SG10202100171UA - Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores - Google Patents

Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores

Info

Publication number
SG10202100171UA
SG10202100171UA SG10202100171UA SG10202100171UA SG10202100171UA SG 10202100171U A SG10202100171U A SG 10202100171UA SG 10202100171U A SG10202100171U A SG 10202100171UA SG 10202100171U A SG10202100171U A SG 10202100171UA SG 10202100171U A SG10202100171U A SG 10202100171UA
Authority
SG
Singapore
Prior art keywords
nanopores
compositions
systems
adjacent
methods
Prior art date
Application number
SG10202100171UA
Inventor
Jeffrey Mandell
Kevin Gunderson
Jens Gundlach
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of SG10202100171UA publication Critical patent/SG10202100171UA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG10202100171UA 2014-06-03 2015-06-02 Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores SG10202100171UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462007248P 2014-06-03 2014-06-03
US201562157371P 2015-05-05 2015-05-05

Publications (1)

Publication Number Publication Date
SG10202100171UA true SG10202100171UA (en) 2021-02-25

Family

ID=53433287

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202100171UA SG10202100171UA (en) 2014-06-03 2015-06-02 Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores
SG11201609692SA SG11201609692SA (en) 2014-06-03 2015-06-02 Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201609692SA SG11201609692SA (en) 2014-06-03 2015-06-02 Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores

Country Status (10)

Country Link
US (4) US9708655B2 (en)
EP (2) EP3152320B1 (en)
CN (2) CN113584139A (en)
AU (3) AU2015271824B2 (en)
CA (2) CA3221500A1 (en)
DK (1) DK3152320T3 (en)
ES (1) ES2846746T3 (en)
HK (1) HK1232257A1 (en)
SG (2) SG10202100171UA (en)
WO (1) WO2015187670A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103748236B (en) 2011-04-15 2018-12-25 约翰·霍普金斯大学 Safe sequencing system
CN109457030B (en) 2012-10-29 2022-02-18 约翰·霍普金斯大学 Papanicolaou test for ovarian and endometrial cancer
EP3303627A1 (en) * 2015-06-03 2018-04-11 Illumina, Inc. Compositions, systems, and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US10102338B2 (en) 2015-09-24 2018-10-16 Genia Technologies, Inc. Adaptive compression and modification of nanopore measurement data
US10935512B2 (en) * 2015-09-24 2021-03-02 Roche Sequencing Solutions, Inc. Encoding state change of nanopore to reduce data size
JP7280590B2 (en) 2016-01-28 2023-05-24 ロズウェル バイオテクノロジーズ,インコーポレイテッド Methods and apparatus for measuring analytes using large-scale molecular electronics sensor arrays
US10712334B2 (en) 2016-01-28 2020-07-14 Roswell Biotechnologies, Inc. Massively parallel DNA sequencing apparatus
WO2017139493A2 (en) 2016-02-09 2017-08-17 Roswell Biotechnologies, Inc. Electronic label-free dna and genome sequencing
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
ES2911439T3 (en) 2016-03-24 2022-05-19 Genia Tech Inc Useful site-specific bioconjugation methods and compositions for nanopore systems
CN109196117B (en) 2016-05-31 2022-12-30 豪夫迈·罗氏有限公司 Methods and systems for nucleic acid sequencing by tunneling recognition
US11124827B2 (en) * 2016-06-23 2021-09-21 Roche Sequencing Solutions, Inc. Period-to-period analysis of AC signals from nanopore sequencing
EP3475447B1 (en) 2016-06-23 2021-04-21 F. Hoffmann-La Roche AG Formation and calibration of nanopore sequencing cells
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
CN110100009B (en) 2016-10-19 2023-11-21 伊鲁米那股份有限公司 Method for chemical ligation of nucleic acids
CA3052062A1 (en) 2017-01-10 2018-07-19 Roswell Biotechnologies, Inc. Methods and systems for dna data storage
KR20230158636A (en) 2017-01-19 2023-11-20 로스웰 바이오테크놀로지스 인코포레이티드 Solid state sequencing devices comprising two dimensional layer materials
US10508296B2 (en) * 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP3615685A4 (en) 2017-04-25 2021-01-20 Roswell Biotechnologies, Inc Enzymatic circuits for molecular sensors
GB201707140D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
CA3057155A1 (en) 2017-05-09 2018-11-15 Roswell Biotechnologies, Inc. Binding probe circuits for molecular sensors
BR112020002555A2 (en) 2017-08-07 2020-08-11 The Johns Hopkins University methods and materials to assess and treat cancer
WO2019046589A1 (en) 2017-08-30 2019-03-07 Roswell Biotechnologies, Inc. Processive enzyme molecular electronic sensors for dna data storage
EP3682023A4 (en) * 2017-09-15 2021-06-02 Illumina, Inc. Tuning and calibration features of a sequence-detection system
US20240003896A1 (en) * 2017-09-15 2024-01-04 lllumina, Inc. Sequence-detection system
US11100404B2 (en) 2017-10-10 2021-08-24 Roswell Biotechnologies, Inc. Methods, apparatus and systems for amplification-free DNA data storage
WO2019129555A1 (en) 2017-12-28 2019-07-04 F. Hoffmann-La Roche Ag Measuring and removing noise in stochastic signals from a nanopore dna sequencing system driven by an alternating signal
GB201809323D0 (en) * 2018-06-06 2018-07-25 Oxford Nanopore Tech Ltd Method
WO2020152563A1 (en) * 2019-01-21 2020-07-30 Fondazione Istituto Italiano Di Tecnologia Method and device for nanopore-based optical recognition of molecules
CN110669660B (en) * 2019-10-19 2023-03-24 上海新微技术研发中心有限公司 Method for manufacturing gene transfer rate control device based on motor protein
US11637540B2 (en) * 2019-10-30 2023-04-25 X-Celeprint Limited Non-linear tethers for suspended devices
MX2022010514A (en) * 2020-02-28 2022-09-21 Univ Arizona State Methods for sequencing biopolymers.
CN111879941B (en) * 2020-06-29 2021-11-02 北京大学 Protein behavior detection system based on self-assembly nano-pores and preparation and use methods thereof
CN114790465A (en) * 2021-01-26 2022-07-26 中国农业大学 Method for improving stability of nano material
EP4314810A1 (en) 2021-03-31 2024-02-07 Illumina, Inc. Nanopore sensor devices
KR20230163282A (en) 2021-03-31 2023-11-30 일루미나, 인코포레이티드 Scalable Circuit for Molecular Detection
CN117813401A (en) 2021-09-22 2024-04-02 因美纳有限公司 Sequencing polynucleotides using nanopores
US20230312856A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Nanopore devices including barriers using diblock or triblock copolymers, and methods of making the same
US20230381718A1 (en) 2022-03-31 2023-11-30 Illumina Cambridge Limited Barriers including molecules covalently bonded to amphiphilic molecules, and methods of making the same
US20230391961A1 (en) 2022-03-31 2023-12-07 Illumina Cambridge Limited Methods for inserting nanopores into polymeric membranes using chaotropic solvents
WO2023187106A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Barriers including cross-linked amphiphilic molecules, and methods of making the same
WO2023187111A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Barriers including biological nanopore for dna sequencing, the barriers being made of co-polymers with end and/or middle groups, and methods of making the same
WO2023187001A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Devices including osmotically balanced barriers, and methods of making and using the same
WO2023187110A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Amphiphilic polymers to be used in barriers and preparation thereof, barriers with nanopores and preparation thereof
WO2023229884A2 (en) 2022-05-27 2023-11-30 Illumina, Inc. 3'-blocked nucleotides, methods of deblocking the same, and methods of synthesizing polynucleotides using the same

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
DE60131194T2 (en) 2000-07-07 2008-08-07 Visigen Biotechnologies, Inc., Bellaire SEQUENCE PROVISION IN REAL TIME
US7358353B2 (en) 2000-08-22 2008-04-15 Agensys, Inc. Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
DK3002289T3 (en) 2002-08-23 2018-04-23 Illumina Cambridge Ltd MODIFIED NUCLEOTIDES FOR POLYNUCLEOTIDE SEQUENCE
GB2423819B (en) 2004-09-17 2008-02-06 Pacific Biosciences California Apparatus and method for analysis of molecules
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US8241573B2 (en) 2006-03-31 2012-08-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
US8889348B2 (en) 2006-06-07 2014-11-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by nanopore using modified nucleotides
EP2089517A4 (en) 2006-10-23 2010-10-20 Pacific Biosciences California Polymerase enzymes and reagents for enhanced nucleic acid sequencing
EP3798317B1 (en) * 2007-04-04 2024-01-03 The Regents of the University of California Compositions, devices, systems, and methods for using a nanopore
US9027947B2 (en) 2008-03-26 2015-05-12 Fox Factory, Inc. Methods and apparatus related to a unitary fork brace
EP2274446B1 (en) 2008-03-31 2015-09-09 Pacific Biosciences of California, Inc. Two slow-step polymerase enzyme systems and methods
US7771903B2 (en) 2008-05-28 2010-08-10 Promos Technologies Pte. Ltd. Photolithography with optical masks having more transparent features surrounded by less transparent features
CN102245760A (en) 2008-07-07 2011-11-16 牛津纳米孔技术有限公司 Enzyme-pore constructs
HUE029215T2 (en) 2008-09-22 2017-02-28 Univ Washington Msp nanopores and related methods
US9017937B1 (en) * 2009-04-10 2015-04-28 Pacific Biosciences Of California, Inc. Nanopore sequencing using ratiometric impedance
US20140335513A9 (en) 2009-09-30 2014-11-13 Quantapore, Inc. Hybrid nanopore device with optical detection and methods of using same
EP2539707B1 (en) 2010-02-23 2021-06-30 University Of Washington Artificial mycolic acid membranes
US8652779B2 (en) 2010-04-09 2014-02-18 Pacific Biosciences Of California, Inc. Nanopore sequencing using charge blockade labels
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
US10443096B2 (en) * 2010-12-17 2019-10-15 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using modified nucleotides and nanopore detection
WO2012121756A1 (en) 2011-03-04 2012-09-13 Quantapore, Inc. Apparatus and methods for performing optical nanopore detection or sequencing
WO2012142174A1 (en) 2011-04-12 2012-10-18 Electronic Biosciences Inc. Site specific chemically modified nanopore devices
WO2012164270A1 (en) * 2011-05-27 2012-12-06 Oxford Nanopore Technologies Limited Coupling method
CA2852812A1 (en) * 2011-10-21 2013-04-25 Oxford Nanopore Technologies Limited Enzyme method
CN112646019B (en) 2012-04-10 2022-08-16 牛津纳米孔科技公开有限公司 Mutant lysenin pore
US9605309B2 (en) * 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
WO2015126494A1 (en) 2014-02-19 2015-08-27 University Of Washington Nanopore-based analysis of protein characteristics

Also Published As

Publication number Publication date
WO2015187670A2 (en) 2015-12-10
HK1232257A1 (en) 2018-01-05
CA2950298A1 (en) 2015-12-10
AU2015271824A1 (en) 2016-12-08
US20170369942A1 (en) 2017-12-28
CA2950298C (en) 2024-01-09
AU2021201245A1 (en) 2021-03-11
US20150344945A1 (en) 2015-12-03
SG11201609692SA (en) 2016-12-29
EP3152320A2 (en) 2017-04-12
WO2015187670A3 (en) 2016-02-25
AU2021201245B2 (en) 2023-03-02
CN113584139A (en) 2021-11-02
AU2023203432A1 (en) 2023-06-29
US11254981B2 (en) 2022-02-22
DK3152320T3 (en) 2021-01-11
EP3683318A1 (en) 2020-07-22
AU2015271824B2 (en) 2020-12-03
EP3152320B1 (en) 2020-10-28
US10364463B2 (en) 2019-07-30
US20220251641A1 (en) 2022-08-11
US9708655B2 (en) 2017-07-18
CN106687574A (en) 2017-05-17
CA3221500A1 (en) 2015-12-10
US20190376135A1 (en) 2019-12-12
ES2846746T3 (en) 2021-07-29
CN106687574B (en) 2021-06-29

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