SG11201406059PA - Cyclic amides as metap-2 inhibitors - Google Patents

Cyclic amides as metap-2 inhibitors

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Publication number
SG11201406059PA
SG11201406059PA SG11201406059PA SG11201406059PA SG11201406059PA SG 11201406059P A SG11201406059P A SG 11201406059PA SG 11201406059P A SG11201406059P A SG 11201406059PA SG 11201406059P A SG11201406059P A SG 11201406059PA SG 11201406059P A SG11201406059P A SG 11201406059PA
Authority
SG
Singapore
Prior art keywords
metap
inhibitors
cyclic amides
amides
cyclic
Prior art date
Application number
SG11201406059PA
Inventor
Timo Heinrich
Frank Zenke
Mireille Krier
Manja Friese-Hamim
Jeyaprakashnarayanan Seenisamy
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201406059PA publication Critical patent/SG11201406059PA/en

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    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015037716A1 (en) * 2013-09-12 2015-03-19 住友化学株式会社 Nitrogen-containing saturated heterocyclic compound
WO2015130958A1 (en) * 2014-02-26 2015-09-03 Howard University 5-oxopyrrolidine derivatives as hiv integrase inhibitors
WO2015130905A1 (en) * 2014-02-27 2015-09-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
US10005756B2 (en) * 2014-08-04 2018-06-26 Merck Patent Gmbh Pyrrolidinone derivatives as MetAP-2 inhibitors
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
AU2016218840A1 (en) * 2015-02-15 2017-08-31 Jiangsu Hengrui Medicine Co., Ltd. Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof
WO2017005069A1 (en) * 2015-07-08 2017-01-12 Eli Lilly And Company Pyrrolidinone compounds
WO2017084096A1 (en) * 2015-11-20 2017-05-26 Eli Lilly And Company Pyrrolidinone compounds
WO2018098781A1 (en) * 2016-12-01 2018-06-07 Eli Lilly And Company Pyrrolidinone compounds
CN111278816B (en) * 2017-09-04 2024-03-15 C4医药公司 Dihydro quinolinones
EP3750885A4 (en) * 2018-02-06 2021-10-27 Shanghai Haihe Pharmaceutical Co., Ltd. Compound having bet inhibitory activity and preparation method and use therefor
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
CA3108676A1 (en) * 2018-08-09 2020-02-13 David J. Guerin Carboxamides as ubiquitin-specific protease inhibitors
JP7309336B2 (en) 2018-09-25 2023-07-18 シャープ株式会社 power generation system
CN110963957B (en) * 2018-09-28 2021-10-22 深圳恩多凯医药科技有限公司 N-aromatic amide compound and preparation method and application thereof
ES2934986T3 (en) * 2019-01-22 2023-02-28 Merck Patent Gmbh heterocyclic derivatives
KR102281485B1 (en) 2019-06-19 2021-07-28 주식회사 오쎄인 Manufacturing methods of bone replacement materials composite material for variations in viscosity of cyanoacrylate to physical properties change, and its composite
FI3994134T3 (en) * 2019-07-03 2024-04-24 Merck Patent Gmbh Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
CN112480100B (en) * 2019-09-11 2022-10-14 康威(广州)生物科技有限公司 Pyrrolidone derivatives
MX2022016060A (en) 2020-07-09 2023-02-02 Merck Patent Gmbh Combination of a methionine aminopeptidase 2 inhibitor and vegfr/vegf inhibitor.
CN111728969B (en) * 2020-08-25 2021-03-19 广州市万千粉丝化妆品有限公司 Application of anti-aging and anti-oxidation compound in preparation of medicines or anti-aging cosmetics
EP4294791A1 (en) * 2021-02-16 2023-12-27 Fmc Corporation Herbicidal cyclic amides n-substituted with a haloalkylsulfonylanilide group
CA3213624A1 (en) * 2021-03-28 2022-10-06 Canwell Biotech Limited Metap-2 inhibitors, pharmaceutical compositions and therapeutic methods thereof
WO2023144053A1 (en) 2022-01-26 2023-08-03 Merck Patent Gmbh Heterocyclic derivatives

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508724A (en) * 1984-02-03 1985-04-02 A. H. Robins Company, Inc. Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity
JPS63208590A (en) * 1987-02-24 1988-08-30 Yamanouchi Pharmaceut Co Ltd Heterocyclic spiro compound and production thereof
DE3814517A1 (en) * 1988-02-05 1989-08-17 Bayer Ag CHINOLON AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THE SAME
US5173484A (en) 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US20080234247A1 (en) 1999-05-25 2008-09-25 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
AU777760B2 (en) * 1999-05-25 2004-10-28 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
UY26664A1 (en) 2000-04-14 2001-11-30 Abbott Lab HYDRAZIDES AND ALCOXIAMIDAS INHIBITORS OF ANGIOGENESIS.
AU2001216218A1 (en) 2000-05-25 2001-12-11 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
US20070161570A1 (en) 2000-11-01 2007-07-12 Praecis Pharmaceuticals, Inc. Methionine aminopeptidase-2 inhibitors and methods of use thereof
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
AU2002306907A1 (en) 2001-04-03 2002-10-21 Smithkline Beecham Corporation Method for inhibiting metap2
AU2003274037A1 (en) * 2002-10-18 2004-05-13 Basf Aktiengesellschaft 1-phenylpyrrolidine-2-one-3-carboxamides
US7691850B2 (en) 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
US20070123508A1 (en) * 2005-05-27 2007-05-31 Roger Olsson PAR2-modulating compounds and their use
CL2008001002A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
DE102008027574A1 (en) * 2008-06-10 2009-12-17 Merck Patent Gmbh New pyrrolidine derivatives as MetAP-2 inhibitors
US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
KR101696960B1 (en) 2010-01-08 2017-01-16 자프겐 인크. Fumagillol type compounds and methods of making and using same
WO2012033956A1 (en) 2010-09-08 2012-03-15 Mithridion, Inc. Cognition enhancing compounds and compositions, methods of making, and methods of treating
DE102010048374A1 (en) * 2010-10-13 2012-04-19 Merck Patent Gmbh Pyrrolidinones as MetAP-2 inhibitors

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