SG10201913868XA - T cell receptors recognizing hla-cw8 restricted mutated kras - Google Patents

T cell receptors recognizing hla-cw8 restricted mutated kras

Info

Publication number
SG10201913868XA
SG10201913868XA SG10201913868XA SG10201913868XA SG10201913868XA SG 10201913868X A SG10201913868X A SG 10201913868XA SG 10201913868X A SG10201913868X A SG 10201913868XA SG 10201913868X A SG10201913868X A SG 10201913868XA SG 10201913868X A SG10201913868X A SG 10201913868XA
Authority
SG
Singapore
Prior art keywords
cell receptors
mutated kras
receptors recognizing
recognizing hla
restricted
Prior art date
Application number
SG10201913868XA
Inventor
Eric Tran
Yong-Chen Lu
Steven A Rosenberg
Original Assignee
The United States Of America As Represented By The Secretary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America As Represented By The Secretary filed Critical The United States Of America As Represented By The Secretary
Publication of SG10201913868XA publication Critical patent/SG10201913868XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
SG10201913868XA 2015-09-15 2016-09-09 T cell receptors recognizing hla-cw8 restricted mutated kras SG10201913868XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562218688P 2015-09-15 2015-09-15

Publications (1)

Publication Number Publication Date
SG10201913868XA true SG10201913868XA (en) 2020-03-30

Family

ID=56985686

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201913868XA SG10201913868XA (en) 2015-09-15 2016-09-09 T cell receptors recognizing hla-cw8 restricted mutated kras

Country Status (15)

Country Link
US (3) US10556940B2 (en)
EP (2) EP3901169A1 (en)
JP (2) JP7185524B2 (en)
KR (1) KR20180044428A (en)
CN (2) CN108350059B (en)
AU (3) AU2016323017B2 (en)
CA (1) CA2998869A1 (en)
DK (1) DK3350213T3 (en)
ES (1) ES2879287T3 (en)
HK (1) HK1257902A1 (en)
IL (1) IL257840B2 (en)
MX (1) MX2018003062A (en)
SA (1) SA518391109B1 (en)
SG (1) SG10201913868XA (en)
WO (1) WO2017048593A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2993431A1 (en) 2015-07-31 2017-02-09 Regents Of The University Of Minnesota Nuclease based knockouts of immunological checkpoint genes in immune cells
DK3494133T3 (en) * 2016-08-02 2022-09-19 Us Health ANTI-KRAS-G12D T-CELL RECEPTORS
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US11898207B2 (en) 2017-03-31 2024-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating neoantigen-specific T cell receptor sequences
CN111406068A (en) * 2017-05-16 2020-07-10 约翰霍普金斯大学 MANAbody and methods of use
EP3645021A4 (en) 2017-06-30 2021-04-21 Intima Bioscience, Inc. Adeno-associated viral vectors for gene therapy
IL273254B1 (en) * 2017-09-20 2024-05-01 Us Health Hla class ii–restricted t cell receptors against mutated ras
US11466071B2 (en) * 2017-12-04 2022-10-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA class I-restricted t cell receptors against mutated RAS
CN112638404A (en) * 2018-06-19 2021-04-09 百欧恩泰美国公司 Novel antigens and uses thereof
WO2020037239A1 (en) * 2018-08-16 2020-02-20 Neon Therapeutics, Inc. T cell receptor constructs and uses thereof
US20220089673A1 (en) * 2019-01-22 2022-03-24 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class ii-restricted t cell receptors against ras with g12r mutation
WO2020172332A1 (en) 2019-02-20 2020-08-27 Fred Hutchinson Cancer Research Center Binding proteins specific for ras neoantigens and uses thereof
US20220175899A1 (en) * 2019-04-11 2022-06-09 The Board Of Trustees Of The Leland Stanford Junior University Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer
CN110172089B (en) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 KRAS mutant multi-antigen combination, targeting KRAS mutant tumor CTL and application thereof
CN112110995A (en) * 2019-06-19 2020-12-22 上海交通大学医学院 Tumor neoantigen polypeptide and application thereof
CN112759641B (en) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 High-affinity TCR for recognizing Kras G12V
MX2022007598A (en) 2019-12-20 2022-09-23 Instil Bio Uk Ltd Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof.
CN111574616B (en) * 2020-06-17 2021-02-02 深圳豪石生物科技有限公司 Isolated T cell receptors and uses
EP4298121A1 (en) 2021-02-25 2024-01-03 Alaunos Therapeutics, Inc. Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN114920824B (en) * 2022-05-27 2023-12-05 重庆医科大学 TCR or antigen binding fragment thereof and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1545204T3 (en) 2002-09-06 2016-11-14 The Government Of The Us Secretary Dept Of Health And Human Services Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy
EP3369812B1 (en) * 2005-08-05 2020-10-07 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Generation of antigen specific t cells
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
SI2618835T1 (en) 2010-09-20 2017-10-30 Biontech Cell & Gene Therapies Gmbh Antigen-specific t cell receptors and t cell epitopes
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
ES2689512T3 (en) * 2011-09-15 2018-11-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors that recognize MAGE restricted by HLA-A1 or HLA-Cw7
GB201314404D0 (en) 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors
EP4286407A3 (en) 2014-11-26 2024-03-06 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-mutated kras t cell receptors

Also Published As

Publication number Publication date
EP3901169A1 (en) 2021-10-27
KR20180044428A (en) 2018-05-02
AU2022209229B2 (en) 2024-05-23
AU2016323017B2 (en) 2020-11-12
JP7185524B2 (en) 2022-12-07
AU2016323017A1 (en) 2018-04-05
MX2018003062A (en) 2018-09-11
WO2017048593A1 (en) 2017-03-23
US20200148739A1 (en) 2020-05-14
DK3350213T3 (en) 2021-06-21
US11667692B2 (en) 2023-06-06
CN108350059B (en) 2021-10-08
SA518391109B1 (en) 2022-02-14
CA2998869A1 (en) 2017-03-23
IL257840B1 (en) 2023-06-01
US10556940B2 (en) 2020-02-11
CN115073583A (en) 2022-09-20
EP3350213A1 (en) 2018-07-25
JP2023025108A (en) 2023-02-21
CN108350059A (en) 2018-07-31
AU2022209229A1 (en) 2022-09-15
JP2018535647A (en) 2018-12-06
AU2021200833A1 (en) 2021-03-04
ES2879287T3 (en) 2021-11-22
IL257840A (en) 2018-04-30
US20190040111A1 (en) 2019-02-07
EP3350213B1 (en) 2021-03-31
HK1257902A1 (en) 2019-11-01
US20230406904A1 (en) 2023-12-21
AU2021200833B2 (en) 2022-04-28
JP7461445B2 (en) 2024-04-03
IL257840B2 (en) 2023-10-01

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