SG10202102467RA - Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond - Google Patents
Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bondInfo
- Publication number
- SG10202102467RA SG10202102467RA SG10202102467RA SG10202102467RA SG10202102467RA SG 10202102467R A SG10202102467R A SG 10202102467RA SG 10202102467R A SG10202102467R A SG 10202102467RA SG 10202102467R A SG10202102467R A SG 10202102467RA SG 10202102467R A SG10202102467R A SG 10202102467RA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugating
- protein
- agent
- methods
- thiol moiety
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462028679P | 2014-07-24 | 2014-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202102467RA true SG10202102467RA (en) | 2021-04-29 |
Family
ID=55163580
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202102467RA SG10202102467RA (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
SG11201700365TA SG11201700365TA (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700365TA SG11201700365TA (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Country Status (15)
Country | Link |
---|---|
US (2) | US11370838B2 (en) |
EP (1) | EP3172219A4 (en) |
JP (3) | JP6956630B2 (en) |
KR (1) | KR102463267B1 (en) |
CN (1) | CN106536540A (en) |
AR (1) | AR101304A1 (en) |
AU (2) | AU2015294389B2 (en) |
BR (1) | BR112017001403A2 (en) |
CA (1) | CA2955007C (en) |
IL (1) | IL250148B2 (en) |
MX (2) | MX2017001022A (en) |
MY (1) | MY198629A (en) |
RU (2) | RU2744978C2 (en) |
SG (2) | SG10202102467RA (en) |
WO (1) | WO2016014360A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6956630B2 (en) * | 2014-07-24 | 2021-11-02 | ジェネンテック, インコーポレイテッド | Method of conjugating to a thiol moiety in a protein containing at least one trisulfide bond of the drug |
EP3580234A1 (en) * | 2017-02-08 | 2019-12-18 | Pfizer Inc. | Large scale production process for capped and un-capped antibody cysteines and their use in therapeutic protein conjugation |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS5896026A (en) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | Novel urokinase derivative, its preparation and thrombolytic agent containing the same |
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
JP2665353B2 (en) * | 1988-09-10 | 1997-10-22 | 住商ファーマインターナショナル株式会社 | Methods for producing bispecific antibodies |
JPH0278699A (en) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | Benzoylurea compound-albumin complex |
JPH02218700A (en) * | 1989-02-17 | 1990-08-31 | Nippon Kayaku Co Ltd | Dispecific antibody and adoptive immunity using the same antibody |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
ZA955789B (en) | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
JPH11124395A (en) | 1997-10-16 | 1999-05-11 | Seiwa Kasei Kk | Peptide containing cysteine introduced thereinto and its production |
SE9802454D0 (en) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
WO2000071716A2 (en) | 1999-05-20 | 2000-11-30 | Scios Inc. | Vascular endothelial growth factor dimers |
JP2004530651A (en) | 2000-10-31 | 2004-10-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド, ア ボディー コーポレイト | Improved protein disaggregation and refolding using high pressure |
PT1545613E (en) | 2002-07-31 | 2011-09-27 | Seattle Genetics Inc | Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
CA2516455C (en) * | 2003-02-20 | 2012-05-01 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
JP4870569B2 (en) * | 2003-11-13 | 2012-02-08 | ハンミ ホールディングス カンパニー リミテッド | Protein conjugate using immunoglobulin fragment and method for producing the same |
AU2005218642B2 (en) * | 2004-03-02 | 2011-04-28 | Seagen Inc. | Partially loaded antibodies and methods of their conjugation |
BRPI0510883B8 (en) * | 2004-06-01 | 2021-05-25 | Genentech Inc | drug-antibody conjugate compound, pharmaceutical composition, method of manufacturing a drug-antibody conjugate compound, and uses of a formulation, a drug-antibody conjugate and a chemotherapeutic agent, and a combination |
ES2344120T3 (en) * | 2004-12-29 | 2010-08-18 | Novo Nordisk Health Care Ag | METHOD TO PREVENT TRAINING OF POLYPEPTIDE TRISULFIDE DERIVATIVES. |
CN103030696B (en) * | 2006-05-30 | 2016-09-28 | 健泰科生物技术公司 | Antibody and immune conjugate and application thereof |
US20080220448A1 (en) | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
JP5394246B2 (en) | 2007-03-30 | 2014-01-22 | ジェネンテック, インコーポレイテッド | Antibodies and immunoconjugates and methods for their use |
AR066476A1 (en) * | 2007-05-08 | 2009-08-19 | Genentech Inc | ANTI-MUC16 ANTIBODIES DESIGNED WITH CYSTEINE AND ANTIBODIES AND PHARMACOS CONJUGAODS |
RU2557319C2 (en) | 2007-07-16 | 2015-07-20 | Дженентек, Инк. | HUMANISED ANTIBODIES AGAINST CD79b AND IMMUNOCONJUGATES AND METHODS OF APPLICATION |
SG183023A1 (en) | 2007-07-16 | 2012-08-30 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
EP2249967B1 (en) * | 2008-01-31 | 2019-03-13 | Ingevity South Carolina, LLC | Oxidized and maleated derivative composition |
WO2009099728A1 (en) | 2008-01-31 | 2009-08-13 | Genentech, Inc. | Anti-cd79b antibodies and immunoconjugates and methods of use |
WO2011041721A1 (en) * | 2009-10-02 | 2011-04-07 | Biogen Idec Ma Inc. | Methods of preventing and removing trisulfide bonds |
WO2011109308A1 (en) * | 2010-03-02 | 2011-09-09 | Seattle Genetics, Inc. | Methods for screening antibodies |
CN103282055A (en) * | 2010-11-05 | 2013-09-04 | CovX科技爱尔兰有限公司 | Anti-diabetic compounds |
US9562252B2 (en) * | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
US10344050B2 (en) * | 2011-10-27 | 2019-07-09 | Genmab A/S | Production of heterodimeric proteins |
CA3111357A1 (en) * | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
KR20150006000A (en) * | 2012-05-01 | 2015-01-15 | 제넨테크, 인크. | Anti-pmel17 antibodies and immunoconjugates |
CA2876365A1 (en) * | 2012-06-19 | 2013-12-27 | Polytherics Limited | Novel process for preparation of antibody conjugates and novel antibody conjugates |
JP6956630B2 (en) * | 2014-07-24 | 2021-11-02 | ジェネンテック, インコーポレイテッド | Method of conjugating to a thiol moiety in a protein containing at least one trisulfide bond of the drug |
-
2015
- 2015-07-17 JP JP2017503957A patent/JP6956630B2/en active Active
- 2015-07-17 BR BR112017001403A patent/BR112017001403A2/en not_active Application Discontinuation
- 2015-07-17 MY MYPI2017000109A patent/MY198629A/en unknown
- 2015-07-17 SG SG10202102467RA patent/SG10202102467RA/en unknown
- 2015-07-17 SG SG11201700365TA patent/SG11201700365TA/en unknown
- 2015-07-17 MX MX2017001022A patent/MX2017001022A/en unknown
- 2015-07-17 AU AU2015294389A patent/AU2015294389B2/en not_active Expired - Fee Related
- 2015-07-17 CN CN201580041071.9A patent/CN106536540A/en active Pending
- 2015-07-17 WO PCT/US2015/040931 patent/WO2016014360A1/en active Application Filing
- 2015-07-17 KR KR1020177003843A patent/KR102463267B1/en active IP Right Grant
- 2015-07-17 RU RU2017105428A patent/RU2744978C2/en active
- 2015-07-17 EP EP15824358.4A patent/EP3172219A4/en active Pending
- 2015-07-17 RU RU2021106673A patent/RU2021106673A/en unknown
- 2015-07-17 CA CA2955007A patent/CA2955007C/en active Active
- 2015-07-24 AR ARP150102358A patent/AR101304A1/en unknown
-
2017
- 2017-01-16 IL IL250148A patent/IL250148B2/en unknown
- 2017-01-20 MX MX2022012589A patent/MX2022012589A/en unknown
- 2017-01-24 US US15/414,330 patent/US11370838B2/en active Active
-
2020
- 2020-12-01 JP JP2020199681A patent/JP7219256B2/en active Active
-
2021
- 2021-07-27 AU AU2021209196A patent/AU2021209196B2/en active Active
-
2022
- 2022-05-24 US US17/752,631 patent/US20220372141A1/en active Pending
-
2023
- 2023-01-26 JP JP2023010054A patent/JP2023052645A/en active Pending
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