SG10201706428XA - Charge-balanced imaging agents - Google Patents

Charge-balanced imaging agents

Info

Publication number
SG10201706428XA
SG10201706428XA SG10201706428XA SG10201706428XA SG10201706428XA SG 10201706428X A SG10201706428X A SG 10201706428XA SG 10201706428X A SG10201706428X A SG 10201706428XA SG 10201706428X A SG10201706428X A SG 10201706428XA SG 10201706428X A SG10201706428X A SG 10201706428XA
Authority
SG
Singapore
Prior art keywords
charge
imaging agents
balanced imaging
balanced
agents
Prior art date
Application number
SG10201706428XA
Inventor
John V Frangioni
M Henary Maged
Original Assignee
Beth Israel Deaconess Medical Ct Inc
Univ Georgia State Res Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Ct Inc, Univ Georgia State Res Found Inc filed Critical Beth Israel Deaconess Medical Ct Inc
Publication of SG10201706428XA publication Critical patent/SG10201706428XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D255/00Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201706428XA 2009-02-06 2010-02-05 Charge-balanced imaging agents SG10201706428XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15052209P 2009-02-06 2009-02-06

Publications (1)

Publication Number Publication Date
SG10201706428XA true SG10201706428XA (en) 2017-09-28

Family

ID=42542392

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201706428XA SG10201706428XA (en) 2009-02-06 2010-02-05 Charge-balanced imaging agents
SG2011056611A SG173567A1 (en) 2009-02-06 2010-02-05 Charge-balanced imaging agents
SG2014009146A SG2014009146A (en) 2009-02-06 2010-02-05 Charge-balanced imaging agents

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG2011056611A SG173567A1 (en) 2009-02-06 2010-02-05 Charge-balanced imaging agents
SG2014009146A SG2014009146A (en) 2009-02-06 2010-02-05 Charge-balanced imaging agents

Country Status (7)

Country Link
US (4) US9023611B2 (en)
EP (1) EP2393420B1 (en)
JP (2) JP5798043B2 (en)
AU (3) AU2010210547B2 (en)
ES (1) ES2684697T3 (en)
SG (3) SG10201706428XA (en)
WO (1) WO2010091243A1 (en)

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US10493169B2 (en) 2009-02-06 2019-12-03 Beth Israel Deaconess Medical Center Use of charge-balanced imaging agents for determining renal function
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
EP2806781B1 (en) 2012-01-23 2018-03-21 Washington University Goggle imaging systems and methods
WO2015064786A1 (en) * 2013-10-31 2015-05-07 주식회사 디케이씨코포레이션 Cyanine dye for labeling biomolecules and method for preparing same
ES2929194T3 (en) 2013-10-31 2022-11-25 Beth Israel Deaconess Medical Ct Inc Near-Infrared Fluorescent Contrast Bioimaging Agents and Methods of Using Them
WO2015066296A1 (en) 2013-10-31 2015-05-07 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
AR102743A1 (en) 2014-11-26 2017-03-22 Li Cor Inc CONTRAST MEANS GO FOR FLUORESCENCE IMAGES
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
CN105111773B (en) * 2015-08-19 2017-06-27 大连理工大学 One class amino cyanine fluorochrome and its preparation method and application
US9808538B2 (en) * 2015-09-09 2017-11-07 On Target Laboratories, LLC PSMA-targeted NIR dyes and their uses
US10405753B2 (en) * 2015-11-10 2019-09-10 Intuitive Surgical Operations, Inc. Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes
US20170296679A1 (en) 2016-04-18 2017-10-19 Intuitive Surgical Operations, Inc. Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands
US10758631B2 (en) 2017-04-11 2020-09-01 Li-Cor, Inc. Solid cyanine dyes
CN107266929B (en) * 2017-06-21 2019-10-29 四川大学 One kind is using Cyanine Dyes Fluorescence group as near infrared fluorescent dye of precursor skeleton structure and the preparation method and application thereof
KR102132885B1 (en) * 2018-09-03 2020-07-10 (주)씨바이오멕스 Zwitterionic fluorescent material linkable to biomolecular material
KR102034113B1 (en) * 2019-06-13 2019-10-18 나우비젼 주식회사 Renal clearable tumor-specific fluorophores and their imaging methods
WO2021049920A1 (en) * 2019-09-11 2021-03-18 (주) 테라베스트 Surface-modified extracellular vesicle and composition comprising same
WO2021119423A1 (en) 2019-12-13 2021-06-17 Washington University Near infrared fluorescent dyes, formulations and related methods
CN111004307B (en) * 2019-12-24 2022-09-13 中山大学 Indocyanine green compound for treating early brain glioma as well as preparation method and application thereof
CN115397923A (en) * 2020-04-24 2022-11-25 富士胶片株式会社 Compound and labeled biological substance using same
US11964965B2 (en) * 2020-05-08 2024-04-23 On Target Laboratories, LLC Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
WO2022258455A1 (en) * 2021-06-07 2022-12-15 Surgvision Gmbh Stable liquid phantom for near-infrared fluorescence verification
WO2022265043A1 (en) * 2021-06-18 2022-12-22 富士フイルム株式会社 Compound and labeled biomaterial using same
WO2023147196A2 (en) * 2022-01-31 2023-08-03 The General Hospital Corporation Ph-sensitive fluorophores
CN114214061B (en) * 2022-02-22 2022-05-17 北京大学 Polyethylene glycol modified zwitterionic fluorescent probe, preparation and application thereof

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Also Published As

Publication number Publication date
AU2016208387B2 (en) 2018-03-15
EP2393420A4 (en) 2015-10-21
JP2016040247A (en) 2016-03-24
US10201621B2 (en) 2019-02-12
JP2012517436A (en) 2012-08-02
JP6078122B2 (en) 2017-02-08
AU2018201540B2 (en) 2020-01-16
US10478512B2 (en) 2019-11-19
US20170290927A1 (en) 2017-10-12
EP2393420A1 (en) 2011-12-14
EP2393420B1 (en) 2018-05-30
US20180177896A1 (en) 2018-06-28
US9687567B2 (en) 2017-06-27
SG173567A1 (en) 2011-09-29
US9023611B2 (en) 2015-05-05
ES2684697T3 (en) 2018-10-04
US20120028291A1 (en) 2012-02-02
AU2010210547A1 (en) 2011-09-22
JP5798043B2 (en) 2015-10-21
AU2010210547B2 (en) 2016-08-18
US20150209451A1 (en) 2015-07-30
SG2014009146A (en) 2014-05-29
WO2010091243A1 (en) 2010-08-12
AU2016208387A1 (en) 2016-08-18
AU2018201540A1 (en) 2018-03-22

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