SG10201913786SA - Modified rna agents with reduced off-target effect - Google Patents
Modified rna agents with reduced off-target effectInfo
- Publication number
- SG10201913786SA SG10201913786SA SG10201913786SA SG10201913786SA SG10201913786SA SG 10201913786S A SG10201913786S A SG 10201913786SA SG 10201913786S A SG10201913786S A SG 10201913786SA SG 10201913786S A SG10201913786S A SG 10201913786SA SG 10201913786S A SG10201913786S A SG 10201913786SA
- Authority
- SG
- Singapore
- Prior art keywords
- reduced
- modified rna
- target effect
- rna agents
- agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425907P | 2016-11-23 | 2016-11-23 | |
| US201762548589P | 2017-08-22 | 2017-08-22 | |
| US201762561514P | 2017-09-21 | 2017-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913786SA true SG10201913786SA (en) | 2020-03-30 |
Family
ID=60888585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913786SA SG10201913786SA (en) | 2016-11-23 | 2017-11-22 | Modified rna agents with reduced off-target effect |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11504391B1 (en) |
| EP (1) | EP3544617A4 (en) |
| JP (2) | JP7288852B2 (en) |
| KR (2) | KR102645243B1 (en) |
| CN (2) | CN110582283B (en) |
| AU (2) | AU2017363892B2 (en) |
| CA (1) | CA3044598A1 (en) |
| IL (1) | IL266780A (en) |
| MX (1) | MX2019005816A (en) |
| SG (1) | SG10201913786SA (en) |
| WO (1) | WO2018098328A1 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180002688A (en) | 2015-05-06 | 2018-01-08 | 알닐람 파마슈티칼스 인코포레이티드 | (F12), calichein B, plasma (Fletcher factor) 1 (KLKB1) and kininogen 1 (KNG1) iRNA compositions and methods for their use |
| CA3044598A1 (en) | 2016-11-23 | 2018-05-31 | Alnylam Pharmaceuticals, Inc. | Modified rna agents with reduced off-target effect |
| FR3060947A1 (en) * | 2016-12-28 | 2018-06-29 | Ynsect | METHOD OF TREATING INSECTS COMPRISING THE SEPARATION OF CUTICLES FROM THE MOLLE PART OF INSECTS THEN SEPARATING THE MOLLE PART INTO THREE FRACTIONS |
| EP3649243A1 (en) * | 2017-07-07 | 2020-05-13 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing contact-activation pathway-associated diseases using irna compositions targeting factor xii (hageman factor) (f12) |
| EP3790557A4 (en) * | 2018-05-07 | 2022-03-02 | Alnylam Pharmaceuticals Inc. | Compositions and methods for improving strand biased |
| JP7384833B2 (en) * | 2018-05-16 | 2023-11-21 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | Modified RNA agents with reduced off-target effects |
| US11066669B2 (en) | 2018-06-05 | 2021-07-20 | Hoffmann-La Roche Inc. | Oligonucleotides for modulating ATXN2 expression |
| AU2019300324A1 (en) | 2018-07-13 | 2021-01-21 | F. Hoffmann-La Roche Ag | Oligonucleotides for modulating RTEL1 expression |
| MX2021001056A (en) * | 2018-08-13 | 2021-04-12 | Alnylam Pharmaceuticals Inc | HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF. |
| SG11202110745VA (en) | 2019-04-03 | 2021-10-28 | Bristol Myers Squibb Co | Angptl2 antisense oligonucleotides and uses thereof |
| EP4000638A4 (en) * | 2019-07-16 | 2023-12-27 | The University of Tokyo | Rna molecule, chimeric na molecule, double-stranded rna molecule, and double-stranded chimeric na molecule |
| WO2021030778A1 (en) | 2019-08-15 | 2021-02-18 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
| CN114616331A (en) * | 2019-09-03 | 2022-06-10 | 阿尔尼拉姆医药品有限公司 | Compositions and methods for inhibiting expression of LECT2 gene |
| JP2023502038A (en) * | 2019-11-13 | 2023-01-20 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | Methods and compositions for treating angiotensinogen (AGT) related disorders |
| CN115516091A (en) | 2019-12-19 | 2022-12-23 | 豪夫迈·罗氏有限公司 | Use of COPS3 inhibitors for the treatment of hepatitis b virus infection |
| CN114829601A (en) | 2019-12-19 | 2022-07-29 | 豪夫迈·罗氏有限公司 | Use of SBDS inhibitors for the treatment of hepatitis b virus infection |
| CN114901821A (en) | 2019-12-19 | 2022-08-12 | 豪夫迈·罗氏有限公司 | Use of SEPT9 inhibitors for treating hepatitis B virus infection |
| CN114867856A (en) | 2019-12-19 | 2022-08-05 | 豪夫迈·罗氏有限公司 | Use of SARAF inhibitors for the treatment of hepatitis B virus infection |
| WO2021122869A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of scamp3 inhibitors for treating hepatitis b virus infection |
| MX2022007908A (en) | 2019-12-24 | 2022-07-21 | Hoffmann La Roche | Pharmaceutical combination of a therapeutic oligonucleotide targeting hbv and a tlr7 agonist for treatment of hbv. |
| JP2023509872A (en) | 2019-12-24 | 2023-03-10 | エフ． ホフマン－ラ ロシュ アーゲー | Pharmaceutical combinations of antiviral agents targeting HBV and/or immunomodulatory agents for the treatment of HBV |
| EP4150084A1 (en) | 2020-05-11 | 2023-03-22 | Genentech, Inc. | Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same |
| EP4150085A1 (en) | 2020-05-11 | 2023-03-22 | Genentech, Inc. | Complement component c1r inhibitors for treating a neurological disease, and related compositions, systems and methods of using same |
| JP2023527684A (en) | 2020-05-11 | 2023-06-30 | ジェネンテック， インコーポレイテッド | Complement component C1S inhibitors for treating neurological disorders and related compositions, systems and methods of using same |
| CN116157522A (en) | 2020-08-21 | 2023-05-23 | 豪夫迈·罗氏有限公司 | Use of A1CF inhibitors for the treatment of hepatitis B virus infection |
| AU2021345266A1 (en) * | 2020-09-17 | 2023-04-27 | Q-State Biosciences, Inc. | Therapeutic compositions for treating pain via multiple targets |
| WO2022154123A1 (en) * | 2021-01-15 | 2022-07-21 | 国立大学法人 東京大学 | Rna molecule, chimeric na molecule, double-stranded rna molecule, and double-stranded chimeric na molecule |
| WO2022174000A2 (en) | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| US11912779B2 (en) | 2021-09-16 | 2024-02-27 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
| WO2023083906A2 (en) | 2021-11-11 | 2023-05-19 | F. Hoffmann-La Roche Ag | Pharmaceutical combinations for treatment of hbv |
| WO2023111210A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Combination of oligonucleotides for modulating rtel1 and fubp1 |
| WO2023131170A1 (en) * | 2022-01-05 | 2023-07-13 | 大睿生物医药科技(上海)有限公司 | Double-stranded rna having nucleotide analog |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103045601B (en) | 2004-04-22 | 2015-04-01 | 雷加多生物科学公司 | Improved modulators of coagulation factors |
| EP1681347A1 (en) * | 2005-01-18 | 2006-07-19 | Metanomics GmbH & Co. KGaA | Improved methods for double-stranded RNA mediated gene silencing |
| EP2002004B1 (en) * | 2006-03-23 | 2015-10-14 | Roche Innovation Center Copenhagen A/S | Small internally segmented interfering rna |
| US20140170191A1 (en) | 2008-10-23 | 2014-06-19 | Hemispher Biopharma, Inc. | Novel double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20110111056A1 (en) | 2009-06-03 | 2011-05-12 | Dicerna Pharmaceuticals, Inc. | Peptide dicer substrate agents and methods for their specific inhibition of gene expression |
| WO2011109427A2 (en) * | 2010-03-01 | 2011-09-09 | Alnylam Pharmaceuticals, Inc. | Improving the biological activity of sirna through modulation of its thermodynamic profile |
| WO2011133876A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| ES2536640T3 (en) * | 2010-12-02 | 2015-05-27 | Keygene N.V. | Targeted alteration of DNA with oligonucleotides |
| RU2014106024A (en) * | 2011-07-19 | 2015-08-27 | Юниверсити Оф Айдахо | OPTIONS FOR IMPLEMENTING THE PROBE AND METHODS OF DIRECTED ACTION FOR NUCLEIC ACIDS |
| EP3137605B1 (en) * | 2014-05-01 | 2020-10-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating angiopoietin-like 3 expression |
| NZ767118A (en) | 2014-08-20 | 2024-02-23 | Alnylam Pharmaceuticals Inc | Modified double-stranded rna agents |
| AU2015364508A1 (en) | 2014-12-18 | 2017-07-06 | Alnylam Pharmaceuticals, Inc. | ReversirTM compounds |
| CA3044598A1 (en) | 2016-11-23 | 2018-05-31 | Alnylam Pharmaceuticals, Inc. | Modified rna agents with reduced off-target effect |
| WO2021072395A1 (en) | 2019-10-11 | 2021-04-15 | Alnylam Pharmaceuticals, Inc. | Modified oligonucleotides |
-
2017
- 2017-11-22 CA CA3044598A patent/CA3044598A1/en active Pending
- 2017-11-22 CN CN201780084435.0A patent/CN110582283B/en active Active
- 2017-11-22 EP EP17873158.4A patent/EP3544617A4/en active Pending
- 2017-11-22 KR KR1020197018071A patent/KR102645243B1/en active IP Right Grant
- 2017-11-22 KR KR1020247007251A patent/KR20240035907A/en not_active Application Discontinuation
- 2017-11-22 MX MX2019005816A patent/MX2019005816A/en unknown
- 2017-11-22 WO PCT/US2017/063078 patent/WO2018098328A1/en unknown
- 2017-11-22 JP JP2019527517A patent/JP7288852B2/en active Active
- 2017-11-22 US US16/461,523 patent/US11504391B1/en active Active
- 2017-11-22 CN CN202311754990.3A patent/CN117757791A/en active Pending
- 2017-11-22 AU AU2017363892A patent/AU2017363892B2/en active Active
- 2017-11-22 SG SG10201913786SA patent/SG10201913786SA/en unknown
-
2019
- 2019-05-21 IL IL266780A patent/IL266780A/en unknown
-
2022
- 2022-09-30 US US17/937,256 patent/US20230256001A1/en active Pending
-
2023
- 2023-01-20 JP JP2023007453A patent/JP2023053963A/en active Pending
- 2023-09-05 AU AU2023226646A patent/AU2023226646A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023053963A (en) | 2023-04-13 |
| CN110582283B (en) | 2024-01-02 |
| WO2018098328A1 (en) | 2018-05-31 |
| JP7288852B2 (en) | 2023-06-08 |
| CN117757791A (en) | 2024-03-26 |
| KR20240035907A (en) | 2024-03-18 |
| IL266780A (en) | 2019-08-29 |
| US20230256001A1 (en) | 2023-08-17 |
| KR102645243B1 (en) | 2024-03-11 |
| EP3544617A4 (en) | 2020-08-05 |
| CN110582283A (en) | 2019-12-17 |
| EP3544617A1 (en) | 2019-10-02 |
| CA3044598A1 (en) | 2018-05-31 |
| JP2019535288A (en) | 2019-12-12 |
| AU2017363892A1 (en) | 2019-06-13 |
| MX2019005816A (en) | 2019-10-07 |
| AU2017363892B2 (en) | 2023-06-15 |
| KR20190086001A (en) | 2019-07-19 |
| AU2023226646A1 (en) | 2023-11-16 |
| US11504391B1 (en) | 2022-11-22 |
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