SG10202112528QA - Nsg mice lacking mhc class i and class ii - Google Patents

Nsg mice lacking mhc class i and class ii

Info

Publication number
SG10202112528QA
SG10202112528QA SG10202112528QA SG10202112528QA SG10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA
Authority
SG
Singapore
Prior art keywords
class
nsg mice
mice lacking
lacking mhc
mhc class
Prior art date
Application number
SG10202112528QA
Inventor
Michael Brehm
Michael Wiles
Dale Greiner
Leonard Shultz
Original Assignee
Jackson Lab
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson Lab, Univ Massachusetts filed Critical Jackson Lab
Publication of SG10202112528QA publication Critical patent/SG10202112528QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
SG10202112528QA 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii SG10202112528QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762505264P 2017-05-12 2017-05-12
US201862649099P 2018-03-28 2018-03-28

Publications (1)

Publication Number Publication Date
SG10202112528QA true SG10202112528QA (en) 2021-12-30

Family

ID=62598038

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202112528QA SG10202112528QA (en) 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii

Country Status (10)

Country Link
US (1) US11778994B2 (en)
EP (2) EP4144213A1 (en)
JP (2) JP7129426B2 (en)
KR (1) KR102652838B1 (en)
CN (2) CN110868850B (en)
AU (1) AU2018265887B2 (en)
CA (1) CA3063368A1 (en)
RU (1) RU2019140867A (en)
SG (1) SG10202112528QA (en)
WO (1) WO2018209344A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11712026B2 (en) * 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development
CN112094869A (en) * 2020-08-06 2020-12-18 郑州大学 Pancreatic cancer animal model preparation method based on gene knockout Syrian hamster and application thereof
KR20230074758A (en) * 2020-09-24 2023-05-31 더 잭슨 래보라토리 Humanized Mouse Models for Evaluating Immune Cell Therapy
WO2024054904A1 (en) * 2022-09-08 2024-03-14 The Jackson Laboratory Humanized immunodeficient mouse models

Family Cites Families (27)

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GB9100481D0 (en) 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6830910B1 (en) 1999-07-21 2004-12-14 Albert Einstein College Of Medicine Of Yeshiva University Drosophila recombination-associated protein and methods for use
CN1230540C (en) 1999-07-21 2005-12-07 犹太大学阿尔伯特爱因斯坦医学院 Drosophila recombination-associated protein and methods for use
FR2827302B1 (en) 2001-07-13 2003-10-10 Genoway TRANSGENIC CELL AND ANIMAL MODELING HUMAN ANTIGENIC PRESENTATION AND USES THEREOF
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
CN101022824A (en) * 2004-07-01 2007-08-22 匹兹堡大学联邦***高等教育 Immunosuppressive exosomes
PT1802193E (en) 2004-10-19 2014-06-23 Regeneron Pharma Method for generating a mouse homozygous for a genetic modification
EP1913149A4 (en) 2005-07-26 2009-08-05 Sangamo Biosciences Inc Targeted integration and expression of exogenous nucleic acid sequences
JP2007244268A (en) * 2006-03-15 2007-09-27 Osaka Prefecture Univ Method for producing monoclonal antibody recognizing canine hematopoietic precursor cell
EP2213731B1 (en) 2006-05-25 2013-12-04 Sangamo BioSciences, Inc. Variant foki cleavage half-domains
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
CN101715485A (en) * 2007-04-06 2010-05-26 国际干细胞公司 Come from the patient-specific stem cell line of people's monogenesis blastocyst
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
EP2510096B2 (en) 2009-12-10 2018-02-07 Regents of the University of Minnesota Tal effector-mediated dna modification
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US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
CN116574185A (en) 2012-07-25 2023-08-11 塞尔德克斯医疗公司 anti-KIT antibodies and uses thereof
DK3939423T3 (en) * 2012-11-05 2024-05-06 Regeneron Pharma Genetically modified non-human animals and methods of use thereof
US20190320633A1 (en) 2016-11-30 2019-10-24 The Jackson Laboratory Humanized mouse model with improved human innate immune cell development
US11712026B2 (en) 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development

Also Published As

Publication number Publication date
JP2022159551A (en) 2022-10-17
EP4144213A1 (en) 2023-03-08
US11778994B2 (en) 2023-10-10
CN115851834A (en) 2023-03-28
WO2018209344A8 (en) 2019-12-05
CN110868850A (en) 2020-03-06
RU2019140867A (en) 2021-06-15
AU2018265887B2 (en) 2024-05-09
KR102652838B1 (en) 2024-04-01
CA3063368A1 (en) 2018-11-15
JP7129426B2 (en) 2022-09-01
KR20200006109A (en) 2020-01-17
US20200060245A1 (en) 2020-02-27
EP3621433A1 (en) 2020-03-18
CN110868850B (en) 2023-07-14
AU2018265887A1 (en) 2019-11-28
JP2020519282A (en) 2020-07-02
EP3621433B1 (en) 2022-07-27
WO2018209344A1 (en) 2018-11-15

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