SG10201804469RA - Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods - Google Patents
Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methodsInfo
- Publication number
- SG10201804469RA SG10201804469RA SG10201804469RA SG10201804469RA SG10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA
- Authority
- SG
- Singapore
- Prior art keywords
- variants
- methods
- timp
- compositions
- tissue inhibitor
- Prior art date
Links
- 102000005876 Tissue Inhibitor of Metalloproteinases Human genes 0.000 title abstract 2
- 108010005246 Tissue Inhibitor of Metalloproteinases Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 title 1
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them. 5 No Suitable Figure
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782613P | 2013-03-14 | 2013-03-14 | |
| US201361798160P | 2013-03-15 | 2013-03-15 | |
| US201361802988P | 2013-03-18 | 2013-03-18 | |
| US201461940673P | 2014-02-17 | 2014-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201804469RA true SG10201804469RA (en) | 2018-06-28 |
Family
ID=50473803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507524TA SG11201507524TA (en) | 2013-03-14 | 2014-03-13 | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| SG10201804469RA SG10201804469RA (en) | 2013-03-14 | 2014-03-13 | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507524TA SG11201507524TA (en) | 2013-03-14 | 2014-03-13 | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10189890B2 (en) |
| EP (1) | EP2970407B1 (en) |
| JP (4) | JP2016513666A (en) |
| KR (1) | KR102258564B1 (en) |
| CN (2) | CN111499733A (en) |
| AP (1) | AP2015008729A0 (en) |
| AU (5) | AU2014236683B2 (en) |
| BR (1) | BR112015022491A2 (en) |
| CA (1) | CA2906053C (en) |
| CL (1) | CL2015002663A1 (en) |
| EA (1) | EA034200B1 (en) |
| HK (1) | HK1219959A1 (en) |
| IL (1) | IL241246B (en) |
| MX (1) | MX2015012891A (en) |
| PE (1) | PE20151894A1 (en) |
| PH (1) | PH12015502059A1 (en) |
| SG (2) | SG11201507524TA (en) |
| TN (1) | TN2015000423A1 (en) |
| TW (3) | TWI733138B (en) |
| WO (1) | WO2014152012A2 (en) |
| ZA (2) | ZA201506746B (en) |
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| SG11201701122XA (en) * | 2014-08-27 | 2017-03-30 | Amgen Inc | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| CA2957960C (en) | 2014-10-14 | 2023-08-22 | Amgen, Inc. | Drug injection device with visual and audible indicators |
| EP3689394A1 (en) | 2014-12-19 | 2020-08-05 | Amgen Inc. | Drug delivery device with live button or user interface field |
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| ES2905870T3 (en) | 2015-02-27 | 2022-04-12 | Amgen Inc | Drug delivery device having a needle guard mechanism with an adjustable threshold resistance to movement of the needle guard |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| EP3386573B1 (en) | 2015-12-09 | 2019-10-02 | Amgen Inc. | Auto-injector with signaling cap |
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| EP3465124A1 (en) | 2016-06-03 | 2019-04-10 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| WO2018136398A1 (en) | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
| WO2018152073A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
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| US11571511B2 (en) | 2017-03-07 | 2023-02-07 | Amgen Inc. | Insertion mechanism and method of inserting a needle of a drug delivery device |
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| US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| JPH09235300A (en) * | 1996-02-29 | 1997-09-09 | Fuji Yakuhin Kogyo Kk | Human timp-3 and anti-human timp-3 monoclonal antibody and use thereof |
| JP5025045B2 (en) * | 2001-02-02 | 2012-09-12 | マルホ株式会社 | Enhancement of TIMP production by polysulfated polysaccharides |
| US7183256B2 (en) | 2003-03-21 | 2007-02-27 | Cleveland Clinic Foundation | TIMP3 as VEGF inhibitor |
| US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| AR053275A1 (en) * | 2005-05-12 | 2007-04-25 | Glaxo Group Ltd | VACCINE COMPOSITION |
| CA2617138A1 (en) * | 2005-07-29 | 2007-02-08 | Imperial Innovations Limited | Mutant timp-3 |
| EP2136831B1 (en) * | 2007-03-02 | 2012-09-12 | The Cleveland Clinic Foundation | Anti-angiogenic peptides |
| CN102105582A (en) * | 2008-04-21 | 2011-06-22 | 诺沃-诺迪斯克有限公司 | Hyperglycosylated human coagulation factor IX |
| EP2370581B1 (en) * | 2008-12-04 | 2016-08-03 | CuRNA, Inc. | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| CA2769206A1 (en) * | 2009-07-31 | 2011-02-03 | Amgen Inc. | Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
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