SG10201710727UA - Antibody locker for the inactivation of protein drug - Google Patents
Antibody locker for the inactivation of protein drugInfo
- Publication number
- SG10201710727UA SG10201710727UA SG10201710727UA SG10201710727UA SG10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA
- Authority
- SG
- Singapore
- Prior art keywords
- locker
- inactivation
- antibody
- protein drug
- drug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361827763P | 2013-05-28 | 2013-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201710727UA true SG10201710727UA (en) | 2018-02-27 |
Family
ID=51989521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201710727UA SG10201710727UA (en) | 2013-05-28 | 2014-05-28 | Antibody locker for the inactivation of protein drug |
SG11201509595PA SG11201509595PA (en) | 2013-05-28 | 2014-05-28 | Antibody locker for the inactivation of protein drug |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201509595PA SG11201509595PA (en) | 2013-05-28 | 2014-05-28 | Antibody locker for the inactivation of protein drug |
Country Status (15)
Country | Link |
---|---|
US (1) | US10633453B2 (en) |
EP (1) | EP3003370B1 (en) |
JP (1) | JP6545666B2 (en) |
KR (1) | KR102182485B1 (en) |
CN (1) | CN105377297B (en) |
AU (1) | AU2014274215B2 (en) |
CA (1) | CA2913051C (en) |
EA (1) | EA035322B1 (en) |
HK (1) | HK1221426A1 (en) |
IL (1) | IL242772B (en) |
MX (1) | MX2015016329A (en) |
SG (2) | SG10201710727UA (en) |
TW (1) | TWI582111B (en) |
WO (1) | WO2014193973A2 (en) |
ZA (1) | ZA201508673B (en) |
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US10633453B2 (en) | 2013-05-28 | 2020-04-28 | Kaohsiung Medical University | Antibody locker for the inactivation of protein drug |
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AU2015210862B2 (en) | 2014-01-31 | 2020-04-23 | Cytomx Therapeutics, Inc | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
US9751946B2 (en) | 2014-09-12 | 2017-09-05 | Genentech, Inc. | Anti-CLL-1 antibodies and immunoconjugates |
MA41374A (en) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | MATRIX METALLOPROTEASE CLIVABLE AND SERINE PROTEASE CLIVABLE SUBSTRATES AND METHODS OF USE THEREOF |
EP3261669B1 (en) | 2015-02-25 | 2022-08-03 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
KR20180006916A (en) | 2015-04-17 | 2018-01-19 | 메모리얼 슬로안-케터링 캔서 센터 | Use of MVA or MVA delta E3L as an immunotherapeutic agent for solid tumors |
JP2018520642A (en) * | 2015-05-01 | 2018-08-02 | ジェネンテック, インコーポレイテッド | Mask anti-CD3 antibody and method of use thereof |
CN107847568B (en) | 2015-06-16 | 2022-12-20 | 豪夫迈·罗氏有限公司 | anti-CLL-1 antibodies and methods of use |
MX2018002226A (en) | 2015-08-28 | 2018-03-23 | Amunix Operating Inc | Chimeric polypeptide assembly and methods of making and using the same. |
EP4310503A3 (en) | 2015-12-30 | 2024-03-20 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
CN116440176A (en) | 2016-02-25 | 2023-07-18 | 纪念斯隆凯特琳癌症中心 | Replication-competent attenuated vaccinia virus with thymidine kinase deficiency and with or without human FLT3L or GM-CSF expression |
AU2017222687B2 (en) | 2016-02-25 | 2022-02-24 | Memorial Sloan Kettering Cancer Center | Recombinant MVA or MVADELE3L expressing human Flt3L and use thereof as immuno-therapeutic agents against solid tumors |
WO2017165306A1 (en) * | 2016-03-20 | 2017-09-28 | Middle Tennessee State University | ASSAY FOR HIGH-THROUGHPUT lDENTIFICATION OF THERAPEUTIC COMPOUNDS |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
EP3458588A4 (en) * | 2016-05-18 | 2020-01-15 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
CN107446016A (en) * | 2016-05-30 | 2017-12-08 | 上海交通大学 | A kind of cell-penetrating peptide of Stearate Modified and its preparation and application |
WO2017211278A1 (en) * | 2016-06-06 | 2017-12-14 | Asclepiumm Taiwan Co., Ltd | Antibody fusion proteins for drug delivery |
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KR20190089034A (en) * | 2016-12-09 | 2019-07-29 | 시애틀 지네틱스, 인크. | Antibodies shielded by coiled coils |
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US11242509B2 (en) | 2017-05-12 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
US11939385B2 (en) * | 2017-05-16 | 2024-03-26 | ALX Oncology Inc. | Activatable antibodies and methods of use thereof |
AU2018375375A1 (en) | 2017-12-01 | 2020-05-28 | Seagen Inc. | CD47 antibodies and uses thereof for treating cancer |
AU2019218959A1 (en) | 2018-02-08 | 2020-09-03 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
KR102245552B1 (en) * | 2018-02-28 | 2021-04-29 | 부산대학교 산학협력단 | Nanodrug Composites, preparation method therof, and use for the same |
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TW202112354A (en) | 2019-06-05 | 2021-04-01 | 美商西雅圖遺傳學公司 | Masked antibody formulations |
US20220306727A1 (en) | 2019-06-05 | 2022-09-29 | Seagen Inc. | Methods of Purifying Masked Antibodies |
WO2023288236A1 (en) | 2021-07-14 | 2023-01-19 | Seagen Inc. | Antibody masking domains |
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US10633453B2 (en) | 2013-05-28 | 2020-04-28 | Kaohsiung Medical University | Antibody locker for the inactivation of protein drug |
HRP20220553T1 (en) | 2013-07-25 | 2022-06-10 | Cytomx Therapeutics Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
CA3214529A1 (en) | 2013-09-25 | 2015-04-02 | Cytomx Therapeutics, Inc. | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
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-
2014
- 2014-05-28 US US14/893,509 patent/US10633453B2/en active Active
- 2014-05-28 AU AU2014274215A patent/AU2014274215B2/en active Active
- 2014-05-28 EP EP14803825.0A patent/EP3003370B1/en active Active
- 2014-05-28 MX MX2015016329A patent/MX2015016329A/en active IP Right Grant
- 2014-05-28 KR KR1020157036785A patent/KR102182485B1/en active IP Right Grant
- 2014-05-28 WO PCT/US2014/039821 patent/WO2014193973A2/en active Application Filing
- 2014-05-28 SG SG10201710727UA patent/SG10201710727UA/en unknown
- 2014-05-28 CA CA2913051A patent/CA2913051C/en active Active
- 2014-05-28 JP JP2016516786A patent/JP6545666B2/en active Active
- 2014-05-28 EA EA201592049A patent/EA035322B1/en not_active IP Right Cessation
- 2014-05-28 SG SG11201509595PA patent/SG11201509595PA/en unknown
- 2014-05-28 TW TW103118542A patent/TWI582111B/en active
- 2014-05-28 CN CN201480031238.9A patent/CN105377297B/en active Active
-
2015
- 2015-11-25 IL IL242772A patent/IL242772B/en active IP Right Grant
- 2015-11-25 ZA ZA2015/08673A patent/ZA201508673B/en unknown
-
2016
- 2016-08-15 HK HK16109736.2A patent/HK1221426A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN105377297A (en) | 2016-03-02 |
TWI582111B (en) | 2017-05-11 |
TW201520230A (en) | 2015-06-01 |
EP3003370A4 (en) | 2017-01-25 |
MX2015016329A (en) | 2016-07-20 |
AU2014274215B2 (en) | 2019-02-28 |
CN105377297B (en) | 2019-09-17 |
WO2014193973A3 (en) | 2015-02-19 |
SG11201509595PA (en) | 2015-12-30 |
CA2913051C (en) | 2023-09-05 |
EA035322B1 (en) | 2020-05-28 |
CA2913051A1 (en) | 2014-12-04 |
AU2014274215A1 (en) | 2015-12-03 |
ZA201508673B (en) | 2017-05-31 |
US20160185875A1 (en) | 2016-06-30 |
EP3003370A2 (en) | 2016-04-13 |
EA201592049A1 (en) | 2016-04-29 |
JP2016520614A (en) | 2016-07-14 |
IL242772B (en) | 2020-04-30 |
US10633453B2 (en) | 2020-04-28 |
JP6545666B2 (en) | 2019-07-17 |
WO2014193973A2 (en) | 2014-12-04 |
EP3003370B1 (en) | 2020-01-22 |
KR102182485B1 (en) | 2020-11-25 |
HK1221426A1 (en) | 2017-06-02 |
KR20160032041A (en) | 2016-03-23 |
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