SG10201913462XA - Dna alkylating agents - Google Patents

Dna alkylating agents

Info

Publication number
SG10201913462XA
SG10201913462XA SG10201913462XA SG10201913462XA SG10201913462XA SG 10201913462X A SG10201913462X A SG 10201913462XA SG 10201913462X A SG10201913462X A SG 10201913462XA SG 10201913462X A SG10201913462X A SG 10201913462XA SG 10201913462X A SG10201913462X A SG 10201913462XA
Authority
SG
Singapore
Prior art keywords
alkylating agents
dna alkylating
dna
agents
alkylating
Prior art date
Application number
SG10201913462XA
Inventor
Jian-Xin Duan
Yeyu Cao
Xiaohong Cai
Hailong Jiao
jing yuan Ma
Mark Matteucci
Original Assignee
Ascentawits Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascentawits Pharmaceuticals Ltd filed Critical Ascentawits Pharmaceuticals Ltd
Publication of SG10201913462XA publication Critical patent/SG10201913462XA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2454Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2466Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of cycloaliphatic amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/04Nitro compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • A61K31/06Phenols the aromatic ring being substituted by nitro groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/664Amides of phosphorus acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564Three-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/904Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
SG10201913462XA 2015-03-10 2016-03-09 Dna alkylating agents SG10201913462XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131163P 2015-03-10 2015-03-10
US201562255916P 2015-11-16 2015-11-16

Publications (1)

Publication Number Publication Date
SG10201913462XA true SG10201913462XA (en) 2020-03-30

Family

ID=56879139

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201707293VA SG11201707293VA (en) 2015-03-10 2016-03-09 Dna alkylating agents
SG10201913462XA SG10201913462XA (en) 2015-03-10 2016-03-09 Dna alkylating agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201707293VA SG11201707293VA (en) 2015-03-10 2016-03-09 Dna alkylating agents

Country Status (14)

Country Link
US (2) US10364261B2 (en)
EP (2) EP3277380B1 (en)
JP (1) JP6704421B2 (en)
KR (4) KR102034618B1 (en)
CN (1) CN107530556B (en)
AU (1) AU2016229136B2 (en)
BR (1) BR112017019287B1 (en)
CA (1) CA2979251C (en)
ES (2) ES2896960T3 (en)
IL (1) IL254377B (en)
MY (1) MY192888A (en)
SG (2) SG11201707293VA (en)
TW (1) TWI674258B (en)
WO (1) WO2016145092A1 (en)

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US20230026163A1 (en) * 2019-12-20 2023-01-26 Ascentawits Pharmaceuticals, Ltd. Anticancer compound and medical use thereof
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KR20230154252A (en) 2021-03-05 2023-11-07 아센타위츠 파마슈티컬즈 리미티드 Primer-probe compositions, kits and detection methods
CN115869325A (en) 2021-09-26 2023-03-31 深圳艾欣达伟医药科技有限公司 Use of compound for preparing medicine for treating KRAS mutant cancer patient
WO2023077452A1 (en) * 2021-11-05 2023-05-11 深圳艾欣达伟医药科技有限公司 Akr1c3-activated dna alkylating agent, and medical application thereof
CN114106042B (en) * 2021-11-12 2022-09-16 深圳艾欣达伟医药科技有限公司 Deuterated compound and preparation method and application thereof
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Also Published As

Publication number Publication date
ES2828026T3 (en) 2021-05-25
KR102034618B1 (en) 2019-10-21
AU2016229136A1 (en) 2017-10-05
KR102398323B1 (en) 2022-05-16
AU2016229136B2 (en) 2018-08-09
CA2979251C (en) 2021-03-23
BR112017019287A2 (en) 2018-05-02
MY192888A (en) 2022-09-14
SG11201707293VA (en) 2017-10-30
US20190225633A1 (en) 2019-07-25
EP3747508A1 (en) 2020-12-09
TW201706262A (en) 2017-02-16
KR102189066B1 (en) 2020-12-09
IL254377B (en) 2021-08-31
US20180044360A1 (en) 2018-02-15
EP3277380A1 (en) 2018-02-07
KR20190072689A (en) 2019-06-25
CN107530556B (en) 2020-04-10
US10364261B2 (en) 2019-07-30
CN107530556A (en) 2018-01-02
CA2979251A1 (en) 2016-09-15
WO2016145092A1 (en) 2016-09-15
KR102284031B1 (en) 2021-07-30
KR20170128280A (en) 2017-11-22
JP2018513876A (en) 2018-05-31
JP6704421B2 (en) 2020-06-03
ES2896960T3 (en) 2022-02-28
US10766914B2 (en) 2020-09-08
BR112017019287B1 (en) 2024-01-02
EP3747508B1 (en) 2021-10-13
EP3277380A4 (en) 2018-08-01
EP3277380B1 (en) 2020-09-16
TWI674258B (en) 2019-10-11
IL254377A0 (en) 2017-11-30
KR20190072688A (en) 2019-06-25
KR20210095231A (en) 2021-07-30

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