SG11201404789XA - Sequence symmetric modified igg4 bispecific antibodies - Google Patents
Sequence symmetric modified igg4 bispecific antibodiesInfo
- Publication number
- SG11201404789XA SG11201404789XA SG11201404789XA SG11201404789XA SG11201404789XA SG 11201404789X A SG11201404789X A SG 11201404789XA SG 11201404789X A SG11201404789X A SG 11201404789XA SG 11201404789X A SG11201404789X A SG 11201404789XA SG 11201404789X A SG11201404789X A SG 11201404789XA
- Authority
- SG
- Singapore
- Prior art keywords
- bispecific antibodies
- modified igg4
- igg4 bispecific
- symmetric modified
- sequence symmetric
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1203051.6A GB201203051D0 (en) | 2012-02-22 | 2012-02-22 | Biological products |
PCT/EP2013/053614 WO2013124450A1 (en) | 2012-02-22 | 2013-02-22 | Sequence symmetric modified igg4 bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201404789XA true SG11201404789XA (en) | 2014-09-26 |
Family
ID=45940018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201404789XA SG11201404789XA (en) | 2012-02-22 | 2013-02-22 | Sequence symmetric modified igg4 bispecific antibodies |
Country Status (16)
Country | Link |
---|---|
US (2) | US10221251B2 (en) |
EP (2) | EP3156416B1 (en) |
JP (2) | JP6308952B2 (en) |
KR (2) | KR102077331B1 (en) |
CN (2) | CN108586615B (en) |
AU (2) | AU2013224003B2 (en) |
CA (1) | CA2864439C (en) |
DK (2) | DK3156416T3 (en) |
EA (1) | EA035050B1 (en) |
ES (2) | ES2768780T3 (en) |
GB (1) | GB201203051D0 (en) |
HK (1) | HK1202563A1 (en) |
IL (1) | IL234102B (en) |
MX (1) | MX356288B (en) |
SG (1) | SG11201404789XA (en) |
WO (1) | WO2013124450A1 (en) |
Families Citing this family (55)
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JP5334319B2 (en) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
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EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
TWI452136B (en) | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
KR102398736B1 (en) | 2011-10-31 | 2022-05-16 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
GB201203051D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
GB201203071D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
KR101895634B1 (en) * | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | IgG4 Fc fragment comprising modified hinge region |
WO2015046467A1 (en) | 2013-09-27 | 2015-04-02 | 中外製薬株式会社 | Method for producing polypeptide heteromultimer |
EP2944962A1 (en) * | 2014-05-14 | 2015-11-18 | UCB Biopharma SPRL | Method for determining antibody specificity |
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TWI691512B (en) * | 2015-02-20 | 2020-04-21 | 日商橘生藥品工業股份有限公司 | Fc fusion high affinity IgE receptor alpha chain |
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BR112018009312A8 (en) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | method for promoting purification efficiency of fc region-containing polypeptide |
RU2746754C2 (en) | 2016-03-14 | 2021-04-20 | Чугаи Сейяку Кабусики Кайся | Cell damage inducing therapeutic medicinal product for anticancer therapy |
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TW201829453A (en) * | 2016-10-06 | 2018-08-16 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | Antibodies with reduced binding to process impurities |
US10995152B2 (en) | 2016-10-26 | 2021-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
JP7062669B2 (en) * | 2016-12-23 | 2022-05-06 | ブリストル-マイヤーズ スクイブ カンパニー | Design of therapeutic immunoglobulin G4 for improved bioanalytic and bioprocessing properties |
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US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
US11220550B2 (en) * | 2017-05-25 | 2022-01-11 | Bristol-Myers Squibb Company | Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity |
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EP3641802A1 (en) | 2017-06-22 | 2020-04-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of fibrosis with agents capable of inhibiting the activation of mucosal-associated invariant t (mait) cells |
JP6982226B2 (en) | 2017-07-06 | 2021-12-17 | 日東紡績株式会社 | Anti-human IgG4 monoclonal antibody and human IgG4 measurement reagent using the antibody |
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JP2022521937A (en) | 2019-02-21 | 2022-04-13 | マレンゴ・セラピューティクス,インコーポレーテッド | Antibody molecules that bind to NKp30 and their use |
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KR20230028242A (en) | 2020-04-24 | 2023-02-28 | 마렝고 테라퓨틱스, 인크. | Multifunctional molecules that bind to T cell-associated cancer cells and their uses |
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-
2012
- 2012-02-22 GB GBGB1203051.6A patent/GB201203051D0/en not_active Ceased
-
2013
- 2013-02-22 KR KR1020147026256A patent/KR102077331B1/en active IP Right Grant
- 2013-02-22 AU AU2013224003A patent/AU2013224003B2/en active Active
- 2013-02-22 MX MX2014010018A patent/MX356288B/en active IP Right Grant
- 2013-02-22 CN CN201810388711.9A patent/CN108586615B/en active Active
- 2013-02-22 KR KR1020207003552A patent/KR20200018706A/en not_active IP Right Cessation
- 2013-02-22 EP EP16180209.5A patent/EP3156416B1/en active Active
- 2013-02-22 EP EP13705504.2A patent/EP2817332B1/en active Active
- 2013-02-22 US US14/380,309 patent/US10221251B2/en active Active
- 2013-02-22 EA EA201491569A patent/EA035050B1/en not_active IP Right Cessation
- 2013-02-22 CA CA2864439A patent/CA2864439C/en active Active
- 2013-02-22 CN CN201380016707.5A patent/CN104321341B/en active Active
- 2013-02-22 WO PCT/EP2013/053614 patent/WO2013124450A1/en active Application Filing
- 2013-02-22 JP JP2014558131A patent/JP6308952B2/en active Active
- 2013-02-22 SG SG11201404789XA patent/SG11201404789XA/en unknown
- 2013-02-22 DK DK16180209.5T patent/DK3156416T3/en active
- 2013-02-22 ES ES16180209T patent/ES2768780T3/en active Active
- 2013-02-22 DK DK13705504.2T patent/DK2817332T3/en active
- 2013-02-22 ES ES13705504.2T patent/ES2599503T3/en active Active
-
2014
- 2014-08-13 IL IL234102A patent/IL234102B/en active IP Right Grant
-
2015
- 2015-03-27 HK HK15103109.5A patent/HK1202563A1/en unknown
-
2018
- 2018-02-21 AU AU2018201232A patent/AU2018201232B2/en active Active
- 2018-03-13 JP JP2018045460A patent/JP6814761B2/en active Active
-
2019
- 2019-01-08 US US16/242,378 patent/US11059911B2/en active Active
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HK1202563A1 (en) | Sequence symmetric modified igg4 bispecific antibodies igg4 | |
IL264558A (en) | Anti-il-23p19 antibodies | |
HK1204627A1 (en) | Anti-fcrn antibodies fcrn | |
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HK1210192A1 (en) | Anti-siglec-15 antibodies siglec-15 | |
ZA201406227B (en) | Humanized antibodies that recognize alpha-synuclein | |
ZA201407272B (en) | Anti-baff-anti-il-17 bispecific antibodies | |
HK1210186A1 (en) | Anti-h7cr antibodies h7cr | |
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IL235188A0 (en) | Anti-pdgf-c antibodies | |
GB201209584D0 (en) | Modified antibodies |