SG10201803473WA - Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide - Google Patents

Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Info

Publication number
SG10201803473WA
SG10201803473WA SG10201803473WA SG10201803473WA SG10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA
Authority
SG
Singapore
Prior art keywords
methods
binding polypeptide
immunosuppressive therapy
alpha beta
tcr
Prior art date
Application number
SG10201803473WA
Inventor
Gregor Blank
Rupert Handgretinger
Karin Schilbach
Gina Lacorcia
Daniel Snell
Andreas Menrad
Original Assignee
Genzyme Corp
Univ Eberhard Karls Tuebingen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Univ Eberhard Karls Tuebingen filed Critical Genzyme Corp
Publication of SG10201803473WA publication Critical patent/SG10201803473WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Abstract

METHODS FOR ENHANCING IMMUNOSUPPRESSIVE THERAPY BY MULTIPLE ADMINISTRATION OF ALPHA BETA TCR-BINDING POLYPEPTIDE 5 The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (αβ -TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-αβ -TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel 10 methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibod ies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibod ies and/or fragments thereof) to reduce  T cells in the subject relative to γδ T cells in the subject are provided. 15 [No Figure]
SG10201803473WA 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide SG10201803473WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361897809P 2013-10-30 2013-10-30

Publications (1)

Publication Number Publication Date
SG10201803473WA true SG10201803473WA (en) 2018-06-28

Family

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Family Applications (2)

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SG10201803473WA SG10201803473WA (en) 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide
SG11201603193PA SG11201603193PA (en) 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (8)

Country Link
US (2) US11142575B2 (en)
EP (1) EP3063174B1 (en)
CN (1) CN106795220A (en)
AU (2) AU2014342182B2 (en)
CA (1) CA2928756A1 (en)
MX (1) MX2016005687A (en)
SG (2) SG10201803473WA (en)
WO (1) WO2015066379A2 (en)

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Publication number Priority date Publication date Assignee Title
SG10201803473WA (en) * 2013-10-30 2018-06-28 Genzyme Corp Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
US20180298099A1 (en) * 2015-09-16 2018-10-18 Harry C. Ledebur, Jr. T-Cell Recepter (TCR) Targeting Therapies for Immune-Mediated Adverse Drug Reactions (ADRs) and Other Conditions
CN108070644B (en) * 2016-11-08 2021-06-29 国家卫生计生委科学技术研究所 Diagnosis system for gestational hypertension
EP3650539A4 (en) * 2017-07-07 2021-08-18 Hanmi Pharm. Co., Ltd. Novel therapeutic enzyme fusion protein and use thereof
CN109777778B (en) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 Genetically modified gamma delta T cells
DE102017127984B4 (en) * 2017-11-27 2019-12-05 Immatics US, Inc. Method for the propagation and activation of γδ T cells
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
MA55529A (en) * 2019-04-03 2022-02-09 Genzyme Corp REDUCED FRAGMENTATION ANTI-ALPHA BETA TCR BINDING POLYPEPTIDES
AU2020384369A1 (en) * 2019-11-14 2022-05-26 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
AU2020416273A1 (en) * 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy

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Publication number Priority date Publication date Assignee Title
CA2018248A1 (en) * 1989-06-07 1990-12-07 Clyde W. Shearman Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20050058641A1 (en) 2002-05-22 2005-03-17 Siemionow Maria Z. Tolerance induction and maintenance in hematopoietic stem cell allografts
EP2221315A1 (en) 2003-12-04 2010-08-25 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
EP1866339B8 (en) 2005-03-25 2021-12-01 GITR, Inc. Gitr binding molecules and uses therefor
JP5597793B2 (en) 2006-06-19 2014-10-01 メルク・シャープ・アンド・ドーム・コーポレーション ILT3-binding molecules and uses thereof
DK2740744T3 (en) 2007-01-09 2018-04-23 Biogen Ma Inc Sp35 antibodies and uses thereof
AU2009288354A1 (en) 2008-08-26 2010-03-11 Macrogenics Inc. T-cell receptor antibodies and methods of use thereof
ME03447B (en) 2010-03-04 2020-01-20 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
WO2012012737A2 (en) * 2010-07-23 2012-01-26 The University Of Toledo Stable tregs and related materials and methods
UY34317A (en) 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
SG10201803473WA (en) * 2013-10-30 2018-06-28 Genzyme Corp Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Also Published As

Publication number Publication date
WO2015066379A3 (en) 2015-07-09
MX2016005687A (en) 2017-03-30
CA2928756A1 (en) 2015-05-07
AU2014342182B2 (en) 2020-05-14
US11142575B2 (en) 2021-10-12
EP3063174A2 (en) 2016-09-07
EP3063174B1 (en) 2020-12-09
US20160244523A1 (en) 2016-08-25
US20220098299A1 (en) 2022-03-31
SG11201603193PA (en) 2016-05-30
AU2020217395A1 (en) 2020-09-03
WO2015066379A2 (en) 2015-05-07
AU2014342182A1 (en) 2016-05-19
CN106795220A (en) 2017-05-31

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