SG11201500370SA - <i>IN VITRO</i> ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITY - Google Patents
<i>IN VITRO</i> ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITYInfo
- Publication number
- SG11201500370SA SG11201500370SA SG11201500370SA SG11201500370SA SG11201500370SA SG 11201500370S A SG11201500370S A SG 11201500370SA SG 11201500370S A SG11201500370S A SG 11201500370SA SG 11201500370S A SG11201500370S A SG 11201500370SA SG 11201500370S A SG11201500370S A SG 11201500370SA
- Authority
- SG
- Singapore
- Prior art keywords
- vitro
- assay
- cell toxicity
- proximal tubular
- tubular cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5412—IL-6
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5421—IL-8
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261674018P | 2012-07-20 | 2012-07-20 | |
US201261675680P | 2012-07-25 | 2012-07-25 | |
PCT/IB2013/001944 WO2014013334A2 (en) | 2012-07-20 | 2013-07-22 | In vitro assay for predicting renal proximal tubular cell toxicity |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201500370SA true SG11201500370SA (en) | 2015-02-27 |
Family
ID=49949307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201500370SA SG11201500370SA (en) | 2012-07-20 | 2013-07-22 | <i>IN VITRO</i> ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITY |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150197802A1 (en) |
EP (1) | EP2875360B1 (en) |
CN (1) | CN104641237B (en) |
SG (1) | SG11201500370SA (en) |
WO (1) | WO2014013334A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
ES2860423T3 (en) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Methods and Systems for Converting Stem Cells to Gastric Tissues by Targeted Differentiation |
AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
EP3344264B1 (en) * | 2015-09-03 | 2023-03-15 | The Brigham and Women's Hospital, Inc. | Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease |
CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US11767515B2 (en) | 2016-12-05 | 2023-09-26 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CN107219201B (en) * | 2017-04-20 | 2019-11-12 | 浙江工商大学 | Utilize the immune rear bullfrog antibody of fluorescence microscope citrinin and affine method |
CN113960302B (en) * | 2021-09-29 | 2024-04-23 | 中国人民解放军军事科学院军事医学研究院 | Nephrotoxicity detection method based on high content technology and application thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
US8076090B2 (en) * | 2005-04-05 | 2011-12-13 | Corning Incorporated | Label free biosensors and cells |
US8603806B2 (en) * | 2005-11-02 | 2013-12-10 | The Ohio State Universtiy Research Foundation | Materials and methods for cell-based assays |
WO2008101231A2 (en) * | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
CN101848993A (en) | 2007-07-19 | 2010-09-29 | 新加坡科技研究局 | Method for differentiating embryonic stem cells into cells expressing AQP-1 |
US20090220982A1 (en) * | 2008-02-29 | 2009-09-03 | Achaogen Inc.. | Compositions and methods for determining nephrotoxicity |
KR20110094307A (en) * | 2008-11-13 | 2011-08-23 | 펨타 파마슈티컬스, 인크. | Humanized anti-il-6 antibodies |
KR20110091780A (en) * | 2008-11-25 | 2011-08-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US20110236874A1 (en) * | 2008-12-02 | 2011-09-29 | Daniele Zink | Method for formation of renal tubules |
US20120179381A1 (en) * | 2010-06-17 | 2012-07-12 | Mckim James M | Toxicity screening methods |
-
2013
- 2013-07-22 WO PCT/IB2013/001944 patent/WO2014013334A2/en active Application Filing
- 2013-07-22 SG SG11201500370SA patent/SG11201500370SA/en unknown
- 2013-07-22 CN CN201380048888.XA patent/CN104641237B/en not_active Expired - Fee Related
- 2013-07-22 US US14/416,020 patent/US20150197802A1/en not_active Abandoned
- 2013-07-22 EP EP13820192.6A patent/EP2875360B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
EP2875360A2 (en) | 2015-05-27 |
CN104641237A (en) | 2015-05-20 |
US20150197802A1 (en) | 2015-07-16 |
WO2014013334A2 (en) | 2014-01-23 |
EP2875360B1 (en) | 2018-08-08 |
EP2875360A4 (en) | 2015-12-23 |
CN104641237B (en) | 2017-04-05 |
WO2014013334A3 (en) | 2014-03-13 |
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