SG10201805073VA - Multilayered nanoparticle and methods of manufacturing and using the same - Google Patents
Multilayered nanoparticle and methods of manufacturing and using the sameInfo
- Publication number
- SG10201805073VA SG10201805073VA SG10201805073VA SG10201805073VA SG10201805073VA SG 10201805073V A SG10201805073V A SG 10201805073VA SG 10201805073V A SG10201805073V A SG 10201805073VA SG 10201805073V A SG10201805073V A SG 10201805073VA SG 10201805073V A SG10201805073V A SG 10201805073VA
- Authority
- SG
- Singapore
- Prior art keywords
- manufacturing
- methods
- same
- nanoparticle
- multilayered nanoparticle
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
MULTILAYERED NANOPARTICLE AND METHODS OF MANUFACTURING AND USING THE SAME The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA. Figure 1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361915790P | 2013-12-13 | 2013-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201805073VA true SG10201805073VA (en) | 2018-07-30 |
Family
ID=53371583
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201805073VA SG10201805073VA (en) | 2013-12-13 | 2014-12-09 | Multilayered nanoparticle and methods of manufacturing and using the same |
SG11201604763PA SG11201604763PA (en) | 2013-12-13 | 2014-12-09 | Multilayered nanoparticle and methods of manufacturing and using the same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201604763PA SG11201604763PA (en) | 2013-12-13 | 2014-12-09 | Multilayered nanoparticle and methods of manufacturing and using the same |
Country Status (6)
Country | Link |
---|---|
US (1) | US10465189B2 (en) |
EP (1) | EP3079705A4 (en) |
JP (1) | JP2017500312A (en) |
CN (1) | CN107073028A (en) |
SG (2) | SG10201805073VA (en) |
WO (1) | WO2015088445A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017120504A1 (en) | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
CN110582302A (en) | 2016-12-14 | 2019-12-17 | 利甘达尔股份有限公司 | Compositions and methods for nucleic acid and/or protein payload delivery |
US11357735B2 (en) | 2017-02-01 | 2022-06-14 | Centre National De La Recherche Scientifique | Particles and compositions comprising the same for transfection |
US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
EP3645092B1 (en) * | 2017-06-30 | 2024-04-03 | Avectas Limited | Electrospray catheter |
AU2018305148B2 (en) * | 2017-07-26 | 2023-09-28 | Albert-Ludwigs-Universität Freiburg | Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells |
US11059016B2 (en) * | 2018-06-25 | 2021-07-13 | Microsoft Technology Licensing, Llc | Silica encapsulated DNA on magnetic nanoparticles |
WO2021140509A1 (en) * | 2020-01-06 | 2021-07-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Stimuli-responsive microcapsule-in-microcapsule multiple load carriers, uses thereof and processes for their preparation |
WO2021202772A1 (en) * | 2020-04-01 | 2021-10-07 | University Of Florida Research Foundation, Incorporated | Multilamellar rna nanoparticle vaccine against sars-cov-2 |
US20230183695A1 (en) * | 2020-05-22 | 2023-06-15 | Formulytica Pty Ltd. | Compositions and methods for the delivery of agents to biological targets |
WO2022019842A1 (en) * | 2020-07-24 | 2022-01-27 | Nanyang Technological University | Layer-by-layer coated nanolipsome for oral delivery of insulin |
CN114376988B (en) * | 2022-01-20 | 2024-02-20 | 国家纳米科学中心 | Nucleic acid delivery nano-carrier acting on phagocytic cells and preparation method and application thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5590882B2 (en) * | 2006-06-26 | 2014-09-17 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | Cysteine-rich acidic secreted protein (SPARC) as a chemosensitizer |
JP2011517279A (en) * | 2007-10-29 | 2011-06-02 | ユニバーシティ オブ マサチューセッツ | Yeast cell wall particles (YCWP) multi-layered nanoparticles for nucleic acid (siRNA) delivery |
WO2011041680A2 (en) * | 2009-10-02 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods of prophylaxis for contact dermatitis |
US20130309173A2 (en) * | 2009-10-09 | 2013-11-21 | SingaporeHealth Services Pte. Ltd. | Methods and compositions for maintenance of a functional wound |
US9265844B2 (en) * | 2010-12-01 | 2016-02-23 | The Methodist Hospital System | Protease degradable polypeptides and uses thereof |
US9074187B2 (en) * | 2011-03-21 | 2015-07-07 | Board Of Trustees Of The University Of Arkansas | Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same |
KR101255149B1 (en) * | 2011-10-14 | 2013-04-22 | 포항공과대학교 산학협력단 | Composition for nucleic acid delivery using metal nanoparticles and preparing method thereof |
US10278927B2 (en) * | 2012-04-23 | 2019-05-07 | Massachusetts Institute Of Technology | Stable layer-by-layer coated particles |
-
2014
- 2014-12-09 CN CN201480075581.3A patent/CN107073028A/en active Pending
- 2014-12-09 EP EP14870520.5A patent/EP3079705A4/en not_active Withdrawn
- 2014-12-09 WO PCT/SG2014/000587 patent/WO2015088445A1/en active Application Filing
- 2014-12-09 JP JP2016539028A patent/JP2017500312A/en active Pending
- 2014-12-09 US US15/104,123 patent/US10465189B2/en active Active
- 2014-12-09 SG SG10201805073VA patent/SG10201805073VA/en unknown
- 2014-12-09 SG SG11201604763PA patent/SG11201604763PA/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2017500312A (en) | 2017-01-05 |
WO2015088445A1 (en) | 2015-06-18 |
EP3079705A1 (en) | 2016-10-19 |
US20160319280A1 (en) | 2016-11-03 |
CN107073028A (en) | 2017-08-18 |
US10465189B2 (en) | 2019-11-05 |
SG11201604763PA (en) | 2016-07-28 |
EP3079705A4 (en) | 2017-07-19 |
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