SG11201500881XA - Method for the production and selection of molecules comprising at least two different entities and uses thereof - Google Patents
Method for the production and selection of molecules comprising at least two different entities and uses thereofInfo
- Publication number
- SG11201500881XA SG11201500881XA SG11201500881XA SG11201500881XA SG11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA
- Authority
- SG
- Singapore
- Prior art keywords
- molecules
- selection
- production
- different entities
- entities
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/2207—Sortase A (3.4.22.70)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12184473 | 2012-09-14 | ||
| PCT/EP2013/068910 WO2014041072A1 (en) | 2012-09-14 | 2013-09-12 | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201500881XA true SG11201500881XA (en) | 2015-03-30 |
Family
ID=46967992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201500881XA SG11201500881XA (en) | 2012-09-14 | 2013-09-12 | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9862779B2 (en) |
| EP (1) | EP2895496B1 (en) |
| JP (1) | JP6405311B2 (en) |
| KR (1) | KR20150052085A (en) |
| CN (1) | CN104619715B (en) |
| BR (1) | BR112015003938A2 (en) |
| CA (1) | CA2879499A1 (en) |
| HK (1) | HK1210189A1 (en) |
| MX (1) | MX2015002407A (en) |
| RU (1) | RU2646159C2 (en) |
| SG (1) | SG11201500881XA (en) |
| WO (1) | WO2014041072A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2011034605A2 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| AR080793A1 (en) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | BISPECIFIC ANTIBODIES |
| RU2013110875A (en) | 2010-08-24 | 2014-09-27 | Ф.Хоффманн-Ля Рош Аг | SPECIFIC ANTIBODIES CONTAINING DISSULPHIDE-STABILIZED Fv Fragment |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| MX342034B (en) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Monovalent antigen binding proteins. |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| CA2861124A1 (en) | 2012-02-10 | 2013-08-15 | Genentech, Inc. | Single-chain antibodies and other heteromultimers |
| CN104411718B (en) | 2012-06-27 | 2018-04-24 | 弗·哈夫曼-拉罗切有限公司 | It is used to prepare method of antibody Fc district conjugate of at least one binding entity comprising specific binding target and application thereof |
| MX354862B (en) * | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof. |
| BR112015003938A2 (en) * | 2012-09-14 | 2018-09-04 | Hoffmann La Roche | polypeptide production methods, multispecific binder production, multispecific binder selection, bispecific antibody selection and combination determination, bispecific antibody, pharmaceutical formulation and use of bispecific antibody |
| CN105612182B (en) | 2013-10-11 | 2019-12-10 | 豪夫迈·罗氏有限公司 | Multispecific domain exchange consensus variable light chain antibodies |
| PL3227332T3 (en) | 2014-12-03 | 2020-06-15 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| KR20180053751A (en) | 2015-09-25 | 2018-05-23 | 에프. 호프만-라 로슈 아게 | Recombinant immunoglobulin heavy chain comprising a sirtase conjugation loop and conjugate thereof |
| JP6998863B2 (en) * | 2015-09-25 | 2022-02-04 | エフ．ホフマン－ラ ロシュ アーゲー | Amide group transfer using sortase A in deep eutectic solvent |
| CN106191015B (en) * | 2016-08-25 | 2019-09-13 | 北京大学 | The efficient mutant of staphylococcus aureus sorting enzyme A |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2018162517A1 (en) * | 2017-03-10 | 2018-09-13 | F. Hoffmann-La Roche Ag | Method for producing multispecific antibodies |
| US20200157210A1 (en) * | 2017-06-26 | 2020-05-21 | Riken | Fusion protein |
| ES2929416T3 (en) * | 2018-06-21 | 2022-11-29 | Novo Nordisk As | New compounds for the treatment of obesity |
| WO2021185360A1 (en) * | 2020-03-20 | 2021-09-23 | Westlake Therapeutics (Hangzhou) Co., Limited | Novel truncated sortase variants |
| JP2024504875A (en) * | 2021-02-01 | 2024-02-01 | ▲い▼尊生物医薬（浙江）有限公司 | Targeted protein degradation system and its applications |
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| EP2391714B2 (en) * | 2009-01-30 | 2019-07-24 | Whitehead Institute for Biomedical Research | Methods for ligation and uses thereof |
| EP2403530B1 (en) | 2009-02-27 | 2016-05-11 | Massachusetts Institute of Technology | Engineered proteins with high affinity for dota chelates |
| BRPI1014089A2 (en) | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | multispecific antibodies comprising full length antibodies and single chain fab fragments |
| EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
| CA2761233A1 (en) | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Tri- or tetraspecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| EP2659275B1 (en) | 2010-12-23 | 2017-11-22 | Roche Diagnostics GmbH | Detection of a polypeptide dimer by a bivalent binding agent |
| EP2655414B1 (en) | 2010-12-23 | 2018-08-29 | Roche Diagniostics GmbH | Bispecific binding agent |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| US10081684B2 (en) | 2011-06-28 | 2018-09-25 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| EP2867255B1 (en) | 2012-06-27 | 2017-07-19 | F. Hoffmann-La Roche AG | Method for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof |
| MX354862B (en) | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof. |
| CN104411718B (en) | 2012-06-27 | 2018-04-24 | 弗·哈夫曼-拉罗切有限公司 | It is used to prepare method of antibody Fc district conjugate of at least one binding entity comprising specific binding target and application thereof |
| BR112015003938A2 (en) * | 2012-09-14 | 2018-09-04 | Hoffmann La Roche | polypeptide production methods, multispecific binder production, multispecific binder selection, bispecific antibody selection and combination determination, bispecific antibody, pharmaceutical formulation and use of bispecific antibody |
-
2013
- 2013-09-12 BR BR112015003938A patent/BR112015003938A2/en active Search and Examination
- 2013-09-12 JP JP2015531559A patent/JP6405311B2/en active Active
- 2013-09-12 MX MX2015002407A patent/MX2015002407A/en unknown
- 2013-09-12 SG SG11201500881XA patent/SG11201500881XA/en unknown
- 2013-09-12 CN CN201380047702.9A patent/CN104619715B/en active Active
- 2013-09-12 KR KR1020157006400A patent/KR20150052085A/en not_active Application Discontinuation
- 2013-09-12 CA CA2879499A patent/CA2879499A1/en not_active Abandoned
- 2013-09-12 RU RU2015111708A patent/RU2646159C2/en not_active IP Right Cessation
- 2013-09-12 EP EP13759782.9A patent/EP2895496B1/en active Active
- 2013-09-12 WO PCT/EP2013/068910 patent/WO2014041072A1/en active Application Filing
-
2015
- 2015-03-13 US US14/658,078 patent/US9862779B2/en active Active
- 2015-11-04 HK HK15110887.8A patent/HK1210189A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015003938A2 (en) | 2018-09-04 |
| JP6405311B2 (en) | 2018-10-17 |
| CN104619715B (en) | 2018-06-05 |
| BR112015003938A8 (en) | 2017-07-04 |
| US20150291704A1 (en) | 2015-10-15 |
| RU2015111708A (en) | 2016-11-10 |
| MX2015002407A (en) | 2015-06-22 |
| WO2014041072A1 (en) | 2014-03-20 |
| US9862779B2 (en) | 2018-01-09 |
| EP2895496B1 (en) | 2017-06-07 |
| HK1210189A1 (en) | 2016-04-15 |
| CA2879499A1 (en) | 2014-03-20 |
| CN104619715A (en) | 2015-05-13 |
| EP2895496A1 (en) | 2015-07-22 |
| RU2646159C2 (en) | 2018-03-01 |
| JP2016500511A (en) | 2016-01-14 |
| KR20150052085A (en) | 2015-05-13 |
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