SG10201707394PA - Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set - Google Patents
Uniquely tagged rearranged adaptive immune receptor genes in a complex gene setInfo
- Publication number
- SG10201707394PA SG10201707394PA SG10201707394PA SG10201707394PA SG10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA SG 10201707394P A SG10201707394P A SG 10201707394PA
- Authority
- SG
- Singapore
- Prior art keywords
- adaptive immune
- gene set
- immune receptor
- receptor genes
- complex gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/155—Modifications characterised by incorporating/generating a new priming site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789408P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/045994 WO2013188831A1 (en) | 2012-06-15 | 2013-06-14 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201707394PA true SG10201707394PA (en) | 2017-10-30 |
Family
ID=51538155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201506991VA SG11201506991VA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| SG10201707394PA SG10201707394PA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201506991VA SG11201506991VA (en) | 2013-03-15 | 2014-03-17 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160024493A1 (en) |
| EP (1) | EP2971105B1 (en) |
| JP (1) | JP6431895B2 (en) |
| KR (1) | KR20150132479A (en) |
| CN (1) | CN105452483B (en) |
| AU (2) | AU2014232314B2 (en) |
| CA (1) | CA2906218A1 (en) |
| IL (1) | IL241394B (en) |
| SG (2) | SG11201506991VA (en) |
| WO (1) | WO2014145992A1 (en) |
Families Citing this family (57)
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| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| WO2010083456A1 (en) | 2009-01-15 | 2010-07-22 | Imdaptive Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| JP6302847B2 (en) | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | Determination of paired immunoreceptor chains from frequency matched subunits |
| RU2631797C2 (en) | 2012-05-08 | 2017-09-26 | Эдэптив Байотекнолоджиз Корпорейшн | Compositions and methods of measurement and calibration of systematic mistake of amplification in multiplex pcr-reactions |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| ES2777529T3 (en) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| US10400281B2 (en) | 2014-05-22 | 2019-09-03 | The University Of British Columbia | Methods for determining lymphocyte receptor chain pairs |
| EP3212790B1 (en) | 2014-10-29 | 2020-03-25 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CA2968543C (en) | 2014-11-25 | 2024-04-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN104562215B (en) * | 2014-12-29 | 2017-03-22 | 北京诺禾致源科技股份有限公司 | Method for constructing amplicon library |
| EP3247804B1 (en) * | 2015-01-23 | 2020-08-05 | Qiagen Sciences, LLC | High multiplex pcr with molecular barcoding |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016138488A2 (en) | 2015-02-26 | 2016-09-01 | The Broad Institute Inc. | T cell balance gene expression, compositions of matters and methods of use thereof |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| WO2016176322A1 (en) * | 2015-04-27 | 2016-11-03 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
| WO2017013170A1 (en) * | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| GB201516275D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516265D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516269D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516274D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516270D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516276D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| CN108473984A (en) * | 2015-11-04 | 2018-08-31 | 阿特雷卡公司 | The group of nucleic acid bar code for analyzing nucleic acid associated with individual cells is combined |
| US20210180106A1 (en) * | 2016-02-12 | 2021-06-17 | Curevac Ag | Method for analyzing rna |
| US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
| CN109072288A (en) * | 2016-05-02 | 2018-12-21 | 赛卢拉研究公司 | Accurate molecule bar coding |
| US11098360B2 (en) | 2016-06-01 | 2021-08-24 | Roche Sequencing Solutions, Inc. | Immuno-PETE |
| CN106283201B (en) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | The detection of TCR diversity and library construction based on high-flux sequence |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| RU2019123063A (en) | 2016-12-23 | 2021-01-26 | Вистерра, Инк. | BINDING POLYPEPTIDES AND METHODS FOR THEIR PREPARATION |
| WO2018132635A1 (en) * | 2017-01-12 | 2018-07-19 | Massachusetts Institute Of Technology | Methods for analyzing t cell receptors and b cell receptors |
| CN110249060A (en) * | 2017-01-17 | 2019-09-17 | 生命技术公司 | Composition and method for the sequencing of immune group library |
| EP3577234B1 (en) * | 2017-01-31 | 2024-03-20 | Ludwig Institute For Cancer Research Ltd. | Enhanced immune cell receptor sequencing methods |
| EP4212631A1 (en) | 2017-09-01 | 2023-07-19 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| CN115927566A (en) * | 2017-09-20 | 2023-04-07 | 深圳华大智造科技股份有限公司 | Sequencing method, sequencing reagent and application for Small RNA |
| IL274179B2 (en) * | 2017-10-27 | 2024-02-01 | Univ California | Targeted replacement of endogenous t cell receptors |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| EP3752832A1 (en) | 2018-02-12 | 2020-12-23 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| CN108374203B (en) * | 2018-03-01 | 2021-07-23 | 艾吉泰康生物科技(北京)有限公司 | Construction method of amplicon library for bidirectional sequencing |
| WO2020018837A1 (en) * | 2018-07-18 | 2020-01-23 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| WO2020041702A1 (en) * | 2018-08-24 | 2020-02-27 | Swift Biosciences, Inc. | Asymmetric targeted amplification methods |
| US11149322B2 (en) * | 2019-06-07 | 2021-10-19 | Chapter Diagnostics, Inc. | Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification |
| WO2021046121A1 (en) * | 2019-09-03 | 2021-03-11 | The Regents Of The University Of California | Method to sequence mrna in single cells in parallel with quantification of intracellular phenotype |
| EP4139486A1 (en) * | 2020-04-24 | 2023-03-01 | The Board of Trustees of the Leland Stanford Junior University | Novel t-cell specificities and uses thereof |
| US10941453B1 (en) * | 2020-05-20 | 2021-03-09 | Paragon Genomics, Inc. | High throughput detection of pathogen RNA in clinical specimens |
| JP2024512608A (en) | 2021-03-24 | 2024-03-19 | ジェネンテック， インコーポレイテッド | Efficient TCR gene editing in T lymphocytes |
| WO2022207682A1 (en) * | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
| US11680293B1 (en) | 2022-04-21 | 2023-06-20 | Paragon Genomics, Inc. | Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules |
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| US6031091A (en) | 1987-09-21 | 2000-02-29 | Gen-Probe Incorporated | Non-nucleotide linking reagents for nucleotide probes |
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| WO1993022461A1 (en) | 1992-05-06 | 1993-11-11 | Gen-Probe Incorporated | Nucleic acid sequence amplification method, composition and kit |
| US5596090A (en) | 1992-07-24 | 1997-01-21 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human VCAM-1 RNA |
| US5571711A (en) | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
| EP0668350B2 (en) | 1994-02-16 | 2008-12-03 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Melanoma associated antigenic polypeptide, epitopes thereof and vaccines against melanoma |
| US5821122A (en) | 1995-06-07 | 1998-10-13 | Inserm (Institute Nat'l De La Sante Et De La Recherche . .) | Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof |
| JPH0975090A (en) | 1995-09-13 | 1997-03-25 | Kanegafuchi Chem Ind Co Ltd | Member for adhering cell |
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| US20120058902A1 (en) * | 2009-06-25 | 2012-03-08 | Livingston Robert J | Method of measuring adaptive immunity |
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| EP2596127A2 (en) * | 2010-07-23 | 2013-05-29 | Esoterix Genetic Laboratories, LLC | Identification of differentially represented fetal or maternal genomic regions and uses thereof |
| WO2012083069A2 (en) * | 2010-12-15 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and monitoring of cell clonality |
| US20140057799A1 (en) | 2010-12-16 | 2014-02-27 | Gigagen | System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells |
| US9920110B2 (en) * | 2011-03-09 | 2018-03-20 | Cell Signaling Technology, Inc. | Methods and reagents for creating monoclonal antibodies |
| RS64230B1 (en) * | 2011-05-24 | 2023-06-30 | BioNTech SE | Individualized vaccines for cancer |
| JP6302847B2 (en) * | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | Determination of paired immunoreceptor chains from frequency matched subunits |
-
2014
- 2014-03-17 SG SG11201506991VA patent/SG11201506991VA/en unknown
- 2014-03-17 EP EP14722474.5A patent/EP2971105B1/en active Active
- 2014-03-17 CA CA2906218A patent/CA2906218A1/en not_active Abandoned
- 2014-03-17 JP JP2016502574A patent/JP6431895B2/en active Active
- 2014-03-17 WO PCT/US2014/030859 patent/WO2014145992A1/en active Application Filing
- 2014-03-17 AU AU2014232314A patent/AU2014232314B2/en active Active
- 2014-03-17 SG SG10201707394PA patent/SG10201707394PA/en unknown
- 2014-03-17 KR KR1020157029634A patent/KR20150132479A/en not_active Application Discontinuation
- 2014-03-17 CN CN201480025490.9A patent/CN105452483B/en active Active
- 2014-03-17 US US14/777,294 patent/US20160024493A1/en not_active Abandoned
-
2015
- 2015-09-09 IL IL241394A patent/IL241394B/en active IP Right Grant
-
2020
- 2020-08-06 AU AU2020213348A patent/AU2020213348B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160024493A1 (en) | 2016-01-28 |
| CN105452483A (en) | 2016-03-30 |
| WO2014145992A1 (en) | 2014-09-18 |
| AU2020213348A1 (en) | 2020-08-27 |
| AU2020213348B2 (en) | 2022-05-19 |
| JP6431895B2 (en) | 2018-12-05 |
| KR20150132479A (en) | 2015-11-25 |
| CA2906218A1 (en) | 2014-09-18 |
| IL241394B (en) | 2019-12-31 |
| IL241394A0 (en) | 2015-11-30 |
| EP2971105A1 (en) | 2016-01-20 |
| JP2016512685A (en) | 2016-05-09 |
| SG11201506991VA (en) | 2015-10-29 |
| AU2014232314B2 (en) | 2020-05-14 |
| CN105452483B (en) | 2019-01-11 |
| EP2971105B1 (en) | 2018-08-01 |
| AU2014232314A1 (en) | 2015-09-17 |
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| GB201309132D0 (en) | Regulatable gene expression | |
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