2971008A1 (en) 2016-01-20
US20150374766A1 (en) 2015-12-31
CA2903582A1 (en) 2014-09-25
EP2971008A4 (en) 2016-09-14
JP2016516407A (en) 2016-06-09
WO2014153204A1 (en) 2014-09-25
AU2014236207A1 (en) 2015-09-17
CA3115891A1 (en) 2014-09-25
EP2971008B1 (en) 2018-07-25
CA2903582C (en) 2021-06-08
US20220096577A1 (en) 2022-03-31
KR20150130441A (en) 2015-11-23

Similar Documents

Publication Publication Date Title
HRP20182159T1 (en) Improved adenovirus formulations
GB201304662D0 (en) Compositions
GB201319525D0 (en) Composition
EP2889350A4 (en) Tacky-adhesive composition
SG11201507393TA (en) Oncolytic adenovirus compositions
GB201608461D0 (en) Compositions
EP3006525A4 (en) Asphalt-urethane composition
GB201319540D0 (en) Composition
GB201318489D0 (en) Composition
GB201317388D0 (en) Composition
GB201301457D0 (en) Freeze-dried composition
EP3066178A4 (en) Lumbricant composition
GB201319538D0 (en) Composition
GB201306984D0 (en) Composition
GB201320303D0 (en) Composition
GB201317196D0 (en) Composition
GB201307622D0 (en) Composition
GB201320504D0 (en) Composition
GB201308502D0 (en) Composition
GB201301774D0 (en) Composition
GB201320962D0 (en) Compositions
GB201318394D0 (en) Composition
GB201320959D0 (en) Compositions
GB201320675D0 (en) Composition
GB201305622D0 (en) Composition