SG10201902831UA - Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers - Google Patents

Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

Info

Publication number
SG10201902831UA
SG10201902831UA SG10201902831UA SG10201902831UA SG10201902831UA SG 10201902831U A SG10201902831U A SG 10201902831UA SG 10201902831U A SG10201902831U A SG 10201902831UA SG 10201902831U A SG10201902831U A SG 10201902831UA SG 10201902831U A SG10201902831U A SG 10201902831UA
Authority
SG
Singapore
Prior art keywords
kits
methods
compositions
stress protein
acquired cytoresistance
Prior art date
Application number
SG10201902831UA
Inventor
Richard Zager
Ali Cm Johnson
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of SG10201902831UA publication Critical patent/SG10201902831UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COMPOSITIONS, KITS, AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin Bl and, optionally, agents that impact heme protein metabolism. Figure for publication: None 104
SG10201902831UA 2014-09-29 2015-09-28 Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers SG10201902831UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462057047P 2014-09-29 2014-09-29
US201562212232P 2015-08-31 2015-08-31

Publications (1)

Publication Number Publication Date
SG10201902831UA true SG10201902831UA (en) 2019-04-29

Family

ID=55631749

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201902831UA SG10201902831UA (en) 2014-09-29 2015-09-28 Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
SG11201702080UA SG11201702080UA (en) 2014-09-29 2015-09-28 Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201702080UA SG11201702080UA (en) 2014-09-29 2015-09-28 Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

Country Status (24)

Country Link
US (5) US10639321B2 (en)
EP (2) EP3200582B1 (en)
JP (3) JP6894837B2 (en)
KR (2) KR102578217B1 (en)
CN (2) CN112057470B (en)
AU (2) AU2015324103C1 (en)
BR (1) BR112017006531B1 (en)
CA (2) CA2963089C (en)
DK (1) DK3200582T3 (en)
ES (1) ES2974905T3 (en)
FI (1) FI3200582T3 (en)
HR (1) HRP20240229T1 (en)
HU (1) HUE065216T2 (en)
IL (3) IL287607B (en)
LT (1) LT3200582T (en)
MX (1) MX2017004148A (en)
NZ (1) NZ729754A (en)
PL (1) PL3200582T3 (en)
PT (1) PT3200582T (en)
RS (1) RS65182B1 (en)
SG (2) SG10201902831UA (en)
SI (1) SI3200582T1 (en)
WO (1) WO2016053882A2 (en)
ZA (1) ZA202305280B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ729754A (en) 2014-09-29 2023-01-27 Hutchinson Fred Cancer Res Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
US20190358242A1 (en) * 2017-02-08 2019-11-28 Fred Hutchinson Cancer Research Center Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
CN111936059A (en) * 2018-03-27 2020-11-13 精密科学公司 Method for stabilizing haemoglobin and reagent for carrying out said method
WO2019227055A1 (en) * 2018-05-24 2019-11-28 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure
SI3930686T1 (en) 2019-02-28 2023-11-30 Renibus Therapeutics, Inc. Novel iron compositions and methods of making and using the same
US20230346823A1 (en) * 2020-07-22 2023-11-02 Niigata University Utilization of vitamin b12 in inhibiting renal disorder
US20220079984A1 (en) * 2020-09-11 2022-03-17 Renibus Therapeutics, Inc. Method for treating cancer with kidney protection
JP7412723B2 (en) * 2021-03-12 2024-01-15 国立大学法人 新潟大学 Suppression of renal damage induced by rhabdomyolysis
CN116472037A (en) * 2021-03-12 2023-07-21 国立大学法人新潟大学 Inhibition of renal injury induced by hemolytic reaction
US12042501B2 (en) 2021-07-12 2024-07-23 Renibus Therapeutics, Inc. Metal protoporphyrin for treatment of BK virus
CN114891707B (en) * 2022-05-20 2024-04-05 中国科学院微生物研究所 Recombinant strain and method for producing bilirubin by whole cell catalysis thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579533A (en) 1968-03-18 1971-05-18 Antioch College Preparation of porphin,substituted porphin and metal chelates thereof
GB1596298A (en) 1977-04-07 1981-08-26 Morgan Ltd P K Method of and apparatus for detecting or measuring changes in the cross-sectional area of a non-magnetic object
US4692440A (en) 1985-03-25 1987-09-08 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4657902A (en) 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4668670A (en) 1986-06-20 1987-05-26 The Rockefeller University Tin diiododeuteroporphyrin and therapeutic use thereof
US4782049A (en) 1986-12-08 1988-11-01 The Rockefeller University Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
WO1992016221A1 (en) 1991-03-15 1992-10-01 Synergen, Inc. Pegylation of polypeptides
US5108767A (en) * 1991-06-10 1992-04-28 Abbott Laboratories Liquid nutritional product for persons receiving renal dialysis
US5274090A (en) 1992-11-09 1993-12-28 The Board Of Trustees Of The Leland Stanford Junior University Tetraphenylporphyrin compounds and method
AU7103594A (en) 1993-06-14 1995-01-03 Rockefeller University, The Treatment of neonatal hyperbilirubin with metalloporphyrin
DE19502255C2 (en) * 1995-01-25 1996-11-28 Windmoeller & Hoelscher Device for applying notes from plastic film on flat workpieces
US5804551A (en) * 1996-11-12 1998-09-08 Baxter International Inc. Pretraumatic use of hemoglobin
US20100293669A2 (en) 1999-05-06 2010-11-18 Jingdong Liu Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
AU4243400A (en) 1999-10-15 2001-04-30 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging agents and as antitumor agents
US6573258B2 (en) 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
US6517492B2 (en) 2001-02-22 2003-02-11 Texon Technologies Ltd. Method and apparatus for assessment of cardiac function by monitoring movement of the trachea
AR037699A1 (en) 2001-12-04 2004-12-01 Monsanto Technology Llc TRANSGENIC CORN WITH IMPROVED PHENOTYPE
CA2487426C (en) 2002-06-04 2010-09-07 Wellspring Pharmaceutical Corporation Preparation of metal mesoporphyrin halide compounds
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
EP2270166A3 (en) 2002-09-18 2011-08-10 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
AU2003286474A1 (en) 2002-10-18 2004-05-04 The General Hospital Corporation Compositions, solutions, and methods used for transplantation
JP2004307404A (en) * 2003-04-08 2004-11-04 Nipro Corp Pharmaceutical composition containing artificial oxygen transporter
US7008937B2 (en) 2003-06-10 2006-03-07 Frontier Scientific, Inc. Porphyrins and metalloporphyrins for inhibiting heme iron uptake
US7067659B2 (en) 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
EP2661963B1 (en) * 2004-05-06 2015-09-16 The Trustees of Columbia University in the City of New York Method for diagnosing acute renal failure or chronic renal failure
US20090092550A1 (en) 2004-07-15 2009-04-09 The University Of Sydney Porphyrin linked metronidazole against gum disease: porphyromonas gingivalis
US7585527B2 (en) 2005-09-19 2009-09-08 Bala Venkataraman Composition and method for treating iron deficiency anemia
PL2079472T3 (en) 2006-10-04 2012-01-31 Infacare Pharmaceutical Corp High-purity large-scale preparation of stannsoporfin
US20080317725A1 (en) 2007-06-20 2008-12-25 Baum Seth J Compositions and methods of treating chronic kidney disease
WO2009029836A2 (en) * 2007-08-31 2009-03-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes
ES2609110T3 (en) 2011-03-30 2017-04-18 Infacare Pharmaceutical Corporation Synthesis procedures of metallic mesoporphyrins
CN103355655A (en) * 2012-03-30 2013-10-23 北京因科瑞斯医药科技有限公司 Composition with alimentary anemia improving function and preparation method of composition
US9350026B2 (en) 2012-09-28 2016-05-24 Uchicago Argonne, Llc Nanofibrous electrocatalysts
US20140273273A1 (en) * 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
JP6573620B2 (en) 2014-02-10 2019-09-11 フレッド ハッチンソン キャンサー リサーチ センター Halogen treatment for heart attack and ischemic injury
JP6523335B2 (en) 2014-05-05 2019-05-29 サントル ナシオナル ドゥ ラ ルシェルシュ シアンティフィーク(セーエヌエールエス) Porphyrin molecular catalysts for selective electrochemical reduction of CO2 to CO
NZ729754A (en) 2014-09-29 2023-01-27 Hutchinson Fred Cancer Res Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

Also Published As

Publication number Publication date
WO2016053882A3 (en) 2016-05-06
CN112057470A (en) 2020-12-11
US20160271164A1 (en) 2016-09-22
KR102578217B1 (en) 2023-09-15
HRP20240229T1 (en) 2024-04-26
RS65182B1 (en) 2024-03-29
NZ729754A (en) 2023-01-27
BR112017006531B1 (en) 2023-01-24
KR20230132636A (en) 2023-09-15
CN107072190A (en) 2017-08-18
US11878029B2 (en) 2024-01-23
BR112017006531A2 (en) 2017-12-19
US9844563B2 (en) 2017-12-19
AU2015324103C1 (en) 2020-08-20
JP6894837B2 (en) 2021-06-30
CN112057470B (en) 2022-11-15
SG11201702080UA (en) 2017-04-27
ES2974905T3 (en) 2024-07-02
ZA202305280B (en) 2023-12-20
EP3200582A4 (en) 2018-04-04
DK3200582T3 (en) 2024-02-19
US20240108646A1 (en) 2024-04-04
FI3200582T3 (en) 2024-02-14
US10912793B2 (en) 2021-02-09
US20210275567A1 (en) 2021-09-09
SI3200582T1 (en) 2024-04-30
US20170112869A1 (en) 2017-04-27
CA2963089A1 (en) 2016-04-07
PL3200582T3 (en) 2024-04-08
AU2015324103A1 (en) 2017-03-23
EP3200582B1 (en) 2023-11-15
CA3220985A1 (en) 2016-04-07
AU2020202652B2 (en) 2022-06-30
EP4327808A3 (en) 2024-05-15
HUE065216T2 (en) 2024-05-28
IL251455A0 (en) 2017-05-29
LT3200582T (en) 2024-03-12
US20190091255A1 (en) 2019-03-28
JP2021130710A (en) 2021-09-09
KR20170057433A (en) 2017-05-24
JP2017535522A (en) 2017-11-30
US10639321B2 (en) 2020-05-05
CA2963089C (en) 2024-01-09
JP2023054797A (en) 2023-04-14
IL287607B (en) 2022-07-01
IL274891A (en) 2020-07-30
AU2020202652A1 (en) 2020-05-14
IL287607A (en) 2021-12-01
MX2017004148A (en) 2017-07-07
IL274891B (en) 2021-12-01
PT3200582T (en) 2024-02-19
WO2016053882A2 (en) 2016-04-07
EP3200582A2 (en) 2017-08-09
EP4327808A2 (en) 2024-02-28
CN107072190B (en) 2020-10-09
AU2015324103B2 (en) 2020-05-21
IL251455B (en) 2020-06-30

Similar Documents

Publication Publication Date Title
ZA202305280B (en) Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
PH12020500240A1 (en) Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies
PH12018500714A1 (en) Anti-tigit antigen-binding proteins and methods of use thereof
EA201990566A1 (en) COMPOSITIONS CONTAINING BACTERIAL STRAINS
BR112019000327A8 (en) ANTICLAUDIN 18A2 ANTIBODY AND USE THEREOF
EA201890285A1 (en) ANTIBODIES AGAINST PD-1, ACTIVATED ANTIBODIES AGAINST PD-1 AND METHODS OF THEIR APPLICATION
NZ730563A (en) Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
MA40576B1 (en) Anti-her2 antibodies and immunoconjugates
EA201792616A1 (en) MEANS, METHODS OF APPLICATION AND METHODS OF TREATMENT FOR SYNUCLEOPATHY
SG10201811841UA (en) Methods of treating cancer using tigit inhibitors and anti-cancer agents
NZ715201A (en) Afucosylated anti-fgfr2iiib antibodies
MA40074A (en) Multivalent ras binding compounds
WO2016019134A8 (en) Flagellin-based agents and uses including effective vaccination
PH12019501405A1 (en) Anti-neuropilin antigen-binding proteins and methods of use thereof
EA201890747A1 (en) METHODS OF TREATING INFLAMMATORY DISEASES
MY190647A (en) Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof
MY191539A (en) Streptococcal vaccine
WO2016073763A3 (en) Beta-glucan methods and compositions that affect the tumor microenvironment
MX2018011875A (en) Enhanced direct cardiac reprogramming.
EA201890753A1 (en) APPLICATION OF TRIENTINE FOR DELIVERY OF COPPER IN THE CHECKED TISSUE
EP3702470A3 (en) Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
EA201990181A1 (en) OBTAINING ACTIVATED CLOSTRIDIAL NEUROTOXINS
MY186302A (en) Beta-caseins and gut microbiota
BR112017011490A2 (en) method for treating ischemic or inflammatory condition in a patient's organ or tissue
MA43426A (en) COMPOSITIONS AND METHODS FOR ADMINISTERING THERAPEUTIC AGENTS