SG10201906329VA - Prohemostatic proteins for the treatment of bleeding - Google Patents
Prohemostatic proteins for the treatment of bleedingInfo
- Publication number
- SG10201906329VA SG10201906329VA SG10201906329VA SG10201906329VA SG10201906329VA SG 10201906329V A SG10201906329V A SG 10201906329VA SG 10201906329V A SG10201906329V A SG 10201906329VA SG 10201906329V A SG10201906329V A SG 10201906329VA SG 10201906329V A SG10201906329V A SG 10201906329VA
- Authority
- SG
- Singapore
- Prior art keywords
- bleeding
- treatment
- proteins
- prohemostatic
- subject
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING The present invention relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject. No suitable figure
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14169895 | 2014-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201906329VA true SG10201906329VA (en) | 2019-08-27 |
Family
ID=50774744
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201609811TA SG11201609811TA (en) | 2014-05-26 | 2015-05-26 | Prohemostatic proteins for the treatment of bleeding |
SG10201906329VA SG10201906329VA (en) | 2014-05-26 | 2015-05-26 | Prohemostatic proteins for the treatment of bleeding |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201609811TA SG11201609811TA (en) | 2014-05-26 | 2015-05-26 | Prohemostatic proteins for the treatment of bleeding |
Country Status (25)
Country | Link |
---|---|
US (4) | US10537618B2 (en) |
EP (2) | EP3149163B1 (en) |
JP (3) | JP6640198B2 (en) |
KR (2) | KR102245264B1 (en) |
CN (1) | CN106536566A (en) |
AU (2) | AU2015268149B2 (en) |
BR (1) | BR112016027649A2 (en) |
CA (1) | CA2949349A1 (en) |
DK (1) | DK3149163T3 (en) |
EA (2) | EA202190813A1 (en) |
ES (1) | ES2813440T3 (en) |
HR (1) | HRP20201311T1 (en) |
HU (1) | HUE052098T2 (en) |
IL (2) | IL249132B (en) |
LT (1) | LT3149163T (en) |
MA (2) | MA40042B1 (en) |
MX (2) | MX2016015567A (en) |
NZ (1) | NZ727444A (en) |
PL (1) | PL3149163T3 (en) |
PT (1) | PT3149163T (en) |
RS (1) | RS60706B1 (en) |
SG (2) | SG11201609811TA (en) |
SI (1) | SI3149163T1 (en) |
WO (1) | WO2015183085A1 (en) |
ZA (1) | ZA201608017B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2949349A1 (en) | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
CN108486197B (en) * | 2018-03-06 | 2021-10-22 | 爱斯特(成都)生物制药股份有限公司 | Preparation method of high-purity edoxaban intermediate |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
DK0574402T3 (en) | 1990-11-26 | 1998-05-18 | Chiron Corp | Expression of PACE in Host Cells and Methods for Using Them |
US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
DE4203965A1 (en) | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | ANTIDOT FOR HIRUDIN AND SYNTHETIC THROMBIN INHIBITORS |
AT404357B (en) | 1995-06-13 | 1998-11-25 | Immuno Ag | PROTHROMINE DERIVATIVES |
DE19605126A1 (en) | 1996-02-12 | 1997-08-14 | Basf Ag | Thrombin muteins as an antidote for thrombin inhibitors |
US6200955B1 (en) | 1996-06-11 | 2001-03-13 | Commonwealth Biotechnologies, Inc. | Heparin binding peptides |
US6624141B1 (en) | 1999-03-17 | 2003-09-23 | The Regents Of The University Of Michigan | Protamine fragment compositions and methods of use |
EP1728798A1 (en) | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
MX336958B (en) * | 2005-11-15 | 2016-02-05 | Philadelphia Children Hospital | METHODS AND COMPOSITIONS TO MODULATE HEMOSTASIA. |
EP1820508A1 (en) * | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
CN103451172A (en) * | 2007-04-13 | 2013-12-18 | 催化剂生物科学公司 | Modified factor vii polypeptides and uses thereof |
ES2849426T3 (en) * | 2007-09-28 | 2021-08-18 | Alexion Pharma Inc | Antidotes for Factor Xa Inhibitors and Procedures for Using Them |
TWI465247B (en) * | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | Factor vii polypeptides that are modified and uses thereof |
CA2767858C (en) | 2009-07-15 | 2019-02-12 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same |
EA028865B1 (en) | 2012-07-25 | 2018-01-31 | Каталист Биосайенсиз, Инк. | Modified factor x polypeptides and uses thereof |
JP6437458B2 (en) | 2013-01-31 | 2018-12-12 | ファイザー・インク | Compositions and methods for neutralizing factor Xa inhibition |
US10119101B2 (en) | 2014-04-28 | 2018-11-06 | Ecolab Usa Inc. | Method of minimizing enzyme based aerosol mist using a pressure spray system |
CA2949349A1 (en) * | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
-
2015
- 2015-05-26 CA CA2949349A patent/CA2949349A1/en active Pending
- 2015-05-26 HU HUE15731411A patent/HUE052098T2/en unknown
- 2015-05-26 EA EA202190813A patent/EA202190813A1/en unknown
- 2015-05-26 MA MA40042A patent/MA40042B1/en unknown
- 2015-05-26 WO PCT/NL2015/050377 patent/WO2015183085A1/en active Application Filing
- 2015-05-26 LT LTEP15731411.3T patent/LT3149163T/en unknown
- 2015-05-26 SG SG11201609811TA patent/SG11201609811TA/en unknown
- 2015-05-26 US US15/313,881 patent/US10537618B2/en active Active
- 2015-05-26 SG SG10201906329VA patent/SG10201906329VA/en unknown
- 2015-05-26 MX MX2016015567A patent/MX2016015567A/en unknown
- 2015-05-26 PL PL15731411T patent/PL3149163T3/en unknown
- 2015-05-26 BR BR112016027649A patent/BR112016027649A2/en active IP Right Grant
- 2015-05-26 RS RS20200990A patent/RS60706B1/en unknown
- 2015-05-26 EA EA201692161A patent/EA037991B1/en unknown
- 2015-05-26 PT PT157314113T patent/PT3149163T/en unknown
- 2015-05-26 KR KR1020167033773A patent/KR102245264B1/en active IP Right Grant
- 2015-05-26 NZ NZ727444A patent/NZ727444A/en unknown
- 2015-05-26 SI SI201531321T patent/SI3149163T1/en unknown
- 2015-05-26 EP EP15731411.3A patent/EP3149163B1/en active Active
- 2015-05-26 JP JP2017515659A patent/JP6640198B2/en active Active
- 2015-05-26 ES ES15731411T patent/ES2813440T3/en active Active
- 2015-05-26 MA MA051688A patent/MA51688A/en unknown
- 2015-05-26 AU AU2015268149A patent/AU2015268149B2/en active Active
- 2015-05-26 DK DK15731411.3T patent/DK3149163T3/en active
- 2015-05-26 KR KR1020217011631A patent/KR102351728B1/en active IP Right Grant
- 2015-05-26 CN CN201580039023.6A patent/CN106536566A/en active Pending
- 2015-05-26 EP EP20177786.9A patent/EP3744840A1/en active Pending
-
2016
- 2016-11-18 ZA ZA2016/08017A patent/ZA201608017B/en unknown
- 2016-11-22 IL IL249132A patent/IL249132B/en active IP Right Grant
- 2016-11-25 MX MX2020013410A patent/MX2020013410A/en unknown
-
2019
- 2019-12-18 US US16/719,866 patent/US11357836B2/en active Active
- 2019-12-18 US US16/719,875 patent/US11304995B2/en active Active
- 2019-12-25 JP JP2019235197A patent/JP2020062039A/en active Pending
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2020
- 2020-08-21 HR HRP20201311TT patent/HRP20201311T1/en unknown
- 2020-09-15 IL IL277377A patent/IL277377B/en unknown
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2021
- 2021-06-10 AU AU2021203838A patent/AU2021203838B2/en active Active
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2022
- 2022-05-31 US US17/829,180 patent/US20220288172A1/en active Pending
- 2022-06-24 JP JP2022102258A patent/JP2022134139A/en active Pending
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