SG10201907249WA - Human cytomegalovirus comprising exogenous antigens - Google Patents

Human cytomegalovirus comprising exogenous antigens

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Publication number
SG10201907249WA
SG10201907249WA SG10201907249WA SG10201907249WA SG10201907249WA SG 10201907249W A SG10201907249W A SG 10201907249WA SG 10201907249W A SG10201907249W A SG 10201907249WA SG 10201907249W A SG10201907249W A SG 10201907249WA SG 10201907249W A SG10201907249W A SG 10201907249WA
Authority
SG
Singapore
Prior art keywords
human cytomegalovirus
exogenous antigens
antigens
vectors
exogenous
Prior art date
Application number
SG10201907249WA
Inventor
Klaus Frueh
Scott Hansen
Jay Nelson
Louis Picker
Patrizia Caposio
Original Assignee
Univ Oregon Health & Science
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Publication date
Application filed by Univ Oregon Health & Science filed Critical Univ Oregon Health & Science
Publication of SG10201907249WA publication Critical patent/SG10201907249WA/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/86—Viral vectors
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/161—HIV-1 ; HIV-2 gag-pol, e.g. p55, p24/25, p17/18, p7, p6, p66/68, p51/52, p31/34, p32, p40
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    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
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Abstract

HUMAN CYTOMEGALOVIRUS COMPRISING EXOGENOUS ANTIGENS Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71. No suitable figure
SG10201907249WA 2014-07-16 2015-07-16 Human cytomegalovirus comprising exogenous antigens SG10201907249WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462025348P 2014-07-16 2014-07-16

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SG10201907249WA true SG10201907249WA (en) 2019-09-27

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SG11201700315YA SG11201700315YA (en) 2014-07-16 2015-07-16 Human cytomegalovirus comprising exogenous antigens

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Country Status (16)

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US (3) US10428118B2 (en)
EP (2) EP4194558A1 (en)
JP (4) JP6487026B2 (en)
KR (3) KR101996427B1 (en)
CN (2) CN107002048B (en)
AP (1) AP2017009743A0 (en)
AU (2) AU2015289560B2 (en)
BR (1) BR112017000696B1 (en)
CA (2) CA2955306C (en)
EA (1) EA039174B1 (en)
IL (1) IL250130B (en)
MX (2) MX2017000658A (en)
NZ (1) NZ728208A (en)
SG (2) SG10201907249WA (en)
UA (1) UA120938C2 (en)
WO (1) WO2016011293A1 (en)

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