SG10201912906RA - Affinity-oligonucleotide conjugates and uses thereof - Google Patents
Affinity-oligonucleotide conjugates and uses thereofInfo
- Publication number
- SG10201912906RA SG10201912906RA SG10201912906RA SG10201912906RA SG10201912906RA SG 10201912906R A SG10201912906R A SG 10201912906RA SG 10201912906R A SG10201912906R A SG 10201912906RA SG 10201912906R A SG10201912906R A SG 10201912906RA SG 10201912906R A SG10201912906R A SG 10201912906RA
- Authority
- SG
- Singapore
- Prior art keywords
- affinity
- oligonucleotide conjugates
- conjugates
- oligonucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70517—CD8
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232209P | 2015-09-24 | 2015-09-24 | |
| PCT/US2016/053598 WO2017053905A1 (en) | 2015-09-24 | 2016-09-24 | Affinity-oligonucleotide conjugates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912906RA true SG10201912906RA (en) | 2020-02-27 |
Family
ID=57121536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912906RA SG10201912906RA (en) | 2015-09-24 | 2017-01-12 | Affinity-oligonucleotide conjugates and uses thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US11156611B2 (es) |
| EP (3) | EP3353326B1 (es) |
| JP (2) | JP6869233B2 (es) |
| KR (2) | KR20180085717A (es) |
| CN (2) | CN108291257B (es) |
| AU (1) | AU2016326737B2 (es) |
| BR (1) | BR112018005937A2 (es) |
| CA (2) | CA2999888C (es) |
| ES (1) | ES2928681T3 (es) |
| IL (1) | IL258248B (es) |
| MX (3) | MX2018003532A (es) |
| MY (2) | MY193806A (es) |
| PH (2) | PH12018500647A1 (es) |
| RU (1) | RU2763554C2 (es) |
| SA (1) | SA518391159B1 (es) |
| SG (1) | SG10201912906RA (es) |
| WO (1) | WO2017053905A1 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| EP3321378B1 (en) | 2012-02-27 | 2021-11-10 | Becton, Dickinson and Company | Compositions for molecular counting |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9567631B2 (en) | 2012-12-14 | 2017-02-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA3216609A1 (en) | 2012-08-14 | 2014-02-20 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014124338A1 (en) | 2013-02-08 | 2014-08-14 | 10X Technologies, Inc. | Polynucleotide barcode generation |
| KR102182834B1 (ko) | 2013-08-28 | 2020-11-27 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
| CN114534806B (zh) | 2014-04-10 | 2024-03-29 | 10X基因组学有限公司 | 用于封装和分割试剂的流体装置、***和方法及其应用 |
| EP4270006A3 (en) | 2014-06-13 | 2024-01-10 | Immudex ApS | General detection and isolation of specific cells by binding of labeled molecules |
| WO2015200893A2 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| MX2017005267A (es) | 2014-10-29 | 2017-07-26 | 10X Genomics Inc | Metodos y composiciones para la secuenciacion de acidos nucleicos seleccionados como diana. |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| KR102321863B1 (ko) | 2015-01-12 | 2021-11-08 | 10엑스 제노믹스, 인크. | 핵산 시퀀싱 라이브러리의 제조 방법 및 시스템 및 이를 이용하여 제조한 라이브러리 |
| EP4286516A3 (en) | 2015-02-24 | 2024-03-06 | 10X Genomics, Inc. | Partition processing methods and systems |
| AU2016222719B2 (en) | 2015-02-24 | 2022-03-31 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
| US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
| WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
| US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
| RU2757135C2 (ru) | 2015-09-24 | 2021-10-11 | АБВИТРО ЭлЭлСи | Композиции антител к вич и способы их применения |
| ES2928681T3 (es) | 2015-09-24 | 2022-11-21 | Abvitro Llc | Conjugados de afinidad-oligonucleótido y usos de los mismos |
| SG10202108763UA (en) | 2015-12-04 | 2021-09-29 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| BR112019005900A2 (pt) | 2016-09-26 | 2019-06-11 | Becton Dickinson Co | medição de expressão de proteínas usando reagentes com sequências de oligonucleotídeos com código de barras |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10011872B1 (en) * | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| GB201622222D0 (en) | 2016-12-23 | 2017-02-08 | Cs Genetics Ltd | Reagents and methods for molecular barcoding of nucleic acids of single cells |
| CN117512066A (zh) | 2017-01-30 | 2024-02-06 | 10X基因组学有限公司 | 用于基于微滴的单细胞条形编码的方法和*** |
| EP3577232A1 (en) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
| CA3054901A1 (en) * | 2017-03-24 | 2018-09-27 | National University Of Singapore | Methods for multiplex detection of molecules |
| JP6846832B2 (ja) | 2017-05-02 | 2021-03-24 | 国立大学法人 東京大学 | 一細胞の非破壊的計測情報とゲノム関連情報とを一体的に検出する方法 |
| CN110621782B (zh) * | 2017-05-02 | 2023-10-24 | 国立大学法人东京大学 | 监测细胞或来源于其的物质的动态变化的方法及使用其的细胞分类方法 |
| CA3064205A1 (en) * | 2017-05-26 | 2018-11-29 | Abvitro Llc | High-throughput polynucleotide library sequencing and transcriptome analysis |
| US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| EP4230746A3 (en) | 2017-05-26 | 2023-11-01 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| CA3059559A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
| US20200292526A1 (en) | 2017-09-07 | 2020-09-17 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US20200354767A1 (en) * | 2017-11-16 | 2020-11-12 | The Regents Of The University Of Colorado, A Body Corporate | Methods to measure functional heterogeneity among single cells |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| GB201801481D0 (en) * | 2018-01-30 | 2018-03-14 | Immunovia Ab | Methods, conjugates and systems |
| EP3752832A1 (en) | 2018-02-12 | 2020-12-23 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| EP3775271A1 (en) | 2018-04-06 | 2021-02-17 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
| CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
| JP7358388B2 (ja) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | 反対側の転写物末端における分子バーコーディング |
| AU2019274469A1 (en) * | 2018-05-21 | 2020-11-26 | The Regents Of The University Of California | Single cell mapping and transcriptome analysis |
| US20210332360A1 (en) * | 2018-06-04 | 2021-10-28 | Chan Zuckerberg Biohub, Inc. | Compositions and methods involving non-natural aptamer libraries |
| US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
| EP3877520A1 (en) | 2018-11-08 | 2021-09-15 | Becton Dickinson and Company | Whole transcriptome analysis of single cells using random priming |
| US20210395742A1 (en) * | 2018-11-14 | 2021-12-23 | University Of Hawaii | Compositions and methods for the synthesis and identification of covalent aptamers |
| WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
| MX2021007292A (es) * | 2018-12-18 | 2021-09-21 | Mbl Int Corp | Composiciones de conjugados de estreptavidina-oligo de ocupación de pmhc. |
| WO2020142724A1 (en) * | 2019-01-04 | 2020-07-09 | Cogen Immune Medicine, Inc. | Peptide libraries and methods of use thereof |
| CN113574178A (zh) | 2019-01-23 | 2021-10-29 | 贝克顿迪金森公司 | 与抗体关联的寡核苷酸 |
| AU2020218446B2 (en) * | 2019-02-04 | 2023-05-25 | National University Corporation Ehime University | "CAR LIBRARY AND scFv MANUFACTURING METHOD |
| CN109979528B (zh) * | 2019-03-28 | 2021-06-25 | 广州基迪奥生物科技有限公司 | 一种单细胞免疫组库测序数据的分析方法 |
| US20200392589A1 (en) * | 2019-04-02 | 2020-12-17 | Mission Bio, Inc. | Methods and systems for proteomic profiling and characterization |
| WO2020237222A1 (en) | 2019-05-22 | 2020-11-26 | Mission Bio, Inc. | Method and apparatus for simultaneous targeted sequencing of dna, rna and protein |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| AU2020327987A1 (en) * | 2019-08-12 | 2022-03-10 | Mission Bio, Inc. | Method, system and apparatus for multi-omic simultaneous detection of protein expression, single nucleotide variations, and copy number variations in the same single cells |
| CA3153119A1 (en) * | 2019-10-03 | 2021-04-08 | Regeneron Pharmaceuticals, Inc. | High-throughput method to screen cognate t cell and epitope reactivities in primary human cells |
| EP4037815A4 (en) * | 2019-10-05 | 2024-01-24 | Mission Bio Inc | METHODS, SYSTEMS AND APPARATUS ASSOCIATED WITH COPY NUMBER VARIATIONS AND SINGLE NUCLEOTIDE VARIATIONS DETECTED SIMULTANEOUSLY IN SINGLE CELLS |
| KR20220088437A (ko) * | 2019-10-25 | 2022-06-27 | 피토넥스, 인코포레이티드 | 폴리뉴클레오티드-연결된 바이오컨쥬게이트 및 제조 및 이용 방법 |
| US11773436B2 (en) | 2019-11-08 | 2023-10-03 | Becton, Dickinson And Company | Using random priming to obtain full-length V(D)J information for immune repertoire sequencing |
| CN111223532B (zh) * | 2019-11-14 | 2023-06-20 | 腾讯科技（深圳）有限公司 | 确定目标化合物的反应物的方法、设备、装置、介质 |
| EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
| IL296435A (en) * | 2020-03-18 | 2022-11-01 | Chan Zuckerberg Biohub Inc | Single-cell combinatorial index sequencing cytometry |
| US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022076914A1 (en) * | 2020-10-09 | 2022-04-14 | 10X Genomics, Inc. | Methods and compositions for profiling immune repertoire |
| CN116635533A (zh) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | 高表达的蛋白和低表达的蛋白的谱分析 |
| EP4298237A1 (en) * | 2021-02-23 | 2024-01-03 | 10X Genomics, Inc. | Single cell glycan profiling |
| WO2022190733A1 (ja) * | 2021-03-10 | 2022-09-15 | ソニーグループ株式会社 | 生体粒子分析方法及び生体粒子分析用試薬キット |
| US11753677B2 (en) * | 2021-11-10 | 2023-09-12 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| WO2023108000A1 (en) * | 2021-12-07 | 2023-06-15 | Fred Hutchinson Cancer Center | Synthetic constructs and methods for processing antigen-specific cells |
| WO2023225201A1 (en) * | 2022-05-20 | 2023-11-23 | 10X Genomics, Inc. | Compositions and methods for characterizing t cell, or t cell-like, receptors from single cells |
| WO2024015378A1 (en) * | 2022-07-13 | 2024-01-18 | 10X Genomics, Inc. | Methods and systems for characterizing antigen-binding molecules expressed by immune cells |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US5019384A (en) | 1986-06-30 | 1991-05-28 | Massachusetts Institute Of Technology | Immunonodulating compositions and their use |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| WO1989012624A2 (en) | 1988-06-14 | 1989-12-28 | Cetus Corporation | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
| US5168038A (en) | 1988-06-17 | 1992-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | In situ transcription in cells and tissues |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5733523A (en) | 1990-12-10 | 1998-03-31 | Akzo Nobel N.V. | Targeted delivery of a therapeutic entity using complementary oligonucleotides |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US5550215A (en) | 1991-11-22 | 1996-08-27 | Holmes; Christopher P. | Polymer reversal on solid surfaces |
| ATE241426T1 (de) | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | Verfahren zur herstellung von polymerarrays |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| AU2360195A (en) | 1994-05-05 | 1995-11-29 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5635363A (en) | 1995-02-28 | 1997-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for the detection, quantitation and purification of antigen-specific T cells |
| US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| SE504798C2 (sv) | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| DE69612013T2 (de) * | 1995-11-21 | 2001-08-02 | Univ Yale New Haven | Unimolekulare segmentamplifikation und bestimmung |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US5981956A (en) | 1996-05-16 | 1999-11-09 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
| EP0912761A4 (en) | 1996-05-29 | 2004-06-09 | Cornell Res Foundation Inc | DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION |
| CA2257109C (en) | 1996-06-04 | 2009-10-06 | University Of Utah Research Foundation | Monitoring hybridization during pcr |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| PT985032E (pt) | 1997-05-28 | 2004-02-27 | Discerna Ltd | Complexos ribossomicos como particulas de seleccao para apresentacao in vitro e evolucao de proteinas |
| JP2001521753A (ja) | 1997-10-31 | 2001-11-13 | アフィメトリックス インコーポレイテッド | 成人臓器及び胎児臓器中の発現プロフィール |
| US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
| US6428752B1 (en) | 1998-05-14 | 2002-08-06 | Affymetrix, Inc. | Cleaning deposit devices that form microarrays and the like |
| US6054276A (en) | 1998-02-23 | 2000-04-25 | Macevicz; Stephen C. | DNA restriction site mapping |
| US5936324A (en) | 1998-03-30 | 1999-08-10 | Genetic Microsystems Inc. | Moving magnet scanner |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| WO1999057321A1 (en) | 1998-05-01 | 1999-11-11 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and dna molecules |
| EP1097935B1 (en) | 1998-07-10 | 2003-12-03 | Meiji Seika Kaisha Ltd. | X-ray intercepting metal complexes of chlorin derivatives |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| EP1165839A2 (en) | 1999-03-26 | 2002-01-02 | Whitehead Institute For Biomedical Research | Universal arrays |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| US7306904B2 (en) | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
| US6686184B1 (en) | 2000-05-25 | 2004-02-03 | President And Fellows Of Harvard College | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks |
| US7902121B2 (en) | 2001-07-02 | 2011-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | MHC-antigen arrays for detection and characterization of immune responses |
| PL208712B1 (pl) | 2001-08-31 | 2011-05-31 | Avidex Ltd | Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| JP4436319B2 (ja) | 2002-10-09 | 2010-03-24 | メディジーン リミテッド | 単鎖組換えｔ細胞レセプター |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| EP3616781A1 (en) | 2003-04-10 | 2020-03-04 | President and Fellows of Harvard College | Formation and control of fluidic species |
| BRPI0414004A (pt) | 2003-08-27 | 2006-10-24 | Harvard College | controle eletrÈnico de espécies fluìdicas |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7643818B2 (en) | 2004-11-22 | 2010-01-05 | Seven Networks, Inc. | E-mail messaging to/from a mobile terminal |
| EP2248578B1 (en) | 2005-03-04 | 2012-06-06 | President and Fellows of Harvard College | Method for forming multiple emulsions |
| JP5452922B2 (ja) | 2005-09-13 | 2014-03-26 | アフィメトリックス・インコーポレーテッド | コード化されたマイクロ粒子 |
| EP2363205A3 (en) | 2006-01-11 | 2014-06-04 | Raindance Technologies, Inc. | Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors |
| GB0600927D0 (en) * | 2006-01-17 | 2006-02-22 | Glaxosmithkline Biolog Sa | Assay and materials therefor |
| DE602007009811D1 (de) | 2006-01-27 | 2010-11-25 | Harvard College | Koaleszenz fluider tröpfchen |
| GB0605584D0 (en) | 2006-03-20 | 2006-04-26 | Olink Ab | Method for analyte detection using proximity probes |
| US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
| WO2009014848A2 (en) | 2007-06-25 | 2009-01-29 | Affymetrix, Inc. | Patterned microcodes |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| WO2009135093A2 (en) | 2008-04-30 | 2009-11-05 | Integrated Dna Technologies, Inc. | Rnase-h-based assays utilizing modified rna monomers |
| GB2477053B (en) | 2008-09-23 | 2013-11-13 | Quantalife Inc | Droplet-based assay system |
| WO2011044186A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
| ES2966040T3 (es) * | 2010-10-08 | 2024-04-18 | Harvard College | Alto rendimiento de células individuales con código de barra |
| WO2012048340A2 (en) * | 2010-10-08 | 2012-04-12 | President And Fellows Of Harvard College | High-throughput immune sequencing |
| CA2906076A1 (en) * | 2013-03-15 | 2014-09-18 | Abvitro, Inc. | Single cell bar-coding for antibody discovery |
| EP3736573A1 (en) | 2013-03-15 | 2020-11-11 | Prognosys Biosciences, Inc. | Methods for detecting peptide/mhc/tcr binding |
| WO2015006379A2 (en) * | 2013-07-08 | 2015-01-15 | The Trustees Of Columbia University In The City Of New York | Selection of cells for elimination |
| KR20220119751A (ko) | 2013-12-30 | 2022-08-30 | 아트레카, 인크. | 핵산 바코드를 이용하는 단일 세포와 관련된 핵산의 분석 |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| AU2015271324B2 (en) * | 2014-06-06 | 2019-09-12 | Herlev Hospital | Determining antigen recognition through barcoding of MHC multimers |
| EP4270006A3 (en) * | 2014-06-13 | 2024-01-10 | Immudex ApS | General detection and isolation of specific cells by binding of labeled molecules |
| JP6672310B2 (ja) * | 2014-09-15 | 2020-03-25 | アブビトロ， エルエルシー | ハイスループットヌクレオチドライブラリーシークエンシング |
| EP3757211A1 (en) | 2014-12-19 | 2020-12-30 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
| ES2928681T3 (es) * | 2015-09-24 | 2022-11-21 | Abvitro Llc | Conjugados de afinidad-oligonucleótido y usos de los mismos |
-
2016
- 2016-09-24 ES ES16778964T patent/ES2928681T3/es active Active
- 2016-09-24 CA CA2999888A patent/CA2999888C/en active Active
- 2016-09-24 EP EP16778964.3A patent/EP3353326B1/en active Active
- 2016-09-24 AU AU2016326737A patent/AU2016326737B2/en active Active
- 2016-09-24 EP EP21178308.9A patent/EP3933047A1/en active Pending
- 2016-09-24 US US15/762,446 patent/US11156611B2/en active Active
- 2016-09-24 IL IL258248A patent/IL258248B/en unknown
- 2016-09-24 JP JP2018515549A patent/JP6869233B2/ja active Active
- 2016-09-24 BR BR112018005937-4A patent/BR112018005937A2/pt active Search and Examination
- 2016-09-24 MY MYPI2018701151A patent/MY193806A/en unknown
- 2016-09-24 CN CN201680068588.1A patent/CN108291257B/zh active Active
- 2016-09-24 KR KR1020187011650A patent/KR20180085717A/ko not_active Application Discontinuation
- 2016-09-24 MX MX2018003532A patent/MX2018003532A/es unknown
- 2016-09-24 WO PCT/US2016/053598 patent/WO2017053905A1/en active Application Filing
-
2017
- 2017-01-12 CA CA3037845A patent/CA3037845A1/en active Pending
- 2017-01-12 US US15/405,301 patent/US10393743B2/en active Active
- 2017-01-12 MX MX2019003272A patent/MX2019003272A/es unknown
- 2017-01-12 RU RU2019112395A patent/RU2763554C2/ru active
- 2017-01-12 KR KR1020197010646A patent/KR20190052084A/ko not_active Application Discontinuation
- 2017-01-12 MY MYPI2019001588A patent/MY191035A/en unknown
- 2017-01-12 CN CN201780072719.8A patent/CN109996889A/zh active Pending
- 2017-01-12 SG SG10201912906RA patent/SG10201912906RA/en unknown
- 2017-01-12 EP EP17702983.2A patent/EP3516069B1/en active Active
-
2018
- 2018-03-21 SA SA518391159A patent/SA518391159B1/ar unknown
- 2018-03-22 PH PH12018500647A patent/PH12018500647A1/en unknown
- 2018-03-22 MX MX2022012937A patent/MX2022012937A/es unknown
-
2019
- 2019-03-22 PH PH12019500627A patent/PH12019500627A1/en unknown
- 2019-08-03 US US16/531,038 patent/US11061030B2/en active Active
-
2021
- 2021-04-13 JP JP2021067709A patent/JP7282121B2/ja active Active
- 2021-09-23 US US17/483,274 patent/US20220065856A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL258248A (en) | Attraction Oligonucleotide Conjugates and Their Uses | |
| IL285516B (en) | Amatoxin antibody conjugates | |
| HK1256143A1 (zh) | 醛結合物和其用途 | |
| IL290457A (en) | Antibodies and their conjugates | |
| GB201416112D0 (en) | Pyrrolobenzodiazepines and conjugates thereof | |
| IL265471A (en) | Pulling-oligonucleotide conjugates and their uses | |
| GB201513607D0 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| IL258759A (en) | Anti-cd3-folate conjugates and their uses | |
| ZA201608327B (en) | Curcumin-peptide conjugates and formulations thereof | |
| HK1247122A1 (zh) | 組合及其用途 | |
| IL254241A0 (en) | Etv2 and its uses | |
| PT3544637T (pt) | Conjugados omv-antigénio nativos e sua utilização | |
| HK1257229A1 (zh) | Cck2r-藥物偶聯物 | |
| PL3270711T3 (pl) | Koniugaty cukier-dipeptyd | |
| SG10201506686WA (en) | Conjugates | |
| GB201818562D0 (en) | Pyrrolobenzodiazephones and conjugates thereof | |
| GB201517852D0 (en) | Novel compounds and conjugates | |
| GB201603124D0 (en) | Novel compounds and conjugates | |
| GB201518839D0 (en) | Conjugates | |
| GB201513605D0 (en) | Pyrrolobenzodiazepine-antibody conjugates |