SG11201406890YA - Triazolo compounds as pde10 inhibitors - Google Patents
Triazolo compounds as pde10 inhibitorsInfo
- Publication number
- SG11201406890YA SG11201406890YA SG11201406890YA SG11201406890YA SG11201406890YA SG 11201406890Y A SG11201406890Y A SG 11201406890YA SG 11201406890Y A SG11201406890Y A SG 11201406890YA SG 11201406890Y A SG11201406890Y A SG 11201406890YA SG 11201406890Y A SG11201406890Y A SG 11201406890YA
- Authority
- SG
- Singapore
- Prior art keywords
- pde10 inhibitors
- triazolo compounds
- triazolo
- compounds
- pde10
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12169954 | 2012-05-30 | ||
PCT/EP2013/060838 WO2013178572A1 (en) | 2012-05-30 | 2013-05-27 | Triazolo compounds as pde10 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201406890YA true SG11201406890YA (en) | 2014-11-27 |
Family
ID=48534382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201406890YA SG11201406890YA (en) | 2012-05-30 | 2013-05-27 | Triazolo compounds as pde10 inhibitors |
Country Status (21)
Country | Link |
---|---|
US (1) | US9394311B2 (en) |
EP (1) | EP2855455B1 (en) |
JP (1) | JP5992096B2 (en) |
KR (1) | KR101666293B1 (en) |
CN (1) | CN104364249B (en) |
AR (1) | AR091185A1 (en) |
AU (1) | AU2013269800A1 (en) |
BR (1) | BR112014026828A2 (en) |
CA (1) | CA2868240A1 (en) |
CL (1) | CL2014002847A1 (en) |
CO (1) | CO7091174A2 (en) |
CR (1) | CR20140481A (en) |
EA (1) | EA201492069A1 (en) |
IL (1) | IL235829A0 (en) |
MX (1) | MX2014014468A (en) |
PE (1) | PE20142366A1 (en) |
PH (1) | PH12014502294A1 (en) |
SG (1) | SG11201406890YA (en) |
TW (1) | TW201402564A (en) |
WO (1) | WO2013178572A1 (en) |
ZA (1) | ZA201407695B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015005375A (en) * | 2012-11-07 | 2015-07-21 | Hoffmann La Roche | Triazolo compounds. |
EA201991095A1 (en) | 2016-11-03 | 2019-09-30 | Бристол-Маерс Сквибб Компани | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS |
CN111875583B (en) * | 2017-10-17 | 2021-06-15 | 中国科学院上海药物研究所 | Triazole derivative and preparation method and application thereof |
CN112384515A (en) | 2018-02-27 | 2021-02-19 | 因赛特公司 | Imidazopyrimidines and triazolopyrimidines as A2A/A2B inhibitors |
MX2020012376A (en) | 2018-05-18 | 2021-03-09 | Incyte Corp | Fused pyrimidine derivatives as a2a / a2b inhibitors. |
EP3818063A1 (en) | 2018-07-05 | 2021-05-12 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
WO2020094592A1 (en) | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Compounds for treating negative symptoms and cognitive impairments |
WO2020094591A1 (en) | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Pde10a inhibitors for treating negative symptoms and cognitive impairments in a patient suffering from schizophrenia |
TWI829857B (en) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
CN114466845A (en) * | 2019-09-25 | 2022-05-10 | 昂科艾伦迪治疗法公司 | Process for the preparation of 5- (4- ((2S,5S) -5- (4-chlorobenzyl) -2-methylmorpholino) piperidin-1-yl) -1H-1,2, 4-triazol-3-amine |
CN113929634A (en) * | 2021-11-22 | 2022-01-14 | 山西永津集团有限公司 | Synthesis method of 2, 3-dibromoquinoxaline |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2744116A (en) * | 1953-12-04 | 1956-05-01 | Purdue Research Foundation | Bis-(aminotriazolyl-)-hydrocarbons |
AR022229A1 (en) * | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | TRIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND USE OF THE SAME TO PREPARE SUCH COMPOSITION |
US6887870B1 (en) * | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
US20080234252A1 (en) * | 2005-05-18 | 2008-09-25 | Pfizer Inc | Compounds Useful in Therapy |
NZ565494A (en) * | 2005-08-10 | 2011-06-30 | Glaxosmithkline Llc | Xanthine derivatives as selective HM74A agonists |
WO2008103357A1 (en) * | 2007-02-21 | 2008-08-28 | E. I. Du Pont De Nemours And Company | Fungicidal tricyclic 1,2,4-triazoles |
BRPI0812360A2 (en) * | 2007-05-21 | 2015-01-27 | Sgx Pharmaceuticals Inc | HYPEROCYCLIC KINASE MODULATING COMPOUNDS AND METHOD OF MODULATING THE ACTIVITY OF A TYROSINE KINASE PROTEIN |
TWI501965B (en) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | Novel phenylimidazole derivatives as pde10a enzyme inhibitors |
TWI487705B (en) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors |
US8969349B2 (en) * | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
PL2603511T3 (en) * | 2010-08-12 | 2017-08-31 | Boehringer Ingelheim Int | 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors |
EP2629616A4 (en) * | 2010-10-21 | 2014-03-26 | Merck Sharp & Dohme | Substituted amino-triazolyl pde10 inhibitors |
-
2013
- 2013-05-27 SG SG11201406890YA patent/SG11201406890YA/en unknown
- 2013-05-27 WO PCT/EP2013/060838 patent/WO2013178572A1/en active Application Filing
- 2013-05-27 AU AU2013269800A patent/AU2013269800A1/en not_active Abandoned
- 2013-05-27 EP EP13725360.5A patent/EP2855455B1/en not_active Not-in-force
- 2013-05-27 CN CN201380027925.9A patent/CN104364249B/en not_active Expired - Fee Related
- 2013-05-27 PE PE2014001616A patent/PE20142366A1/en not_active Application Discontinuation
- 2013-05-27 CA CA2868240A patent/CA2868240A1/en not_active Abandoned
- 2013-05-27 MX MX2014014468A patent/MX2014014468A/en unknown
- 2013-05-27 JP JP2015514445A patent/JP5992096B2/en not_active Expired - Fee Related
- 2013-05-27 KR KR1020147036637A patent/KR101666293B1/en active IP Right Grant
- 2013-05-27 EA EA201492069A patent/EA201492069A1/en unknown
- 2013-05-27 BR BR112014026828A patent/BR112014026828A2/en not_active Application Discontinuation
- 2013-05-28 TW TW102118823A patent/TW201402564A/en unknown
- 2013-05-29 AR ARP130101863 patent/AR091185A1/en unknown
-
2014
- 2014-09-26 CO CO14213791A patent/CO7091174A2/en unknown
- 2014-10-10 PH PH12014502294A patent/PH12014502294A1/en unknown
- 2014-10-16 CR CR20140481A patent/CR20140481A/en unknown
- 2014-10-22 CL CL2014002847A patent/CL2014002847A1/en unknown
- 2014-10-22 ZA ZA2014/07695A patent/ZA201407695B/en unknown
- 2014-11-20 IL IL235829A patent/IL235829A0/en unknown
- 2014-11-25 US US14/552,837 patent/US9394311B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN104364249B (en) | 2018-04-17 |
TW201402564A (en) | 2014-01-16 |
EP2855455A1 (en) | 2015-04-08 |
MX2014014468A (en) | 2015-02-12 |
KR101666293B1 (en) | 2016-10-13 |
US20150148332A1 (en) | 2015-05-28 |
CO7091174A2 (en) | 2014-10-21 |
CL2014002847A1 (en) | 2015-01-30 |
PH12014502294A1 (en) | 2014-12-15 |
CA2868240A1 (en) | 2013-12-05 |
IL235829A0 (en) | 2015-02-01 |
BR112014026828A2 (en) | 2017-06-27 |
AU2013269800A1 (en) | 2014-10-09 |
CN104364249A (en) | 2015-02-18 |
ZA201407695B (en) | 2016-08-31 |
PE20142366A1 (en) | 2015-01-10 |
WO2013178572A1 (en) | 2013-12-05 |
US9394311B2 (en) | 2016-07-19 |
AR091185A1 (en) | 2015-01-14 |
JP5992096B2 (en) | 2016-09-14 |
EP2855455B1 (en) | 2017-11-08 |
EA201492069A1 (en) | 2015-03-31 |
KR20150027143A (en) | 2015-03-11 |
JP2015518018A (en) | 2015-06-25 |
CR20140481A (en) | 2014-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL265007B (en) | Pyrazolopyrimidine compounds as kinase inhibitors | |
IL261282A (en) | Purinone compounds as kinase inhibitors | |
HRP20181041T1 (en) | Pyrazolopyrimidine compounds | |
HK1215253A1 (en) | Pyrrolopyrimidine compounds as kinase inhibitors | |
HK1210775A1 (en) | Imidazotriazinecarbonitriles useful as kinase inhibitors | |
HK1212984A1 (en) | Imidazopyridine compounds | |
HK1211029A1 (en) | Pyrazolopyrimidine compounds | |
SG11201501173SA (en) | PI3Kδ INHIBITOR | |
IL235829A0 (en) | Triazolo compounds as pde10 inhibitors | |
EP2785183A4 (en) | Triazolopyridinone pde10 inhibitors | |
HK1204617A1 (en) | Triazolo compounds as pde10 inhibitors pde10 |