SG11201503942RA - Egfr and c-met-fibronectin type iii domain binding molecules - Google Patents
Egfr and c-met-fibronectin type iii domain binding moleculesInfo
- Publication number
- SG11201503942RA SG11201503942RA SG11201503942RA SG11201503942RA SG11201503942RA SG 11201503942R A SG11201503942R A SG 11201503942RA SG 11201503942R A SG11201503942R A SG 11201503942RA SG 11201503942R A SG11201503942R A SG 11201503942RA SG 11201503942R A SG11201503942R A SG 11201503942RA
- Authority
- SG
- Singapore
- Prior art keywords
- egfr
- met
- binding molecules
- type iii
- fibronectin type
- Prior art date
Links
- 108060006698 EGF receptor Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261728914P | 2012-11-21 | 2012-11-21 | |
US201261728912P | 2012-11-21 | 2012-11-21 | |
US201261728906P | 2012-11-21 | 2012-11-21 | |
US201361782550P | 2013-03-14 | 2013-03-14 | |
US201361809541P | 2013-04-08 | 2013-04-08 | |
PCT/US2013/071267 WO2014081944A2 (en) | 2012-11-21 | 2013-11-21 | Egfr and c-met-fibronectin type iii domain binding molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201503942RA true SG11201503942RA (en) | 2015-06-29 |
Family
ID=50776675
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201707488TA SG10201707488TA (en) | 2012-11-21 | 2013-11-21 | Egfr and c-met-fibronectin type iii domain binding molecules |
SG11201503942RA SG11201503942RA (en) | 2012-11-21 | 2013-11-21 | Egfr and c-met-fibronectin type iii domain binding molecules |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201707488TA SG10201707488TA (en) | 2012-11-21 | 2013-11-21 | Egfr and c-met-fibronectin type iii domain binding molecules |
Country Status (21)
Country | Link |
---|---|
US (4) | US9695228B2 (en) |
EP (3) | EP2922566B1 (en) |
JP (3) | JP6393270B2 (en) |
KR (2) | KR102210196B1 (en) |
CN (5) | CN108546300B (en) |
AU (3) | AU2013347952B2 (en) |
CA (1) | CA2891485A1 (en) |
CL (1) | CL2015001353A1 (en) |
EA (2) | EA035559B1 (en) |
ES (2) | ES2696148T3 (en) |
HK (1) | HK1215680A1 (en) |
IL (2) | IL238730B (en) |
MX (2) | MX369334B (en) |
MY (1) | MY176820A (en) |
NI (1) | NI201500070A (en) |
NZ (1) | NZ708349A (en) |
PH (1) | PH12015501134A1 (en) |
SG (2) | SG10201707488TA (en) |
UA (1) | UA118096C2 (en) |
WO (1) | WO2014081944A2 (en) |
ZA (1) | ZA201504427B (en) |
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PT2855509T (en) | 2012-05-25 | 2018-08-03 | Janssen Biotech Inc | Non-natural consensus albumin binding domains |
US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
SI2922872T1 (en) | 2012-11-21 | 2019-01-31 | Janssen Biotech, Inc., | Bispecific egfr/c-met antibodies |
JP6412503B2 (en) | 2012-11-21 | 2018-10-24 | ピーティーシー セラピューティクス, インコーポレイテッド | Substituted reverse pyrimidine Bmi-1 inhibitors |
SG11201505508TA (en) * | 2013-01-25 | 2015-08-28 | Janssen Biotech Inc | Kv1.3 antagonists and methods of use |
TWI692477B (en) | 2013-08-30 | 2020-05-01 | 美商Ptc治療公司 | Substituted pyrimidine bmi-1 inhibitors |
CN105899226B (en) | 2013-10-14 | 2020-05-12 | 詹森生物科技公司 | Cysteine engineered fibronectin type III domain binding molecules |
EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
CN105085489B (en) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | Pyrimidine or pyridine compounds and their, preparation method and medical usage |
CN116832890A (en) * | 2015-04-06 | 2023-10-03 | 中尺度技术有限责任公司 | Method of operating an assay system and ECL immunoassay system |
KR20180002782A (en) | 2015-05-06 | 2018-01-08 | 얀센 바이오테크 인코포레이티드 | Prostate specific membrane antigen (PSMA) bispecific binding agents and uses thereof |
MA42060A (en) | 2015-05-06 | 2018-03-14 | Janssen Biotech Inc | TYPE III FIELDS OF FIBRONECTINES BINDING PROSTATE-SPECIFIC MEMBRANARY ANTIGEN |
US20170002058A1 (en) * | 2015-06-30 | 2017-01-05 | Regents Of The University Of Minnesota | Compositions and methods that involve protein scaffolds that specifically bind to hepatocyte growth factor receptor |
US10584152B2 (en) * | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
KR102444835B1 (en) | 2016-05-26 | 2022-09-19 | 리커리엄 아이피 홀딩스, 엘엘씨 | EGFR inhibitor compounds |
SG11201810687SA (en) * | 2016-06-03 | 2018-12-28 | Janssen Biotech Inc | Serum albumin-binding fibronectin type iii domains |
AU2017281083B2 (en) * | 2016-06-21 | 2022-01-27 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type III domain binding molecules |
TWI782930B (en) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | Anti-met antibodies, bispecific antigen binding molecules that bind met, and methods of use thereof |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
JP7104703B2 (en) | 2016-12-14 | 2022-07-21 | ヤンセン バイオテツク,インコーポレーテツド | CD8A-binding fibronectin type III domain |
WO2018111978A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
CN111093696B (en) * | 2017-07-17 | 2023-10-27 | 詹森生物科技公司 | Antigen binding regions of anti-type III fibronectin domains and methods of use thereof |
US20190184028A1 (en) * | 2017-12-14 | 2019-06-20 | Janssen Biotech, Inc. | Targeting with firbronectin type iii like domain molecules |
BR112021022828A2 (en) * | 2019-05-14 | 2022-04-12 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and third-generation egfr tyrosine kinase inhibitors |
KR20220063185A (en) | 2019-09-16 | 2022-05-17 | 리제너론 파마슈티칼스 인코포레이티드 | Radiolabeled MET binding protein for immuno-PET imaging |
US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
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US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
SI2922872T1 (en) * | 2012-11-21 | 2019-01-31 | Janssen Biotech, Inc., | Bispecific egfr/c-met antibodies |
CN105899226B (en) * | 2013-10-14 | 2020-05-12 | 詹森生物科技公司 | Cysteine engineered fibronectin type III domain binding molecules |
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2013
- 2013-11-20 US US14/085,340 patent/US9695228B2/en active Active
- 2013-11-21 CN CN201810391538.8A patent/CN108546300B/en active Active
- 2013-11-21 CN CN202110937807.8A patent/CN113667020A/en active Pending
- 2013-11-21 WO PCT/US2013/071267 patent/WO2014081944A2/en active Application Filing
- 2013-11-21 NZ NZ708349A patent/NZ708349A/en unknown
- 2013-11-21 MY MYPI2015701606A patent/MY176820A/en unknown
- 2013-11-21 CN CN201610884250.5A patent/CN107098975B/en active Active
- 2013-11-21 JP JP2015544132A patent/JP6393270B2/en active Active
- 2013-11-21 SG SG10201707488TA patent/SG10201707488TA/en unknown
- 2013-11-21 CN CN201380071078.6A patent/CN104955473B/en active Active
- 2013-11-21 CN CN201610885343.XA patent/CN106977606B/en active Active
- 2013-11-21 EA EA201590998A patent/EA035559B1/en unknown
- 2013-11-21 ES ES13856353T patent/ES2696148T3/en active Active
- 2013-11-21 KR KR1020157016173A patent/KR102210196B1/en active IP Right Grant
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