SG11201505301XA - Vaccines with higher carbohydrate antigen density and novel saponin adjuvant - Google Patents

Vaccines with higher carbohydrate antigen density and novel saponin adjuvant

Info

Publication number
SG11201505301XA
SG11201505301XA SG11201505301XA SG11201505301XA SG11201505301XA SG 11201505301X A SG11201505301X A SG 11201505301XA SG 11201505301X A SG11201505301X A SG 11201505301XA SG 11201505301X A SG11201505301X A SG 11201505301XA SG 11201505301X A SG11201505301X A SG 11201505301XA
Authority
SG
Singapore
Prior art keywords
vaccines
carbohydrate antigen
antigen density
saponin adjuvant
higher carbohydrate
Prior art date
Application number
SG11201505301XA
Inventor
Wei Han Lee
Nan-Hsuan Wang
Chung Hao Chang
Yih-Huang Hsieh
Cheng-Chi Wang
Yu-Hsin Lin
Yu-Chen Lin
I-Ju Chen
Cheng Der Tony Yu
Original Assignee
Obi Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obi Pharma Inc filed Critical Obi Pharma Inc
Publication of SG11201505301XA publication Critical patent/SG11201505301XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001169Tumor associated carbohydrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0016Combination vaccines based on diphtheria-tetanus-pertussis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6081Albumin; Keyhole limpet haemocyanin [KLH]
SG11201505301XA 2013-01-04 2014-01-06 Vaccines with higher carbohydrate antigen density and novel saponin adjuvant SG11201505301XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361748880P 2013-01-04 2013-01-04
PCT/US2014/010310 WO2014107652A2 (en) 2013-01-04 2014-01-06 Vaccines with higher carbohydrate antigen density and novel saponin adjuvant

Publications (1)

Publication Number Publication Date
SG11201505301XA true SG11201505301XA (en) 2015-08-28

Family

ID=51062556

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505301XA SG11201505301XA (en) 2013-01-04 2014-01-06 Vaccines with higher carbohydrate antigen density and novel saponin adjuvant

Country Status (17)

Country Link
US (2) US10517936B2 (en)
EP (2) EP3792272A1 (en)
JP (2) JP6359561B2 (en)
KR (2) KR101806370B1 (en)
CN (2) CN105026413B (en)
AU (2) AU2014203977B2 (en)
CA (2) CA3044471C (en)
CL (2) CL2015001900A1 (en)
ES (1) ES2843509T3 (en)
HK (1) HK1213266A1 (en)
IL (2) IL239785B (en)
PH (1) PH12015501519A1 (en)
RU (1) RU2015131033A (en)
SG (1) SG11201505301XA (en)
TW (2) TWI572356B (en)
WO (1) WO2014107652A2 (en)
ZA (1) ZA201504813B (en)

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US20170348414A1 (en) * 2014-09-15 2017-12-07 Wayne State University Novel synthetic anticancer, antifungal, and antibacterial vaccines
JP6774941B2 (en) * 2014-09-15 2020-10-28 オービーアイ ファーマ,インコーポレイテッド Immunogenic / Therapeutic Sugar Conjugate Compositions and Their Use
WO2017041027A1 (en) * 2015-09-04 2017-03-09 Obi Pharma, Inc. Glycan arrays and method of use
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
KR20180121786A (en) 2016-03-29 2018-11-08 오비아이 파머 인코퍼레이티드 Antibodies, pharmaceutical compositions and methods
KR20230110820A (en) * 2016-04-22 2023-07-25 오비아이 파머 인코퍼레이티드 Cancer immunotherapy by immune activation or immune modulation via globo series antigens
CN110072545A (en) 2016-07-27 2019-07-30 台湾浩鼎生技股份有限公司 Immunogenicity/therapeutic glycan pool object and application thereof
KR102528998B1 (en) 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 Human Antibodies, Pharmaceutical Compositions and Methods
JP2019535731A (en) 2016-11-21 2019-12-12 オービーアイ ファーマ,インコーポレイテッド Conjugated biological molecules, pharmaceutical compositions and methods
CN112513635B (en) * 2018-05-11 2024-04-16 台湾浩鼎生技股份有限公司 Method for predicting immune response in human body
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
CN114805454B (en) * 2021-01-21 2023-07-18 中国科学院生态环境研究中心 Alpha-galactose ceramide compound, and preparation method and application thereof
CN114259559B (en) * 2021-12-28 2024-03-19 天津科技大学 Synthetic tumor vaccine containing alpha-GalCer endogenous adjuvant
CN114306586A (en) * 2022-01-04 2022-04-12 天津科技大学 Tumor vaccine based on TF antigen and chitosan oligosaccharide endogenous adjuvant, method and application

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Also Published As

Publication number Publication date
AU2017200312B2 (en) 2018-05-17
CN105026413B (en) 2020-04-24
CN105026413A (en) 2015-11-04
AU2014203977A1 (en) 2015-07-09
ZA201504813B (en) 2017-11-29
KR20180053599A (en) 2018-05-23
EP2941436A2 (en) 2015-11-11
TW201718004A (en) 2017-06-01
WO2014107652A3 (en) 2014-12-24
CA3044471C (en) 2021-05-11
TW201429488A (en) 2014-08-01
EP2941436B1 (en) 2020-12-02
US10517936B2 (en) 2019-12-31
HK1213266A1 (en) 2016-06-30
EP3792272A1 (en) 2021-03-17
EP2941436A4 (en) 2016-07-27
US20200061169A1 (en) 2020-02-27
CN111499679A (en) 2020-08-07
KR101806370B1 (en) 2017-12-07
IL239785A0 (en) 2015-08-31
CL2015001902A1 (en) 2016-02-12
JP6781204B2 (en) 2020-11-04
JP2018141021A (en) 2018-09-13
US20150328299A1 (en) 2015-11-19
AU2014203977B2 (en) 2016-11-17
CL2015001900A1 (en) 2016-02-12
IL258728B (en) 2019-07-31
RU2015131033A (en) 2017-02-09
TWI611810B (en) 2018-01-21
CA2897084A1 (en) 2014-07-10
JP2016504385A (en) 2016-02-12
CA3044471A1 (en) 2014-07-10
TWI572356B (en) 2017-03-01
IL258728A (en) 2018-06-28
WO2014107652A2 (en) 2014-07-10
BR112015016381A2 (en) 2017-07-11
ES2843509T3 (en) 2021-07-19
AU2017200312A1 (en) 2017-02-02
KR20150111941A (en) 2015-10-06
CN111499679B (en) 2021-07-06
KR102084301B1 (en) 2020-03-03
IL239785B (en) 2018-05-31
US11752204B2 (en) 2023-09-12
JP6359561B2 (en) 2018-07-18
CA2897084C (en) 2019-07-16
PH12015501519A1 (en) 2016-04-18

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