SG10201705189XA - INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES - Google Patents

INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES

Info

Publication number
SG10201705189XA
SG10201705189XA SG10201705189XA SG10201705189XA SG10201705189XA SG 10201705189X A SG10201705189X A SG 10201705189XA SG 10201705189X A SG10201705189X A SG 10201705189XA SG 10201705189X A SG10201705189X A SG 10201705189XA SG 10201705189X A SG10201705189X A SG 10201705189XA
Authority
SG
Singapore
Prior art keywords
factor
inhibition
derivatives
pathway inhibitor
tissue
Prior art date
Application number
SG10201705189XA
Inventor
Genmin Lu
Uma Sinha
Mark Karbarz
Anjali Pandey
Pamela B Conley
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of SG10201705189XA publication Critical patent/SG10201705189XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG10201705189XA 2013-01-24 2013-03-13 INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES SG10201705189XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361756359P 2013-01-24 2013-01-24

Publications (1)

Publication Number Publication Date
SG10201705189XA true SG10201705189XA (en) 2017-07-28

Family

ID=47997935

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201505627RA SG11201505627RA (en) 2013-01-24 2013-03-13 INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES
SG10201705189XA SG10201705189XA (en) 2013-01-24 2013-03-13 INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201505627RA SG11201505627RA (en) 2013-01-24 2013-03-13 INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES

Country Status (9)

Country Link
US (3) US20150352194A1 (en)
EP (1) EP2948168B1 (en)
CN (1) CN105025920A (en)
AU (1) AU2013375294B2 (en)
CA (1) CA2898975C (en)
HK (1) HK1217657A1 (en)
IL (1) IL240063B (en)
SG (2) SG11201505627RA (en)
WO (1) WO2014116275A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102373215B1 (en) 2016-06-17 2022-03-10 포톨라 파마슈티컬스, 인코포레이티드 Preparation of Factor Xa Derivatives
FR3064917A1 (en) * 2017-04-07 2018-10-12 Universite Grenoble Alpes X MUTE FACTOR
EP4270010A1 (en) * 2020-12-28 2023-11-01 Fujimori Kogyo Co., Ltd. Method for evaluating blood coagulation performance, and method for inspecting risk of thrombosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL151857A0 (en) * 2000-03-22 2003-04-10 Octagene Gmbh Production of recombinant blood clotting factors in human cell lines
HUE052423T2 (en) * 2007-09-28 2021-04-28 Alexion Pharma Inc Antidotes for factor xa inhibitors and methods of using the same
MX2011004907A (en) * 2008-11-14 2011-07-29 Portola Pharm Inc Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents.
WO2010117729A1 (en) * 2009-03-30 2010-10-14 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP6163304B2 (en) * 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド Unit dose formulations of factor Xa inhibitor antidote and methods of use thereof
FR2972114B1 (en) * 2011-03-01 2013-03-15 Univ Grenoble 1 A NEW MOLECULAR LURE PROCOAGULANT FOR THE TREATMENT OF HEMOPHILS A OR B WITH OR WITHOUT INHIBITOR
KR102373215B1 (en) * 2016-06-17 2022-03-10 포톨라 파마슈티컬스, 인코포레이티드 Preparation of Factor Xa Derivatives

Also Published As

Publication number Publication date
EP2948168B1 (en) 2018-07-18
IL240063B (en) 2020-03-31
HK1217657A1 (en) 2017-01-20
CN105025920A (en) 2015-11-04
EP2948168A1 (en) 2015-12-02
US20150352194A1 (en) 2015-12-10
US20210379163A1 (en) 2021-12-09
AU2013375294B2 (en) 2018-08-09
US20180333469A1 (en) 2018-11-22
AU2013375294A1 (en) 2015-08-27
CA2898975A1 (en) 2014-07-31
SG11201505627RA (en) 2015-08-28
WO2014116275A1 (en) 2014-07-31
IL240063A0 (en) 2015-09-24
CA2898975C (en) 2021-06-15

Similar Documents

Publication Publication Date Title
HK1212691A1 (en) Inhibitors of the kynurenine pathway
IL279682A (en) Benzoquinolone inhibitors of vmat2
SMT201600135B (en) NEW INHIBITORS OF THE S-NITROSOGLUTATION RIDUTTASI
HUE057851T2 (en) Inhibitors of plasma kallikrein
HUE14755117T2 (en) Inhibitors of plasma kallikrein
HK1215262A1 (en) Pro-drug antibodies against tissue factor pathway inhibitor
HRP20181710T1 (en) Use of benzimidazole-proline derivatives
HK1215196A1 (en) Compositions and methods for counteracting factor xa inhibition xa
EP3036226A4 (en) Inhibitors of human 12/15-lipoxygenase
EP3632467C0 (en) Inhibitors of complement factor h
HK1222339A1 (en) Inhibitors of metallo-ss-lactamase-enzymes --
HK1221645A1 (en) Benzoquinolone inhibitors of vmat2 vmat2
EP2961403A4 (en) Heterocyclic inhibitors of the sodium channel
IL240763B (en) Halogenopyrazoles as inhibitors of therombin
HK1217657A1 (en) Inhibition of tissue factor pathway inhibitor with factor xa derivatives xa
HK1226072A1 (en) 2-benzoylaminobenzamide derivatives as bcl-3 inhibitors
GB201323021D0 (en) Use of kinase inhibitors
GB201321227D0 (en) Use of kinase inhibitors
AU2013902317A0 (en) Inhibition of periodontopathogenic bacteria
GB201322036D0 (en) New therapeutic uses of enzyme inhibitors
GB201310488D0 (en) New therapeutic uses of enzyme inhibitors