SG10201912002YA - Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof - Google Patents

Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof

Info

Publication number
SG10201912002YA
SG10201912002YA SG10201912002YA SG10201912002YA SG10201912002YA SG 10201912002Y A SG10201912002Y A SG 10201912002YA SG 10201912002Y A SG10201912002Y A SG 10201912002YA SG 10201912002Y A SG10201912002Y A SG 10201912002YA SG 10201912002Y A SG10201912002Y A SG 10201912002YA
Authority
SG
Singapore
Prior art keywords
tl1a
tnf
antigen binding
binding proteins
bispecific antigen
Prior art date
Application number
SG10201912002YA
Inventor
Hailing Hsu
Gunasekaran Kannan
Kenneth W Walker
Michelle Hortter
Edward J Belouski
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2016/052006 external-priority patent/WO2017049004A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201912002YA publication Critical patent/SG10201912002YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201912002YA 2015-12-16 2016-12-14 Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof SG10201912002YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268432P 2015-12-16 2015-12-16
US201662333063P 2016-05-06 2016-05-06
PCT/US2016/052006 WO2017049004A1 (en) 2015-09-15 2016-09-15 Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
SG10201912002YA true SG10201912002YA (en) 2020-02-27

Family

ID=59057540

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201912002YA SG10201912002YA (en) 2015-12-16 2016-12-14 Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof
SG11201804857WA SG11201804857WA (en) 2015-12-16 2016-12-14 Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201804857WA SG11201804857WA (en) 2015-12-16 2016-12-14 Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof

Country Status (24)

Country Link
US (2) US11104745B2 (en)
EP (1) EP3390444A1 (en)
JP (1) JP7263007B2 (en)
KR (1) KR20180099723A (en)
CN (1) CN109311971A (en)
AU (2) AU2016370659B2 (en)
BR (1) BR112018012096A2 (en)
CA (1) CA3008267A1 (en)
CL (3) CL2018001596A1 (en)
CO (1) CO2018007355A2 (en)
CR (1) CR20180365A (en)
EA (1) EA201891322A1 (en)
IL (1) IL259847A (en)
JO (1) JO3816B1 (en)
MA (1) MA44060A (en)
MX (1) MX2018007424A (en)
PH (1) PH12018501284A1 (en)
SG (2) SG10201912002YA (en)
TN (1) TN2019000275A1 (en)
TW (1) TWI799368B (en)
UA (1) UA124305C2 (en)
UY (1) UY37027A (en)
WO (1) WO2017106383A1 (en)
ZA (1) ZA201904491B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
EP2760889A4 (en) 2011-09-30 2015-04-15 Teva Pharmaceuticals Australia Pty Ltd Antibodies against tl1a and uses thereof
UY35148A (en) * 2012-11-21 2014-05-30 Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
BR112015024752A2 (en) 2013-03-27 2017-07-18 Cedars Sinai Medical Center mitigation and reversal of fibrosis and inflammation through inhibition of tl1a function and related signaling pathways
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
TWI703158B (en) 2015-09-18 2020-09-01 美商希佛隆公司 Antibodies that specifically bind to tl1a
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
KR102464372B1 (en) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
CN110121509B (en) 2016-10-26 2024-05-07 西达-赛奈医疗中心 Neutralizing anti-TL 1A monoclonal antibodies
WO2019005642A1 (en) * 2017-06-25 2019-01-03 Systimmune, Inc. Methods of making and using guidance and navigation control proteins
EP3456738A1 (en) 2017-09-19 2019-03-20 Tillotts Pharma Ag Antibody variants
WO2019136241A1 (en) * 2018-01-05 2019-07-11 Modernatx, Inc. Polynucleotides encoding anti-chikungunya virus antibodies
KR20210005169A (en) 2018-04-25 2021-01-13 프로메테우스 바이오사이언시즈, 인크. Optimized anti-TL1A antibody
CN111909268B (en) * 2019-05-07 2022-04-19 北京天成新脉生物技术有限公司 anti-TNF-alpha humanized monoclonal antibody TCX060 with low immunogenicity and low ADCC/CDC function and application thereof
KR20220088529A (en) * 2019-05-14 2022-06-27 프로메테우스 바이오사이언시즈, 인크. TL1A Patient Selection Methods, Systems and Devices
EP3998286A4 (en) * 2019-07-11 2023-04-26 Wuhan Yzy Biopharma Co., Ltd. Tetravalent symmetric bispecific antibody
EP4004051A4 (en) 2019-07-19 2023-08-23 Oncoresponse, Inc. Immunomodulatory antibodies and methods of use thereof
MX2022004942A (en) 2019-10-24 2022-07-27 Prometheus Biosciences Inc Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof.
CN113121696A (en) * 2019-12-31 2021-07-16 周易 Bispecific antibody formed by Fab modification induction and preparation method and application thereof
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
US20230159649A1 (en) * 2020-04-02 2023-05-25 La Jolla Institute For Immunology Methods and combinations for dual targeting of tnf family members
IL298263A (en) * 2020-05-20 2023-01-01 Univ Columbia Potent neutralizing antibodies against sars-cov-2, generation and uses thereof
WO2022010921A1 (en) 2020-07-06 2022-01-13 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting sars-cov-2
TW202216760A (en) 2020-07-23 2022-05-01 愛爾蘭商歐薩爾普羅席納有限公司 Anti-abeta antibodies
WO2022040466A1 (en) * 2020-08-20 2022-02-24 Amgen Inc. Antigen binding proteins with non-canonical disulfide in fab region
KR20230058434A (en) 2020-08-26 2023-05-03 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 Antigen binding molecules targeting SARS-CoV-2

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603044A (en) 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
JP3202999B2 (en) 1991-01-31 2001-08-27 協和醗酵工業株式会社 Hepatic liposome preparation
US5830877A (en) 1993-08-26 1998-11-03 The Regents Of The University Of California Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
ATE387495T1 (en) 1996-12-03 2008-03-15 Amgen Fremont Inc FULLY HUMANE ANTIBODIES THAT BIND EGFR
CA2323929C (en) 1998-04-03 2004-03-09 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
TR200603997T1 (en) 1999-03-25 2010-01-21 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing them.
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
AU783682B2 (en) 1999-08-04 2005-11-24 Amgen, Inc. Fhm, a novel member of the TNF ligand supergene family
JP4754219B2 (en) 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド Antibodies directed against tumor necrosis factor and their use
EP1667730B1 (en) 2003-08-20 2013-06-26 University of Miami Compositions and methods for treating inflammatory lung disease
JP5620626B2 (en) 2005-03-31 2014-11-05 中外製薬株式会社 Polypeptide production method by association control
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US20110217310A1 (en) 2007-01-10 2011-09-08 Siegel Richard M Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
WO2009064854A2 (en) 2007-11-13 2009-05-22 Cogenesys, Inc Humanized antibodies against tl1a
PL2235064T3 (en) 2008-01-07 2016-06-30 Amgen Inc Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
EP2281845B1 (en) 2008-04-25 2020-09-02 Kyowa Kirin Co., Ltd. Stable polyvalent antibody
KR20110124368A (en) 2009-04-07 2011-11-16 로슈 글리카트 아게 Bispecific anti-erbb-2/anti-c-met antibodies
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
JO3375B1 (en) 2010-11-08 2019-03-13 Regeneron Pharma Human antibodies to human tnf-like ligand 1a (tl1a)
EP2654792A4 (en) 2010-12-22 2016-05-11 Abbvie Inc Half immunoglobulin binding proteins and uses thereof
WO2012088290A2 (en) 2010-12-22 2012-06-28 Abbott Laboratories Tri-variable domain binding proteins and uses thereof
MX2013013329A (en) 2011-05-20 2014-04-16 Us Government Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof.
JP2014533929A (en) 2011-09-23 2014-12-18 アムゲン リサーチ （ミュンヘン） ゲーエムベーハー Bispecific binding molecules for 5T4 and CD3
EP2760889A4 (en) 2011-09-30 2015-04-15 Teva Pharmaceuticals Australia Pty Ltd Antibodies against tl1a and uses thereof
TWI609882B (en) 2012-05-22 2018-01-01 必治妥美雅史谷比公司 Bispecific antibodies and methods of using the same
UY35148A (en) 2012-11-21 2014-05-30 Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
KR102545617B1 (en) 2012-11-28 2023-06-20 자임워크스 비씨 인코포레이티드 Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
EA201591153A1 (en) 2013-01-02 2016-01-29 Гленмарк Фармасьютикалс С.А. ANTIBODIES CONNECTING TL1A AND THEIR APPLICATION
TW201444867A (en) 2013-03-08 2014-12-01 Lilly Co Eli Anti-TNF-anti-IL-17 bispecific antibodies
JOP20140087B1 (en) 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
CN105189557A (en) 2013-03-15 2015-12-23 默克专利有限公司 Tetravalent bispecific antibodies
EP2968541A4 (en) * 2013-03-15 2017-02-08 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
UA118028C2 (en) 2013-04-03 2018-11-12 Рош Глікарт Аг Bispecific antibodies specific for fap and dr5, antibodies specific for dr5 and methods of use
IL245001B2 (en) 2013-11-13 2023-05-01 Pfizer Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
US20160052006A1 (en) 2013-11-22 2016-02-25 Sheila S. Pirtle Spray Bottle

Also Published As

Publication number Publication date
TW201731871A (en) 2017-09-16
AU2016370659A1 (en) 2018-06-28
PH12018501284A1 (en) 2019-01-28
TWI799368B (en) 2023-04-21
TN2019000275A1 (en) 2021-05-07
CL2023002597A1 (en) 2024-03-15
CL2018001596A1 (en) 2018-09-28
UY37027A (en) 2017-06-30
KR20180099723A (en) 2018-09-05
EP3390444A1 (en) 2018-10-24
US20190119407A1 (en) 2019-04-25
EA201891322A1 (en) 2019-01-31
JO3816B1 (en) 2021-01-31
MX2018007424A (en) 2018-09-21
CN109311971A (en) 2019-02-05
WO2017106383A4 (en) 2017-09-08
CL2021001179A1 (en) 2021-11-19
AU2024200534A1 (en) 2024-04-11
CA3008267A1 (en) 2017-06-22
US20220213226A1 (en) 2022-07-07
UA124305C2 (en) 2021-08-25
JP2019502692A (en) 2019-01-31
CR20180365A (en) 2018-09-28
JP7263007B2 (en) 2023-04-24
CO2018007355A2 (en) 2018-07-19
WO2017106383A1 (en) 2017-06-22
US11104745B2 (en) 2021-08-31
MA44060A (en) 2018-10-24
BR112018012096A2 (en) 2018-11-27
ZA201904491B (en) 2020-03-25
IL259847A (en) 2018-07-31
AU2016370659B2 (en) 2024-02-15
SG11201804857WA (en) 2018-07-30

Similar Documents

Publication Publication Date Title
ZA201904491B (en) Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof
ZA201808160B (en) Bispecific binding proteins and uses thereof
HRP20181802T1 (en) Human cd3 binding antibody
IL287045A (en) B cell maturation antigen binding proteins
IL283115A (en) Bispecific cd33 and cd3 binding proteins
HK1231490A1 (en) Modified antigen binding polypeptide constructs and uses thereof
IL260846B (en) Antigen binding proteins that bind pd-l1
EP3370769A4 (en) Antibodies specifically binding tim-3 and their uses
DK3356413T3 (en) ANTI-TIGIT ANTIGEN BINDING PROTEINS AND METHODS FOR USING IT
DK3182999T3 (en) ANTI-LAG3 ANTIBODIES AND ANTIGEN BINDING FRAGMENTS
ZA201608811B (en) Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
ZA201701912B (en) Antigen binding proteins that bind cxcr5
HK1231497A1 (en) Vl antigen binding proteins exhibiting distinct binding characteristics vl
HK1253533A1 (en) Cd131 binding proteins and uses thereof
ZA201701941B (en) Antigen binding proteins that bind cxcr3
ZA201906821B (en) Anti-jagged1 antigen binding proteins
GB201415714D0 (en) Antibodies and antigen binding fragments thereof
IL266059A (en) Anti-rankl antibodies and uses thereof
IL258534A (en) Anti-cgrp/anti-il-23 bispecific antibodies and uses thereof
GB201614627D0 (en) Antigen binding proteins
ZA201608812B (en) Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
GB201516008D0 (en) OX40L antibodies and uses thereof