SG10201912858VA - Antisense nucleic acids - Google Patents

Antisense nucleic acids

Info

Publication number: SG10201912858VA
Authority: SG; Singapore
Prior art keywords: nucleic acids; antisense nucleic; antisense; acids; nucleic
Prior art date: 2014-06-17

Application number

SG10201912858VA

Inventor

Naoki Watanabe

Yuuichirou TONE

Shin'ichi Takeda

Tetsuya Nagata

Original Assignee

Nippon Shinyaku Co Ltd

Nat Center Neurology & Psychiatry

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-06-17

Filing date

2015-06-16

Publication date

2020-02-27

2015-06-16 Application filed by Nippon Shinyaku Co Ltd, Nat Center Neurology & Psychiatry filed Critical Nippon Shinyaku Co Ltd

2020-02-27 Publication of SG10201912858VA publication Critical patent/SG10201912858VA/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)

SG10201912858VA 2014-06-17 2015-06-16 Antisense nucleic acids SG10201912858VA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2014124157		2014-06-17

Publications (1)

Publication Number	Publication Date
SG10201912858VA true SG10201912858VA (en)	2020-02-27

Family

ID=54935505

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG11201610130VA SG11201610130VA (en)	2014-06-17	2015-06-16	Antisense nucleic acids
SG10201912858VA SG10201912858VA (en)	2014-06-17	2015-06-16	Antisense nucleic acids

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SG11201610130VA SG11201610130VA (en)	2014-06-17	2015-06-16	Antisense nucleic acids

Country Status (29)

Country	Link
US (3)	US9840706B2 (en)
EP (2)	EP3159409B1 (en)
JP (5)	JP6208349B2 (en)
KR (1)	KR102335810B1 (en)
CN (2)	CN111575282B (en)
AU (3)	AU2015277924B2 (en)
BR (2)	BR122020020864B1 (en)
CA (1)	CA2951221A1 (en)
CO (1)	CO2017000357A2 (en)
CY (1)	CY1122462T1 (en)
DK (1)	DK3159409T3 (en)
ES (1)	ES2765463T3 (en)
HR (1)	HRP20200042T1 (en)
HU (1)	HUE047502T2 (en)
IL (1)	IL249574B (en)
LT (1)	LT3159409T (en)
MX (2)	MX2016016526A (en)
MY (1)	MY194170A (en)
PH (1)	PH12016502501A1 (en)
PL (1)	PL3159409T3 (en)
PT (1)	PT3159409T (en)
RS (1)	RS59764B1 (en)
RU (2)	RU2695430C2 (en)
SG (2)	SG11201610130VA (en)
SI (1)	SI3159409T1 (en)
TW (2)	TWI666317B (en)
UA (1)	UA121117C2 (en)
WO (1)	WO2015194520A1 (en)
ZA (1)	ZA201700142B (en)

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EP3351634A4 (en) *	2015-09-16	2019-05-08	Nippon Shinyaku Co., Ltd.	Antisense nucleic acid for treating amyotrophy
KR20180056766A (en)	2015-10-09	2018-05-29	웨이브 라이프 사이언시스 리미티드	Nucleotide compositions and methods thereof
MA45328A (en)	2016-04-01	2019-02-06	Avidity Biosciences Llc	NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
JP2019525742A (en)	2016-06-30	2019-09-12	サレプタセラピューティクス，インコーポレイテッド	Exon skipping oligomer for muscular dystrophy
NZ755416A (en)	2016-12-19	2023-05-26	Sarepta Therapeutics Inc	Exon skipping oligomer conjugates for muscular dystrophy
CA3047010A1 (en)	2016-12-19	2018-06-28	Sarepta Therapeutics, Inc.	Exon skipping oligomer conjugates for muscular dystrophy
PL3554554T3 (en)	2016-12-19	2022-12-19	Sarepta Therapeutics, Inc.	Exon skipping oligomer conjugates for muscular dystrophy
SG10202107429WA (en)	2017-01-06	2021-08-30	Avidity Biosciences Inc	Nucleic acid-polypeptide compositions and methods of inducing exon skipping
GB201711809D0 (en)	2017-07-21	2017-09-06	Governors Of The Univ Of Alberta	Antisense oligonucleotide
CN111770757A (en) *	2017-09-22	2020-10-13	艾维迪提生物科学公司	Nucleic acid-polypeptide compositions and methods for inducing exon skipping
EA201991450A1 (en)	2017-09-22	2019-12-30	Сарепта Терапьютикс, Инк.	OLIGOMER CONJUGATES FOR EXONISM SKIP IN MUSCULAR DYSTROPHY
KR102443358B1 (en)	2017-12-06	2022-09-14	어비디티 바이오사이언시스 인크.	Compositions and methods for treating muscular dystrophy and myotonic dystrophy
US10765760B2 (en)	2018-05-29	2020-09-08	Sarepta Therapeutics, Inc.	Exon skipping oligomer conjugates for muscular dystrophy
US11168141B2 (en)	2018-08-02	2021-11-09	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
AU2019316103A1 (en)	2018-08-02	2021-03-11	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
CA3108282A1 (en)	2018-08-02	2020-02-06	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2020089325A1 (en) *	2018-11-02	2020-05-07	Biomarin Technologies B.V.	Bispecific antisense oligonucleotides for dystrophin exon skipping
JP2023537798A (en)	2020-03-19	2023-09-06	アビディティーバイオサイエンシーズ，インク．	Compositions and methods for treating facioscapulohumeral muscular dystrophy
EP4330395A1 (en)	2021-04-30	2024-03-06	Sarepta Therapeutics, Inc.	Treatment methods for muscular dystrophy
US11638761B2 (en)	2021-07-09	2023-05-02	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11771776B2 (en)	2021-07-09	2023-10-03	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2023026994A1 (en)	2021-08-21	2023-03-02	武田薬品工業株式会社	Human transferrin receptor binding peptide-drug conjugate
IL311025A (en)	2021-08-24	2024-04-01	Peptidream Inc	Human transferrin receptor-binding antibody-peptide conjugate
WO2023043953A1 (en)	2021-09-16	2023-03-23	Avidity Biosciences, Inc.	Compositions and methods of treating facioscapulohumeral muscular dystrophy
EP4215614A1 (en)	2022-01-24	2023-07-26	Dynacure	Combination therapy for dystrophin-related diseases
EP4230196A1 (en)	2022-02-21	2023-08-23	Som Innovation Biotech, S.A.	Compounds for use in the treatment of dystrophinopathies
WO2023168427A1 (en)	2022-03-03	2023-09-07	Yale University	Compositions and methods for delivering therapeutic polynucleotides for exon skipping
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2015
- 2015-06-16 TW TW104119378A patent/TWI666317B/en active
- 2015-06-16 EP EP15810097.4A patent/EP3159409B1/en active Active
- 2015-06-16 DK DK15810097.4T patent/DK3159409T3/en active
- 2015-06-16 PL PL15810097T patent/PL3159409T3/en unknown
- 2015-06-16 TW TW108121749A patent/TWI721461B/en active
- 2015-06-16 SG SG11201610130VA patent/SG11201610130VA/en unknown
- 2015-06-16 RS RS20200002A patent/RS59764B1/en unknown
- 2015-06-16 HU HUE15810097A patent/HUE047502T2/en unknown
- 2015-06-16 KR KR1020167036291A patent/KR102335810B1/en active IP Right Grant
- 2015-06-16 BR BR122020020864-3A patent/BR122020020864B1/en active IP Right Grant
- 2015-06-16 SG SG10201912858VA patent/SG10201912858VA/en unknown
- 2015-06-16 CN CN202010289118.6A patent/CN111575282B/en active Active
- 2015-06-16 RU RU2017101172A patent/RU2695430C2/en active
- 2015-06-16 WO PCT/JP2015/067238 patent/WO2015194520A1/en active Application Filing
- 2015-06-16 LT LTEP15810097.4T patent/LT3159409T/en unknown
- 2015-06-16 SI SI201531057T patent/SI3159409T1/en unknown
- 2015-06-16 CN CN201580037016.2A patent/CN106661577B/en active Active
- 2015-06-16 EP EP19208809.4A patent/EP3660154A1/en active Pending
- 2015-06-16 ES ES15810097T patent/ES2765463T3/en active Active
- 2015-06-16 RU RU2019121781A patent/RU2019121781A/en unknown
- 2015-06-16 AU AU2015277924A patent/AU2015277924B2/en active Active
- 2015-06-16 PT PT158100974T patent/PT3159409T/en unknown
- 2015-06-16 CA CA2951221A patent/CA2951221A1/en active Pending
- 2015-06-16 MY MYPI2016704648A patent/MY194170A/en unknown
- 2015-06-16 JP JP2016529346A patent/JP6208349B2/en active Active
- 2015-06-16 BR BR112016029369-0A patent/BR112016029369B1/en active IP Right Grant
- 2015-06-16 MX MX2016016526A patent/MX2016016526A/en active IP Right Grant
- 2015-06-16 UA UAA201700424A patent/UA121117C2/en unknown
- 2015-06-16 US US15/314,535 patent/US9840706B2/en active Active
2016
- 2016-12-13 MX MX2020004417A patent/MX2020004417A/en unknown
- 2016-12-14 IL IL249574A patent/IL249574B/en active IP Right Grant
- 2016-12-14 PH PH12016502501A patent/PH12016502501A1/en unknown
2017
- 2017-01-06 ZA ZA2017/00142A patent/ZA201700142B/en unknown
- 2017-01-16 CO CONC2017/0000357A patent/CO2017000357A2/en unknown
- 2017-08-15 US US15/677,071 patent/US11193125B2/en active Active
- 2017-09-06 JP JP2017171127A patent/JP6701139B2/en active Active
2020
- 2020-01-08 CY CY20201100011T patent/CY1122462T1/en unknown
- 2020-01-10 HR HRP20200042TT patent/HRP20200042T1/en unknown
- 2020-05-01 JP JP2020080938A patent/JP7041879B2/en active Active
2021
- 2021-05-25 AU AU2021203383A patent/AU2021203383B2/en active Active
- 2021-11-02 US US17/517,006 patent/US20220049257A1/en active Pending
2022
- 2022-03-01 JP JP2022030557A patent/JP2022082539A/en not_active Withdrawn
2023
- 2023-12-26 JP JP2023218761A patent/JP2024023899A/en active Pending
2024
- 2024-02-27 AU AU2024201290A patent/AU2024201290A1/en active Pending

Also Published As

Publication number	Publication date
RU2019121781A (en)	2019-07-22
ZA201700142B (en)	2020-05-27
JP2020182459A (en)	2020-11-12
PH12016502501A1 (en)	2017-03-22
RS59764B1 (en)	2020-02-28
AU2015277924A1 (en)	2017-02-02
JP2018027087A (en)	2018-02-22
JP2022082539A (en)	2022-06-02
PT3159409T (en)	2020-01-21
NZ728103A (en)	2021-11-26
EP3660154A1 (en)	2020-06-03
MY194170A (en)	2022-11-16
AU2015277924B2 (en)	2021-02-25
US11193125B2 (en)	2021-12-07
CN111575282B (en)	2024-05-14
AU2024201290A1 (en)	2024-03-21
US9840706B2 (en)	2017-12-12
EP3159409A4 (en)	2018-01-10
IL249574B (en)	2021-02-28
LT3159409T (en)	2020-01-27
KR102335810B1 (en)	2021-12-03
CN106661577A (en)	2017-05-10
US20180044675A1 (en)	2018-02-15
ES2765463T3 (en)	2020-06-09
KR20170017939A (en)	2017-02-15
JP6701139B2 (en)	2020-05-27
JP7041879B2 (en)	2022-03-25
JP2024023899A (en)	2024-02-21
BR112016029369B1 (en)	2020-12-08
IL249574A0 (en)	2017-02-28
US20220049257A1 (en)	2022-02-17
RU2017101172A3 (en)	2018-12-24
BR122020020864B1 (en)	2022-06-21
TW201625274A (en)	2016-07-16
JPWO2015194520A1 (en)	2017-04-20
AU2021203383A1 (en)	2021-06-24
TWI721461B (en)	2021-03-11
UA121117C2 (en)	2020-04-10
RU2695430C2 (en)	2019-07-23
SI3159409T1 (en)	2020-02-28
CN111575282A (en)	2020-08-25
TWI666317B (en)	2019-07-21
JP6208349B2 (en)	2017-10-04
PL3159409T3 (en)	2020-05-18
MX2016016526A (en)	2017-04-04
EP3159409A1 (en)	2017-04-26
SG11201610130VA (en)	2017-01-27
BR112016029369A2 (en)	2018-01-09
CA2951221A1 (en)	2015-12-23
CN106661577B (en)	2020-05-12
TW201936922A (en)	2019-09-16
CY1122462T1 (en)	2021-01-27
US20170204410A1 (en)	2017-07-20
HRP20200042T1 (en)	2020-03-20
EP3159409B1 (en)	2019-12-04
HUE047502T2 (en)	2020-04-28
CO2017000357A2 (en)	2017-06-09
WO2015194520A1 (en)	2015-12-23
MX2020004417A (en)	2020-08-06
AU2021203383B2 (en)	2023-11-30
RU2017101172A (en)	2018-07-17
DK3159409T3 (en)	2020-01-27

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DK3134131T3 (en)	2022-02-07	Nucleic acid vaccines
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GB201503408D0 (en)	2015-04-15	Oligonucleotides
IL257500A (en)	2018-04-30	Modified cullin1 gene
GB201517241D0 (en)	2015-11-11	DNA modification
SG11201700652PA (en)	2017-02-27	Modified antimir-138 oligonucleotides
GB2524076B (en)	2016-12-14	Improved Heater
GB201516505D0 (en)	2015-11-04	Antisense oligonucleotides
GB201508733D0 (en)	2015-07-01	Antisense oligonucleotides
GB201407865D0 (en)	2014-06-18	Nucleases
GB201403353D0 (en)	2014-04-09	Novel oligonucleotides
GB201403087D0 (en)	2014-04-09	Novel oligonucleotides
GB201403359D0 (en)	2014-04-09	Nucleic acids and uses thereof
GB201403360D0 (en)	2014-04-09	Nucleic acids and uses thereof