SG10201704214VA - Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases - Google Patents
Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseasesInfo
- Publication number
- SG10201704214VA SG10201704214VA SG10201704214VA SG10201704214VA SG10201704214VA SG 10201704214V A SG10201704214V A SG 10201704214VA SG 10201704214V A SG10201704214V A SG 10201704214VA SG 10201704214V A SG10201704214V A SG 10201704214VA SG 10201704214V A SG10201704214V A SG 10201704214VA
- Authority
- SG
- Singapore
- Prior art keywords
- oncology
- antibodies
- extended
- life
- treatment
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14810609P | 2009-01-29 | 2009-01-29 | |
US18418209P | 2009-06-04 | 2009-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201704214VA true SG10201704214VA (en) | 2017-06-29 |
Family
ID=42396023
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201704214VA SG10201704214VA (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
SG2014007637A SG2014007637A (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
SG2011046265A SG172354A1 (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2014007637A SG2014007637A (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
SG2011046265A SG172354A1 (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120034212A1 (en) |
EP (1) | EP2391384A4 (en) |
JP (3) | JP2012516158A (en) |
KR (1) | KR20110108398A (en) |
CN (2) | CN102387814A (en) |
AU (1) | AU2010208125B2 (en) |
BR (1) | BRPI1007005A2 (en) |
CA (1) | CA2749200A1 (en) |
HK (1) | HK1201847A1 (en) |
MX (1) | MX337590B (en) |
RU (2) | RU2650594C1 (en) |
SG (3) | SG10201704214VA (en) |
WO (1) | WO2010088444A1 (en) |
ZA (2) | ZA201104796B (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
SG10201704214VA (en) * | 2009-01-29 | 2017-06-29 | Medimmune Llc | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US20120244158A1 (en) * | 2009-09-03 | 2012-09-27 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
JP6173911B2 (en) * | 2010-09-10 | 2017-08-09 | メディミューン リミテド | Antibody derivatives |
EP2654790B1 (en) * | 2010-12-22 | 2019-02-06 | Teva Pharmaceuticals Australia Pty Ltd | Modified antibody with improved half-life |
SI3489255T1 (en) * | 2011-02-10 | 2021-11-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
WO2012118813A2 (en) | 2011-03-03 | 2012-09-07 | Apexigen, Inc. | Anti-il-6 receptor antibodies and methods of use |
EA201892619A1 (en) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS |
US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
BR112014007687B1 (en) | 2011-09-30 | 2022-12-06 | Chugai Seiyaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION OF ANTIBODIES FOR ELIMINATING ANTIGENS IN PLASMA |
CA2850322C (en) | 2011-09-30 | 2023-10-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
SG11201405137QA (en) | 2012-02-24 | 2014-12-30 | Chugai Pharmaceutical Co Ltd | ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB |
WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
EP2722341B1 (en) | 2012-10-22 | 2017-12-06 | Fountain Biopharma Inc. | Antibodies to interleukin-6 and uses thereof |
BR112015008186A2 (en) * | 2012-10-25 | 2017-09-19 | Medimmune Llc | formulation of a stable, low viscosity antibody |
US10772940B1 (en) * | 2012-12-11 | 2020-09-15 | University Of Kentucky Research Foundation | Cocaine hydrolase-FC fusion proteins for ***e and methods for utilizing the same |
FR2999431B1 (en) * | 2012-12-17 | 2016-03-18 | Lfb Biotechnologies | USE OF MONOCLONAL ANTIBODIES FOR THE TREATMENT OF INFLAMMATION AND BACTERIAL INFECTIONS |
WO2014096672A1 (en) * | 2012-12-17 | 2014-06-26 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Use of monoclonal antibodies for the treatment of inflammation and bacterial infections |
BR112016009460B1 (en) * | 2013-10-31 | 2020-09-29 | Regeneron Pharmaceuticals, Inc. | METHOD FOR DETECTING THE PRESENCE OF NEUTRALIZING ANTIBODIES |
TWI713453B (en) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | Interferon alpha and omega antibody antagonists |
PE20171107A1 (en) | 2014-11-07 | 2017-08-07 | Eleven Biotherapeutics Inc | IMPROVED ANTIBODIES AGAINST IL-6 |
CN113117074A (en) | 2015-07-31 | 2021-07-16 | 米迪缪尼有限公司 | Methods for treating hepcidin-mediated disorders |
MX2018010032A (en) * | 2016-02-23 | 2019-03-11 | Sesen Bio Inc | Il-6 antagonist formulations and uses thereof. |
JP2019519470A (en) * | 2016-04-07 | 2019-07-11 | ヤンセン バイオテツク,インコーポレーテツド | Treatment of depression with agents that block IL-6 binding to the IL-6 receptor |
JP2020506190A (en) * | 2017-02-01 | 2020-02-27 | イェール ユニバーシティーYale University | Treatment of diuretic resistance |
KR20200116089A (en) * | 2018-01-05 | 2020-10-08 | 코비디아 테라퓨틱스, 인크. | Methods for treating IL-6 mediated inflammation without immunosuppression |
EP3840838A2 (en) | 2018-07-24 | 2021-06-30 | MedImmune, LLC | Antibody directed against s.aureus clumping factor a (clfa) |
AU2019357983A1 (en) | 2018-10-09 | 2021-05-27 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
BR112021006704A2 (en) | 2018-10-09 | 2021-08-10 | Medimmune, Llc | antibodies directed against staphylococcus aureus leukotoxins |
JP2022524420A (en) | 2019-03-13 | 2022-05-02 | メディミューン,エルエルシー | Reduction of Staphylococcus aureus infections in colonized patients |
EP3962942A1 (en) | 2019-05-01 | 2022-03-09 | Novo Nordisk A/S | Anti-il-6 antibody formulation |
CN111057152B (en) * | 2019-12-11 | 2022-03-11 | 中国人民解放军第四军医大学 | Anti-human IL-6Ra monoclonal antibody and application thereof |
JP2023508592A (en) * | 2019-12-31 | 2023-03-02 | ペプチノフ | Pharmaceutical composition for preventing or treating postoperative pain |
WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
CN115697491A (en) | 2020-05-17 | 2023-02-03 | 阿斯利康(英国)有限公司 | SARS-COV-2 antibodies and methods of selection and use thereof |
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WO2008086395A2 (en) * | 2007-01-09 | 2008-07-17 | Wyeth | Anti-il-13 antibody formulations and uses thereof |
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JP5513380B2 (en) * | 2007-06-25 | 2014-06-04 | アムジエン・インコーポレーテツド | Composition of specific binding agents for hepatocyte growth factor |
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SG10201704214VA (en) * | 2009-01-29 | 2017-06-29 | Medimmune Llc | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
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2010
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- 2010-01-29 CN CN2010800103915A patent/CN102387814A/en active Pending
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- 2010-01-29 CN CN201410349897.9A patent/CN104119438A/en active Pending
- 2010-01-29 CA CA2749200A patent/CA2749200A1/en not_active Abandoned
- 2010-01-29 BR BRPI1007005A patent/BRPI1007005A2/en not_active Application Discontinuation
- 2010-01-29 SG SG2014007637A patent/SG2014007637A/en unknown
- 2010-01-29 MX MX2011007832A patent/MX337590B/en active IP Right Grant
- 2010-01-29 AU AU2010208125A patent/AU2010208125B2/en active Active
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- 2010-01-29 RU RU2015150249A patent/RU2650594C1/en active
- 2010-01-29 KR KR1020117019221A patent/KR20110108398A/en not_active Application Discontinuation
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2011
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CN102387814A (en) | 2012-03-21 |
MX337590B (en) | 2016-03-11 |
AU2010208125A1 (en) | 2011-07-21 |
KR20110108398A (en) | 2011-10-05 |
HK1201847A1 (en) | 2015-09-11 |
MX2011007832A (en) | 2011-10-06 |
EP2391384A4 (en) | 2012-12-26 |
WO2010088444A1 (en) | 2010-08-05 |
CA2749200A1 (en) | 2010-08-05 |
EP2391384A1 (en) | 2011-12-07 |
JP2012516158A (en) | 2012-07-19 |
CN104119438A (en) | 2014-10-29 |
SG2014007637A (en) | 2014-03-28 |
ZA201207249B (en) | 2013-08-28 |
US20120034212A1 (en) | 2012-02-09 |
JP2017206519A (en) | 2017-11-24 |
US20140302058A1 (en) | 2014-10-09 |
US20170101468A1 (en) | 2017-04-13 |
SG172354A1 (en) | 2011-07-28 |
RU2650594C1 (en) | 2018-04-17 |
ZA201104796B (en) | 2018-11-28 |
AU2010208125B2 (en) | 2015-02-12 |
RU2011135422A (en) | 2013-03-10 |
BRPI1007005A2 (en) | 2016-03-22 |
JP2016019517A (en) | 2016-02-04 |
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