SG10201808258SA - Improved methods for manufacturing adoptive cell therapies - Google Patents
Improved methods for manufacturing adoptive cell therapiesInfo
- Publication number
- SG10201808258SA SG10201808258SA SG10201808258SA SG10201808258SA SG10201808258SA SG 10201808258S A SG10201808258S A SG 10201808258SA SG 10201808258S A SG10201808258S A SG 10201808258SA SG 10201808258S A SG10201808258S A SG 10201808258SA SG 10201808258S A SG10201808258S A SG 10201808258SA
- Authority
- SG
- Singapore
- Prior art keywords
- adoptive cell
- cell therapies
- improved methods
- manufacturing
- manufacturing adoptive
- Prior art date
Links
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
Abstract
IMPROVEDMETHODS FOR MANUFACTURING ADOPTIVE CELL THERAPIES The invention provides compositions and methods for manufacturing adoptive cell therapies. In particular embodiments, the invention provides methods of harvesting populations of cells, isolating and activating PBMCs, expanding T cells, and the T cell therapeutic to a subject in need thereof administering (FIG. ) 106
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461984558P | 2014-04-25 | 2014-04-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201808258SA true SG10201808258SA (en) | 2018-10-30 |
Family
ID=54333268
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201608744VA SG11201608744VA (en) | 2014-04-25 | 2015-04-24 | Improved methods for manufacturing adoptive cell therapies |
SG10201808258SA SG10201808258SA (en) | 2014-04-25 | 2015-04-24 | Improved methods for manufacturing adoptive cell therapies |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201608744VA SG11201608744VA (en) | 2014-04-25 | 2015-04-24 | Improved methods for manufacturing adoptive cell therapies |
Country Status (25)
Country | Link |
---|---|
US (1) | US20170051252A1 (en) |
EP (2) | EP3738597A1 (en) |
JP (4) | JP6817069B2 (en) |
KR (3) | KR20160141865A (en) |
CN (2) | CN106456670B (en) |
AU (2) | AU2015249376C1 (en) |
BR (1) | BR112016024957A2 (en) |
CA (1) | CA2946552A1 (en) |
CY (1) | CY1123142T1 (en) |
DK (1) | DK3134095T3 (en) |
ES (1) | ES2800906T3 (en) |
HR (1) | HRP20200978T1 (en) |
HU (1) | HUE049514T2 (en) |
IL (2) | IL248349B (en) |
LT (1) | LT3134095T (en) |
MX (2) | MX370018B (en) |
NZ (1) | NZ725201A (en) |
PL (1) | PL3134095T3 (en) |
PT (1) | PT3134095T (en) |
RS (1) | RS60544B1 (en) |
RU (1) | RU2741899C2 (en) |
SG (2) | SG11201608744VA (en) |
SI (1) | SI3134095T1 (en) |
WO (1) | WO2015164745A1 (en) |
ZA (2) | ZA201607175B (en) |
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