SG10201909638UA - Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules - Google Patents

Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules

Info

Publication number
SG10201909638UA
SG10201909638UA SG10201909638UA SG10201909638UA SG 10201909638U A SG10201909638U A SG 10201909638UA SG 10201909638U A SG10201909638U A SG 10201909638UA SG 10201909638U A SG10201909638U A SG 10201909638UA
Authority
SG
Singapore
Prior art keywords
genetically modified
mhc
molecules
major histocompatibility
histocompatibility complex
Prior art date
Application number
Inventor
Lynn Macdonald
Andrew Murphy
Naxin Tu
Cagan Gurer
Vera Voronina
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201909638UA publication Critical patent/SG10201909638UA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) II MOLECULES The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II  and  polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided. [No Figure]
SG10201909638U 2011-10-28 2012-10-26 Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules SG10201909638UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161552584P 2011-10-28 2011-10-28

Publications (1)

Publication Number Publication Date
SG10201909638UA true SG10201909638UA (en) 2019-11-28

Family

ID=47430036

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201510056SA SG10201510056SA (en) 2011-10-28 2012-10-26 Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
SG10201909638U SG10201909638UA (en) 2011-10-28 2012-10-26 Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
SG11201400938UA SG11201400938UA (en) 2011-10-28 2012-10-26 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201510056SA SG10201510056SA (en) 2011-10-28 2012-10-26 Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201400938UA SG11201400938UA (en) 2011-10-28 2012-10-26 Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules

Country Status (25)

Country Link
US (6) US8847005B2 (en)
EP (4) EP2770822B9 (en)
JP (2) JP6285361B2 (en)
KR (2) KR101926442B1 (en)
CN (3) CN108401986B (en)
AU (4) AU2012327205B2 (en)
BR (1) BR112014009941B1 (en)
CA (1) CA2852962C (en)
CY (2) CY1119283T1 (en)
DK (3) DK2770822T3 (en)
ES (3) ES2914374T3 (en)
HK (2) HK1196999A1 (en)
HR (3) HRP20220616T1 (en)
HU (2) HUE034374T2 (en)
IL (3) IL231895B (en)
IN (1) IN2014CN03892A (en)
LT (3) LT2770822T (en)
MX (1) MX355726B (en)
PL (3) PL2770822T3 (en)
PT (3) PT3590332T (en)
RS (3) RS63220B1 (en)
RU (1) RU2660564C2 (en)
SG (3) SG10201510056SA (en)
SI (3) SI2770822T1 (en)
WO (1) WO2013063340A1 (en)

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DK3590332T3 (en) 2022-05-23
AU2021200438B2 (en) 2023-11-02
ES2774488T3 (en) 2020-07-21
US11219195B2 (en) 2022-01-11
EP3272214A1 (en) 2018-01-24
AU2018201402C1 (en) 2021-05-06
BR112014009941B1 (en) 2022-11-29
CY1122700T1 (en) 2021-03-12
PL3590332T3 (en) 2022-06-13
CN108401986A (en) 2018-08-17
HUE034374T2 (en) 2018-02-28
IL260209B (en) 2019-12-31
SG11201400938UA (en) 2014-04-28
KR102113108B1 (en) 2020-05-20
ES2640241T3 (en) 2017-11-02
NZ623146A (en) 2016-06-24
US20190239496A1 (en) 2019-08-08
EP2770822B9 (en) 2019-12-11
IN2014CN03892A (en) 2015-10-16
EP2770822B1 (en) 2017-06-14
US20190239497A1 (en) 2019-08-08
KR101926442B1 (en) 2018-12-12
RU2018115251A (en) 2019-03-04
AU2012327205B2 (en) 2016-01-14
CA2852962C (en) 2022-05-03
US20150040253A1 (en) 2015-02-05
JP6652529B2 (en) 2020-02-26
JP6285361B2 (en) 2018-02-28
HUE048511T2 (en) 2020-07-28
IL231895B (en) 2018-07-31
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RU2018115251A3 (en) 2021-09-07
CN104039133B (en) 2018-05-04
LT3272214T (en) 2020-03-10
PT2770822T (en) 2017-09-18
RU2660564C2 (en) 2018-07-06
KR20140089558A (en) 2014-07-15
EP3590332A1 (en) 2020-01-08
JP2018019700A (en) 2018-02-08
CN104039133A (en) 2014-09-10
PT3272214T (en) 2020-03-04
HK1196999A1 (en) 2015-01-02
US10986822B2 (en) 2021-04-27
WO2013063340A1 (en) 2013-05-02
IL231895A0 (en) 2014-05-28
EP3590332B1 (en) 2022-02-23
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LT2770822T (en) 2017-10-10
BR112014009941A2 (en) 2020-12-22
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JP2014532411A (en) 2014-12-08
RU2014116577A (en) 2015-12-10
PL3272214T3 (en) 2020-06-29
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AU2012327205A1 (en) 2013-05-23
MX2014004896A (en) 2014-09-12
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