SG10201903290YA - Modified double-stranded rna agents - Google Patents

Modified double-stranded rna agents

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Publication number
SG10201903290YA
SG10201903290YA SG10201903290YA SG10201903290YA SG10201903290YA SG 10201903290Y A SG10201903290Y A SG 10201903290YA SG 10201903290Y A SG10201903290Y A SG 10201903290YA SG 10201903290Y A SG10201903290Y A SG 10201903290YA SG 10201903290Y A SG10201903290Y A SG 10201903290YA
Authority
SG
Singapore
Prior art keywords
dsrna
stranded rna
agents
double
inhibiting
Prior art date
Application number
SG10201903290YA
Inventor
Martin Maier
Don Foster
Stuart Milstein
Satya Kuchimanchi
Vasant Jadhav
Kallanthottathil Rajeev
Muthiah Manoharan
Rubina Parmar
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of SG10201903290YA publication Critical patent/SG10201903290YA/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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Abstract

MODIFIED DOUBLE-STRANDED RNA AGENTS One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The sense strand of the dsRNA agent comprises at least one thermally destabilizing nucleotide, and at least one said thermally destabilizing nucleotide occurring at a site opposite to the seed region (positions 2-8) of the antisense strand; and the antisense strand of the dsRNA agent comprises.at least two modified nucleotides that provide the nucleotide a steric bulk that is less than or equal to the steric bulk of a 2’-OMe modification, wherein said modified nucleotides are separated by 11 nucleotides in length. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g. , for the treatment of various disease conditions. [No suitable figure]
SG10201903290YA 2014-08-20 2015-08-14 Modified double-stranded rna agents SG10201903290YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462039507P 2014-08-20 2014-08-20
US201462083744P 2014-11-24 2014-11-24
US201462093919P 2014-12-18 2014-12-18

Publications (1)

Publication Number Publication Date
SG10201903290YA true SG10201903290YA (en) 2019-05-30

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SG11201701166UA SG11201701166UA (en) 2014-08-20 2015-08-14 Modified double-stranded rna agents
SG10201903290YA SG10201903290YA (en) 2014-08-20 2015-08-14 Modified double-stranded rna agents
SG10201913791QA SG10201913791QA (en) 2014-08-20 2015-08-14 Modified double-stranded rna agents

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US (9) US10233448B2 (en)
EP (3) EP3812462A1 (en)
JP (4) JP7289610B2 (en)
KR (3) KR20240010762A (en)
CN (2) CN114181942A (en)
CA (1) CA2958758A1 (en)
EA (1) EA201790420A1 (en)
IL (2) IL250448B (en)
MX (1) MX2017002144A (en)
NZ (2) NZ767118A (en)
SG (3) SG11201701166UA (en)
WO (1) WO2016028649A1 (en)

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