SG10201912768YA - Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder - Google Patents
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorderInfo
- Publication number
- SG10201912768YA SG10201912768YA SG10201912768YA SG10201912768YA SG10201912768YA SG 10201912768Y A SG10201912768Y A SG 10201912768YA SG 10201912768Y A SG10201912768Y A SG 10201912768YA SG 10201912768Y A SG10201912768Y A SG 10201912768YA SG 10201912768Y A SG10201912768Y A SG 10201912768YA
- Authority
- SG
- Singapore
- Prior art keywords
- prophylaxis
- treatment
- blood coagulation
- von willebrand
- willebrand factor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16198497 | 2016-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201912768YA true SG10201912768YA (en) | 2020-02-27 |
Family
ID=57389201
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912768YA SG10201912768YA (en) | 2016-11-11 | 2017-11-10 | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
SG11201903954WA SG11201903954WA (en) | 2016-11-11 | 2017-11-10 | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201903954WA SG11201903954WA (en) | 2016-11-11 | 2017-11-10 | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
Country Status (12)
Country | Link |
---|---|
US (1) | US11890327B2 (en) |
EP (1) | EP3538134B1 (en) |
JP (1) | JP2020504082A (en) |
KR (1) | KR20190073576A (en) |
CN (1) | CN110381986B (en) |
AU (1) | AU2017358865A1 (en) |
CA (1) | CA3043397A1 (en) |
DK (1) | DK3538134T3 (en) |
ES (1) | ES2908008T3 (en) |
SG (2) | SG10201912768YA (en) |
TW (1) | TW201828974A (en) |
WO (1) | WO2018087271A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019222682A1 (en) | 2018-05-18 | 2019-11-21 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
AU2020300820A1 (en) | 2019-07-04 | 2022-03-03 | CSL Behring Lengnau AG | A truncated von willebrand factor (vWF) for increasing the in vitro stability of coagulation factor VIII |
US20220348637A1 (en) | 2019-11-11 | 2022-11-03 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
KR102647642B1 (en) * | 2021-05-04 | 2024-03-15 | (주)케어젠 | Peptides having blood coagulation activity and use thereof |
Family Cites Families (48)
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US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4970300A (en) | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
WO1994015625A1 (en) | 1993-01-15 | 1994-07-21 | Enzon, Inc. | Factor viii - polymeric conjugates |
SE504074C2 (en) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Protein preparation for subcutaneous, intramuscular or intradermal administration |
IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
WO1996018412A1 (en) | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
WO1997003193A1 (en) | 1995-07-11 | 1997-01-30 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered metal-binding properties |
SE9503380D0 (en) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
AT403764B (en) * | 1996-03-15 | 1998-05-25 | Immuno Ag | STABLE FACTOR VIII / VWF COMPLEX |
US20040092442A1 (en) | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
EP0910628B1 (en) | 1996-04-24 | 2006-03-08 | The Regents of The University of Michigan | Inactivation resistant factor viii |
US6593294B1 (en) | 1998-04-27 | 2003-07-15 | Opperbas Holding B.V. | Pharmaceutical composition comprising Factor VIII and neutral liposomes |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
JP2005518181A (en) | 2001-01-12 | 2005-06-23 | ジ・アメリカン・ナショナル・レッド・クロス | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII |
WO2002103024A2 (en) | 2001-06-14 | 2002-12-27 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
WO2003076567A2 (en) | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
DE60332011D1 (en) | 2002-04-29 | 2010-05-20 | Sanquin Bloedvoorziening | ANTAGONISTS OF INTERACTION BETWEEN FACTOR VIII AND LRP (LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN) |
US7041635B2 (en) | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
US7199223B2 (en) | 2003-02-26 | 2007-04-03 | Nektar Therapeutics Al, Corporation | Polymer-factor VIII moiety conjugates |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
EP3552627A1 (en) | 2003-05-06 | 2019-10-16 | Bioverativ Therapeutics Inc. | Clotting factor-fc chimeric proteins to treat hemophilia |
SI1641823T1 (en) | 2003-06-12 | 2011-12-30 | Lilly Co Eli | Glp-1 analog fusion proteins |
RU2370276C2 (en) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ERYTHROPOIETIN FUSED PROTEIN WITH IMPROVED PHARMACOKINETICS |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
KR101483917B1 (en) | 2004-11-12 | 2015-01-16 | 바이엘 헬스케어 엘엘씨 | Site-directed modification of fviii |
DK1835938T3 (en) | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand factor conjugates |
CA2604299A1 (en) | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation factor viii with enhanced stability and its derivates |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
MX2008012600A (en) | 2006-03-31 | 2008-12-12 | Baxter Int | Pegylated factor viii. |
EP2032607B2 (en) | 2006-06-14 | 2017-02-22 | CSL Behring GmbH | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
US8754194B2 (en) | 2006-12-22 | 2014-06-17 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
WO2008151817A1 (en) | 2007-06-13 | 2008-12-18 | Csl Behring Gmbh | Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders |
DK2291523T3 (en) | 2008-06-24 | 2015-03-23 | Csl Behring Gmbh | Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life |
RU2579977C2 (en) | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | PREPARATIONS CONTAINING VON WILLEBRAND FACTOR (vWF) AND METHODS, KITS AND APPLICATIONS RELATED TO THEM |
WO2013093760A2 (en) | 2011-12-19 | 2013-06-27 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
CN111499760A (en) | 2012-01-12 | 2020-08-07 | 比奥贝拉蒂治疗公司 | Chimeric factor VIII polypeptides and uses thereof |
EP2814502B1 (en) | 2012-02-15 | 2017-09-13 | CSL Behring GmbH | Von willebrand factor variants having improved factor viii binding affinity |
US20150080309A1 (en) * | 2012-04-24 | 2015-03-19 | Nova Nordisk A/S | Compounds Suitable for Treatment of Haemophilia |
JP2015519313A (en) * | 2012-04-24 | 2015-07-09 | ノヴォ ノルディスク アー/エス | Pharmaceutical composition suitable for the treatment of hemophilia |
CN110054699A (en) | 2012-07-11 | 2019-07-26 | 比奥贝拉蒂治疗公司 | Factor IX compound with XTEN and vWF ELISA albumen, and application thereof |
EP2796145B1 (en) * | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
WO2014198699A2 (en) | 2013-06-12 | 2014-12-18 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
ES2895798T3 (en) | 2014-06-06 | 2022-02-22 | Octapharma Ag | Preparation comprising peptides of factor VIII and von Willebrand factor |
CA2953593C (en) | 2014-07-02 | 2023-09-26 | Csl Limited | Modified von willebrand factor |
KR20180012303A (en) | 2015-05-22 | 2018-02-05 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | Method for producing modified von Willebrand factor |
-
2017
- 2017-11-10 DK DK17801644.0T patent/DK3538134T3/en active
- 2017-11-10 AU AU2017358865A patent/AU2017358865A1/en not_active Abandoned
- 2017-11-10 JP JP2019524345A patent/JP2020504082A/en active Pending
- 2017-11-10 WO PCT/EP2017/078840 patent/WO2018087271A1/en unknown
- 2017-11-10 US US16/349,002 patent/US11890327B2/en active Active
- 2017-11-10 SG SG10201912768YA patent/SG10201912768YA/en unknown
- 2017-11-10 EP EP17801644.0A patent/EP3538134B1/en active Active
- 2017-11-10 KR KR1020197016644A patent/KR20190073576A/en not_active Application Discontinuation
- 2017-11-10 ES ES17801644T patent/ES2908008T3/en active Active
- 2017-11-10 SG SG11201903954WA patent/SG11201903954WA/en unknown
- 2017-11-10 CN CN201780069945.0A patent/CN110381986B/en active Active
- 2017-11-10 TW TW106139051A patent/TW201828974A/en unknown
- 2017-11-10 CA CA3043397A patent/CA3043397A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2018087271A1 (en) | 2018-05-17 |
US11890327B2 (en) | 2024-02-06 |
EP3538134A1 (en) | 2019-09-18 |
KR20190073576A (en) | 2019-06-26 |
CA3043397A1 (en) | 2018-05-17 |
US20210268071A1 (en) | 2021-09-02 |
EP3538134B1 (en) | 2021-12-29 |
ES2908008T3 (en) | 2022-04-27 |
CN110381986A (en) | 2019-10-25 |
SG11201903954WA (en) | 2019-05-30 |
DK3538134T3 (en) | 2022-02-07 |
TW201828974A (en) | 2018-08-16 |
AU2017358865A1 (en) | 2019-05-09 |
JP2020504082A (en) | 2020-02-06 |
CN110381986B (en) | 2023-08-18 |
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