SG11201506461TA - ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS - Google Patents

ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS

Info

Publication number
SG11201506461TA
SG11201506461TA SG11201506461TA SG11201506461TA SG11201506461TA SG 11201506461T A SG11201506461T A SG 11201506461TA SG 11201506461T A SG11201506461T A SG 11201506461TA SG 11201506461T A SG11201506461T A SG 11201506461TA SG 11201506461T A SG11201506461T A SG 11201506461TA
Authority
SG
Singapore
Prior art keywords
carbons
carbonyl
activation
chemical transformations
transformations
Prior art date
Application number
SG11201506461TA
Inventor
Yonggui Chi
Zhenqian Fu
Original Assignee
Univ Nanyang Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nanyang Tech filed Critical Univ Nanyang Tech
Publication of SG11201506461TA publication Critical patent/SG11201506461TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201506461TA 2013-03-15 2014-03-14 ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS SG11201506461TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361790857P 2013-03-15 2013-03-15
PCT/SG2014/000123 WO2014142755A1 (en) 2013-03-15 2014-03-14 ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS

Publications (1)

Publication Number Publication Date
SG11201506461TA true SG11201506461TA (en) 2015-09-29

Family

ID=51537213

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201506461TA SG11201506461TA (en) 2013-03-15 2014-03-14 ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS
SG10201707625SA SG10201707625SA (en) 2013-03-15 2014-03-14 Activation of carbonyl beta-carbons for chemical transformations
SG10201913443VA SG10201913443VA (en) 2013-03-15 2014-03-14 Activation of carbonyl beta-carbons for chemical transformations

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201707625SA SG10201707625SA (en) 2013-03-15 2014-03-14 Activation of carbonyl beta-carbons for chemical transformations
SG10201913443VA SG10201913443VA (en) 2013-03-15 2014-03-14 Activation of carbonyl beta-carbons for chemical transformations

Country Status (4)

Country Link
US (2) US20160039827A1 (en)
CN (1) CN105473559B (en)
SG (3) SG11201506461TA (en)
WO (1) WO2014142755A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018505170A (en) * 2015-01-30 2018-02-22 ザ・ユニバーシティ・オブ・シドニー Anticancer compounds
TWI828644B (en) 2017-12-06 2024-01-11 仁新醫藥股份有限公司 Tubulin inhibitors
US20230398526A1 (en) * 2020-11-18 2023-12-14 Shenzhen Bay Laboratory Pingshan Translational Medicine Center Nitrogen heterocyclic carbene catalyst and preparation method therefor
CN112479966B (en) * 2020-12-11 2022-05-17 南京工业大学 Method for synthesizing rolipram

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19704273A1 (en) * 1996-03-08 1997-09-11 Basf Ag Producing optically active alpha-hydroxy-ketone(s), useful in synthesis
BRPI0710570B1 (en) 2006-04-21 2023-05-16 Parker-Hannifin Corporation INTEGRATED CROSS-FLOW RESERVOIR AND FILTER ELEMENT
US8501658B2 (en) * 2006-04-21 2013-08-06 The Regents Of The University Of California Enantioselective reactions catalyzed by chiral triazolium salts
EP2139829A4 (en) * 2007-03-22 2010-04-28 Agency Science Tech & Res N-heterocyclic carbene (nhc) catalyzed synthesis of hydroxamic acids

Also Published As

Publication number Publication date
SG10201707625SA (en) 2017-10-30
SG10201913443VA (en) 2020-03-30
US11306097B2 (en) 2022-04-19
US20160039827A1 (en) 2016-02-11
US20190337955A1 (en) 2019-11-07
CN105473559A (en) 2016-04-06
CN105473559B (en) 2019-05-10
WO2014142755A1 (en) 2014-09-18

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