SG10201907807XA - Anti-her3 antibody-drug conjugate - Google Patents

Anti-her3 antibody-drug conjugate

Info

Publication number
SG10201907807XA
SG10201907807XA SG10201907807XA SG10201907807XA SG10201907807XA SG 10201907807X A SG10201907807X A SG 10201907807XA SG 10201907807X A SG10201907807X A SG 10201907807XA SG 10201907807X A SG10201907807X A SG 10201907807XA SG 10201907807X A SG10201907807X A SG 10201907807XA
Authority
SG
Singapore
Prior art keywords
her3 antibody
antitumor
drug
drug conjugate
antibody
Prior art date
Application number
SG10201907807XA
Inventor
Thore Hettmann
Reimar Abraham
Sabine Blum
Suguru Ueno
Original Assignee
Daiichi Sankyo Co Ltd
Daiichi Sankyo Europe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53008825&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201907807X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd, Daiichi Sankyo Europe Gmbh filed Critical Daiichi Sankyo Co Ltd
Publication of SG10201907807XA publication Critical patent/SG10201907807XA/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract

Anti-Her3 Antibody-Drug Conjudate [] To provide an antitumor drug having excellent therapeutic effect, which is excellent in terms of 5 antitumor effect and safety. Provided is an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER3 antibody via a linker having a structure represented by the formula: -L1-L2-LP-NH-(CH 2)n 1-La-(CH 2)n 2-C(=O)- or -L1-L2-LP- (the anti- 10 HER3 antibody is connected to the terminal of L 1, the antitumor compound is connected to the carbonyl group of - (CH 2)n 2-C(=O)- moiety or the C terminal of L P, with the nitrogen atom of the amino group at position 1 as a connecting position). 15 [Chem. 1] Conjugate
SG10201907807XA 2014-04-10 2015-04-10 Anti-her3 antibody-drug conjugate SG10201907807XA (en)

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